LOCUS       NM_010476               4574 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 7 (Hsd17b7),
            mRNA.
ACCESSION   NM_010476
VERSION     NM_010476.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4574)
  AUTHORS   Wedel M, Frob F, Elsesser O, Wittmann MT, Lie DC, Reis A and Wegner
            M.
  TITLE     Transcription factor Tcf4 is the preferred heterodimerization
            partner for Olig2 in oligodendrocytes and required for
            differentiation
  JOURNAL   Nucleic Acids Res 48 (9), 4839-4857 (2020)
   PUBMED   32266943
REFERENCE   2  (bases 1 to 4574)
  AUTHORS   Driver AM, Kratz LE, Kelley RI and Stottmann RW.
  TITLE     Altered cholesterol biosynthesis causes precocious neurogenesis in
            the developing mouse forebrain
  JOURNAL   Neurobiol Dis 91, 69-82 (2016)
   PUBMED   26921468
REFERENCE   3  (bases 1 to 4574)
  AUTHORS   Sisecioglu M, Budak H, Geffers L, Cankaya M, Ciftci M, Thaller C,
            Eichele G, Kufrevioglu OI and Ozdemir H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   4  (bases 1 to 4574)
  AUTHORS   Layer JV, Barnes BM, Yamasaki Y, Barbuch R, Li L, Taramino S,
            Balliano G and Bard M.
  TITLE     Characterization of a mutation that results in independence of
            oxidosqualene cyclase (Erg7) activity from the downstream
            3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic
            pathway
  JOURNAL   Biochim Biophys Acta 1831 (2), 361-369 (2013)
   PUBMED   23022663
REFERENCE   5  (bases 1 to 4574)
  AUTHORS   Stottmann RW, Turbe-Doan A, Tran P, Kratz LE, Moran JL, Kelley RI
            and Beier DR.
  TITLE     Cholesterol metabolism is required for intracellular hedgehog
            signal transduction in vivo
  JOURNAL   PLoS Genet 7 (9), e1002224 (2011)
   PUBMED   21912524
  REMARK    GeneRIF: a recessive mutation, rudolph, that causes abnormal
            forebrain development was identified in hydroxysteroid (17-beta)
            dehydrogenase 7 gene, an enzyme necessary for cholesterol
            biosynthesis.
            GeneRIF: The ENU-induced rudolph mouse mutant has defects in both
            central nervous system and skeletal development, and carries a
            mutation of Hsd17b7. These developmental defects appear to be a
            consequence of abnormalities in Hedgehog signaling.
REFERENCE   6  (bases 1 to 4574)
  AUTHORS   Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J and
            Breitling R.
  TITLE     Closing the gap: identification of human 3-ketosteroid reductase,
            the last unknown enzyme of mammalian cholesterol biosynthesis
  JOURNAL   Mol Endocrinol 17 (9), 1715-1725 (2003)
   PUBMED   12829805
REFERENCE   7  (bases 1 to 4574)
  AUTHORS   Torn S, Nokelainen P, Kurkela R, Pulkka A, Menjivar M, Ghosh S,
            Coca-Prados M, Peltoketo H, Isomaa V and Vihko P.
  TITLE     Production, purification, and functional analysis of recombinant
            human and mouse 17beta-hydroxysteroid dehydrogenase type 7
  JOURNAL   Biochem Biophys Res Commun 305 (1), 37-45 (2003)
   PUBMED   12732193
REFERENCE   8  (bases 1 to 4574)
  AUTHORS   Krusche CA, Moller G, Beier HM and Adamski J.
  TITLE     Expression and regulation of 17beta-hydroxysteroid dehydrogenase 7
            in the rabbit
  JOURNAL   Mol Cell Endocrinol 171 (1-2), 169-177 (2001)
   PUBMED   11165026
REFERENCE   9  (bases 1 to 4574)
  AUTHORS   Nokelainen P, Peltoketo H, Mustonen M and Vihko P.
