LOCUS       NM_008293               1870 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
            steroid delta-isomerase 1 (Hsd3b1), transcript variant 1, mRNA.
ACCESSION   NM_008293
VERSION     NM_008293.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Whiley,P.A.F., Luu,M.C.M., O'Donnell,L., Handelsman,D.J. and
            Loveland,K.L.
  TITLE     Testis exposure to unopposed/elevated activin A in utero affects
            somatic and germ cells and alters steroid levels mimicking
            phthalate exposure
  JOURNAL   Front Endocrinol (Lausanne) 14, 1234712 (2023)
   PUBMED   37727456
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Gu,X., Heinrich,A., Li,S.Y. and DeFalco,T.
  TITLE     Testicular macrophages are recruited during a narrow fetal time
            window and promote organ-specific developmental functions
  JOURNAL   Nat Commun 14 (1), 1439 (2023)
   PUBMED   36922518
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1870)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1870)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   7  (bases 1 to 1870)
  AUTHORS   Krozowski,Z., MaGuire,J.A., Stein-Oakley,A.N., Dowling,J.,
            Smith,R.E. and Andrews,R.K.
  TITLE     Immunohistochemical localization of the 11 beta-hydroxysteroid
            dehydrogenase type II enzyme in human kidney and placenta
  JOURNAL   J Clin Endocrinol Metab 80 (7), 2203-2209 (1995)
   PUBMED   7608280
REFERENCE   8  (bases 1 to 1870)
  AUTHORS   Lee,C.H. and Taketo,T.
  TITLE     Normal onset, but prolonged expression, of Sry gene in the B6.YDOM
            sex-reversed mouse gonad
  JOURNAL   Dev Biol 165 (2), 442-452 (1994)
   PUBMED   7958412
REFERENCE   9  (bases 1 to 1870)
  AUTHORS   Bain,P.A., Meisler,M.H., Taylor,B.A. and Payne,A.H.
  TITLE     The genes encoding gonadal and nongonadal forms of 3
            beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are
            closely linked on mouse chromosome 3
  JOURNAL   Genomics 16 (1), 219-223 (1993)
   PUBMED   8486361
REFERENCE   10 (bases 1 to 1870)
  AUTHORS   Bain,P.A., Yoo,M., Clarke,T., Hammond,S.H. and Payne,A.H.
  TITLE     Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta
            5-delta 4 isomerase and differential expression in gonads, adrenal
            glands, liver, and kidneys of both sexes
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 8870-8874 (1991)
   PUBMED   1924345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147114.1 and BC052659.1.
            
            On Feb 12, 2015 this sequence version replaced NM_008293.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147114.1, BM453585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1852              AK147114.1         2-1853
            1853-1870           BC052659.1         1595-1612
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.89 cM"
     gene            1..1870
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /note="hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                     steroid delta-isomerase 1"
                     /db_xref="GeneID:15492"
                     /db_xref="MGI:MGI:96233"
     exon            1..123
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /inference="alignment:Splign:2.1.0"
     exon            124..313
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /inference="alignment:Splign:2.1.0"
     exon            314..520
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..1497
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /EC_number="1.1.1.145"
                     /EC_number="5.3.3.1"
                     /EC_number="1.1.1.270"
                     /EC_number="1.1.1.210"
                     /note="steroid Delta-isomerase; delta-5-3-ketosteroid
                     isomerase; dihydrotestosterone oxidoreductase;
