LOCUS       NM_001359741            1853 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
            steroid delta-isomerase 2 (Hsd3b2), transcript variant 2, mRNA.
ACCESSION   NM_001359741 XM_006501038
VERSION     NM_001359741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Ran,H., Kong,S., Zhang,S., Cheng,J., Zhou,C., He,B., Xin,Q.,
            Lydon,J.P., DeMayo,F.J., Feng,G.S., Xia,G., Lu,Z., Wang,C. and
            Wang,H.
  TITLE     Nuclear Shp2 directs normal embryo implantation via facilitating
            the ERalpha tyrosine phosphorylation by the Src kinase
  JOURNAL   Proc Natl Acad Sci U S A 114 (18), 4816-4821 (2017)
   PUBMED   28424251
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Chadwick,J.A., Swager,S.A., Lowe,J., Welc,S.S., Tidball,J.G.,
            Gomez-Sanchez,C.E., Gomez-Sanchez,E.P. and Rafael-Fortney,J.A.
  TITLE     Myeloid cells are capable of synthesizing aldosterone to exacerbate
            damage in muscular dystrophy
  JOURNAL   Hum Mol Genet 25 (23), 5167-5177 (2016)
   PUBMED   27798095
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Bandiera,R., Vidal,V.P., Motamedi,F.J., Clarkson,M.,
            Sahut-Barnola,I., von Gise,A., Pu,W.T., Hohenstein,P., Martinez,A.
            and Schedl,A.
  TITLE     WT1 maintains adrenal-gonadal primordium identity and marks a
            population of AGP-like progenitors within the adrenal gland
  JOURNAL   Dev Cell 27 (1), 5-18 (2013)
   PUBMED   24135228
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Rajapaksha,M., Prasad,M., Thomas,J.L., Whittal,R.M. and Bose,H.S.
  TITLE     Chaperones rejuvenate folding and activity of 3-beta hydroxysteroid
            dehydrogenase 2
  JOURNAL   ACS Chem Biol 8 (5), 1000-1008 (2013)
   PUBMED   23485106
  REMARK    GeneRIF: molecular chaperone-assisted folding of 3-beta
            hydroxysteroid dehydrogenase-2 is a physiological requirement
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Clarke,T.R., Bain,P.A., Burmeister,M. and Payne,A.H.
  TITLE     Isolation and characterization of several members of the murine
            Hsd3b gene family
  JOURNAL   DNA Cell Biol 15 (5), 387-399 (1996)
   PUBMED   8924213
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Abbaszade,I.G., Clarke,T.R., Park,C.H. and Payne,A.H.
  TITLE     The mouse 3 beta-hydroxysteroid dehydrogenase multigene family
            includes two functionally distinct groups of proteins
  JOURNAL   Mol Endocrinol 9 (9), 1214-1222 (1995)
   PUBMED   7491113
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Payne,A.H., Clarke,T.R. and Bain,P.A.
  TITLE     The murine 3 beta-hydroxysteroid dehydrogenase multigene family:
            structure, function and tissue-specific expression
  JOURNAL   J Steroid Biochem Mol Biol 53 (1-6), 111-118 (1995)
   PUBMED   7626443
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Bain,P.A., Meisler,M.H., Taylor,B.A. and Payne,A.H.
  TITLE     The genes encoding gonadal and nongonadal forms of 3
            beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are
            closely linked on mouse chromosome 3
  JOURNAL   Genomics 16 (1), 219-223 (1993)
   PUBMED   8486361
REFERENCE   10 (bases 1 to 1853)
  AUTHORS   Bain,P.A., Yoo,M., Clarke,T., Hammond,S.H. and Payne,A.H.
  TITLE     Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4 isomerase and differential expression in gonads, adrenal
            glands, liver, and kidneys of both sexes
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 8870-8874 (1991)
   PUBMED   1924345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606755.7 and BX639392.1.
