LOCUS       NM_019657               1839 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 12 (Hsd17b12),
            mRNA.
ACCESSION   NM_019657
VERSION     NM_019657.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1839)
  AUTHORS   Heikela,H., Mairinoja,L., Ruohonen,S.T., Rytkonen,K.T., de Brot,S.,
            Laiho,A., Koskinen,S., Suomi,T., Elo,L.L., Strauss,L. and
            Poutanen,M.
  TITLE     Disruption of HSD17B12 in mouse hepatocytes leads to reduced body
            weight and defect in the lipid droplet expansion associated with
            microvesicular steatosis
  JOURNAL   FASEB J 38 (17), e70034 (2024)
   PUBMED   39248019
REFERENCE   2  (bases 1 to 1839)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1839)
  AUTHORS   Heikela,H., Ruohonen,S.T., Adam,M., Viitanen,R., Liljenback,H.,
            Eskola,O., Gabriel,M., Mairinoja,L., Pessia,A., Velagapudi,V.,
            Roivainen,A., Zhang,F.P., Strauss,L. and Poutanen,M.
  TITLE     Hydroxysteroid (17beta) dehydrogenase 12 is essential for metabolic
            homeostasis in adult mice
  JOURNAL   Am J Physiol Endocrinol Metab 319 (3), E494-E508 (2020)
   PUBMED   32691632
  REMARK    GeneRIF: Hydroxysteroid (17beta) dehydrogenase 12 is essential for
            metabolic homeostasis in adult mice.
REFERENCE   4  (bases 1 to 1839)
  AUTHORS   Kemilainen,H., Adam,M., Maki-Jouppila,J., Damdimopoulou,P.,
            Damdimopoulos,A.E., Kere,J., Hovatta,O., Laajala,T.D.,
            Aittokallio,T., Adamski,J., Ryberg,H., Ohlsson,C., Strauss,L. and
            Poutanen,M.
  TITLE     The Hydroxysteroid (17beta) Dehydrogenase Family Gene HSD17B12 Is
            Involved in the Prostaglandin Synthesis Pathway, the Ovarian
            Function, and Regulation of Fertility
  JOURNAL   Endocrinology 157 (10), 3719-3730 (2016)
   PUBMED   27490311
  REMARK    GeneRIF: important role in female fertility through its role in
            arachidonic acid metabolism
REFERENCE   5  (bases 1 to 1839)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 1839)
  AUTHORS   Ehrich,T.H., Kenney,J.P., Vaughn,T.T., Pletscher,L.S. and
            Cheverud,J.M.
  TITLE     Diet, obesity, and hyperglycemia in LG/J and SM/J mice
  JOURNAL   Obes Res 11 (11), 1400-1410 (2003)
   PUBMED   14627762
REFERENCE   7  (bases 1 to 1839)
  AUTHORS   Moon,Y.A. and Horton,J.D.
  TITLE     Identification of two mammalian reductases involved in the
            two-carbon fatty acyl elongation cascade
  JOURNAL   J Biol Chem 278 (9), 7335-7343 (2003)
   PUBMED   12482854
REFERENCE   8  (bases 1 to 1839)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1839)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   10 (bases 1 to 1839)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BX284932.7 and
            AL772372.4.
            
            On Apr 29, 2007 this sequence version replaced NM_019657.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081869.1, AK078841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               BX284932.7         21412-21611         c
            201-247             AL772372.4         189635-189681       c
            248-323             AL772372.4         187198-187273       c
            324-431             AL772372.4         155372-155479       c
            432-496             AL772372.4         138614-138678       c
            497-541             AL772372.4         137759-137803       c
            542-576             AL772372.4         124459-124493       c
            577-658             AL772372.4         117566-117647       c
            659-724             AL772372.4         116078-116143       c
            725-874             AL772372.4         106132-106281       c
            875-1839            AL772372.4         104902-105866       c
FEATURES             Location/Qualifiers
     source          1..1839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.62 cM"
     gene            1..1839
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /note="hydroxysteroid (17-beta) dehydrogenase 12"
                     /db_xref="GeneID:56348"
                     /db_xref="MGI:MGI:1926967"
     exon            1..200
