LOCUS       NM_008295               1607 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
            steroid delta-isomerase 5 (Hsd3b5), mRNA.
ACCESSION   NM_008295 XM_981158 XM_981199 XM_981232 XM_981264
VERSION     NM_008295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Bochkis,I.M., Schug,J., Ye,D.Z., Kurinna,S., Stratton,S.A.,
            Barton,M.C. and Kaestner,K.H.
  TITLE     Genome-wide location analysis reveals distinct transcriptional
            circuitry by paralogous regulators Foxa1 and Foxa2
  JOURNAL   PLoS Genet 8 (6), e1002770 (2012)
   PUBMED   22737085
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Hu,P., Zhang,M. and Napoli,J.L.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim Biophys Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Suraweera,N., Haines,J., McCart,A., Rogers,P., Latchford,A.,
            Coster,M., Polanco-Echeverry,G., Guenther,T., Wang,J., Sieber,O.,
            Tomlinson,I. and Silver,A.
  TITLE     Genetic determinants modulate susceptibility to
            pregnancy-associated tumourigenesis in a recombinant line of Min
            mice
  JOURNAL   Hum Mol Genet 15 (23), 3429-3435 (2006)
   PUBMED   17062636
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1607)
  AUTHORS   Abbaszade,I.G., Arensburg,J., Park,C.H., Kasa-Vubu,J.Z., Orly,J.
            and Payne,A.H.
  TITLE     Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase
            isoform, 3beta-HSD VI, expressed during early pregnancy
  JOURNAL   Endocrinology 138 (4), 1392-1399 (1997)
   PUBMED   9075693
  REMARK    Erratum:[Endocrinology 1998 Jan;139(1):218]
REFERENCE   8  (bases 1 to 1607)
  AUTHORS   Park,C.H., Abbaszade,I.G. and Payne,A.H.
  TITLE     Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase
            in the mouse liver during fetal and postnatal development
  JOURNAL   Mol Cell Endocrinol 116 (2), 157-164 (1996)
   PUBMED   8647315
REFERENCE   9  (bases 1 to 1607)
  AUTHORS   Abbaszade,I.G., Clarke,T.R., Park,C.H. and Payne,A.H.
  TITLE     The mouse 3 beta-hydroxysteroid dehydrogenase multigene family
            includes two functionally distinct groups of proteins
  JOURNAL   Mol Endocrinol 9 (9), 1214-1222 (1995)
   PUBMED   7491113
REFERENCE   10 (bases 1 to 1607)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097811.1, AC122044.3 and BY460328.1.
            
            On Aug 31, 2006 this sequence version replaced NM_008295.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012715.1, BI328950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               BY097811.1         84-385
            303-424             AC122044.3         49831-49952         c
            425-1380            AC122044.3         46691-47646         c
            1381-1607           BY460328.1         241-467
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.82 cM"
     gene            1..1607
                     /gene="Hsd3b5"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 5"
                     /db_xref="GeneID:15496"
                     /db_xref="MGI:MGI:104645"
     exon            1..62
                     /gene="Hsd3b5"
                     /inference="alignment:Splign:2.1.0"
     exon            63..259
                     /gene="Hsd3b5"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1236
                     /gene="Hsd3b5"
                     /EC_number="1.1.1.270"
                     /EC_number="1.1.1.210"
                     /note="3 beta-hydroxysteroid dehydrogenase type 5;