            
            On Jan 13, 2018 this sequence version replaced XM_006501038.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040397.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL606755.7         68634-68704         c
            72-131              AL606755.7         67994-68053         c
            132-256             AL606755.7         63821-63945         c
            257-467             AL606755.7         60577-60787         c
            468-632             AL606755.7         57589-57753         c
            633-1842            AL606755.7         55269-56478         c
            1843-1853           BX639392.1         7-17                c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.85 cM"
     gene            1..1853
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 2"
                     /db_xref="GeneID:15493"
                     /db_xref="MGI:MGI:96234"
     exon            1..71
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /inference="alignment:Splign:2.1.0"
     exon            72..131
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /inference="alignment:Splign:2.1.0"
     exon            132..256
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /inference="alignment:Splign:2.1.0"
     exon            257..467
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1444
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /EC_number="1.1.1.145"
                     /EC_number="5.3.3.1"
                     /note="3 beta-hydroxysteroid dehydrogenase 2; 3
                     beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
                     type II; hydroxysteroid dehydrogenase-2, delta<5>-3-beta"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type 2"
                     /protein_id="NP_001346670.1"
                     /db_xref="CCDS:CCDS17667.1"
                     /db_xref="GeneID:15493"
                     /db_xref="MGI:MGI:96234"
                     /translation="MPGWSCLVTGAGGFLGQRIIQLLVQEEDLEEIRVLDKVFRPETR
                     KEFFNLETSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNL
                     KGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKEIVLNGHEEECHESTWSDPYPYSKK
                     MAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSPLISNIIIMALKHKGILRSFGKF
                     NTANPVYVGNVAWAHILAARGLRDPKKSPNIQGEFYYISDDTPHQSFDDISYTLSKEW
                     GFCLDSSWSLPVPLLYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLSGSTFTFSYKKA
                     QRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ"
     exon            468..632
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1843
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1819..1824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="Hsd3b2"
                     /gene_synonym="3-beta-HSD II"
                     /note="major polyA site"
ORIGIN      
        1 ctgtgtccta atcaagaagg gagctctcaa ttgtgcctgc cttcaggatc tccaactctt
       61 ggaaacaaaa tatcaaaaat ggagatctca actgctcttg tttcatgatc tacaatcctt
      121 gaaaacaaaa cagaccagaa ccagcctttc taagcttgtg tcatcctgga ctaggaacca
      181 gctgcgatcc agaaaccttc cttctaagat tccagctcca gtttgggact gctgacacac
      241 cacaccctgt ggctgaccat ctccagtgtc acgtacatta agttaacctc actcccactg
      301 tgatctgctt actgtgttga ccatgcctgg gtggagctgc ctggtgactg gagcaggagg
      361 gtttttgggg cagaggatca tccagttgtt ggtgcaagag gaagatctgg aggagatcag
      421 ggtcctggac aaggtcttca gaccagaaac aaggaaggaa ttcttcaacc tagagacaag
      481 catcaaggtg acagtgttgg aaggagacat tcttgacacc cagtacctga ggagagcttg
      541 ccagggcatc tctgttgtca tccatactgc tgccatcatt gatgtcacag gtgtcattcc
      601 caggcagacc atcctagatg tcaatctgaa aggtacccag aacttattgg aggcctgtat
      661 ccaagccagt gtgccagcct tcatcttctc cagctcagtt gatgttgcag ggcccaactc
      721 ttacaaggag attgtcttga atggccatga ggaagagtgt catgaaagta catggtctga
      781 tccataccca tacagcaaaa agatggctga gaaggcagtg ctggcagcca atgggagcat
      841 gctgaaaaat ggtggcactt tgcaaacttg tgcattaagg cccatgtgca tttatgggga
      901 gagaagtcca ctcatttcta acataataat tatggccctt aaacataagg gtattctgag
      961 aagttttggc aaattcaaca cagccaaccc agtatatgtg ggcaatgtag cctgggcaca
     1021 cattctggct gccaggggcc ttcgagaccc caagaagtca ccaaatatcc aaggagagtt
     1081 ctactacatc tcagatgaca cccctcacca aagctttgat gatataagtt acaccttgag
     1141 caaggagtgg ggcttctgcc ttgattccag ctggagcctt cctgtgcccc tactgtactg
     1201 gcttgcattc ctgctggaaa ctgtgagctt cctcctgagt ccaatctaca gatatatacc
     1261 tccctttaac cgccacttgg tcacactgtc aggtagcaca ttcactttct cctacaagaa
     1321 agctcagcga gatctgggct atgagccact tgtcagctgg gaggaagcca agcagaaaac
     1381 ctcagagtgg atcgggacac tagtggagca gcacagggag acactggaca caaagtctca
     1441 gtgatggaag agggtgagac atggccctgg gtgtaatcaa gtccttcagc aagtagagac
     1501 acacaagaca ggtgctgctg ccttcttttg acacagaggc caatttagtg ccttaatcaa
     1561 gtcaccaaag ccttgccagt cactgaccca gccacaagcc ttttttctga aattcctctc
     1621 caaagacaca cgggcatctg tgccccagct tctgggtcca agcccctcag cacctctcat
     1681 acctcagagc tctttccatt aatttctctc cgcattcaaa acatgtatag ccttcagaaa
     1741 attctgcttg ctttatgaag cccaatggaa gaaacaatta tttgtcaata cctcatctgt
     1801 ggattgtgat tttctgtaaa taaacaatta tatgtccctt ctaaaaaaaa aaa
//