  TITLE     Expression of mouse 17beta-hydroxysteroid
            dehydrogenase/17-ketosteroid reductase type 7 in the ovary, uterus,
            and placenta: localization from implantation to late pregnancy
  JOURNAL   Endocrinology 141 (2), 772-778 (2000)
   PUBMED   10650959
REFERENCE   10 (bases 1 to 4574)
  AUTHORS   Nokelainen P, Peltoketo H, Vihko R and Vihko P.
  TITLE     Expression cloning of a novel estrogenic mouse 17
            beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase
            (m17HSD7), previously described as a prolactin receptor-associated
            protein (PRAP) in rat
  JOURNAL   Mol Endocrinol 12 (7), 1048-1059 (1998)
   PUBMED   9658408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY228199.1, AK050211.1 and BB767054.1.
            
            [WARNING] On Apr 27, 2023 this sequence was replaced by
            NM_010476.4.
            
            On Feb 11, 2006 this sequence version replaced NM_010476.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050211.1, AK028380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY228199.1         7-49
            44-3846             AK050211.1         1-3803
            3847-4240           AK050211.1         3805-4198
            4241-4574           BB767054.1         222-555
FEATURES             Location/Qualifiers
     source          1..4574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..4574
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /note="hydroxysteroid (17-beta) dehydrogenase 7"
                     /db_xref="GeneID:15490"
                     /db_xref="MGI:MGI:1330808"
     exon            1..108
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1078
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.270"
                     /EC_number="1.1.1.210"
                     /note="3-keto-steroid reductase; 17-beta-HSD 7; estradiol
                     17-beta-dehydrogenase 7; 17-beta-hydroxysteroid
                     dehydrogenase 7; dihydrotestosterone oxidoreductase"
                     /codon_start=1
                     /product="3-keto-steroid reductase/17-beta-hydroxysteroid
                     dehydrogenase 7"
                     /protein_id="NP_034606.3"
                     /db_xref="CCDS:CCDS35766.1"
                     /db_xref="GeneID:15490"
                     /db_xref="MGI:MGI:1330808"
                     /translation="MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKARAV
                     RDTLLASHPSAEVSIVQMDVSSLQSVVRGAEEVKQKFQRLDYLYLNAGILPNPQFNLK
                     AFFCGIFSRNVIHMFTTAEGILTQNDSVTADGLQEVFETNLFGHFILIRELEPLLCHA
                     DNPSQLIWTSSRNAKKANFSLEDIQHSKGPEPYSSSKYATDLLNVALNRNFNQKGLYS
                     SVMCPGVVMTNMTYGILPPFIWTLLLPIMWLLRFFVNALTVTPYNGAEALVWLFHQKP
                     ESLNPLTKYASATSGFGTNYVTGQKMDIDEDTAEKFYEVLLELEKRVRTTVQKSDHPS
                     "
     exon            109..312
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     exon            313..405
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     exon            406..520
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     exon            521..715
