LOCUS       NM_010475               1352 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1),
            mRNA.
ACCESSION   NM_010475
VERSION     NM_010475.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Junnila,A., Zhang,F.P., Martinez Nieto,G., Hakkarainen,J.,
            Makela,J.A., Ohlsson,C., Sipila,P. and Poutanen,M.
  TITLE     HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse Testis
            but Not in Adults
  JOURNAL   Endocrinology 165 (6) (2024)
   PUBMED   38785348
  REMARK    GeneRIF: HSD17B1 Compensates for HSD17B3 Deficiency in Fetal Mouse
            Testis but Not in Adults.
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Whiley,P.A.F., Luu,M.C.M., O'Donnell,L., Handelsman,D.J. and
            Loveland,K.L.
  TITLE     Testis exposure to unopposed/elevated activin A in utero affects
            somatic and germ cells and alters steroid levels mimicking
            phthalate exposure
  JOURNAL   Front Endocrinol (Lausanne) 14, 1234712 (2023)
   PUBMED   37727456
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   5  (bases 1 to 1352)
  AUTHORS   Bowles,J., Feng,C.W., Ineson,J., Miles,K., Spiller,C.M.,
            Harley,V.R., Sinclair,A.H. and Koopman,P.
  TITLE     Retinoic Acid Antagonizes Testis Development in Mice
  JOURNAL   Cell Rep 24 (5), 1330-1341 (2018)
   PUBMED   30067986
REFERENCE   6  (bases 1 to 1352)
  AUTHORS   Sha,J.A., Dudley,K., Rajapaksha,W.R. and O'Shaughnessy,P.J.
  TITLE     Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA
            and tissue distribution of the type 1 and type 3 isoform mRNAs
  JOURNAL   J Steroid Biochem Mol Biol 60 (1-2), 19-24 (1997)
   PUBMED   9182854
REFERENCE   7  (bases 1 to 1352)
  AUTHORS   Sha,J., Baker,P. and O'Shaughnessy,P.J.
  TITLE     Both reductive forms of 17 beta-hydroxysteroid dehydrogenase (types
            1 and 3) are expressed during development in the mouse testis
  JOURNAL   Biochem Biophys Res Commun 222 (1), 90-94 (1996)
   PUBMED   8630080
REFERENCE   8  (bases 1 to 1352)
  AUTHORS   Nokelainen,P., Puranen,T., Peltoketo,H., Orava,M., Vihko,P. and
            Vihko,R.
  TITLE     Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase
            type 1 and characterization of enzyme activity
  JOURNAL   Eur J Biochem 236 (2), 482-490 (1996)
   PUBMED   8612620
REFERENCE   9  (bases 1 to 1352)
  AUTHORS   Ramirez-Solis,R., Liu,P. and Bradley,A.
  TITLE     Chromosome engineering in mice
  JOURNAL   Nature 378 (6558), 720-724 (1995)
   PUBMED   7501018
REFERENCE   10 (bases 1 to 1352)
  AUTHORS   Deyashiki,Y., Ohshima,K., Nakanishi,M., Sato,K., Matsuura,K. and
            Hara,A.
  TITLE     Molecular cloning and characterization of mouse estradiol 17
            beta-dehydrogenase (A-specific), a member of the aldoketoreductase
            family
  JOURNAL   J Biol Chem 270 (18), 10461-10467 (1995)
   PUBMED   7737980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X89627.1 and BE691221.1.
