LOCUS       NM_008292               2685 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4),
            mRNA.
ACCESSION   NM_008292
VERSION     NM_008292.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Swinkels,D., Kocherlakota,S., Das,Y., Dane,A.D., Wever,E.J.M.,
            Vaz,F.M., Bazan,N.G., Van Veldhoven,P.P. and Baes,M.
  TITLE     DHA Shortage Causes the Early Degeneration of Photoreceptors and
            RPE in Mice With Peroxisomal beta-Oxidation Deficiency
  JOURNAL   Invest Ophthalmol Vis Sci 64 (14), 10 (2023)
   PUBMED   37934161
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Peperstraete,K., Baes,M. and Swinkels,D.
  TITLE     Unexpected failure of rod bipolar cell targeting using L7Cre-2 mice
  JOURNAL   Exp Eye Res 228, 109406 (2023)
   PUBMED   36740160
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Swinkels,D., Das,Y., Kocherlakota,S., Vinckier,S., Wever,E., van
            Kampen,A.H.C., Vaz,F.M. and Baes,M.
  TITLE     Cell Type-Selective Loss of Peroxisomal beta-Oxidation Impairs
            Bipolar Cell but Not Photoreceptor Survival in the Retina
  JOURNAL   Cells 11 (1), 161 (2022)
   PUBMED   35011723
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2685)
  AUTHORS   Lee,S.A., Lee,J., Kim,K., Moon,H., Min,C., Moon,B., Kim,D.,
            Yang,S., Park,H., Lee,G., Park,R. and Park,D.
  TITLE     The Peroxisomal Localization of Hsd17b4 Is Regulated by Its
            Interaction with Phosphatidylserine
  JOURNAL   Mol Cells 44 (4), 214-222 (2021)
   PUBMED   33935042
  REMARK    GeneRIF: The Peroxisomal Localization of Hsd17b4 Is Regulated by
            Its Interaction with Phosphatidylserine.
REFERENCE   6  (bases 1 to 2685)
  AUTHORS   Qin,Y.M., Poutanen,M.H. and Novikov,D.K.
  TITLE     Substrate specificities of peroxisomal members of short-chain
            alcohol dehydrogenase superfamily: expression and characterization
            of dehydrogenase part of Candida tropicalis multifunctional enzyme
  JOURNAL   J Lipid Res 41 (1), 93-98 (2000)
   PUBMED   10627506
REFERENCE   7  (bases 1 to 2685)
  AUTHORS   Mustonen,M.V., Poutanen,M.H., Isomaa,V.V., Vihko,P.T. and
            Vihko,R.K.
  TITLE     Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and
            analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in
            mouse embryos and adult tissues
  JOURNAL   Biochem J 325 (Pt 1) (Pt 1), 199-205 (1997)
   PUBMED   9224647
REFERENCE   8  (bases 1 to 2685)
  AUTHORS   Carstensen,J.F., Tesdorpf,J.G., Kaufmann,M., Markus,M.M., Husen,B.,
            Leenders,F., Jakob,F., de Launoit,Y. and Adamski,J.
  TITLE     Characterization of 17 beta-hydroxysteroid dehydrogenase IV
  JOURNAL   J Endocrinol 150 Suppl, S3-S12 (1996)
   PUBMED   8943781
REFERENCE   9  (bases 1 to 2685)
  AUTHORS   Seedorf,U., Engel,T., Assmann,G., Leenders,F. and Adamski,J.
  TITLE     Intrinsic sterol- and phosphatidylcholine transfer activities of 17
            beta-hydroxysteroid dehydrogenase type IV
  JOURNAL   J Steroid Biochem Mol Biol 55 (5-6), 549-553 (1995)
   PUBMED   8547181
REFERENCE   10 (bases 1 to 2685)
  AUTHORS   Normand,T., Husen,B., Leenders,F., Pelczar,H., Baert,J.L.,
            Begue,A., Flourens,A.C., Adamski,J. and de Launoit,Y.
  TITLE     Molecular characterization of mouse 17 beta-hydroxysteroid
            dehydrogenase IV
  JOURNAL   J Steroid Biochem Mol Biol 55 (5-6), 541-548 (1995)
   PUBMED   8547180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004866.1 and AC118632.7.
