LOCUS       NM_013821               1821 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
            steroid delta-isomerase 6 (Hsd3b6), mRNA.
ACCESSION   NM_013821
VERSION     NM_013821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Aksel,S., Cao,M., Derpinghaus,A., Baskin,L.S. and Cunha,G.R.
  TITLE     Ontogeny of mouse Sertoli, Leydig and peritubular myoid cells from
            embryonic day 10 to adulthood
  JOURNAL   Differentiation 129, 96-108 (2023)
   PUBMED   35317954
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Sasaki,L., Hamada,Y., Yarimizu,D., Suzuki,T., Nakamura,H.,
            Shimada,A., Pham,K.T.N., Shao,X., Yamamura,K., Inatomi,T.,
            Morinaga,H., Nishimura,E.K., Kudo,F., Manabe,I., Haraguchi,S.,
            Sugiura,Y., Suematsu,M., Kinoshita,S., Machida,M., Nakajima,T.,
            Kiyonari,H., Okamura,H., Yamaguchi,Y., Miyake,T. and Doi,M.
  TITLE     Intracrine activity involving NAD-dependent circadian steroidogenic
            activity governs age-associated meibomian gland dysfunction
  JOURNAL   Nat Aging 2 (2), 105-114 (2022)
   PUBMED   37117756
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Scovell,J.M., Bournat,J.C., Szafran,A.T., Solis,M., Moore,J.,
            Rivera,A., Chen,C.H., Zhang,J., Wilken,N., Seth,A. and Jorgez,C.J.
  TITLE     PRSS50 is a testis protease responsible for proper sperm tail
            formation and function
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33913480
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Peng,L. and Payne,A.H.
  TITLE     AP-2 gamma and the homeodomain protein distal-less 3 are required
            for placental-specific expression of the murine 3
            beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6
  JOURNAL   J Biol Chem 277 (10), 7945-7954 (2002)
   PUBMED   11773066
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Baker,P.J., Sha,J.A., McBride,M.W., Peng,L., Payne,A.H. and
            O'Shaughnessy,P.J.
  TITLE     Expression of 3beta-hydroxysteroid dehydrogenase type I and type VI
            isoforms in the mouse testis during development
  JOURNAL   Eur J Biochem 260 (3), 911-917 (1999)
   PUBMED   10103023
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   O'Shaughnessy,P.J., Baker,P., Sohnius,U., Haavisto,A.M.,
            Charlton,H.M. and Huhtaniemi,I.
  TITLE     Fetal development of Leydig cell activity in the mouse is
            independent of pituitary gonadotroph function
  JOURNAL   Endocrinology 139 (3), 1141-1146 (1998)
   PUBMED   9492048
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Abbaszade,I.G., Arensburg,J., Park,C.H., Kasa-Vubu,J.Z., Orly,J.
            and Payne,A.H.
  TITLE     Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase
            isoform, 3beta-HSD VI, expressed during early pregnancy
  JOURNAL   Endocrinology 138 (4), 1392-1399 (1997)
   PUBMED   9075693
  REMARK    Erratum:[Endocrinology 1998 Jan;139(1):218]
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Clarke,T.R., Bain,P.A., Burmeister,M. and Payne,A.H.
  TITLE     Isolation and characterization of several members of the murine
            Hsd3b gene family
  JOURNAL   DNA Cell Biol 15 (5), 387-399 (1996)
   PUBMED   8924213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142267.1 and BC053501.1.
