LOCUS       NM_015820               1784 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heparan sulfate 6-O-sulfotransferase 3 (Hs6st3), mRNA.
ACCESSION   NM_015820
VERSION     NM_015820.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1784)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1784)
  AUTHORS   Gezelius,H., Moreno-Juan,V., Mezzera,C., Thakurela,S.,
            Rodriguez-Malmierca,L.M., Pistolic,J., Benes,V., Tiwari,V.K. and
            Lopez-Bendito,G.
  TITLE     Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals
            Putative Sensory-Modality Specific Genes
  JOURNAL   Cereb Cortex 27 (11), 5054-5069 (2017)
   PUBMED   27655933
REFERENCE   3  (bases 1 to 1784)
  AUTHORS   Paul,A., Crow,M., Raudales,R., He,M., Gillis,J. and Huang,Z.J.
  TITLE     Transcriptional Architecture of Synaptic Communication Delineates
            GABAergic Neuron Identity
  JOURNAL   Cell 171 (3), 522-539 (2017)
   PUBMED   28942923
REFERENCE   4  (bases 1 to 1784)
  AUTHORS   Nagai,N., Habuchi,H., Sugaya,N., Nakamura,M., Imamura,T.,
            Watanabe,H. and Kimata,K.
  TITLE     Involvement of heparan sulfate 6-O-sulfation in the regulation of
            energy metabolism and the alteration of thyroid hormone levels in
            male mice
  JOURNAL   Glycobiology 23 (8), 980-992 (2013)
   PUBMED   23690091
REFERENCE   5  (bases 1 to 1784)
  AUTHORS   Anower-E-Khuda,M.F., Habuchi,H., Nagai,N., Habuchi,O., Yokochi,T.
            and Kimata,K.
  TITLE     Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory
            effects of heparin on the activities of various proteases in mast
            cells and the biosynthesis of 6-O-sulfated heparin
  JOURNAL   J Biol Chem 288 (6), 3705-3717 (2013)
   PUBMED   23223449
REFERENCE   6  (bases 1 to 1784)
  AUTHORS   Sedita,J., Izvolsky,K. and Cardoso,W.V.
  TITLE     Differential expression of heparan sulfate 6-O-sulfotransferase
            isoforms in the mouse embryo suggests distinctive roles during
            organogenesis
  JOURNAL   Dev Dyn 231 (4), 782-794 (2004)
   PUBMED   15499561
  REMARK    GeneRIF: 6OST3 appears at later stages and in a more restricted
            manner than its isoenzymes during development
REFERENCE   7  (bases 1 to 1784)
  AUTHORS   Nagai,N., Habuchi,H., Esko,J.D. and Kimata,K.
  TITLE     Stem domains of heparan sulfate 6-O-sulfotransferase are required
            for Golgi localization, oligomer formation and enzyme activity
  JOURNAL   J Cell Sci 117 (Pt 15), 3331-3341 (2004)
   PUBMED   15226404
REFERENCE   8  (bases 1 to 1784)
  AUTHORS   Smeds,E., Habuchi,H., Do,A.T., Hjertson,E., Grundberg,H.,
            Kimata,K., Lindahl,U. and Kusche-Gullberg,M.
  TITLE     Substrate specificities of mouse heparan sulphate glucosaminyl
            6-O-sulphotransferases
  JOURNAL   Biochem J 372 (Pt 2), 371-380 (2003)
   PUBMED   12611590
REFERENCE   9  (bases 1 to 1784)
  AUTHORS   Ford-Perriss,M., Guimond,S.E., Greferath,U., Kita,M., Grobe,K.,
            Habuchi,H., Kimata,K., Esko,J.D., Murphy,M. and Turnbull,J.E.
  TITLE     Variant heparan sulfates synthesized in developing mouse brain
            differentially regulate FGF signaling
  JOURNAL   Glycobiology 12 (11), 721-727 (2002)
   PUBMED   12460940
REFERENCE   10 (bases 1 to 1784)
  AUTHORS   Habuchi,H., Tanaka,M., Habuchi,O., Yoshida,K., Suzuki,H., Ban,K.
            and Kimata,K.
  TITLE     The occurrence of three isoforms of heparan sulfate
            6-O-sulfotransferase having different specificities for hexuronic
            acid adjacent to the targeted N-sulfoglucosamine
  JOURNAL   J Biol Chem 275 (4), 2859-2868 (2000)
   PUBMED   10644753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139324.1, BC117529.1 and AB024567.1.
