LOCUS       NM_053262               1699 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 11 (Hsd17b11),
            mRNA.
ACCESSION   NM_053262 XM_984195
VERSION     NM_053262.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Horiguchi,Y., Araki,M. and Motojima,K.
  TITLE     Identification and characterization of the ER/lipid
            droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase
            type 11
  JOURNAL   Arch Biochem Biophys 479 (2), 121-130 (2008)
   PUBMED   18804447
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Yokoi,Y., Horiguchi,Y., Araki,M. and Motojima,K.
  TITLE     Regulated expression by PPARalpha and unique localization of
            17beta-hydroxysteroid dehydrogenase type 11 protein in mouse
            intestine and liver
  JOURNAL   FEBS J 274 (18), 4837-4847 (2007)
   PUBMED   17714510
  REMARK    GeneRIF: data indicate that 17beta-HSD11 localizes both in the
            endoplasmic reticulum and in lipid droplets, depending on
            physiologic conditions
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Chai,Z., Brereton,P., Suzuki,T., Sasano,H., Obeyesekere,V.,
            Escher,G., Saffery,R., Fuller,P., Enriquez,C. and Krozowski,Z.
  TITLE     17 beta-hydroxysteroid dehydrogenase type XI localizes to human
            steroidogenic cells
  JOURNAL   Endocrinology 144 (5), 2084-2091 (2003)
   PUBMED   12697717
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Brereton,P., Suzuki,T., Sasano,H., Li,K., Duarte,C.,
            Obeyesekere,V., Haeseleer,F., Palczewski,K., Smith,I.,
            Komesaroff,P. and Krozowski,Z.
  TITLE     Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung
  JOURNAL   Mol Cell Endocrinol 171 (1-2), 111-117 (2001)
   PUBMED   11165019
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL714024.31.
            
            On Nov 17, 2006 this sequence version replaced NM_053262.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038340.1, AK155327.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AL714024.31        117009-117275
            268-375             AL714024.31        120524-120631
            376-507             AL714024.31        128879-129010
            508-614             AL714024.31        130120-130226
            615-752             AL714024.31        135496-135633
            753-869             AL714024.31        145871-145987
            870-1699            AL714024.31        148211-149040
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.52 cM"
     gene            1..1699
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /note="hydroxysteroid (17-beta) dehydrogenase 11"
                     /db_xref="GeneID:114664"
                     /db_xref="MGI:MGI:2149821"
     exon            1..267
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..954
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /EC_number="1.1.1.62"
                     /note="dehydrogenase/reductase (SDR family) member 8;
                     retinal short-chain dehydrogenase/reductase 2; estradiol
                     17-beta-dehydrogenase 11; retinal short-chain
                     dehydrogenase/reductase SDR2; 17bHSD11; 17betaHSD11;
                     17betaHSDXI; 17-beta-HSD 11; 17-beta-HSD XI;
                     17-beta-hydroxysteroid dehydrogenase 11;
                     17-beta-hydroxysteroid dehydrogenase XI; 17beta-HSD11"
                     /codon_start=1
                     /product="estradiol 17-beta-dehydrogenase 11 precursor"
                     /protein_id="NP_444492.1"
                     /db_xref="CCDS:CCDS19481.1"
                     /db_xref="GeneID:114664"
                     /db_xref="MGI:MGI:2149821"
                     /translation="MKYLLDLILLLPLLIVFSIESLVKLFIPKKKKSVAGEIVLITGA
                     GHGIGRLTAYEFAKLNTKLVLWDINKNGIEETAAKCRKLGAQAHPFVVDCSQREEIYS
                     AAKKVKEEVGDVSILVNNAGVVYTADLFATQDPQIEKTFEVNVLAHFWTTKAFLPVMM
                     KNNHGHIVTVASAAGHTVVPFLLAYCSSKFAAVGFHRALTDELAALGRTGVRTSCLCP
                     NFINTGFIKNPSTNLGPTLEPEEVVEHLMHGILTEKQMIFVPSSIALLTVLERIVPER
                     FLQVLKHRINVKFDAVVGYKDK"
     exon            268..375
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..507
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..614
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..752
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..869
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1699
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /note="hexamer: AATAAA"
     polyA_site      1692
                     /gene="Hsd17b11"
                     /gene_synonym="Dhrs8; Pan1b; retSDR2; SDR2"
                     /note="major polyA site"
ORIGIN      
        1 cgacaccctc cagaggccgt ttaggaccgg gaacgagagc accgggcctc caaaaggatg
       61 aagtatcttc ttgacttgat cctgctgctg cctttgctca tcgtcttcag cattgagtct
      121 cttgtcaagc tttttattcc caagaagaaa aaatctgtcg ccggagagat cgtcctgatc
      181 accggagctg gtcatgggat tggaagactg actgcctacg aatttgccaa acttaacacc
      241 aaactggttc tctgggatat caataagaac ggcatcgagg aaacagctgc taagtgcagg
      301 aagctgggtg cccaggccca tccctttgtg gtggactgca gccagcggga agagatttac
      361 agcgctgcga aaaaggtaaa ggaagaagtt ggagatgtta gcattctggt aaataacgct
      421 ggcgttgtct acactgcaga cttatttgct acgcaggacc ctcagattga aaagactttc
      481 gaagtcaatg tgcttgcaca cttttggacc accaaggcat ttctcccagt gatgatgaag
      541 aataatcatg gccacattgt cactgtggca tcagcagcag gccacaccgt ggtccccttc
      601 ttgctggctt actgctccag caagtttgct gccgttggct tccacagagc cttgactgat
      661 gagctggctg ccttgggacg aacaggagtg cgaacatcgt gcctctgccc caacttcata
      721 aacaccggct tcatcaagaa cccaagcacc aatttaggac ccaccctgga acccgaggag
      781 gtggtggaac atctcatgca cgggatcctc actgagaagc aaatgatttt cgttccgagt
      841 tccatagcac ttctgacagt attggaaagg atcgtccctg agaggttcct gcaagtccta
      901 aaacacagga tcaacgtcaa gttcgatgca gttgttgggt acaaagacaa gtgacgcagc
      961 ctgctccggt tccctgaaag ccgattgact ggatcaaagt tgatttcttc taatattaat
     1021 caaaagtttg atgtttttaa tgttttctct gtatcttgtt tcttcactgt ctcctcttga
     1081 agctgtgacc attgtcatga aagccagttt catgtcctag acccaaacag ccctaaggaa
     1141 gttgcgccta tggaaaaggc tggggggggg gggggacgac ggtgggacgg aggggtgggg
     1201 gagacggggg gggggggggg gggacaggac gggacacgac gacggggacg atgacgattg
     1261 atttcgtgat gataatttcc ccagattctg tggctcatca ccaggttttc agagcttgta
     1321 ctgtcggttt tcatttacag tgtctgtaac tgcactttga gtttgtataa ttcacacttc
     1381 ctgttctacc ccatataaaa ttagaaacct taacctctca cggtggaatg aaggactgag
     1441 tgtagtgtca tttcacagcg gagtcatgtg ctctgtaacg ttccattccg tggatcagcg
     1501 ctatttcctg agataccagc ccaagggagc ttggaggaaa agcgtctgtg ggattgcagt
     1561 ctgcgtactg gaaaacacgc ggacagatgg acagacagaa ataataaatg gaccaaatct
     1621 cacgctcagt gtctccatct gctgcagaga ccatggcttg acctttaaat aaaaggaaaa
     1681 tcaatgactc gataaagta
//
