LOCUS       NM_013543                981 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hydroxysteroid 17-beta dehydrogenase 8 (Hsd17b8),
            mRNA.
ACCESSION   NM_013543
VERSION     NM_013543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 981)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 981)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 981)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   4  (bases 1 to 981)
  AUTHORS   Woo,D., Lee,G.Y., Anderson,E. and Aziz,N.
  TITLE     Immature ovaries and polycystic kidneys in the congenital
            polycystic kidney mouse may be due to abnormal sex steroid
            metabolism
  JOURNAL   Mol Cell Endocrinol 176 (1-2), 155-162 (2001)
   PUBMED   11369455
REFERENCE   5  (bases 1 to 981)
  AUTHORS   Aziz,N., Anderson,E., Lee,G.Y. and Woo,D.D.
  TITLE     Arrested testis development in the cpk mouse may be the result of
            abnormal steroid metabolism
  JOURNAL   Mol Cell Endocrinol 171 (1-2), 83-88 (2001)
   PUBMED   11165015
REFERENCE   6  (bases 1 to 981)
  AUTHORS   Maxwell,M.M., Nearing,J. and Aziz,N.
  TITLE     Ke 6 gene. Sequence and organization and aberrant regulation in
            murine polycystic kidney disease
  JOURNAL   J Biol Chem 270 (42), 25213-25219 (1995)
   PUBMED   7559658
REFERENCE   7  (bases 1 to 981)
  AUTHORS   Aziz,N.
  TITLE     Animal models of polycystic kidney disease
  JOURNAL   Bioessays 17 (8), 703-712 (1995)
   PUBMED   7661851
  REMARK    Review article
REFERENCE   8  (bases 1 to 981)
  AUTHORS   Nagata,T., Weiss,E.H., Abe,K., Kitagawa,K., Ando,A.,
            Yara-Kikuti,Y., Seldin,M.F., Ozato,K., Inoko,H. and Taketo,M.
  TITLE     Physical mapping of the retinoid X receptor B gene in mouse and
            human
  JOURNAL   Immunogenetics 41 (2-3), 83-90 (1995)
   PUBMED   7806300
REFERENCE   9  (bases 1 to 981)
  AUTHORS   Aziz,N., Maxwell,M.M. and Brenner,B.M.
  TITLE     Coordinate regulation of 11 beta-HSD and Ke 6 genes in cpk mouse:
            implications for steroid metabolic defect in PKD
  JOURNAL   Am J Physiol 267 (5 Pt 2), F791-F797 (1994)
   PUBMED   7977782
REFERENCE   10 (bases 1 to 981)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC086927.1 and CX243612.1.
            
            On Oct 6, 2007 this sequence version replaced NM_013543.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086927.1, KJ650217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               BC086927.1         1-127
            128-704             CX243612.1         97-673
            705-981             BC086927.1         705-981
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..981
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /note="hydroxysteroid 17-beta dehydrogenase 8"
                     /db_xref="GeneID:14979"
                     /db_xref="MGI:MGI:95911"
     exon            1..54
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..788
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.239"
                     /EC_number="1.1.1.n12"
                     /note="17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD
                     8; estradiol 17-beta-dehydrogenase 8; H2-K region
                     expressed gene 6; estrogen 17-oxidoreductase; testosterone
                     17-beta-dehydrogenase 8; 3-oxoacyl-[acyl-carrier-protein]
                     reductase; KAR alpha subunit;
                     3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit"
                     /codon_start=1
                     /product="(3R)-3-hydroxyacyl-CoA dehydrogenase"
                     /protein_id="NP_038571.2"
                     /db_xref="CCDS:CCDS50071.1"
                     /db_xref="GeneID:14979"
                     /db_xref="MGI:MGI:95911"
                     /translation="MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDLDGA
                     AAQDTVRLLGSPGSEDGAPRGKHAAFQADVSQGPAARRLLEEVQACFSRPPSVVVSCA
                     GITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIIGKVG
                     NIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKMPEKVKDKVTA
                     MIPLGHMGDPEDVADVVAFLASEDSGYITGASVEVSGGLFM"
     exon            55..272
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..389
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..482
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..568
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..653
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..696
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..771
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..964
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      937..942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /note="hexamer: AATAAA"
     polyA_site      964
                     /gene="Hsd17b8"
                     /gene_synonym="D17H6S112E; H-2Ke6; H2-Ke6; Ke-6; Ke6;
                     Ring2"
                     /note="major polyA site"
ORIGIN      
        1 cagccgccat ggcgtctcag ctccggctcc gctctgcgct ggccctggtc acaggtgcgg
       61 gtagcggcat cggccgtgcg atcagcgtgc gcctagcggc agagggcgcc gccgtggccg
      121 cctgcgacct ggacggggcc gcggcacagg acacggtgcg gctgctggga agcccgggga
      181 gcgaggacgg ggcgccgcgc ggcaagcacg ctgccttcca agcggatgtg tctcagggcc
      241 ccgcagccag acgcctgctg gaggaagtgc aggcctgctt ttctcgcccg ccatctgtcg
      301 ttgtgtcctg tgcgggcatc acacgcgatg agtttctgct ccacatgtca gaagaagact
      361 gggacagagt catagctgtc aacctcaagg gcaccttcct agtcactcag gctgcagccc
      421 aggctttagt gtccagtggc ggtcgtggct ccatcatcaa cattagtagc atcattggaa
      481 aggtggggaa tatcggacaa acgaattatg cgtcgtccaa agcaggagtg attgggctca
      541 cccagactgc ggcccgggag cttggacgac atggaatccg atgtaactcg gtcctcccag
      601 ggttcattgc aacgcccatg acccagaaaa tgccagagaa agtgaaggac aaggtaactg
      661 caatgattcc gttgggacac atgggggacc ctgaggatgt ggcagatgtg gttgcattct
      721 tggcatctga agacagtgga tacatcacag gggcctccgt ggaagtcagt ggaggtcttt
      781 tcatgtaact gcctgatgga agccggactc tgctcactcc cccaccactg cctggccctc
      841 ctgctgatga ggacgctaag ttcccaggct acaaaagaga tggcagtgtg tggctcaggc
      901 atgctgaata tggaaggcag gggtgcttgt gaccctaata aattccaaat cctcttccct
      961 gccaaaaaaa aaaaaaaaaa a
//
