LOCUS       NM_008289               1874 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2),
            mRNA.
ACCESSION   NM_008289
VERSION     NM_008289.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Gasparini,S., Peltekian,L., McDonough,M.C., Mitchell,C.J.,
            Hefti,M., Resch,J.M. and Geerling,J.C.
  TITLE     Aldosterone-induced salt appetite requires HSD2 neurons
  JOURNAL   JCI Insight 9 (23), e175087 (2024)
   PUBMED   39446486
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Whiley,P.A.F., Luu,M.C.M., O'Donnell,L., Handelsman,D.J. and
            Loveland,K.L.
  TITLE     Testis exposure to unopposed/elevated activin A in utero affects
            somatic and germ cells and alters steroid levels mimicking
            phthalate exposure
  JOURNAL   Front Endocrinol (Lausanne) 14, 1234712 (2023)
   PUBMED   37727456
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Salazar-Petres,E., Pereira-Carvalho,D., Lopez-Tello,J. and
            Sferruzzi-Perri,A.N.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Gasparini,S., Resch,J.M., Gore,A.M., Peltekian,L. and Geerling,J.C.
  TITLE     Pre-locus coeruleus neurons in rat and mouse
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 320 (3), R342-R361 (2021)
   PUBMED   33296280
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Wieczorek,A., Perani,C.V., Nixon,M., Constancia,M., Sandovici,I.,
            Zazara,D.E., Leone,G., Zhang,M.Z., Arck,P.C. and Solano,M.E.
  TITLE     Sex-specific regulation of stress-induced fetal glucocorticoid
            surge by the mouse placenta
  JOURNAL   Am J Physiol Endocrinol Metab 317 (1), E109-E120 (2019)
   PUBMED   30990748
REFERENCE   6  (bases 1 to 1874)
  AUTHORS   Oppermann,U.C., Persson,B. and Jornvall,H.
  TITLE     Function, gene organization and protein structures of
            11beta-hydroxysteroid dehydrogenase isoforms
  JOURNAL   Eur J Biochem 249 (2), 355-360 (1997)
   PUBMED   9370340
  REMARK    Review article
REFERENCE   7  (bases 1 to 1874)
  AUTHORS   Condon,J., Ricketts,M.L., Whorwood,C.B. and Stewart,P.M.
  TITLE     Ontogeny and sexual dimorphic expression of mouse type 2
            11beta-hydroxysteroid dehydrogenase
  JOURNAL   Mol Cell Endocrinol 127 (2), 121-128 (1997)
   PUBMED   9099907
REFERENCE   8  (bases 1 to 1874)
  AUTHORS   Li,K.X., Smith,R.E., Ferrari,P., Funder,J.W. and Krozowski,Z.S.
  TITLE     Rat 11 beta-hydroxysteroid dehydrogenase type 2 enzyme is expressed
            at low levels in the placenta and is modulated by adrenal steroids
            in the kidney
  JOURNAL   Mol Cell Endocrinol 120 (1), 67-75 (1996)
   PUBMED   8809740
REFERENCE   9  (bases 1 to 1874)
  AUTHORS   Campbell,L.E., Yu,M. and Yang,K.
  TITLE     Ovine 11 beta-hydroxysteroid dehydrogenase type 2 gene predicts a
            protein distinct from that deduced by the cloned kidney cDNA at the
            C-terminus
  JOURNAL   Mol Cell Endocrinol 119 (1), 113-118 (1996)
   PUBMED   8793860
REFERENCE   10 (bases 1 to 1874)
  AUTHORS   Cole,T.J.
  TITLE     Cloning of the mouse 11 beta-hydroxysteroid dehydrogenase type 2
            gene: tissue specific expression and localization in distal
            convoluted tubules and collecting ducts of the kidney
  JOURNAL   Endocrinology 136 (10), 4693-4696 (1995)
   PUBMED   7664690
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618868.1, AC151573.2 and BC066209.1.