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     exon            716..820
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     exon            821..877
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     exon            878..976
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
     exon            977..4574
                     /gene="Hsd17b7"
                     /gene_synonym="ERG27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgtggtc acggatcaag gttcaggcta agagaacccc ggtgcagttc tacttcggtg
       61 cagggcgtgg aagatgcgga aggtggtttt gatcaccggg gcgagcagtg gcattgggct
      121 agccctttgc ggtcgactgc tggcagaaga cgatgacctc cacctgtgtt tggcgtgtag
      181 gaacctgagc aaagcaagag ctgttcgaga taccctgctg gcctctcacc cctccgccga
      241 agtcagcatc gtgcagatgg atgtcagcag cctgcagtcg gtggtccggg gtgcagagga
      301 agtcaagcaa aagtttcaaa gattagacta cttatatctg aatgctggaa tcctgcctaa
      361 tccacaattc aacctcaagg catttttctg cggcatcttt tcaagaaatg tgattcatat
      421 gttcaccaca gcggaaggaa ttttgaccca gaatgactcg gtcactgccg acgggttgca
      481 ggaggtgttt gaaaccaatc tctttggcca ctttattctg attcgggaac tggaaccact
      541 tctctgccat gcggacaacc cctctcagct catctggacg tcctctcgca atgcaaagaa
      601 ggctaacttc agcctggagg acatccagca ctccaaaggc ccggaaccct acagctcttc
      661 caaatatgct accgacctcc tgaatgtggc tttgaacagg aatttcaacc agaagggtct
      721 gtattccagt gtgatgtgcc caggcgtcgt gatgaccaat atgacgtatg gaattttgcc
      781 tccctttatc tggacgttgc tcctacccat aatgtggctc cttcgctttt ttgtaaatgc
      841 gctcactgtg acaccgtaca acggagcaga ggccctggtg tggctcttcc accaaaaacc
      901 ggagtctctt aatcctctga ccaaatacgc gagcgccacc tcgggatttg ggactaatta
      961 cgtcacgggc caaaagatgg acatagatga agacactgct gaaaaattct atgaggtctt
     1021 actggagctg gaaaagcgtg tcaggaccac cgttcagaaa tcggatcacc cgagctgatg
     1081 taggcgttcc tcagggcacc ccgtgggcac ctcctgtacg ccatggcaca cgtggctttc
     1141 catctcgctg ggtgatacac atttgcagta aaccataagc catgacgatc tctcctccta
     1201 cctttcacag tgatctccaa gactgtgtgt gtgcacattt ttgcaggcgt gcacacacat
     1261 gtgagaaagg actggcaaag tagagggacc aactacttac ccctccagag cagtgtcctg
     1321 ttggaactgc tagaggtttc ctgcggtgca tccttggatc gctttctgcc tcctagagcc
     1381 cagtagtttt gacttgtgtg atggggacac agtacagcct gaagcttctt ttagtctcag
     1441 cacggagggg caatgccact gggtaggact tctacttctt gtttttcctc cacgatcccc
     1501 tcttttactc tctttacatt ctccttcata tgctgctttg gctaatctta ttcattcatg
     1561 gtccgtccat gtagtcattt tcaagagaaa ggtattcaag agaaaggtgt gaatgtgttt
     1621 gggccacaag cattattttc ggtctttaat aacatctata ctatagatgt attcattatg
     1681 aacagcttat tgtcatgatc atatttcact ggaattaaac ttagagcaaa agaaaatatt
     1741 catgtttcaa aaaaaaaatt ttaaaaaccc tgacaaactg ctaggacgcc atccggtaca
     1801 cagtagaagc agaagagttg acttttatgt gtcagatgat gagtttttca aaccttttct
     1861 ccataaatct taagagccat ccctgagtat cagaacgcta gagatggcaa gacattttta
     1921 tcataaaggc atcctatctc tcgggataaa attctgaaca aaagtaagaa agtgatagat
     1981 acataaatat aatctcccta caacttgtgg tatgaaaact ttctggttag agtgtctcta
     2041 attttgttga ctacgttttc ttttgtaaag atacagagga gaatgagtcc acacccacgg
