LOCUS       NM_008288               1381 bp    mRNA    linear   ROD 03-APR-2023
DEFINITION  Mus musculus hydroxysteroid 11-beta dehydrogenase 1 (Hsd11b1),
            transcript variant 1, mRNA.
ACCESSION   NM_008288
VERSION     NM_008288.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1381)
  AUTHORS   Webster JM, Waaijenberg K, van de Worp WRPH, Kelders MCJM,
            Lambrichts S, Martin C, Verhaegen F, Van der Heyden B, Smith C,
            Lavery GG, Schols AMWJ, Hardy RS and Langen RCJ.
  TITLE     11beta-HSD1 determines the extent of muscle atrophy in a model of
            acute exacerbation of COPD
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 324 (4), L400-L412 (2023)
   PUBMED   36807882
  REMARK    GeneRIF: 11beta-HSD1 determines the extent of muscle atrophy in a
            model of acute exacerbation of COPD.
REFERENCE   2  (bases 1 to 1381)
  AUTHORS   Morgan SA, Gathercole LL, Hassan-Smith ZK, Tomlinson J, Stewart PM
            and Lavery GG.
  TITLE     11beta-HSD1 contributes to age-related metabolic decline in male
            mice
  JOURNAL   J Endocrinol 255 (3), 117-129 (2022)
   PUBMED   36205523
  REMARK    GeneRIF: 11beta-HSD1 contributes to age-related metabolic decline
            in male mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1381)
  AUTHORS   Akalestou E, Lopez-Noriega L, Christakis I, Hu M, Miras AD, Leclerc
            I and Rutter GA.
  TITLE     Vertical sleeve gastrectomy normalizes circulating glucocorticoid
            levels and lowers glucocorticoid action tissue-selectively in mice
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020576 (2022)
   PUBMED   36246869
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1381)
  AUTHORS   Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J and
            Sferruzzi-Perri AN.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   5  (bases 1 to 1381)
  AUTHORS   Hu M, Han T, Pan Q, Ni D, Gao F, Wang L, Ren H, Zhang X, Jiao H,
            Wang Y, Dai D, Man Y, Tang W, Sun Y, Li W, Li J and Li G.
  TITLE     The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation
            Induced by Overexpression of 11beta-HSD1
  JOURNAL   Int J Biol Sci 18 (8), 3107-3121 (2022)
   PUBMED   35637957
  REMARK    GeneRIF: The GR-gp78 Pathway is involved in Hepatic Lipid
            Accumulation Induced by Overexpression of 11beta-HSD1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1381)
  AUTHORS   Oppermann UC, Persson B and Jornvall H.
  TITLE     Function, gene organization and protein structures of
            11beta-hydroxysteroid dehydrogenase isoforms
  JOURNAL   Eur J Biochem 249 (2), 355-360 (1997)
   PUBMED   9370340
  REMARK    Review article
REFERENCE   7  (bases 1 to 1381)
  AUTHORS   Aziz N, Brown D, Lee WS and Naray-Fejes-Toth A.
  TITLE     Aberrant 11beta-hydroxysteroid dehydrogenase-1 activity in the cpk
            mouse: implications for regulation by the Ke 6 gene
  JOURNAL   Endocrinology 137 (12), 5581-5588 (1996)
   PUBMED   8940387
REFERENCE   8  (bases 1 to 1381)
  AUTHORS   Voice MW, Seckl JR and Chapman KE.
  TITLE     The sequence of 5' flanking DNA from the mouse 11
            beta-hydroxysteroid dehydrogenase type 1 gene and analysis of
            putative transcription factor binding sites
  JOURNAL   Gene 181 (1-2), 233-235 (1996)
   PUBMED   8973338
REFERENCE   9  (bases 1 to 1381)
  AUTHORS   Rajan V, Chapman KE, Lyons V, Jamieson P, Mullins JJ, Edwards CR
            and Seckl JR.
  TITLE     Cloning, sequencing and tissue-distribution of mouse 11
            beta-hydroxysteroid dehydrogenase-1 cDNA
  JOURNAL   J Steroid Biochem Mol Biol 52 (2), 141-147 (1995)
   PUBMED   7873449
REFERENCE   10 (bases 1 to 1381)
  AUTHORS   Oppermann UC, Netter KJ and Maser E.
  TITLE     Cloning and primary structure of murine 11 beta-hydroxysteroid
            dehydrogenase/microsomal carbonyl reductase
  JOURNAL   Eur J Biochem 227 (1-2), 202-208 (1995)
   PUBMED   7851387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI182353.1, DQ089001.1 and AI132676.1.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_008288.3.