            
            On Dec 14, 2007 this sequence version replaced NM_013821.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053501.1, AK142267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1799              AK142267.1         3-1801
            1800-1821           BC053501.1         1786-1807
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.88 cM"
     gene            1..1821
                     /gene="Hsd3b6"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 6"
                     /db_xref="GeneID:15497"
                     /db_xref="MGI:MGI:109598"
     exon            1..262
                     /gene="Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
     exon            263..469
                     /gene="Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1446
                     /gene="Hsd3b6"
                     /EC_number="1.1.1.145"
                     /EC_number="5.3.3.1"
                     /note="3-beta-HSD VI; 3 beta-hydroxysteroid
                     dehydrogenase/Delta 5-->4-isomerase type VI;
                     hydroxysteroid dehydrogenase-6, delta<5>-3-beta; 3beta-HSD
                     VI; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 6 pseudogene"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type 6"
                     /protein_id="NP_038849.2"
                     /db_xref="CCDS:CCDS17669.1"
                     /db_xref="GeneID:15497"
                     /db_xref="MGI:MGI:109598"
                     /translation="MPGWSCLVTGAGGFLGQRIVQLLMQEKDLEEIRVLDKFFRPETR
                     EQFFNLDTNIKVTVLEGDILDTQYLRKACQGISVVIHTAAVIDVTGVIPRQTILDVNL
                     KGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKEIILNGNEEEHHESIWSDPYPYSKK
                     MAEKAVLAANGSMLKIGGTLHTCALRPMYIYGERSPFISNTIITALKNKNILGCTGKF
                     STANPVYVGNVAWAHILAARGLRDPKKSPNIQGEFYYISDDTPHQSYDDLNYTLSKEW
                     GFCPDSSWSLPVPLLYWLAFMLETVSFLLSPIYRFIPPFNRHLVTLTGSTFTFSYKKA
                     QRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ"
     exon            470..634
                     /gene="Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1802
                     /gene="Hsd3b6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1780..1785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd3b6"
                     /note="hexamer: AATAAA"
     polyA_site      1802
                     /gene="Hsd3b6"
                     /note="major polyA site"
ORIGIN      
        1 gacaccgtgc tggctttgct tccccctctc atctgagttg actggcagtg ctgctgctgc
       61 tgctgctgct gctgctgctg ctgctgctgc tgctgctact actgcttctg ctgctgctgc
      121 tgctggttcc tttgcagaga tcagaaccag ccattccaag cttgtatcac cgtggactag
      181 ggaccagctg ggatacagaa accatccttc cacagttcta gctccagact gggactgctg
      241 acaccccaca ccttgtggct gaccatctcc agggtcactg tacattaatc tcacaccaac
      301 tgtgatctgc ttcctgtgtt gaccatgcct gggtggagct gcctggtaac tggagcagga
      361 gggtttttgg gccagaggat tgtccagttg ttgatgcagg agaaagatct ggaggagatc
      421 agggtcctgg acaagttctt cagaccagaa accagggagc aattcttcaa cctagataca
      481 aacatcaagg tgacagtgtt ggaaggagac attcttgaca cccagtacct gaggaaagcc
      541 tgccagggca tctctgttgt tatccacact gcagctgtca ttgatgtcac aggtgtcatt
      601 cccaggcaga ccatcctaga tgtcaatctg aaaggtaccc agaacttatt ggaggcctgt
      661 atccaagcca gtgttccagc cttcatcttc tccagctcag ttgatgttgc agggcccaac
      721 tcatacaagg agataatcct gaatggcaac gaggaagagc atcatgaaag catatggtct
      781 gatccatacc catacagcaa aaagatggct gagaaggcag tgctggcagc caatgggagc
      841 atgctgaaaa ttggtggcac tttgcatact tgtgcattaa ggcccatgta tatttatggg
      901 gagagaagtc cattcatttc taacacaata attacggccc tcaaaaataa gaatattctc
      961 ggttgtacgg gcaaattctc cacagccaac ccagtatatg tgggtaatgt agcctgggca
     1021 cacattctgg ctgccagggg ccttcgagac cccaaaaagt caccaaatat ccaaggagag
     1081 ttctactaca tctcagatga cacccctcac caaagctatg atgatttaaa ttacaccctg
     1141 agcaaggagt ggggcttctg ccctgattcc agctggagcc ttcctgtgcc cctactgtac
     1201 tggcttgcat tcatgctgga aactgtgagc ttcctgctga gtccaatcta cagatttata
     1261 cctcccttta accgccactt ggtcacactg acaggtagca cgttcacttt ctcctacaag
     1321 aaagctcagc gagatctggg ctatgagcca cttgtcagct gggaggaagc caagcagaaa
     1381 acctcagagt ggatcgggac actagtggag cagcacaggg agacactgga cacaaagtct
     1441 cagtgatggg aagagggtgg agacatggct ctgggtgtta ccaggtcctc cagtaaggac
     1501 aaaagcacaa cacaggtgct gctgccttct tttgacacag aggccaattt agtgccttaa
     1561 tcaagtcacc aaagccttgc cagtcactga cccagccaca agccttcttt ctgaaatacc
     1621 tccccaaaga cacacaggca tctgtgcccc agctcctggg tccaagcctc tcagcacctc
     1681 ttgtacctca gagctctctc cattattttc tctccccatt cagagcatgt atagccttca
     1741 gaaaattcta cttgctttat gaaacccaat ggaagaaaca ataaatactt gtcaatacct
     1801 caaaaaaaaa aaaaaaaaaa a
//