            
            On Mar 20, 2007 this sequence version replaced NM_008289.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014753.1, AK155153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-611               BB618868.1         4-614
            612-639             AC151573.2         139819-139846
            640-1874            BC066209.1         587-1821
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1874
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /note="hydroxysteroid 11-beta dehydrogenase 2"
                     /db_xref="GeneID:15484"
                     /db_xref="MGI:MGI:104720"
     exon            1..384
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1280
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /EC_number="1.1.1.146"
                     /note="corticosteroid 11-beta-dehydrogenase isozyme 2;
                     11-DH2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid
                     dehydrogenase"
                     /codon_start=1
                     /product="11-beta-hydroxysteroid dehydrogenase type 2"
                     /protein_id="NP_032315.2"
                     /db_xref="CCDS:CCDS40460.1"
                     /db_xref="GeneID:15484"
                     /db_xref="MGI:MGI:104720"
                     /translation="MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAAL
                     DWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKL
                     DAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTG
                     LWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVG
                     SPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLW
                     EKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQP
                     RSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA"
     exon            385..597
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..783
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..921
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1849
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /note="hexamer: AATAAA"
     polyA_site      1846
                     /gene="Hsd11b2"
                     /gene_synonym="11HSD2"
                     /note="major polyA site"
ORIGIN      
        1 aaagcgagta tccctcccac cccaggccgg tgttcctctg cattccgtgt cctagcctcg
       61 agtccctctc ggcgctcccc aaccaggccc ccgccccgcc ccagcccggc cccgaagtca
      121 tggagcgctg gccttggccg tcgggcggcg cctggctgct ggtggctgcc cgcgcgctgc
      181 tgcagctgct gcgctcagac ctgcgtctgg gccgcccgtt gttggcggca ctggccctgc
      241 tggctgctct cgactggctg tgccagcgcc tgctgccccc gccggcggca ctcgtggtgc
      301 tggctggtgc tggctggatc gcgttgtccc gcctagcgcg ccctcctcgc ctgccggtgg
      361 ccactcgcgc ggtgctcatc accggttgtg acactggttt tggcaaggag acagctaaga
      421 aactggatgc catgggcttc acggtgctgg ccacagtgtt ggatttgaat agccctggtg
      481 ccctagaact gcgtgacctc tgttctcctc gcctgaagct gctgcagatg gatctgacca
      541 aggcagagga catcagccgt gttctggaaa tcaccaaggc ccacacggcc agcactggcc
      601 tgtggggtct ggttaacaac gctggcctca atatcgtagt ggctgacgtg gaactgtctc
      661 cagtggcgac tttccgcaag tgcatggagg tgaacttctt tggtgcactt gagctgacca
      721 agggcctcct gccactcttg cgtcactcga ggggacgtat tgtgaccgtt ggcagcccag
      781 caggagacat gccatacccc tgcttggcag cctacggcac ctccaaggca gcaatagcac
      841 tgcttatgga cacattcggc tgtgagctgc ttccctgggg tatcaaggtc agcattatca
      901 agcctggctg cttcaagaca gatgcagtga ctaatgtgaa cctctgggag aaacgcaagc
      961 aactgctgct ggccaacatt cctagagagc tgctccaggc ctatggtgaa gactacattg
     1021 agcacgtgca cgggcagttc ctgaattcac tcagaatggc attgcctgac cttagcccag
     1081 ttgtagatgc catcatcgat gcattgctgg cagctcagcc acgaagccgc tactacccag
     1141 gccgtggcct ggggctcatg tatttcatcc accactacct gccagagggc ctgcgacgct
     1201 gcttcctaca gaacttcttt atcaatcacc ttctgccccg agcactgagg cccggccaac
     1261 atggccctgc tcctgcttaa gacacaccct tccccagtgg cagctctgtg agccacaaac
     1321 ctaggtgttt tagcaggatg ggcttcttca gcccttggcc ctctcccctg cccattatag
     1381 acaccccccc cccccagcct taccctagag tctgtgttaa gcccagccca gcctctattg
     1441 ctgatgcctc gtccagccca ggacgtggaa gtctgctagt gagcctctgg acctctcctc
     1501 tgcttcttga gcccacacat accctaccag gcacaatgct ctacactgca gcttggaaaa
     1561 cccaggtgga tggagagttt agtataagat tttggctgta gcctttgata gtactctaca
     1621 gaccatttct gtgctaactt tagaatgatt aggcaggtgg ggacctcctc agaattcttt
     1681 tgggacccac agtctcagtg ctgcaagtcc agagtaaatc ccaactgcct cttgactggc
     1741 tcaagattta ggtcctcaat tactggcccc cagccacatg gaagctgtat gttgtacctg
     1801 cctggttgtt ggcattttaa aataaagata cattttattt ctactagaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaa
//