            
            On Feb 15, 2018 this sequence version replaced NM_010475.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X89627.1, AK143346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1317              X89627.1           1-1317
            1318-1352           BE691221.1         1-35                c
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.17 cM"
     gene            1..1352
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /note="hydroxysteroid (17-beta) dehydrogenase 1"
                     /db_xref="GeneID:15485"
                     /db_xref="MGI:MGI:105077"
     exon            1..128
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1066
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.51"
                     /note="estradiol 17-beta-dehydrogenase 1; 17-beta-HSD 1"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase type 1"
                     /protein_id="NP_034605.1"
                     /db_xref="CCDS:CCDS25445.1"
                     /db_xref="GeneID:15485"
                     /db_xref="MGI:MGI:105077"
                     /translation="MDPTVVLITGCSSGIGMHLAVRLASDRSQSFKVYATLRDLKAQG
                     PLLEAARTQGCPPGSLEILELDVRDSKSVAAAQACVTEGRVDVLVCNAGRGLFGPLEA
                     HELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASK
                     FALEGLCESLAILLPLFGVHVSLIECGAVHTAFYEKLVGGPGGALERADAQTRHLFAH
                     YLRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYV
                     AAMHQEAFSNLQTQENAKAGAQVPGVSDTASSALICLPECAIPRVASELGWSASDKPG
                     QDNSCYQQKI"
     exon            129..296
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /inference="alignment:Splign:2.1.0"
     exon            297..476
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /inference="alignment:Splign:2.1.0"
     exon            477..570
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /inference="alignment:Splign:2.1.0"
     exon            571..745
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1339
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1310..1315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /note="hexamer: AATAAA"
     polyA_site      1329
                     /gene="Hsd17b1"
                     /gene_synonym="17beta-HSD; 17HSDB1; E2DH; Hsd17ba"
                     /note="major polyA site"
ORIGIN      
        1 ttgcttgctc tgaactttag tactattcca catggacccc acggtagtgc tcattaccgg
       61 ttgctcctct ggaatcggca tgcacttggc tgttcgccta gcttctgacc gttcccagag
      121 cttcaaagtt tatgccacat tgcgggacct gaaggcacag ggaccattgt tggaggccgc
      181 caggactcaa ggatgccctc ctggctcctt ggagatactg gaattggatg tcagagactc
      241 caaatctgtg gctgctgccc aggcatgcgt gactgagggt cgtgtggatg tactggtctg
      301 taatgctggc cgcggcttgt ttgggccgct agaagcacat gaattgaacg ctgtgggtgc
      361 tgtgttggat gtgaatgtgc ttgggaccat tcggatgctg caggcctttc tgccagacat
      421 gaagaggcgc cactctgggc gtgtgctggt gaccgcgagt gtgggaggct tgatgggact
      481 gccattccac gaagtgtact gtgccagcaa gtttgcgctc gaaggtttgt gcgagagtct
      541 ggcgatcctg ctgccgctct ttggagtcca tgtgagcctc atcgagtgtg gggcagtgca
      601 cacagccttc tatgaaaagc tggtgggcgg ccccggcggg gctctggaac gagcagatgc
      661 ccagacccgc cacctctttg cgcactacct gcgtggttat gagcaagccc tgagcgaggc
      721 gcaggaccca gaggaggtga cggagctctt cttgactgca atgcgagccc cgcagcccgc
      781 gctgcgctac ttctccacga accgcttcct acccctggcc cgaatgcgca cagaggatcc
      841 cagtggcagc agctatgtcg cggccatgca ccaagaagcc ttctctaatc tgcagaccca
      901 ggagaatgcc aaggctgggg cccaagtccc gggggtctcg gacacggcct ccagcgccct
      961 catttgcctc cctgaatgtg caatccctag ggtggcatct gaattggggt ggtctgcatc
     1021 ggataaaccg ggtcaggaca attcatgtta ccagcaaaag atctaagcca gcatctcttt
     1081 tttcttattt tagaatgagt tttgttttaa gacagggttt cactatgtag ccctgtgttg
     1141 ccagtaactc ataaagaccc acctgcctct gcctcctgcg tgctgggacc ttagatgtgt
     1201 gcaaccacac acttctcaga atcatttgaa atagtgccag catcttcatg ggtcaagata
     1261 agagggctga tatccaaggt gctaggctaa gggttttttt tttccttcca ataaatttat
     1321 ttattattat tatcatgtaa aaaaaaaaaa aa
//
