LOCUS       NM_024219               1178 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus heat shock factor binding protein 1 (Hsbp1), mRNA.
ACCESSION   NM_024219
VERSION     NM_024219.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Jung,H., Park,H., Choi,Y., Kang,H., Lee,E., Kweon,H., Roh,J.D.,
            Ellegood,J., Choi,W., Kang,J., Rhim,I., Choi,S.Y., Bae,M.,
            Kim,S.G., Lee,J., Chung,C., Yoo,T., Park,H., Kim,Y., Ha,S.,
            Um,S.M., Mo,S., Kwon,Y., Mah,W., Bae,Y.C., Kim,H., Lerch,J.P.,
            Paik,S.B. and Kim,E.
  TITLE     Sexually dimorphic behavior, neuronal activity, and gene expression
            in Chd8-mutant mice
  JOURNAL   Nat Neurosci 21 (9), 1218-1228 (2018)
   PUBMED   30104731
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Eroglu,B., Min,J.N., Zhang,Y., Szurek,E., Moskophidis,D., Eroglu,A.
            and Mivechi,N.F.
  TITLE     An essential role for heat shock transcription factor binding
            protein 1 (HSBP1) during early embryonic development
  JOURNAL   Dev Biol 386 (2), 448-460 (2014)
   PUBMED   24380799
  REMARK    GeneRIF: HSBP1 plays an essential role during early mouse and
            zebrafish embryonic development; lack of hsbp1 in embryoid bodies
            leads to disorganization of the germ layers and a reduction in the
            endoderm-specific markers.
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Farooqui-Kabir,S.R., Diss,J.K., Henderson,D., Marber,M.S.,
            Latchman,D.S., Budhram-Mahadeo,V. and Heads,R.J.
  TITLE     Cardiac expression of Brn-3a and Brn-3b POU transcription factors
            and regulation of Hsp27 gene expression
  JOURNAL   Cell Stress Chaperones 13 (3), 297-312 (2008)
   PUBMED   18368538
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Koh,T.J. and Escobedo,J.
  TITLE     Cytoskeletal disruption and small heat shock protein translocation
            immediately after lengthening contractions
  JOURNAL   Am J Physiol Cell Physiol 286 (3), C713-C722 (2004)
   PUBMED   14627610
  REMARK    GeneRIF: loss of z-disk and membrane scaffolding proteins
            immediately after lengthening contractions, and concomitant
            translocation of HSP25 and alphaB-crystallin to the z-disk, which
            may help to stabilize or repair cytoskeletal elements at this site.
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Shimada,M., Yamamoto,M., Wakayama,T., Iseki,S. and Amano,O.
  TITLE     Different expression of 25-kDa heat-shock protein (Hsp25) in
            Meckel's cartilage compared with other cartilages in the mouse
  JOURNAL   Anat Embryol (Berl) 206 (3), 163-173 (2003)
   PUBMED   12592567
  REMARK    GeneRIF: In embryonic mandibles, chondrocytes in the anterior and
            intermediate portions of Meckel's cartilage showed Hsp25
            immunoreactivity from the 12th day of gestation (E12) through E15.
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC002153.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002153.1, AK078498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 67.54 cM"
     gene            1..1178
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /note="heat shock factor binding protein 1"
                     /db_xref="GeneID:68196"
                     /db_xref="MGI:MGI:1915446"
     exon            1..83
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..269
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /codon_start=1
                     /product="heat shock factor-binding protein 1"
                     /protein_id="NP_077181.1"
                     /db_xref="CCDS:CCDS40492.1"
                     /db_xref="GeneID:68196"
                     /db_xref="MGI:MGI:1915446"
                     /translation="MAETDPKTMQDITLVVETLLQQMQDKFQIMSDQIIGRIDDMSSR
                     IDDLEKNIADLMTQAGVEELDPENKIPTAQKS"
     exon            84..150
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /inference="alignment:Splign:2.1.0"
     exon            151..271
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /inference="alignment:Splign:2.1.0"
     exon            272..1165
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      463..468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /note="hexamer: ATTAAA"
     regulatory      470..475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /note="hexamer: ACTAAA"
     polyA_site      493
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /note="major polyA site"
     polyA_site      496
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
     regulatory      1136..1141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
                     /note="hexamer: AATAAA"
     polyA_site      1165
                     /gene="Hsbp1"
                     /gene_synonym="0610007A03Rik; Hsp25"
ORIGIN      
        1 ggttccgaga catcgccgcc aagctgggca ccggggagat ggccgagacg gaccccaaga
       61 ccatgcagga catcaccttg gtggtggaga cgctcttgca gcagatgcaa gacaagtttc
      121 agatcatgtc agaccagatc atcggaagga tagatgacat gagcagtcgg attgacgacc
      181 tggagaagaa tatcgctgac ctcatgaccc aggctggagt agaagaactg gaccctgaaa
      241 acaagattcc tactgcccag aagagttgaa ggctgccggt actgaatcca gaatgttgtt
      301 gtcccgagcc aagacaaaaa ccaagtggct ttctgcaact aactcctatg tgtggacagg
      361 tttataaacg tgcattctta tcacagcctg catagcctag agtaccccta caccccatcc
      421 ctcaaacttg ctatcttcac atcctggtca gttctattaa ttattaaaca ctaaaatttt
      481 ggcggtttct ggataagatt gtcaaacgtt ttagtgattt ttttctgagt tcccctcccc
      541 actgctcctc tgtggtagtt gctgtgtgat aaagtggcag agtactcgtg atcacgtgac
      601 cacagcccct cccctggcag aagccgttcg tgagccgtga gtgtgtaggg ttctttgatt
      661 ttcagtgcaa agtgactgtt gagccgcccg ccactggagt gtcagaagta cttctccaga
      721 tggcccagga catttaatag ttgtttgtgc cgaagcgtct ctcagagttt tgcatgagat
      781 tctagtagcg ttggtaggac ctgccatgct catccggcag ggtatcagag cccagtgacc
      841 ctgtcctccc ttcaagctac tgactgaaag ggaagagacc aaaagaccca agtgagccca
      901 gccctgtcag caaggctgaa aaatgccctt tgacttgtgg gaggtgctgg tttttaagaa
      961 atactatttt acttgaacta tttcttgtct aaattcttgc acaatgagtt ctattattga
     1021 ttaaagaaga cagatttaca ttcaggattc tggtgtctgg aggcttagcc tcaaagccag
     1081 ttttgatgac ttagaaggca atctatgtca ctgtccccac aaagtgattt catacaataa
     1141 aaaccaagag taattaaaca ttgaaaaaaa aaaaaaaa
//
