LOCUS       NM_001163486            1284 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13),
            transcript variant 1, mRNA.
ACCESSION   NM_001163486
VERSION     NM_001163486.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Zhang,H., Chang,J., Dai,Z., Wang,Q., Qiao,R., Huang,Y., Ma,B.,
            Jiang,J., Zhu,C., Su,W., Zhang,X. and Guan,Y.
  TITLE     Expression and localization of HSD17B13 along mouse urinary tract
  JOURNAL   Am J Physiol Renal Physiol 327 (1), F146-F157 (2024)
   PUBMED   38779753
  REMARK    GeneRIF: Expression and localization of HSD17B13 along mouse
            urinary tract.
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Su,W., Wu,S., Yang,Y., Guo,Y., Zhang,H., Su,J., Chen,L., Mao,Z.,
            Lan,R., Cao,R., Wang,C., Xu,H., Zhang,C., Li,S., Gao,M., Chen,X.,
            Zheng,Z., Wang,B., Liu,Y., Liu,Z., Wang,Z., Liu,B., Fan,X.,
            Zhang,X. and Guan,Y.
  TITLE     Phosphorylation of 17beta-hydroxysteroid dehydrogenase 13 at serine
            33 attenuates nonalcoholic fatty liver disease in mice
  JOURNAL   Nat Commun 13 (1), 6577 (2022)
   PUBMED   36323699
  REMARK    GeneRIF: Phosphorylation of 17beta-hydroxysteroid dehydrogenase 13
            at serine 33 attenuates nonalcoholic fatty liver disease in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Ma,Y., Brown,P.M., Lin,D.D., Ma,J., Feng,D., Belyaeva,O.V.,
            Podszun,M.C., Roszik,J., Allen,J.N., Umarova,R., Kleiner,D.E.,
            Kedishvili,N.Y., Gavrilova,O., Gao,B. and Rotman,Y.
  TITLE     17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect
            Mice From Obesogenic Diet Injury
  JOURNAL   Hepatology 73 (5), 1701-1716 (2021)
   PUBMED   32779242
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Adam,M., Heikela,H., Sobolewski,C., Portius,D., Maki-Jouppila,J.,
            Mehmood,A., Adhikari,P., Esposito,I., Elo,L.L., Zhang,F.P.,
            Ruohonen,S.T., Strauss,L., Foti,M. and Poutanen,M.
  TITLE     Hydroxysteroid (17beta) dehydrogenase 13 deficiency triggers
            hepatic steatosis and inflammation in mice
  JOURNAL   FASEB J 32 (6), 3434-3447 (2018)
   PUBMED   29401633
  REMARK    GeneRIF: data indicate that disruption of Hsd17b13 impairs
            hepatic-lipid metabolism in mice, resulting in liver steatosis and
            inflammation, but the enzyme does not play a major role in the
            regulation of reproductive functions.
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Planas-Paz,L., Orsini,V., Boulter,L., Calabrese,D., Pikiolek,M.,
            Nigsch,F., Xie,Y., Roma,G., Donovan,A., Marti,P., Beckmann,N.,
            Dill,M.T., Carbone,W., Bergling,S., Isken,A., Mueller,M.,
            Kinzel,B., Yang,Y., Mao,X., Nicholson,T.B., Zamponi,R.,
            Capodieci,P., Valdez,R., Rivera,D., Loew,A., Ukomadu,C.,
            Terracciano,L.M., Bouwmeester,T., Cong,F., Heim,M.H., Forbes,S.J.,
            Ruffner,H. and Tchorz,J.S.
  TITLE     The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size
  JOURNAL   Nat Cell Biol 18 (5), 467-479 (2016)
   PUBMED   27088858
  REMARK    Erratum:[Nat Cell Biol. 2016 Oct 27;18(11):1260. doi:
            10.1038/ncb3428.. PMID: 27784900]
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Horiguchi,Y., Araki,M. and Motojima,K.
  TITLE     17beta-Hydroxysteroid dehydrogenase type 13 is a liver-specific
            lipid droplet-associated protein
  JOURNAL   Biochem Biophys Res Commun 370 (2), 235-238 (2008)
   PUBMED   18359291
  REMARK    GeneRIF: 17betaHSD type 13 may have a distinct physiological role
            as a lipid droplet-associated protein in the liver.
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Isaacs,A.M., Oliver,P.L., Jones,E.L., Jeans,A., Potter,A.,
            Hovik,B.H., Nolan,P.M., Vizor,L., Glenister,P., Simon,A.K.,
            Gray,I.C., Spurr,N.K., Brown,S.D., Hunter,A.J. and Davies,K.E.
  TITLE     A mutation in Af4 is predicted to cause cerebellar ataxia and
            cataracts in the robotic mouse
  JOURNAL   J Neurosci 23 (5), 1631-1637 (2003)
   PUBMED   12629167
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Brereton,P., Suzuki,T., Sasano,H., Li,K., Duarte,C.,
            Obeyesekere,V., Haeseleer,F., Palczewski,K., Smith,I.,
            Komesaroff,P. and Krozowski,Z.
