LOCUS       NM_008294               1673 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
            steroid delta-isomerase 4 (Hsd3b4), transcript variant 2, mRNA.
ACCESSION   NM_008294 XM_907091
VERSION     NM_008294.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1673)
  AUTHORS   Fujimoto,Y., Tanaka,S.S., Yamaguchi,Y.L., Kobayashi,H., Kuroki,S.,
            Tachibana,M., Shinomura,M., Kanai,Y., Morohashi,K., Kawakami,K. and
            Nishinakamura,R.
  TITLE     Homeoproteins Six1 and Six4 regulate male sex determination and
            mouse gonadal development
  JOURNAL   Dev Cell 26 (4), 416-430 (2013)
   PUBMED   23987514
REFERENCE   2  (bases 1 to 1673)
  AUTHORS   Mukhopadhyay,R., Mishra,M.K., Basu,A. and Bishayi,B.
  TITLE     Modulation of steroidogenic enzymes in murine lymphoid organs after
            immune activation
  JOURNAL   Immunol Invest 38 (1), 14-30 (2009)
   PUBMED   19172483
  REMARK    GeneRIF: present in the lymphoid organs after immunization with
            soluble antigen
REFERENCE   3  (bases 1 to 1673)
  AUTHORS   Tang,H., Brennan,J., Karl,J., Hamada,Y., Raetzman,L. and Capel,B.
  TITLE     Notch signaling maintains Leydig progenitor cells in the mouse
            testis
  JOURNAL   Development 135 (22), 3745-3753 (2008)
   PUBMED   18927153
REFERENCE   4  (bases 1 to 1673)
  AUTHORS   Valerius,M.T. and McMahon,A.P.
  TITLE     Transcriptional profiling of Wnt4 mutant mouse kidneys identifies
            genes expressed during nephron formation
  JOURNAL   Gene Expr Patterns 8 (5), 297-306 (2008)
   PUBMED   18346943
REFERENCE   5  (bases 1 to 1673)
  AUTHORS   Clarke,T.R., Bain,P.A., Burmeister,M. and Payne,A.H.
  TITLE     Isolation and characterization of several members of the murine
            Hsd3b gene family
  JOURNAL   DNA Cell Biol 15 (5), 387-399 (1996)
   PUBMED   8924213
REFERENCE   6  (bases 1 to 1673)
  AUTHORS   Park,C.H., Abbaszade,I.G. and Payne,A.H.
  TITLE     Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase
            in the mouse liver during fetal and postnatal development
  JOURNAL   Mol Cell Endocrinol 116 (2), 157-164 (1996)
   PUBMED   8647315
REFERENCE   7  (bases 1 to 1673)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   8  (bases 1 to 1673)
  AUTHORS   Clarke,T.R., Bain,P.A., Greco,T.L. and Payne,A.H.
  TITLE     A novel mouse kidney 3 beta-hydroxysteroid dehydrogenase
            complementary DNA encodes a 3-ketosteroid reductase instead of a 3
            beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase
  JOURNAL   Mol Endocrinol 7 (12), 1569-1578 (1993)
   PUBMED   8145763
REFERENCE   9  (bases 1 to 1673)
  AUTHORS   Bain,P.A., Meisler,M.H., Taylor,B.A. and Payne,A.H.
  TITLE     The genes encoding gonadal and nongonadal forms of 3
            beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are
            closely linked on mouse chromosome 3
  JOURNAL   Genomics 16 (1), 219-223 (1993)
   PUBMED   8486361
REFERENCE   10 (bases 1 to 1673)
  AUTHORS   Payne,A.H., Youngblood,G.L., Sha,L., Burgos-Trinidad,M. and
            Hammond,S.H.
  TITLE     Hormonal regulation of steroidogenic enzyme gene expression in
            Leydig cells
  JOURNAL   J Steroid Biochem Mol Biol 43 (8), 895-906 (1992)
   PUBMED   22217834
  REMARK    GeneRIF: Data suggest that newly synthesized protein(s) are
            required for cAMP induction of Hsd3b4 and CYP17 mRNA levels (but
            not of CYP11A mRNA levels). [REVIEW]
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI790807.1, BC132402.1 and AA987189.1.