                     3-beta-HSD V; progesterone reductase; 3
                     beta-hydroxysteroid dehydrogenase type V;
                     3-beta-hydroxy-5-ene steroid dehydrogenase;
                     NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid
                     dehydrogenase; hydroxysteroid dehydrogenase-5,
                     delta<5>-3-beta; 3(beta)HSDV; dihydrotestosterone
                     3-ketoreductase"
                     /codon_start=1
                     /product="NADPH-dependent 3-keto-steroid reductase Hsd3b5"
                     /protein_id="NP_032321.2"
                     /db_xref="CCDS:CCDS17666.1"
                     /db_xref="GeneID:15496"
                     /db_xref="MGI:MGI:104645"
                     /translation="MPGWSCLVTGAGGFLGQRIVRMLVQEEELQEIRALFRTFGRKHE
                     EELSKLQTKAKVRVLKGDILDAQCLKRACQGMSAVIHTAAAIDPLGAASRQTILDVNL
                     KGTQLLLDACVEASVPTFIYSSSVLVAGPNSYKEIILNAHEEEHRESTWPNPYPYSKR
                     MAEKAVLATNGRLLKNGGTLHTCALRLPFIYGEECQVTSTTVKTALKNNSIIKKNATF
                     SIANPVYVGNAAWAHILAARSLQDPKKSPSIQGQFYYISDNTPHQSYDDLNYTLSKEW
                     GLCLDSGWSLPLSLLYWLAFLLETVSFLLRPVYNYRPPFNRLLITVLNSVFTISYKKA
                     QRDLGYQPLVSWEEAKQKTSEWIGTLVKQHRETLHKKSQ"
     exon            260..424
                     /gene="Hsd3b5"
                     /inference="alignment:Splign:2.1.0"
     exon            425..1607
                     /gene="Hsd3b5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatccagat caagaaggga actgtgcctg ccttcaggat ctaaagctct tggaaacaaa
       61 aggaacactt tatatcacat ctatatcctc aactatctga ttcctgtgtt gaacatgcct
      121 ggatggagct gcctggtgac aggagcagga gggtttcttg gccagaggat tgtccgaatg
      181 ttggtgcagg aggaagagtt gcaggagatc agagccctgt tcaggacctt cggtcgaaaa
      241 catgaagagg aattgtccaa gctgcagaca aaggccaagg tgagagtact gaagggagac
      301 attctggatg cccaatgcct gaagagagcc tgccagggca tgtctgctgt catccacacc
      361 gctgctgcta ttgaccccct tggtgccgct tccagacaga ccatcctaga tgtcaatctg
      421 aaaggtactc agctcctact ggatgcttgt gtggaagcca gtgtgccaac attcatctac
      481 agcagctcag tgcttgtggc tggaccaaat tcctacaagg agatcatcct gaatgcccat
      541 gaggaagagc atcgtgaaag cacatggcct aacccatacc catacagcaa aaggatggct
      601 gagaaggcag tgctggcaac aaatgggaga ctcctgaaaa atggtggcac tttgcatact
      661 tgtgccttaa gactcccttt catctatggg gaagaatgcc aagtcacttc aaccactgtg
      721 aaaacagcac tgaagaacaa cagcataatt aagaaaaatg ccacattctc catcgccaac
      781 ccagtgtatg tgggcaatgc agcctgggct cacattctgg ctgccaggag cctacaggac
      841 cccaagaagt ccccaagcat ccaaggacag ttctattaca tctctgataa cacccctcac
      901 caaagctatg atgatttaaa ttacaccctg agcaaggagt ggggcctctg ccttgattct
      961 ggctggagcc ttcctctgtc cctgctttac tggcttgcct tcctgctgga aactgtgagc
     1021 ttcctgctac gtccagttta caactatagg ccacccttta accgcctctt gatcacagtg
     1081 ctaaatagcg tgtttaccat ttcctataag aaagctcagc gcgatctagg ctatcagcca
     1141 cttgtcagct gggaggaagc caagcaaaaa acctcagagt ggattggaac actagtgaag
     1201 cagcacaggg agacactaca caaaaagtca cagtgatatg tggagggcga ggacatggcc
     1261 ctgggtgtta tcaggtcctc cagagaggga cttagaaaca actcaactct tatcaattcc
     1321 attttatgca ctgtccaact tgtctttggg tcactagcaa ccttgcaagt cactggccca
     1381 gtcacacacc atcagtccta agcacttgcc cagtaatgca caggctgttg tgactcagct
     1441 gctgtgaccc aagaatctgt ggctggtact gaattgcctg gaacctcttg taggtagaat
     1501 ttcctcagga cttccacatc tcccttccat gtgccaaagc atttcttgtc ttggaacatt
     1561 ttgatacctt tatgaagctc aaagaacaat aaaatctttt aatgctt
//
