LOCUS       NM_001359377            1527 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 6 (Hsd17b6),
            transcript variant 2, mRNA.
ACCESSION   NM_001359377 XM_011243463
VERSION     NM_001359377.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1527)
  AUTHORS   Wei,F., Gu,Y., He,L., Kapoor,A., Lin,X., Dong,Y., Su,Y., Neira,S.V.
            and Tang,D.
  TITLE     HSD17B6 delays type 2 diabetes development via inhibiting SREBP
            activation
  JOURNAL   Metabolism 145, 155631 (2023)
   PUBMED   37330135
  REMARK    GeneRIF: HSD17B6 delays type 2 diabetes development via inhibiting
            SREBP activation.
REFERENCE   2  (bases 1 to 1527)
  AUTHORS   Yi,J., Lu,L., Yanger,K., Wang,W., Sohn,B.H., Stanger,B.Z.,
            Zhang,M., Martin,J.F., Ajani,J.A., Chen,J., Lee,J.S., Song,S. and
            Johnson,R.L.
  TITLE     Large tumor suppressor homologs 1 and 2 regulate mouse liver
            progenitor cell proliferation and maturation through antagonism of
            the coactivators YAP and TAZ
  JOURNAL   Hepatology 64 (5), 1757-1772 (2016)
   PUBMED   27531557
REFERENCE   3  (bases 1 to 1527)
  AUTHORS   Labialle,S., Marty,V., Bortolin-Cavaille,M.L., Hoareau-Osman,M.,
            Pradere,J.P., Valet,P., Martin,P.G. and Cavaille,J.
  TITLE     The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain
            controls neonatal metabolic adaptation
  JOURNAL   EMBO J 33 (19), 2216-2230 (2014)
   PUBMED   25124681
REFERENCE   4  (bases 1 to 1527)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1527)
  AUTHORS   Su,J., Lin,M. and Napoli,J.L.
  TITLE     Complementary deoxyribonucleic acid cloning and enzymatic
            characterization of a novel 17beta/3alpha-hydroxysteroid/retinoid
            short chain dehydrogenase/reductase
  JOURNAL   Endocrinology 140 (11), 5275-5284 (1999)
   PUBMED   10537158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131120.4 and AK008212.1.
            
            On Jan 3, 2018 this sequence version replaced XM_011243463.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008212.1, SRR5189685.115599.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC131120.4         127626-127632       c
            8-872               AK008212.1         2-866
            873-873             AC131120.4         113738-113738       c
            874-1267            AK008212.1         868-1261
            1268-1268           AC131120.4         111213-111213       c
            1269-1303           AK008212.1         1263-1297
            1304-1304           AC131120.4         111177-111177       c
            1305-1454           AK008212.1         1299-1448
            1455-1455           AC131120.4         111026-111026       c
            1456-1522           AK008212.1         1450-1516
            1523-1527           AC131120.4         110954-110958       c
FEATURES             Location/Qualifiers
     source          1..1527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.39 cM"
     gene            1..1527
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /note="hydroxysteroid (17-beta) dehydrogenase 6"
                     /db_xref="GeneID:27400"
                     /db_xref="MGI:MGI:1351670"
     exon            1..129
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            130..244
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            245..571
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1212
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.239"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; hydroxysteroid (17-beta) dehydrogenase 9;
                     17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-HSD6;
                     17-beta-HSD9; 3-alpha->beta-HSE;
                     3-alpha->beta-hydroxysteroid epimerase; oxidative 3-alpha
                     hydroxysteroid dehydrogenase; 17-beta-HSD 6"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase type 6
                     isoform a precursor"
                     /protein_id="NP_001346306.1"
                     /db_xref="CCDS:CCDS24257.1"
                     /db_xref="GeneID:27400"
                     /db_xref="MGI:MGI:1351670"
                     /translation="MWFYLVTLVGLYHLLRWYRERQVVSHLQDKYVFITGCDSGFGNL
                     LARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVG
                     DRGLWGLVNNAGVLQPFAYIEWYRPEDYMPIFQVNLIGLTQVTISMLFLVKKARGRIV
                     NVSSALGRVALFGGFYSCSKYGVEAFSDVLRHEVQDFGVKVSIIEPGSFKTEMTDAEL
                     TIERTKKVWEAAPEHIKESYGQQFFDDFCSTTKRELMKCSRNLSLVTDCMEHALTSTH
                     PRTRYSAGWDAKFFFIPLSYLPASLVDYLLAISRGKPAQAA"
     exon            572..830
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            831..994
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1527
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /note="hexamer: ATTAAA"
     polyA_site      1527
                     /gene="Hsd17b6"
                     /gene_synonym="17betaHSD9; Hsd17b9; Rdh8"
                     /note="major polyA site"
ORIGIN      
        1 aagggcagag tgatagactc ccagcaatgt aggactcacc ctgtgcctcc ctggatcctt
       61 actctgaggg ttatatgatc agtttcattg gatctgaaga cctggacttg gactgagacc
      121 tcaattacac atagactgaa ggaagacccg aggctctcca ggcatcctca aggctttcca
      181 ggacagactg agattgctga ggtgtttggc accgagtctt tctagtgcgc tgtcatcaca
      241 gacagacatt tcttcataat gtggttctac ctggtaactc ttgtgggcct ttaccacctt
      301 ctgcgttggt atcgtgagag gcaggtggtg agccatctcc aagacaagta tgtcttcatc
      361 acgggctgtg actctggctt tgggaacctg ctggccagac agctggacag gagaggcatg
      421 agggtattgg ctgcatgtct gacggagaag ggagccgagg agctgaggaa caagacatct
      481 gacaggctgg agacagtgat cctggatgtc accaagacag agagtattgt ggcagccact
      541 cagtgggtga aggagcgtgt tggagacaga ggactctggg gtttggttaa taatgcaggt
      601 gtgttacaac catttgccta cattgaatgg tacagaccag aggactacat gcctatcttt
      661 caagtgaacc tcattggttt gacccaggtg actataagca tgcttttcct ggtaaagaag
      721 gctcggggca ggatcgtcaa tgtctccagt gctttgggaa gagttgcatt gtttggagga
      781 ttctacagtt gctccaagta tggggttgag gcattttcag atgtgctaag gcatgaggtt
      841 caagatttcg gggtgaaagt cagcataatt gaacctggga gcttcaagac ggaaatgaca
      901 gatgcagagt taaccattga gagaactaag aaagtctggg aagctgcccc tgagcacatc
      961 aaggaatcct acggacagca gttttttgac gacttttgca gcaccaccaa acgagagttg
     1021 atgaagtgta gcaggaacct gagcctagtc acggactgca tggagcacgc cctgacctcc
     1081 acgcatcctc gcacccggta ctcggctggc tgggatgcca agtttttctt catccctcta
     1141 tcttatttgc ctgcgtcact ggtagactac ttattggcca tatctagggg caagccagct
     1201 caagcagcct gaaggatccc ggattggtgg ctgttggaat gaagaaatga ctcagttatt
     1261 cccaacacta gctatctgcg cagacacgct ctctttccga aaccactcaa gtggcggtct
     1321 tttcctttcc ctccaccccc agagacatct ggtctcactc tataaccctg gctggcagca
     1381 actcatagaa gtctgcctct ctctcaatca aggtgttccc attccaggtc tatacaattt
     1441 attactatct taaccacttt ttcctgggaa tatttccata gtatatcatt ctttcttgtc
     1501 ctattaaaca gagccatgta agaacaa
//