            
            On Dec 14, 2007 this sequence version replaced NM_008294.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AI790807.1         1-93
            94-1590             BC132402.1         1-1497
            1591-1673           AA987189.1         1-83                c
FEATURES             Location/Qualifiers
     source          1..1673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.79 cM"
     gene            1..1673
                     /gene="Hsd3b4"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 4"
                     /db_xref="GeneID:15495"
                     /db_xref="MGI:MGI:96236"
     exon            1..115
                     /gene="Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            116..312
                     /gene="Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1289
                     /gene="Hsd3b4"
                     /EC_number="1.1.1.270"
                     /EC_number="1.1.1.210"
                     /note="3 beta-hydroxysteroid dehydrogenase 4; 3
                     beta-hydroxysteroid dehydrogenase type 4; 3-beta-HSD IV;
                     progesterone reductase; 3-beta-hydroxy-5-ene steroid
                     dehydrogenase; 3 beta-hydroxysteroid dehydrogenase type
                     IV; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid
                     dehydrogenase; 3-beta-hydroxysteroid
                     dehydrogenase/delta-5-delta-4 isomerase; hydroxysteroid
                     dehydrogenase-4, delta<5>-3-beta; dihydrotestosterone
                     3-ketoreductase"
                     /codon_start=1
                     /product="NADPH-dependent 3-keto-steroid reductase Hsd3b4"
                     /protein_id="NP_032320.1"
                     /db_xref="CCDS:CCDS17665.1"
                     /db_xref="GeneID:15495"
                     /db_xref="MGI:MGI:96236"
                     /translation="MPGWSCLVTGAGGFLGQRIVRMLVQEEELQEIRALFRTFGRKQE
                     EELSKLQTKTKVTVLKGDILDAQCLKRACQGMSAVIHTAAAIDPLGAASRQTILDVNL
                     KGTQLLLDACVEANVPTFIYSSSVLVAGPNSYKEIILNAHEEEHHESTWSNPYPYSKK
                     MAEKAVLAANGSILKNGGTLHTCALRLSFIYGEECQVTSTTVKTALKNNSIIKKNATF
                     SIANPVYVGNAAWAHILAARSLQDPKKSPSIQGQFYYITDDTPHQSYDDLKCTLSKEW
                     GLRLDTSWSLPLPLLYWLAFLLETVSFLLRPVYNYRPPFNRLLITVLNSVFTFSYKKA
                     QRDLGYEPLVSWEEAKQKTSEWIGTLVMQHREIGNKKSQ"
     exon            313..477
                     /gene="Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1665
                     /gene="Hsd3b4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctaagctt gtttgtagct gaacagttag acattactag aaactgatat atcaaacaag
       61 ggagtagaag ccttgtgcca ctttctcttt cctcagcctg tgcatcactt cctctgagta
      121 ccttatatca catctgcacc ctcaactatc tgattcctgt gttgaccatg cctgggtgga
      181 gctgcctggt gacaggagca ggagggtttc ttggccagag gattgtccga atgttggtgc
      241 aggaggaaga gctgcaggag atcagagccc tgttcaggac cttcggtcga aaacaggaag
      301 aggaattgtc caagctgcag acaaagacca aggtgacagt actgaaggga gacattctgg
      361 atgcccagtg cctgaagaga gcctgccagg gcatgtctgc tgtcatccac accgctgctg
      421 ctattgaccc ccttggtgcc gcttccagac agaccatcct agatgtcaat ctgaaaggta
      481 ctcagctcct actggatgct tgtgtggaag ccaacgtgcc aacattcatc tacagcagct
      541 cagtgcttgt ggctggacca aattcctaca aggagatcat cctgaatgcc catgaggagg
      601 agcatcatga aagcacatgg tctaacccat acccatacag caaaaagatg gctgagaagg
      661 cagtgctggc agccaatggg agcatcctga aaaatggtgg cactttgcat acttgtgcct
      721 taagactctc tttcatctat ggggaagaat gccaagtcac ttcaaccact gtgaaaacag
      781 cactgaagaa caacagcata attaagaaaa atgccacatt ctccatcgcc aacccagtgt
      841 atgtgggcaa tgcagcctgg gctcacattc tggctgccag gagcctacag gaccctaaga
      901 agtccccaag catccaagga cagttctatt acattacaga tgacacccct caccaaagct
      961 atgatgactt aaaatgcacc ctgagcaagg agtggggcct ccgccttgat accagctgga
     1021 gtcttcctct gcccctgctc tactggcttg ccttcctcct ggaaactgtg agcttcctgc
     1081 tacgtccagt ctacaactat agaccaccat ttaaccgcct cttgatcaca gtgctaaata
     1141 gtgtattcac cttctcctac aagaaggctc agcgagatct gggctatgag ccacttgtca
     1201 gctgggagga agccaagcag aaaacctcag agtggatcgg aacactagtg atgcagcaca
     1261 gggagattgg aaacaaaaag tcacagtgat atgaagaggg agaggacatg gccctgggtg
     1321 ttattaggtc ctccagaaag ggacttagaa acaatccaac tcttaacaat tccattttac
     1381 actctgtcca acttgtcttt gggtcaccag aagccttgca agtcactggc ccagttgcaa
     1441 cccttcagct ctaagcactt gtccagcaat gcacaagatg tgcctcagct gctgtgaccc
     1501 aaggataggt ggctgatagt gagttgcctg gaacctcttg taggttagaa tttcatcagg
     1561 gcttcctcat ctcctttcca tgtgccaacg catttcgtgt ctgagaaaat tcccatacct
     1621 ttatgaagct caaagaaaag aacaataaaa tcttttaatg cttaaaaaaa aaa
//
