LOCUS       NM_008290               1280 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 2 (Hsd17b2),
            mRNA.
ACCESSION   NM_008290
VERSION     NM_008290.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1280)
  AUTHORS   Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S,
            Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA and
            Xu S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   2  (bases 1 to 1280)
  AUTHORS   Boucher E, Provost PR, Plante J and Tremblay Y.
  TITLE     Androgen receptor and 17beta-HSD type 2 regulation in neonatal
            mouse lung development
  JOURNAL   Mol Cell Endocrinol 311 (1-2), 109-119 (2009)
   PUBMED   19576262
  REMARK    GeneRIF: These results demonstrate temporal and spatial regulation
            of androgen receptor and 17beta-HSD 2 during the sacculo-alveolar
            transition period of mouse lung development suggesting control of
            androgen action.[17beta HSD2]
REFERENCE   3  (bases 1 to 1280)
  AUTHORS   Plante J, Simard M, Rantakari P, Cote M, Provost PR, Poutanen M and
            Tremblay Y.
  TITLE     Epithelial cells are the major site of hydroxysteroid (17beta)
            dehydrogenase 2 and androgen receptor expression in fetal mouse
            lungs during the period overlapping the surge of surfactant
  JOURNAL   J Steroid Biochem Mol Biol 117 (4-5), 139-145 (2009)
   PUBMED   19737616
REFERENCE   4  (bases 1 to 1280)
  AUTHORS   Rantakari P, Strauss L, Kiviranta R, Lagerbohm H, Paviala J,
            Holopainen I, Vainio S, Pakarinen P and Poutanen M.
  TITLE     Placenta defects and embryonic lethality resulting from disruption
            of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene
  JOURNAL   Mol Endocrinol 22 (3), 665-675 (2008)
   PUBMED   18048640
  REMARK    GeneRIF: HSD17B2 plays a role in the cellular organization of the
            mouse placenta.
REFERENCE   5  (bases 1 to 1280)
  AUTHORS   Kesavan C, Baylink DJ, Kapoor S and Mohan S.
  TITLE     Novel loci regulating bone anabolic response to loading: expression
            QTL analysis in C57BL/6JXC3H/HeJ mice cross
  JOURNAL   Bone 41 (2), 223-230 (2007)
   PUBMED   17543594
REFERENCE   6  (bases 1 to 1280)
  AUTHORS   Tremblay Y and Provost PR.
  TITLE     17Beta-HSD type 5 expression and the emergence of differentiated
            epithelial Type II cells in fetal lung: a novel role for androgen
            during the surge of surfactant
  JOURNAL   Mol Cell Endocrinol 248 (1-2), 118-125 (2006)
   PUBMED   16337335
REFERENCE   7  (bases 1 to 1280)
  AUTHORS   Provost PR, Simard M and Tremblay Y.
  TITLE     A link between lung androgen metabolism and the emergence of mature
            epithelial type II cells
  JOURNAL   Am J Respir Crit Care Med 170 (3), 296-305 (2004)
   PUBMED   15117747
REFERENCE   8  (bases 1 to 1280)
  AUTHORS   Nokelainen P, Peltoketo H, Mustonen M and Vihko P.
  TITLE     Expression of mouse 17beta-hydroxysteroid
            dehydrogenase/17-ketosteroid reductase type 7 in the ovary, uterus,
            and placenta: localization from implantation to late pregnancy
  JOURNAL   Endocrinology 141 (2), 772-778 (2000)
   PUBMED   10650959
REFERENCE   9  (bases 1 to 1280)
  AUTHORS   Mustonen M, Poutanen M, Chotteau-Lelievre A, de Launoit Y, Isomaa
            V, Vainio S, Vihko R and Vihko P.
  TITLE     Ontogeny of 17beta-hydroxysteroid dehydrogenase type 2 mRNA
            expression in the developing mouse placenta and fetus
  JOURNAL   Mol Cell Endocrinol 134 (1), 33-40 (1997)
   PUBMED   9406847
REFERENCE   10 (bases 1 to 1280)
  AUTHORS   Mustonen MV, Poutanen MH, Isomaa VV, Vihko PT and Vihko RK.