                     3-beta-hydroxysteroid 3-dehydrogenase;
                     3-beta-hydroxy-5-ene steroid dehydrogenase;
                     3-beta-hydroxy-Delta(5)-steroid dehydrogenase"
                     /codon_start=1
                     /product="3 beta-hydroxysteroid dehydrogenase/Delta
                     5-->4-isomerase type 1"
                     /protein_id="NP_032319.1"
                     /db_xref="CCDS:CCDS17670.1"
                     /db_xref="GeneID:15492"
                     /db_xref="MGI:MGI:96233"
                     /translation="MAGWSCLVTGAGGFVGQRIIKMLVQEKELQEVRALDKVFRPETK
                     EEFSKLQTKTKVTVLEGDILDAQCLRRACQGISVVIHTAAVIDVTGVIPRQTILDVNL
                     KGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLNGHEEQNHESTWSDPYPYSKK
                     MAEKAVLAANGSMLKNGGTLNTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKF
                     SIANPVYVENVAWAHILAARGLRDPKKSTSIQGQFYYISDDTPHQSYDDLNYTLSKEW
                     GLRPNASWSLPLPLLYWLAFLLETVSFLLRPVYRYRPLFNRHLITLSNSTFTFSYKKA
                     QRDLGYEPLVNWEEAKQKTSEWIGTIVEQHREILDTKCQ"
     exon            521..685
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1855
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1835..1840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="Hsd3b1"
                     /gene_synonym="3-beta-HSD I; D3Ertd383e"
                     /note="major polyA site"
ORIGIN      
        1 gttacgtaat ccttgaagct gcccctgatc ttttcagcca ccaccatctc agacttttga
       61 gaggcttttg ctctctcagt tgtgaccatt tcctacattc tgaactgagc ggctgctgca
      121 caggaataaa ggacataagg tttatcaatc actgggaagg acagaccaca gaaaagaata
      181 aatatggtca cgaagcaggc atgcgtcaag atatgataag tcagcagact agagattaaa
      241 acactagtcc tgatctgagg gctgaggaga tcagcatcca gacactctca tctgactttt
      301 aacaatttaa cagccctcct aagggttacc ctatatcata ccagctccca ctgtcatctg
      361 tttcctgtgt tgaccatggc tggatggagc tgcctggtga caggagcagg agggtttgtg
      421 ggccagagga tcatcaagat gttggtgcag gagaaagaac tgcaggaggt cagagctctg
      481 gacaaagtat tccgaccaga aaccaaggag gaattctcca agctgcagac aaagaccaag
      541 gtgacagtgt tggaaggaga cattctggat gcccagtgcc tgaggagagc ctgccagggc
      601 atctctgttg tcatccacac tgctgctgtc attgatgtca caggtgtcat tcccaggcag
      661 accatcctag atgtcaatct gaaaggtacc cagaacctat tggaggcctg tgttcaagca
      721 agtgtgccag ccttcatctt ctgcagctca gttgatgttg cagggcccaa ctcgtacaag
      781 aagatcgtcc tgaatggcca cgaggaacag aatcatgaaa gcacatggtc tgatccatac
      841 ccatacagca aaaagatggc tgagaaggca gtactggcag ccaatgggag catgctgaaa
      901 aatggtggca ctttgaatac ttgtgcctta agacccatgt acatttatgg ggagagaagt
      961 ccattcattt ttaatgcaat aattagggcc ctcaaaaata agggtattct gtgtgttact
     1021 ggcaaattct ccatagccaa cccagtatat gtggaaaatg tggcctgggc acacattctg
     1081 gcagccaggg gccttcgaga ccccaagaag tctacaagca tccaaggaca gttctactac
     1141 atctcagatg acacccctca ccaaagctat gatgatttaa attacaccct gagtaaggaa
     1201 tgggggctcc gccctaatgc cagctggagc cttcctctgc ccctgctcta ctggcttgcc
     1261 ttcctgctgg aaactgtgag cttcctgcta cgtccagtct acaggtatag acctctcttt
     1321 aaccgccact tgatcacact gtcaaatagc acgttcactt tttcttacaa gaaagctcag
     1381 cgagatctgg gctatgagcc acttgtcaac tgggaggaag caaagcagaa aacctcagag
     1441 tggataggga caatagtgga acagcacagg gagatattgg acacaaagtg ccagtgatgg
     1501 aaaaagggca ggtacatggc tctgggagtt ataaggtcct gtagcaagta cagaggcaca
     1561 agccaggtcc tgctgtctcc tgtagacaca gagaccaact tggtatcttt ctcaagtcac
     1621 cagaagcctt gccagtcact aacccactca caaacttgct tccctaagcc cctgctcaga
     1681 gacaaacata gctgagtctc agttcttagg cttcagcaat tacaatttac tttcacttag
     1741 aacttagtat tgcttttatt tcccccttca agtcctaaat catatcttgc ctttggtaaa
     1801 atcccgttgc tttctgaagc aaaacaaaaa cagcaataaa tattgtaatg ccttaaaaaa
     1861 aaaaaaaaaa
//