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..979
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.330"
                     /note="steroid dehydrogenase; estradiol
                     17-beta-dehydrogenase 12; KAR; 17-beta-HSD 12;
                     3-ketoacyl-CoA reductase; 17-beta-hydroxysteroid
                     dehydrogenase 12; keratonectin; keratoadhesin"
                     /codon_start=1
                     /product="very-long-chain 3-oxoacyl-CoA reductase"
                     /protein_id="NP_062631.1"
                     /db_xref="CCDS:CCDS16458.1"
                     /db_xref="GeneID:56348"
                     /db_xref="MGI:MGI:1926967"
                     /translation="MECAPPAAGFLYWVGASTIAYLALRASYSLFRAFQVWCVGNEAL
                     VGPRLGEWAVVTGGTDGIGKAYAEELAKRGMKIVLISRSQDKLNQVSNNIKEKFNVET
                     RTIAVDFSLDDIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLEIPDLDNTIKKLINI
                     NVLSVCKVTRLVLPGMVERSKGVILNISSASGMLPVPLLTIYSATKAFVDFFSQCLHE
                     EYKSKGIFVQSVMPYLVATKLAKIQKPTLDKPSAETFVKSAIKTVGLQTRTTGYVIHS
                     LMGSINSIMPRWMYFKIIMGFSKSLRNRYLKKRKKN"
     exon            201..247
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..323
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..431
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..496
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..541
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..576
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..658
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..724
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..874
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1839
                     /gene="Hsd17b12"
                     /gene_synonym="2610510O05Rik; KIK-I; Kik1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccccatt caccgtagta gtgaggccta gtcacgagcc atggagtgcg ctcccccggc
       61 ggccggcttc ctgtactggg tgggcgcgag caccattgcc tacctggccc tgcgagcctc
      121 gtactcgctc ttcagggcct tccaggtgtg gtgcgtgggc aacgaggcct tggtcggtcc
      181 gcgactcgga gaatgggcag ttgttacagg tggcactgat ggaattggaa aagcatatgc
      241 agaagagtta gcaaaacgtg gaatgaagat tgtcctgatc agcaggtccc aagataaact
      301 gaatcaggtt tccaacaaca tcaaagaaaa attcaacgtt gaaacaagga ccattgctgt
      361 cgacttttca ttggatgata tttatgataa aattaagaca ggcctgtctg gtcttgagat
      421 tggcgtttta gtgaacaacg tgggcatgtc atacgagtat ccggaatact ttctggaaat
      481 tcccgacttg gacaacacca tcaagaaact gataaatatt aatgtgcttt ccgtttgcaa
      541 ggtgacacgc ttggtgctgc ctggcatggt agaaagatct aaaggggtga ttctcaacat
      601 ctcctcagcc agtggcatgc tcccagttcc attgttgaca atctactctg caaccaaggc
      661 ctttgtagat ttcttctctc agtgcctcca tgaggagtat aagagcaagg gcatctttgt
      721 gcagagtgtc atgccatacc ttgtagctac aaaactggca aaaatacaga agccgacttt
      781 ggataagccc tctgcagaga catttgtgaa gtctgcaatt aaaacagtag gtttgcagac
      841 ccgaaccact ggatatgtga tccactctct catgggctca ataaactcaa tcatgcctcg
      901 ttggatgtat tttaaaataa tcatgggttt cagcaagtct ttgcggaatc gctacctgaa
      961 gaaaaggaag aagaactaag tgctgctgag ttattgggcc ccttggccag gtgtttgacc
     1021 tgtgcctata cactgggcac ctgcctgtcc ccagagtctt cactgttgtc tcagtaatta
     1081 ctaacatggc atagttggca gaaaacaaat tccttttaga ggctcctaac atatattctg
     1141 gatacaacca ggagtaattt gaagtttaat gtaaatgttc ttggcaaatg tatgttcctt
     1201 tgacaaaaag gaacaaatcc cagaatgaca gcggtagaca cagacccatc tggcccacag
     1261 tgccaatgac cacattatat ttggtctgga agctactata aagtgcattt tttattttag
     1321 cattagaggg aacagggctc gattaatttg ttatgggcag attcagtgta gtttacatcg
     1381 agttctgtga gcttttctaa gtgtatgtcc cagcttcgta tttatgtggc actggtcttc
     1441 tcaaaggtgg ctaagacata aaaagagaat tgaaacatgg agttctttct aacacgtaag
     1501 tccacaaaat gttattcttg gaccacacat catgtctgct ctgttcaaat gtatgtaaat
     1561 actgaatgct atatagtgtg cccggaatgt agaggtaagt gggccaaagt gtacatcaag
     1621 accaacaaca tcctgtggta ccgcaggatc caggaaagca gcctgtgtgg acacacagca
     1681 ttcgttgtgt ctgcactgca cccggatact tgcctaggat ggcagactcc ttctggggtg
     1741 ggtggtgggg tcatggaaac atgttctttc taagatggtg tctcatattt agaattcata
     1801 tatctgcttt taataaaaga tgatgtaact gtggtgttg
//