            
            On Apr 7, 2011 this sequence version replaced NM_008292.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004866.1, AK147182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2599              AK004866.1         1-2599
            2600-2685           AC118632.7         97961-98046         c
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 27.24 cM"
     gene            1..2685
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /note="hydroxysteroid (17-beta) dehydrogenase 4"
                     /db_xref="GeneID:15488"
                     /db_xref="MGI:MGI:105089"
     exon            1..209
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2359
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /EC_number="4.2.1.107"
                     /EC_number="4.2.1.119"
                     /EC_number="1.1.1.n12"
                     /note="17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD
                     4; D-bifunctional protein; multifunctional protein 2"
                     /codon_start=1
                     /product="peroxisomal multifunctional enzyme type 2"
                     /protein_id="NP_032318.2"
                     /db_xref="CCDS:CCDS29242.1"
                     /db_xref="GeneID:15488"
                     /db_xref="MGI:MGI:105089"
                     /translation="MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVIVNDLGGD
                     FKGIGKGSSAADKVVAEIRRKGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGI
                     LRDRSFSRISDEDWDIIHRVHLRGSFQVTRAAWDHMKKQNYGRILMTSSASGIYGNFG
                     QANYSAAKLGILGLCNTLAIEGRKNNIHCNTIAPNAGSRMTETVLPEDLVEALKPEYV
                     APLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWEKI
                     CDFSNASKPQTIQESTGGIVEVLHKVDSEGISPNRTSHAAPAATSGFVGAVGHKLPSF
                     SSSYTELQSIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSMMNGGLAE
                     VPGLSFNFAKALHGEQYLELYKPLPRSGELKCEAVIADILDKGSGVVIVMDVYSYSGK
                     ELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPNRPPDAVLRDATSLNQAALYRLSG
                     DWNPLHIDPDFASVAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPV
                     YPGQTLQTEMWKEGNRIHFQTKVHETGDVVISNAYVDLVPASGVSTQTPSEGGELQSA
                     LVFGEIGRRLKSVGREVVKKANAVFEWHITKGGTVAAKWTIDLKSGSGEVYQGPAKGS
                     ADVTIIISDEDFMEVVFGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL"
     exon            210..263
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            264..371
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..431
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..453
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..500
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            501..585
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..773
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..865
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..890
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1019
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1120
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1357
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1409
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1481
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1585
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1651
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1721
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1828
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1915
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2002
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2141
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2269
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2685
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2583..2588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /note="hexamer: AATAAA"
