LOCUS       NM_153571                825 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus HscB iron-sulfur cluster co-chaperone (Hscb),
            transcript variant 1, mRNA.
ACCESSION   NM_153571
VERSION     NM_153571.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 825)
  AUTHORS   Crispin A, Guo C, Chen C, Campagna DR, Schmidt PJ, Lichtenstein D,
            Cao C, Sendamarai AK, Hildick-Smith GJ, Huston NC, Boudreaux J,
            Bottomley SS, Heeney MM, Paw BH, Fleming MD and Ducamp S.
  TITLE     Mutations in the iron-sulfur cluster biogenesis protein HSCB cause
            congenital sideroblastic anemia
  JOURNAL   J Clin Invest 130 (10), 5245-5256 (2020)
   PUBMED   32634119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131961.1 and BC027641.1.
            
            [WARNING] On Nov 27, 2023 this sequence was replaced by
            NM_153571.3.
            
            On Mar 27, 2009 this sequence version replaced NM_153571.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027641.1, AK131961.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-792               AK131961.1         3-794
            793-825             BC027641.1         757-789
FEATURES             Location/Qualifiers
     source          1..825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.72 cM"
     gene            1..825
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /note="HscB iron-sulfur cluster co-chaperone"
                     /db_xref="GeneID:100900"
                     /db_xref="MGI:MGI:2141135"
     exon            1..282
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..754
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; J-type co-chaperone HSC20; iron-sulfur cluster
                     co-chaperone protein HscB, mitochondrial; HscB iron-sulfur
                     cluster co-chaperone homolog"
                     /codon_start=1
                     /product="iron-sulfur cluster co-chaperone protein HscB
                     isoform 1 precursor"
                     /protein_id="NP_705799.2"
                     /db_xref="CCDS:CCDS51613.1"
                     /db_xref="GeneID:100900"
                     /db_xref="MGI:MGI:2141135"
                     /translation="MWGCGARALLGVWEVRLAGFLGRRLLGSNAAAGKSIAPQCWNCG
                     HAREVGCGDEFFCSHCRALQPPDPTRDYFSLMNCNRSFRVDVTKLQHRYQQLQRLVHP
                     DFFSQKSQTEKHFSDKHSTLVNDAYKTLQAPLTRGLYLLKLQGIEIPEGTDYKADSQF
                     LVEIMEINERLADAQSEAAMEEIEATVRAKQKEFTDNINSAFEQGDFEKAKELLTKMR
                     YFSNIEEKIKLSKTPL"
     exon            283..379
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /inference="alignment:Splign:2.1.0"
     exon            380..469
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /inference="alignment:Splign:2.1.0"
     exon            470..614
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /inference="alignment:Splign:2.1.0"
     exon            615..662
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /inference="alignment:Splign:2.1.0"
     exon            663..804
                     /gene="Hscb"
                     /gene_synonym="Hsc20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctttcc ctcgggtctt gctacctagg tcagcgagcg gccgtcccaa tgtggggatg
       61 cggagcccgt gccctgctgg gtgtgtggga ggtgcggctg gcagggttcc tgggaaggag
      121 acttttgggc agcaatgccg ccgcggggaa gagcattgca ccgcagtgct ggaactgcgg
      181 tcacgcaagg gaagtcgggt gtggggatga gttcttctgc tcacactgcc gcgctctgca
      241 gcctcctgac cccactcgtg actacttcag cctcatgaac tgcaaccgct ccttcagggt
      301 ggacgttacg aaacttcagc acaggtacca gcaactgcag cggcttgtcc acccagattt
      361 cttcagccaa aagtctcaga ctgaaaaaca cttctctgac aagcactcca ccctggtgaa
      421 tgatgcctat aagactcttc aggctcccct gaccagagga ctatatcttc taaagctcca
      481 gggaatagaa attcctgaag ggacagatta caaagcagac agtcagttcc ttgtggaaat
      541 catggaaatc aatgaaagac tcgcagacgc ccaaagtgag gccgccatgg aagagataga
      601 agccactgtc agagctaaac agaaagaatt tactgacaat ataaacagcg cttttgaaca
      661 aggtgacttt gaaaaagcca aggaactcct gacaaagatg agatactttt cgaacataga
      721 agaaaagatc aagctaagca agactcctct ctagttgcta acttaaagtt ttagaaataa
      781 actttgtatt tcttttctgg cttcaaaaaa aaaaaaaaaa aaaaa
//