  TITLE     Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and
            analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in
            mouse embryos and adult tissues
  JOURNAL   Biochem J 325 (Pt 1) (Pt 1), 199-205 (1997)
   PUBMED   9224647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004950.1, BE649625.1, AA027607.1 and AV257369.1.
            
            [WARNING] On Oct 12, 2023 this sequence was replaced by
            NM_008290.3.
            
            On Jan 19, 2007 this sequence version replaced NM_008290.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y09517.1, AK004950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-631               AK004950.1         2-632
            632-834             BE649625.1         263-465
            835-1002            AK004950.1         837-1004
            1003-1150           AA027607.1         137-284
            1151-1278           AK004950.1         1153-1280
            1279-1280           AV257369.1         249-250
FEATURES             Location/Qualifiers
     source          1..1280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 64.82 cM"
     gene            1..1280
                     /gene="Hsd17b2"
                     /note="hydroxysteroid (17-beta) dehydrogenase 2"
                     /db_xref="GeneID:15486"
                     /db_xref="MGI:MGI:1096386"
     exon            1..318
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1196
                     /gene="Hsd17b2"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.239"
                     /note="17-beta-HSD 2; testosterone 17-beta-dehydrogenase;
                     17-beta-hydroxysteroid dehydrogenase 2;
                     17-beta-hydroxysteroid dehydrogenase type 2; 17 HSD type
                     2"
                     /codon_start=1
                     /product="estradiol 17-beta-dehydrogenase 2"
                     /protein_id="NP_032316.2"
                     /db_xref="CCDS:CCDS40491.1"
                     /db_xref="GeneID:15486"
                     /db_xref="MGI:MGI:1096386"
                     /translation="MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLW
                     GGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKH
                     LDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDK
                     GLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNV
                     SSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDI
                     WDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARN
                     PSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH"
     exon            319..531
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..717
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..855
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1280
                     /gene="Hsd17b2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgcactca cagtattcac tggcccagag caagtgaagg ccagtggaga atgagcccgt
       61 ttgcctctga gtcagcatgg ctctgcttgg ctgccgctgc agtgctgggg ggcacgcttc
      121 tctgcggatg ccggagtggc aggcagctgc ggagccaggc ggtgtgtctc gctggcctct
      181 ggggaggtgc ctgcctgctc agtctgtccc tcctctgcac cttgttcctc ttatccgtgg
      241 cctgcttcct tcttctgtat atgagttcat ctgaccaaga cttgttacct gtggatcaaa
      301 aggccgtgct ggtgacaggt gctgattccg gtttcggtca cggtttggcc aagcacctgg
      361 acaagctggg tttcacagtg tttgctggag tgctggacaa agagggcccg ggagcagagg
      421 aactgagaaa acactgctct gagcgtcttt cagtgctcca gatggatgtc accaagccag
      481 agcagataaa agatgctcac agcaaagtca cagagaagat acaagacaaa ggactgtggg
      541 ccgtggttaa caatgccggg gtcttccact tacctatcga cggggaactc atacccatga
      601 gcatctacag aaaatgcatg gccgtgaact tcttcggaac tgtcgaggtc accaaggcgt
      661 ttctgcctct acttagaaag tccaagggga ggctggtgaa cgtcagcagc atgggaggca
      721 cggttccact tcaaatgaca tcagcttatg cagccacaaa ggcagctcta accatgttct
      781 caacaatcat cagacaggag cttgacaaat ggggagttaa agttgtgacc atcaaacccg
      841 gaggcttcaa aacaaacatc acaggctcac aggacatttg ggataaaatg gagaaggaaa
      901 tcctggacca cttttccaaa gatattcagg agaactatgg ccaggactac gtccatacac
      961 agaagctcat catcccgacc ttgaaagaga ggtccaaccc ggacatcacc cctgtgcttc
     1021 gggacatcca gcatgccatt tctgcaagga acccctcttc cttttattac ccagggcgaa
     1081 tggcttacct gtgggtctgc ttagcagcct actgccccac cagcttactt gactatgtta
     1141 taaaaaaagg tttttatcca caacccacgc cgagagcttt aaggacagtg cactagaagc
     1201 acaaggcccc agtggggtgg ggaatgtcac attcttaaga tgaaagcaaa acctcttatt
     1261 aaactaattt tctacctcag
//