            
            On Aug 31, 2006 this sequence version replaced NM_008288.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein. An
            in-frame AUG is located 41 codons upstream of the annotated
            translation start site but is not being annotated as a start site
            since it is not conserved and is in a weak Kozak sequence context.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132364.1, BI145088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AI182353.1         1-124
            125-1003            DQ089001.1         1-879
            1004-1381           AI132676.1         1-378               c
FEATURES             Location/Qualifiers
     source          1..1381
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1381
                     /gene="Hsd11b1"
                     /note="hydroxysteroid 11-beta dehydrogenase 1"
                     /db_xref="GeneID:15483"
                     /db_xref="MGI:MGI:103562"
     exon            1..98
                     /gene="Hsd11b1"
                     /inference="alignment:Splign:2.1.0"
     exon            99..212
                     /gene="Hsd11b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1003
                     /gene="Hsd11b1"
                     /EC_number="1.1.1.146"
                     /EC_number="1.1.1.201"
                     /note="corticosteroid 11-beta-dehydrogenase isozyme 1;
                     11-DH; 11-beta-HSD1; 11beta-HSD1A; 11beta-HSD-1;
                     11beta-hydroxysteroid dehydrogenase type 1; Corticosteroid
                     11-beta-dehydrogenase, isozyme 1 (11-DH)
                     (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1)
                     (11beta-HSD1A); 11-beta-HSD1A/MCR; 7-oxosteroid reductase;
                     liver-type 11-beta-HSD; 11-beta-hydroxysteroid
                     dehydrogenase/microsomal carbonyl reductase"
                     /codon_start=1
                     /product="11-beta-hydroxysteroid dehydrogenase 1"
                     /protein_id="NP_032314.2"
                     /db_xref="CCDS:CCDS15635.1"
                     /db_xref="GeneID:15483"
                     /db_xref="MGI:MGI:103562"
                     /translation="MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASK
                     GIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQF
                     IVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQ
                     SNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLI
                     DTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIM
                     EFFSLRYYNKDMFVSN"
     exon            213..343
                     /gene="Hsd11b1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..455
                     /gene="Hsd11b1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..641
                     /gene="Hsd11b1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..785
                     /gene="Hsd11b1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1374
                     /gene="Hsd11b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgagacag aaggatagag aggaggagag agagagaaga gaagcaacca gagataggca
       61 gccaataaaa aggagccgca cttatctgaa gcctcaaggg cgccctgagc caggtccctg
      121 tttgatggca gttatgaaaa attacctcct cccgatcctg gtgctcttcc tggcctacta
      181 ctactattct acaaatgaag agttcagacc agaaatgctc cagggaaaga aagtgattgt
      241 cactggggcc agcaaaggga ttggaagaga aatggcatat catctgtcaa aaatgggagc
      301 ccatgtggta ttgactgcca ggtcggagga aggtctccag aaggtagtgt ctcgctgcct
      361 tgaactcgga gcagcctctg ctcactacat tgctggcact atggaagaca tgacatttgc
      421 ggagcaattt attgtcaagg cgggaaagct catgggcgga ctggacatgc ttattctaaa
      481 ccacatcact cagacctcgc tgtctctctt ccatgacgac atccactctg tgcgaagagt
      541 catggaggtc aacttcctca gctacgtggt catgagcaca gccgccttgc ccatgctgaa
      601 gcagagcaat ggcagcattg ccgtcatctc ctccttggct gggaaaatga cccagcctat
      661 gattgctccc tactctgcaa gcaagtttgc tctggatggg ttcttttcca ccattagaac
      721 agaactctac ataaccaagg tcaacgtgtc catcactctc tgtgtccttg gcctcataga
      781 cacagaaaca gctatgaagg aaatctctgg gataattaac gcccaagctt ctcccaagga
      841 ggagtgcgcc ctggagatca tcaaaggcac agctctacgc aaaagcgagg tgtactatga
      901 caaatcgcct ttgactccaa tcctgcttgg gaacccagga aggaagatca tggaattttt
      961 ttcattacga tattataata aggacatgtt tgtaagtaac taggaactcc tgagccctgg
     1021 tgagtggtct tagaacagtc ctgcctgata cttctgtaag ccctacccac aaaagtatct
     1081 ttccagagat acacaaattt tggggtacac ctcatcatga gaaattcttg caacacttgc
     1141 acagtgaaaa tgtaattgta ataaatgtca caaaccactt tggggcctgc agttgtgaac
     1201 ttgattgtaa ctatggatat aaacacatag tggttgtatc ggctttacct cacactgaat
     1261 gaaacaatga taactaatgt aacattaaat ataataaagg taatatcaac tttgtaaatg
     1321 caaaactagt aactatgaat ggagtttatt caacatgatt cctttaagtc taaaaaaaaa
     1381 a
//
