LOCUS       NM_008291               1286 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 3 (Hsd17b3),
            mRNA.
ACCESSION   NM_008291
VERSION     NM_008291.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Junnila,A., Zhang,F.P., Martinez Nieto,G., Hakkarainen,J.,
            Makela,J.A., Ohlsson,C., Sipila,P. and Poutanen,M.
  TITLE     HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis
            but Not in Adults
  JOURNAL   Endocrinology 165 (6) (2024)
   PUBMED   38785348
  REMARK    GeneRIF: HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse
            Testis but Not in Adults.
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Whiley,P.A.F., Luu,M.C.M., O'Donnell,L., Handelsman,D.J. and
            Loveland,K.L.
  TITLE     Testis exposure to unopposed/elevated activin A in utero affects
            somatic and germ cells and alters steroid levels mimicking
            phthalate exposure
  JOURNAL   Front Endocrinol (Lausanne) 14, 1234712 (2023)
   PUBMED   37727456
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1286)
  AUTHORS   Vainio,S., Heikkila,M., Kispert,A., Chin,N. and McMahon,A.P.
  TITLE     Female development in mammals is regulated by Wnt-4 signalling
  JOURNAL   Nature 397 (6718), 405-409 (1999)
   PUBMED   9989404
REFERENCE   7  (bases 1 to 1286)
  AUTHORS   Baker,P.J., Sha,J.H. and O'Shaughnessy,P.J.
  TITLE     Localisation and regulation of 17beta-hydroxysteroid dehydrogenase
            type 3 mRNA during development in the mouse testis
  JOURNAL   Mol Cell Endocrinol 133 (2), 127-133 (1997)
   PUBMED   9406858
REFERENCE   8  (bases 1 to 1286)
  AUTHORS   Mustonen,M.V., Poutanen,M.H., Isomaa,V.V., Vihko,P.T. and
            Vihko,R.K.
  TITLE     Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and
            analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in
            mouse embryos and adult tissues
  JOURNAL   Biochem J 325 (Pt 1) (Pt 1), 199-205 (1997)
   PUBMED   9224647
REFERENCE   9  (bases 1 to 1286)
  AUTHORS   Sha,J.A., Dudley,K., Rajapaksha,W.R. and O'Shaughnessy,P.J.
  TITLE     Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA
            and tissue distribution of the type 1 and type 3 isoform mRNAs
  JOURNAL   J Steroid Biochem Mol Biol 60 (1-2), 19-24 (1997)
   PUBMED   9182854
REFERENCE   10 (bases 1 to 1286)
  AUTHORS   Sha,J., Baker,P. and O'Shaughnessy,P.J.
  TITLE     Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types
            1 and 3) are expressed during development in the mouse testis
  JOURNAL   Biochem Biophys Res Commun 222 (1), 90-94 (1996)
   PUBMED   8630080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB621153.1, U66827.1 and BB041573.2.
            
            On Jul 25, 2007 this sequence version replaced NM_008291.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-497               BB621153.1         1-497
            498-1000            U66827.1           483-985
            1001-1246           BB041573.2         382-627
            1247-1286           U66827.1           1091-1130
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 33.26 cM"
     gene            1..1286
                     /gene="Hsd17b3"
                     /note="hydroxysteroid (17-beta) dehydrogenase 3"
                     /db_xref="GeneID:15487"
                     /db_xref="MGI:MGI:107177"
     exon            1..215
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            216..262
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            263..338
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            339..446
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            447..514
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            515..550
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..585
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            586..667
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            668..733
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..880
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1286
                     /gene="Hsd17b3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgccctggg aatcacacgg ggataaagac caggtccagc agcatctcca gcaagacagc
       61 tccagaggag gccatggaga agctcttcat tgctgcaggg ctcttcgtgg gcctggtttg
      121 cctggtgaag tgcatgaggt tctcgcagca cctttttctg aggttctgca aggctttgcc
      181 aagctctttc ctgcgatcaa tgggacaatg ggcagtgatt accggagcag gcgatggcat
      241 cgggaaagcc tattcatttg agttggccag acatggactc aatgttgtac ttattagtcg
      301 gacactggaa aagctacaga ccattgcaga agagattgag aggaccactg gaagctgtgt
      361 gaagattgta caagcagatt ttaccagaga agacatctat gaccatatta aagaacacct
      421 tgaaggctta gaaataggaa ttttagtcaa caacgttgga atgctcccca gctttttccc
      481 aagccatttc ctgagcactt ccggtgagag ccagaatctc atccactgca acattacctc
      541 cgtagtcaag atgacacagc ttgttctcaa acacatggag tcaaggagga aaggcctcat
      601 cttgaatatt tcttcaggcg cagcccttcg tccctggcct ctttacagcc tgtactcagc
      661 ttccaaggct tttgtgtaca cattttccaa ggctctgagt gtggaataca gagataaagg
      721 aatcattatt caggtgctga ccccttattc tatttcaacc ccaatgacaa agtacctaaa
      781 taacaagatg accaagaccg ccgatgagtt tgttaaagaa tccttgaaat atgtcacgat
      841 cggagctgaa tcctgtggct gccttgctca tgaaatcatt gcaataattc tgaaccggat
      901 cccttccaga atcttctata gcagcaccgc tcaacgattc ctcctgacac gatactcaga
      961 ttacctcaaa cgcaacatca gcaacagata gtgggggaag ggtgtgtgtg ggggggtaga
     1021 gttagggttg ggtgggggta gggtgaggtg gggctggagg gagagttgag aaggacatcc
     1081 agagctcttc attggtagta gtggccagag ggtggtgacc cttgacctcc tgaaagggag
     1141 ccttccatgc cacaggcaca gtgtgcagtt gttggaattc agagatctta ggaaaagctg
     1201 gggtgtaaag gctgtgtttc tataaaaggg aggctggcat caagggaaat gctggaagaa
     1261 cccctccccc caaataataa atatac
//
