LOCUS       NM_001161743            1716 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
            steroid delta-isomerase 3 (Hsd3b3), transcript variant 2, mRNA.
ACCESSION   NM_001161743
VERSION     NM_001161743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Suraweera,N., Haines,J., McCart,A., Rogers,P., Latchford,A.,
            Coster,M., Polanco-Echeverry,G., Guenther,T., Wang,J., Sieber,O.,
            Tomlinson,I. and Silver,A.
  TITLE     Genetic determinants modulate susceptibility to
            pregnancy-associated tumourigenesis in a recombinant line of Min
            mice
  JOURNAL   Hum Mol Genet 15 (23), 3429-3435 (2006)
   PUBMED   17062636
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Abbaszade,I.G., Arensburg,J., Park,C.H., Kasa-Vubu,J.Z., Orly,J.
            and Payne,A.H.
  TITLE     Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase
            isoform, 3beta-HSD VI, expressed during early pregnancy
  JOURNAL   Endocrinology 138 (4), 1392-1399 (1997)
   PUBMED   9075693
  REMARK    Erratum:[Endocrinology 1998 Jan;139(1):218]
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Clarke,T.R., Bain,P.A., Burmeister,M. and Payne,A.H.
  TITLE     Isolation and characterization of several members of the murine
            Hsd3b gene family
  JOURNAL   DNA Cell Biol 15 (5), 387-399 (1996)
   PUBMED   8924213
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Park,C.H., Abbaszade,I.G. and Payne,A.H.
  TITLE     Expression of multiple forms of 3 beta-hydroxysteroid dehydrogenase
            in the mouse liver during fetal and postnatal development
  JOURNAL   Mol Cell Endocrinol 116 (2), 157-164 (1996)
   PUBMED   8647315
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Bain,P.A., Meisler,M.H., Taylor,B.A. and Payne,A.H.
  TITLE     The genes encoding gonadal and nongonadal forms of 3
            beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are
            closely linked on mouse chromosome 3
  JOURNAL   Genomics 16 (1), 219-223 (1993)
   PUBMED   8486361
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Bain,P.A., Yoo,M., Clarke,T., Hammond,S.H. and Payne,A.H.
  TITLE     Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4 isomerase and differential expression in gonads, adrenal
            glands, liver, and kidneys of both sexes
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 8870-8874 (1991)
   PUBMED   1924345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606755.7.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI326497.1, AA237159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL606755.7         107172-107289       c
            119-178             AL606755.7         106455-106514       c
            179-331             AL606755.7         97472-97624         c
            332-496             AL606755.7         87984-88148         c
            497-1716            AL606755.7         85637-86856         c
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.86 cM"
     gene            1..1716
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 3"
                     /db_xref="GeneID:15494"
                     /db_xref="MGI:MGI:96235"
     exon            1..118
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            119..178
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            179..331
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1308
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /EC_number="1.1.1.145"
                     /EC_number="5.3.3.1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     3-beta-HSD III; 3 beta-hydroxysteroid dehydrogenase/delta
                     5-->4-isomerase type 3; steroid delta-isomerase;
                     delta-5-3-ketosteroid isomerase; progesterone reductase;
                     3-beta-hydroxy-5-ene steroid dehydrogenase; 3
                     beta-hydroxysteroid dehydrogenase 3; hydroxysteroid
                     dehydrogenase-2, delta<5>-3-beta; 3 beta-hydroxysteroid
                     dehydrogenase/Delta 5-->4-isomerase type III"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type 3 isoform 1"
                     /protein_id="NP_001155215.1"
                     /db_xref="CCDS:CCDS51016.1"
                     /db_xref="GeneID:15494"
                     /db_xref="MGI:MGI:96235"
                     /translation="MPGWSCLVTGAGGFLGQRIIQLLVQEKDLEEIRVLDKVFKPETR
                     EQFFNLGTSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNL
                     KGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKDIVLNGHEDEHRESTWSDPYPYSKK
                     MAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSQFLSNTIIKALKNKFILRGGGKF
                     STANPVYVGNVAWAHILAARGLRNPKKSPNIQGEFYYISDDTPHQSYDDLNYTLSKEW
                     GFCLNSRWYLPVPILYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLTASTFTFSYKKA
                     QRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ"
     exon            332..496
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            497..1716
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1647..1652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1669
                     /gene="Hsd3b3"
                     /gene_synonym="9030618K22Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaagtggact ttgaagcttc cagccaatcc tactgcacac tctgctctct ccgtccagat
       61 caaaaaggga gatctcaact gctctggttt catgatctac aacccttgaa aacaaaacat
      121 caaaaaggga gatctcaact gctctggttt catgatctac aacccttgaa aacaaaactg
      181 ttgaccatgc ctgggtggag ctgcctggtg actggagcag gagggttttt gggccagagg
      241 atcatccagt tgttggtgca ggagaaagat cttgaggaga tcagggtcct ggacaaggtc
      301 ttcaaacctg aaaccaggga gcaattcttc aacctaggga caagcatcaa ggtgacagtg
      361 ttggaaggag acattcttga cacccagtac ctgaggagag cttgccaggg catctctgtt
      421 gtcatccata ctgctgccat cattgatgtc acaggtgtca ttcccaggca gaccatccta
      481 gatgtcaatc tgaaaggtac ccagaactta ttggaggcct gtatccaagc cagtgtgcca
      541 gccttcatct tctccagctc agttgacgtt gcagggccca actcttacaa ggacattgtc
      601 ctgaatggcc acgaggacga gcatcgtgaa agcacatggt ctgacccata cccatacagc
      661 aaaaagatgg ctgagaaggc agtgctggca gccaatggga gcatgctgaa aaatggtggc
      721 actttgcaaa cttgtgcatt aaggcccatg tgcatttatg gggagagaag tcaattcctt
      781 tctaacacaa taattaaggc cctcaaaaat aagtttattc tgagaggtgg gggcaaattc
      841 tccacagcca acccagtata tgtgggcaat gtggcctggg cacacattct ggctgccagg
      901 ggccttcgaa accccaagaa gtcaccaaat atccaaggag agttctacta catctcagat
      961 gatacccctc accaaagtta tgatgattta aattacaccc tgagcaagga gtggggcttc
     1021 tgcctcaatt ccaggtggta ccttcctgtg cccatactgt actggcttgc cttcctgctg
     1081 gaaactgtga gcttcctgct gagtccaatc tacagatata tacctccctt taaccgccac
     1141 ttggtcacac tgacagctag tacgttcact ttctcctaca agaaagctca gcgagatctg
     1201 ggctatgagc cacttgtcag ctgggaggaa gccaagcaga aaacctcaga gtggatcggg
     1261 acactagtgg agcagcacag ggagacactg gacacaaagt ctcagtgatg ggaagatgat
     1321 ggagacatgg ccctgggtat taccagtcca gtaaggacag taaggataaa agcacaacac
     1381 aggtgctgtt gccttctttt gacacagagg ccaatttagt gccttaatca agtcaccaaa
     1441 gccttgccag tcactgaccc agccacaagc cttctttctg aagtacctcc caaaagacac
     1501 acagccacct gtgccccagc tcctgggccc aagcccctca gcaccacttg tacctcagag
     1561 ctctctccat tactttctct ccccattcaa agcatgtata gccttccgaa aattctgcta
     1621 gctttatgaa gctcaatgga agaaacaata aatatttgtc aatacctcat atttggtttg
     1681 tgtttttctg taaataaaca gttatgtgtc cctttc
//
