LOCUS       NM_025330               1365 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 14 (Hsd17b14),
            mRNA.
ACCESSION   NM_025330 XM_914789
VERSION     NM_025330.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151602.4.
            
            On Apr 23, 2010 this sequence version replaced NM_025330.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to represent an
            alternate splice pattern represented by human mRNA BC006283.2, and
            mouse ESTs CN676828.1 and BY709969.1.  The updated CDS is more
            supported by the available conservation data and extends the
            N-terminus by 163-aa.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849376,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC151602.4         35398-35536         c
            140-178             AC151602.4         34371-34409         c
            179-261             AC151602.4         34069-34151         c
            262-328             AC151602.4         32790-32856         c
            329-420             AC151602.4         30992-31083         c
            421-525             AC151602.4         27445-27549         c
            526-593             AC151602.4         24442-24509         c
            594-690             AC151602.4         24248-24344         c
            691-1365            AC151602.4         23143-23817         c
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.35 cM"
     gene            1..1365
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /note="hydroxysteroid (17-beta) dehydrogenase 14"
                     /db_xref="GeneID:66065"
                     /db_xref="MGI:MGI:1913315"
     exon            1..139
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..873
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /EC_number="1.1.1.62"
                     /note="dehydrogenase/reductase (SDR family) member 10"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase 14"
                     /protein_id="NP_079606.3"
                     /db_xref="CCDS:CCDS21251.2"
                     /db_xref="GeneID:66065"
                     /db_xref="MGI:MGI:1913315"
                     /translation="MAAVTRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEA
                     GGRALEQELSGTVFIPGDVTQERDLQTLVSETLSRFGHLDCVVNNAGYHPPAQLPEET
                     SAQGFRQLLEVNLLGTYTLIKLALPHLRKSRGNIINISSLVGAIGQSQALTYVATKGA
                     VTAMTKALALDESRHGVRVNCISPGNIWTPLWEELAASTSDPRATILEGTLAQPLGRM
                     GQPAEVAAAAVFLASEATFCTGLELLVTGGAELGYGRKASKSSLGEVPTLPPNVH"
     exon            140..178
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..261
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..328
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..420
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..525
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     exon            526..593
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     exon            594..690
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1365
                     /gene="Hsd17b14"
                     /gene_synonym="0610039E24Rik; Dhrs10; retSDR3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggactgtg gaggtgggaa gaggtccaga gggcgtggga tacagctggg gatggctgca
       61 gtaacccgat attctgggaa ggtggtggtg gtgactggag gcagccgggg catcggggct
      121 gcgatcgtga gagccttcgt ggacagtggg gctcaagtgg ttttctgtga caaggatgag
      181 gctgggggcc gggctctgga gcaggaactc tcgggcactg tttttatccc cggtgacgtg
      241 acacaggaaa gagatttgca gactctggtt tctgagaccc tctctcgatt tggtcacctg
      301 gattgtgtgg tgaataacgc tggctaccac ccacctgcac agctgcccga ggagacctct
      361 gcccagggct tccgtcagct tctggaggtg aacctgctgg ggacatacac cttgatcaag
      421 cttgccctcc cccacctgcg gaagagcaga gggaacatca tcaacatctc cagcttggtc
      481 ggggccatcg gccagtccca ggcccttacc tacgtggcca ccaagggtgc agtgactgcc
      541 atgaccaaag ctttggcttt ggatgaaagc agacatggtg tccgagtcaa ctgcatctcc
      601 ccaggaaaca tctggactcc actgtgggaa gagcttgcag cctcaacttc agaccccagg
      661 gccaccattc tagaaggcac cttggcccag cccctgggcc gcatgggcca gccagccgag
      721 gtggcggctg cagccgtttt cctggcctct gaagccacct tctgtacagg gcttgagctt
      781 ctcgtgaccg ggggtgcaga actggggtat ggacgcaagg ctagtaaaag cagcctcggg
      841 gaagtcccca ctctcccacc taatgtacac taactatgtc ttgcccatcc atttctccct
      901 cccttccttt cttgtagtac tggagattaa acctggatct cttgtgtgct aggcagaggc
      961 tctatcactg agtcacactc cagtgcccca ctggaggatt ctaggcaggg gctctcccac
     1021 ttaactttca ggtcccaaag aaactcagga taagctagct gctggcagcg aggccctctc
     1081 agtacctgct acttcccttg cccctgctcc taacctctct agcccaggga ctttgcgccc
     1141 ctccccgcag cttgattcct ataaaaacct gccattttgg atgaatgtgc tgttcgccct
     1201 tggctccttt cttggtccac ttgccctctc tcttctctct ctctcctttc actttctctg
     1261 cccctccctc cctgatctca tggaccagtt tagtctggac tctacccgat gcctctggct
     1321 atactctccc ttatagctac aataaaagcc atccccccag ttata
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