     polyA_site      2601
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /note="major polyA site"
     regulatory      2657..2662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /note="hexamer: AATAAA"
     polyA_site      2677
                     /gene="Hsd17b4"
                     /gene_synonym="17-beta-HSD; 17[b]-HSD; DBP; MFE-2; Mfp-2;
                     MFP2; MPF-2; perMFE-2"
                     /note="major polyA site"
ORIGIN      
        1 acgcaggcgc acttggaacc accggcgcca gtttcccgag accggcaggt cacttgtttg
       61 tgtgccgccc ctcctctccc cgcccgctgt cccggtcttg ccgagcagta ctcgggacgc
      121 tgccagtgtg tgcgtggtgc aggctagact catggcttcg ccgctgaggt tcgacgggcg
      181 tgtggtcttg gtcaccggcg ccgggggagg attgggccga gcttacgccc tggcgtttgc
      241 agaaagagga gcattagtca ttgtgaacga cttaggaggg gacttcaagg gaattggtaa
      301 aggctcctct gctgcagaca aggttgtggc agagataaga aggaaaggcg gaaaagcagt
      361 ggccaattac gattcagttg aagcaggcga gaagcttgtg aagacggcac tggacacatt
      421 tggcagaata gacgttgtgg tcaacaatgc tggaatcctg agggaccgtt ccttctccag
      481 gataagtgat gaagactggg atataattca tagagttcat ttgcggggct ccttccaagt
      541 gacccgggca gcatgggacc atatgaagaa acagaattat ggaagaatcc ttatgacttc
      601 ctcagcttct ggaatatatg gcaactttgg ccaggcgaat tatagtgctg caaagctggg
      661 cattctgggt ctctgcaata ctctcgccat tgaaggcagg aagaacaaca ttcattgcaa
      721 caccattgcc cccaacgctg ggtcacggat gacggagact gtgttgccgg aagatcttgt
      781 tgaagccctg aagccagagt atgtggcccc tctggtgctt tggctttgcc atgagagctg
      841 tgaggaaaat ggtggcctat ttgaggttgg agcaggatgg attggaaaat tgcgctggga
      901 gaggaccctg ggcgccatcg tcagaaagcg gaatcagccc atgactcccg aggcagtgag
      961 ggacaactgg gagaagatct gtgacttcag caatgccagc aagccgcaga ccattcaaga
     1021 atcaacaggt ggtatagtcg aagttttaca taaggtagat tcagaaggaa tctcaccaaa
     1081 ccgtaccagt cacgcggcac ctgcagccac gtcaggattc gttggtgctg ttggccataa
     1141 acttccttca ttttcttctt cgtatacgga gctgcagagt attatgtatg ccctcggagt
     1201 gggagcgtca gtcaaaaatc caaaggattt gaagtttgtt tatgaaggca gtgctgactt
     1261 ctcctgtttg cccaccttcg gagtcattgt cgctcagaag tccatgatga atggagggct
     1321 ggcagaggtt cctgggctgt cattcaactt tgcaaaggct cttcacgggg agcagtactt
     1381 ggagctgtat aagccacttc ctcgatcagg agaattaaaa tgtgaagcag ttattgctga
     1441 catcctggat aaaggctctg gcgtagtgat tgttatggac gtctattctt attctgggaa
     1501 ggaacttata tgctataatc agttctctgt ctttgttgtt ggctctgggg gctttggtgg
     1561 aaaacggaca tcagaaaaac tcaaagcagc tgtagctgta ccaaatcgac ctccagatgc
     1621 tgtactgaga gatgccacct cactgaatca ggccgcgctg taccgcctca gcggagactg
     1681 gaatcctcta cacattgacc cggactttgc gagcgttgcc ggttttgaga agcccatatt
     1741 acatggacta tgtacctttg gattttctgc aaggcatgtt ttacagcagt ttgcagataa
     1801 tgatgtatca agattcaagg cgattaaggt tcgttttgcc aaaccagtgt atccaggaca
     1861 gactctacaa actgagatgt ggaaggaagg aaacagaatt cattttcaaa ccaaggtcca
     1921 cgagactgga gatgttgtca tttcaaatgc gtacgtggat ctcgtgcctg catctggagt
     1981 ttcaacccag acaccttcag agggtggaga gctccagagt gctcttgtgt ttggggagat
     2041 aggccgccgc ctcaagagtg ttggccgtga ggtggtaaag aaagcgaatg ctgtgtttga
     2101 atggcatatc acgaaaggtg ggactgttgc agccaagtgg accattgacc tgaagagcgg
     2161 ctcaggggag gtgtaccaag gccccgcaaa gggctctgct gatgtgacca tcatcatttc
     2221 cgatgaggat tttatggaag tggtcttcgg caagcttgac ccacagaagg ccttcttcag
     2281 tggcaggctg aaggccagag ggaacatcat gctgagccag aaactacaga tgattcttaa
     2341 agactatgcc aagctctgaa gggacccact gtgtgctgtt aaaggagtca ataattaaat
     2401 actgtctacc cagctgagcc gcagccttct gcgatccaca ggagtgtgca gcagaaatcg
     2461 cttcacattt ccagattcag ataacttgca tattttcatt ttctactaat ttttcacata
     2521 tttttacaag gaactgtaat ctaggtagca aaataatcat tctgttcata gatctgtatc
     2581 ttaataaaaa aaatcaacca agtctggttt ctttagactt tgtaaaagca ttagtatgtg
     2641 aaaggaaaac ggaatgaata aaagccactt taccgcttgt ctccc
//