  TITLE     Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung
  JOURNAL   Mol Cell Endocrinol 171 (1-2), 111-117 (2001)
   PUBMED   11165019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI573700.1, AI048624.1 and DV660487.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY101768.1, SRR5189679.57153.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AI573700.1         1-400
            401-691             AI048624.1         388-678
            692-1284            DV660487.1         118-710
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.46 cM"
     gene            1..1284
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /note="hydroxysteroid (17-beta) dehydrogenase 13"
                     /db_xref="GeneID:243168"
                     /db_xref="MGI:MGI:2140804"
     exon            1..283
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..976
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.105"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 17-beta-hydroxysteroid dehydrogenase 13;
                     short-chain dehydrogenase/reductase 9; 17-beta-HSD 13;
                     hepatic retinol/retinal dehydrogenase"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase 13 isoform
                     1 precursor"
                     /protein_id="NP_001156958.1"
                     /db_xref="CCDS:CCDS51576.1"
                     /db_xref="GeneID:243168"
                     /db_xref="MGI:MGI:2140804"
                     /translation="MNLILEFLLLVGVIIYSYLESLVKFFIPRRRKSVTGQTVLITGA
                     GHGIGRLTAYEFAKQKSRLVLWDINKRGVEETADKCRKLGAVVHVFVVDCSNRAEIYN
                     SVDQVKREVGDVEIVVNNAGAIYPADLLSAKDEEITKTFEVNILGHFWIIKALLPSML
                     RRNSGHIVTVASVCGHGVIPYLIPYCSSKFAAVGFHRALTAELDTLGKTGIQTSCLCP
                     VFVNTGFTKNPSTRLWPVLEPEEVARSLINGILTNKKMIFVPSYINISLILEKFLPER
                     ALKAISRIQNIQFEAIVGHKTKMK"
     exon            284..391
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /inference="alignment:Splign:2.1.0"
     exon            392..523
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /inference="alignment:Splign:2.1.0"
     exon            524..630
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /inference="alignment:Splign:2.1.0"
     exon            631..768
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /inference="alignment:Splign:2.1.0"
     exon            769..885
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1284
                     /gene="Hsd17b13"
                     /gene_synonym="Pan1b; PAN1B-like"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcagccc ataatacctg acagggctct ctgtggagct ctgagcagag gtgtctgttg
       61 tgagaacaga gccatgaacc tcatcctgga atttctcctt ctggtgggcg tcatcatcta
      121 ctcctacctg gagtcactgg taaagttctt cattccccgg agaaggaaat ctgtgaccgg
      181 gcagaccgtt ctcatcacgg gggccggaca cggaataggc aggctgactg catatgaatt
      241 tgcaaagcag aaaagcagac tggttctatg ggatatcaat aagcgtggtg ttgaggaaac
      301 cgcggacaaa tgcaggaaac tgggggccgt cgtgcacgtg tttgtggtgg actgcagcaa
      361 ccgggccgag atttacaact ctgtggatca ggtaaagaga gaagtaggtg atgtcgagat
      421 cgtggtaaac aacgccgggg cgatatatcc agcagacctt cttagtgcca aggacgagga
      481 gatcaccaag acctttgagg tcaatatcct cggacatttt tggatcataa aagcactcct
      541 tccatcgatg ctgagaagaa actctggcca cattgtcaca gtggcttcgg tgtgcggcca
      601 tggagtgatt ccttatctca tcccttattg ctccagcaag tttgctgctg tgggcttcca
      661 ccgagcactg accgcagaac tggacacctt ggggaaaacc ggtatccaaa cctcgtgtct
      721 ctgccctgtg ttcgtgaata ctggcttcac caaaaacccg agtacaaggt tatggcctgt
      781 attagagccg gaagaagttg caaggagtct gatcaatgga atacttacca acaagaaaat
      841 gatcttcgtt ccatcctata tcaatatttc tctgatcctg gaaaagtttc ttcctgagcg
      901 tgccttaaaa gcgatcagtc gtatacagaa cattcaattt gaagcaattg tgggccacaa
      961 aaccaagatg aagtagtgca tgcagagacg tgtggacacc aatgatgtga agccaagttt
     1021 agaggggaca cacagctttc tttcacatgt tttaagtgtt ccacatgttt aaaatgtagg
     1081 cttgacccta gcagccatcg agtgcataag cgtggtcaac tgtccttcta gtttcctata
     1141 cttatagatg tctcagctcc tggtagtggg ttctggcaat ggatatgtaa aggagggaaa
     1201 aggcaatcca tgtgttttta taaaataaat tactaaatag aaatgtgggc aaaagggcaa
     1261 gataataaag tcttgggcaa atgt
//