     2101 gcccctcctc tgtctctggg aagcaagggg tggtttttca ttcttcatcc tgagtgagcc
     2161 cccacttggc aaaggctcca tctcaggggg aactcatgtt tctcatctgc aaagcaaagc
     2221 tgtcaccccc ctgttctgtt cttcgcggcc ttgcctgagg atccgtgttc tgtgtgaacc
     2281 atgagaattc ctcattttgg tagagaatca ggttccttag agatcaataa gccagcatgc
     2341 tgaggcccag acactgcagg ccaccgccct tctgaaggat ggccccttct cttccccatg
     2401 tgcttgtttc caggagacag taccgagctc tgcagtggta tggggaggat tagggtccct
     2461 gcggctgggt agtcataacc ttaacttgcc ttgagagagt ggattgagaa aaagcttggg
     2521 ttttgcttat ttgtgagttt ggagaaaaca cccttttctg gggttgtcaa gttataaaca
     2581 tcaagttatt cttagaagtc tttattaact ttttgctggc ttcattggga attccctctg
     2641 ttttattcct gatactagta tctgcccatg gtcagcaagg caggagcttt tccagtttgc
     2701 tggtatttgc aaagaacctt tgtttctgcc tcattttttt cctagttatt tacatattat
     2761 ccatatagat tattagctct acttgtttta attatctttt tgttttcttt gacttaaagt
     2821 aaaacttttc tagttccttg agttaaaact taggttccat atttggaaat ctttcttaat
     2881 tgttgctata agcatttact tataagcatt taattatcta gatgctattc tcatcccaca
     2941 tgtgccgaca ttgtccggca ttatattaat ttatgttgag gtttcctttt atgaattatt
     3001 aagcaatatt caatgctcat atttttagag atttaaaaga ttgatactgg ctgggaagat
     3061 gacttagtgg ttgagagcac tggctgcctg ccctggaacg cactctgtag accaggctgg
     3121 ccttgaactc agaaaatcac ctgcctctgc ctcccaagtg ctgggactaa aagcatgcac
     3181 taccactgcc cggctactgg ctactctttc aaaggaccca ggtttgattc ctaggaccat
     3241 gtggtggctc acaaacatct ctaacttcag ttctagggga tctgatgccc tcttctggcc
     3301 tcggtgggta ccacaagtgc atccgatgcc caggcatctg tgcagacaaa acacataaga
     3361 ataaatcttt taaaagttgg aactggcttc taggtgtagt ctgttgggat ttcatagttt
     3421 gatgttaata tagtcagggt atattaagtc ctatttctgc attgcatttc ttgactttta
     3481 tttattgtac aggatctgtt gtgcttgaat gagtgttctg tgaatttttc ttcacaccac
     3541 accagctcgt atctcctcct tggaacactc ttgttgttcc ctttgtgttt tgtgcggagt
     3601 tcacgggtgc cttcaggcag gtgttgtgtg ggagggccgc agtgctctgt tagaagcagt
     3661 atttctcacc tttacaccgg cttcatttct cttgtggttt tacccttctg tttctttcct
     3721 gtgctcagtc cgtttttctt gttctatgac catttctggt tttaatttta aaattttggt
     3781 tcacgttatt cttaatttat tttcatgtat ttattttgca tgcttgggcg tattgaattc
     3841 agggccttgg ggctcatctt ctttctgtag ttgattccct aggctggaat gctgctggaa
     3901 tgctgctgga atgctgctgt ggtacttgtc aactgaggct tttgttcggt tggtttgttt
     3961 tgttccagtt ttgttttctt cagtcctcaa taaggtcttc gatagttatt taatctaaaa
     4021 tttcatcata tccctcgggt tctatcatcc ttatttactt tgtaaaaaaa aaaaccaaaa
     4081 tatttatttg aggtctgaag agatggctca gcacttaaga gccccgagtg catagcttca
     4141 ttgcttctgt aggctcctag ccacatttga agctgccgct ctcagaaacg tataccagcg
     4201 ctaagtaact tgtcttcctt gtattgatag agggtgcttt aaaaaaaaat tacctatttt
     4261 tctgtcaagc tgtgtattta tgtctcttac tatttcttgt ttgatttttc acctttggta
     4321 agaagagata ttattatcta tataataaag aatgaagctt ttgcctaaaa atcatttatt
     4381 tatctaacac ttgtgctcat ttctcatgtt tattgtcctt tacttttcca aaggatcagg
     4441 gccaagacct tccatggttg tttctggcta tatttctagt gtttgaccag tgcttgccat
     4501 ttcctgggct cttgatgaat gtatgaacag ttgattgaac aagcatctat ttgaataaaa
     4561 ttatcatgct atct
//