            
            On Mar 24, 2009 this sequence version replaced NM_015820.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024567.1, BC118035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-854               AK139324.1         431-1284
            855-1711            BC117529.1         673-1529
            1712-1784           AB024567.1         1675-1747
FEATURES             Location/Qualifiers
     source          1..1784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 62.67 cM"
     gene            1..1784
                     /gene="Hs6st3"
                     /gene_synonym="6OST3; HS6ST-3"
                     /note="heparan sulfate 6-O-sulfotransferase 3"
                     /db_xref="GeneID:50787"
                     /db_xref="MGI:MGI:1354960"
     exon            1..854
                     /gene="Hs6st3"
                     /gene_synonym="6OST3; HS6ST-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1563
                     /gene="Hs6st3"
                     /gene_synonym="6OST3; HS6ST-3"
                     /EC_number="2.8.2.-"
                     /codon_start=1
                     /product="heparan-sulfate 6-O-sulfotransferase 3"
                     /protein_id="NP_056635.2"
                     /db_xref="CCDS:CCDS27339.1"
                     /db_xref="GeneID:50787"
                     /db_xref="MGI:MGI:1354960"
                     /translation="MDERFNKWLLTPVLTLLFVVIMYQYVSPSCTSSCTNFGEQLRSG
                     EARPPAVPSPARRAQAPLDEWERRPQLPPPPRGPPEGSRGVAAPEDEDEDPGDPEEEE
                     EEEEEEPDPEAPENGSLPRFVPRFNFTLKDLTRFVDFNIKGRDVIVFLHIQKTGGTTF
                     GRHLVKNIRLEQPCSCKAGQKKCTCHRPGKKETWLFSRFSTGWSCGLHADWTELTNCV
                     PAIMEKKDCPRNHSHTRNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPT
                     PDELPTCYPGDDWSGVSLREFMDCSYNLANNRQVRMLADLSLVGCYNLTFMNESERNT
                     ILLQSAKNNLKNMAFFGLTEFQRKTQFLFERTFNLKFISPFTQFNITRASNVDINDGA
                     RQHIEELNFLDMQLYEYAKDLFQQRYHHTKQLEHQRDRQKRREERRLQREHRAHRWPK
                     EDRAMEGTVTEDYNSQVVRW"
     exon            855..1784
                     /gene="Hs6st3"
                     /gene_synonym="6OST3; HS6ST-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccagac agccgttctc ttcggcggca ggggcatgga ggagcggcgg gctccgagcc
       61 gcgccccgga gtccccgaaa cttccgagca ggcgcccgat cgcgccgctg gcgccgcagc
      121 cacctcacct gccggcctga gaacgggacc atggatgaaa ggttcaacaa gtggctgctg
      181 acgccggtgc tcactctcct cttcgtggtc atcatgtacc agtacgtgtc cccttcctgc
      241 accagctcat gcaccaactt cggggagcag ctccgctccg gggaggcccg cccgcccgct
      301 gtcccgagtc ctgcccgacg ggcacaagca ccccttgatg agtgggagcg gcggccccag
      361 ctgccaccgc caccccgggg accgcccgag gggtctcgtg gggtcgcggc tcccgaggat
      421 gaggatgagg atcccgggga cccggaggag gaggaggagg aagaagagga ggagccggac
      481 cccgaggcgc ccgaaaacgg ctccctgccc cggttcgtgc ctcgattcaa cttcaccctc
      541 aaggacctga cccgcttcgt ggacttcaac atcaaagggc gggatgtgat cgtgttcctg
      601 cacatccaga agaccggggg caccacgttc ggccggcacc tggtgaagaa cattcgtctg
      661 gagcagccat gcagctgcaa agctggccag aaaaagtgca cctgccaccg gccgggcaag
      721 aaggagacct ggctcttctc ccgcttctcc accggctgga gctgcgggct gcatgccgac
      781 tggaccgagc tcaccaactg cgtgccggcc atcatggaga agaaggattg tccccgcaac
      841 cacagccaca ccaggaattt ctactacatc acgatgttgc gggacccagt gtcacgttac
      901 ctgagcgaat ggaagcatgt ccagagaggg gccacatgga aaacctctct ccatatgtgc
      961 gacggaagga gccccacacc agatgagctg cctacctgct atcctgggga tgactggtct
     1021 ggggtcagct tgcgggagtt catggattgt agctacaacc tggccaacaa ccgccaagtg
     1081 cgcatgctgg ccgacctcag cctggtgggc tgctacaact tgactttcat gaatgagagc
     1141 gagcggaaca ccatcctgct gcagagcgct aagaacaatc tgaagaatat ggccttcttt
     1201 gggctcactg aattccagag gaagacacag tttctctttg agaggacatt caacctgaag
     1261 ttcatctctc ctttcacaca gttcaacatc acacgggcat ccaacgtgga catcaatgat
     1321 ggagcccgtc agcacatcga ggagttgaat ttcctggaca tgcagcttta tgagtatgcg
     1381 aaggatctct tccagcaacg ctaccatcac accaaacagc tagagcacca gagggaccgc
     1441 caaaagaggc gcgaggagcg gaggctgcag cgagagcaca gagcacaccg gtggcccaaa
     1501 gaggataggg ccatggaggg gactgtcact gaggactaca acagccaagt ggtcagatgg
     1561 tgaccctctg cctgctcctt ttgtatgaag ggggataagc aggcccctcc tccttctctt
     1621 ggattacttg gaagaagttg ggccatgatg aggacctctg gctttatgtg acttcatttg
     1681 gacccatgct tcccctctgc cttcatttcc aatccagctg ggattttccg tcccgttctc
     1741 cttcttttct agacattttc tgatcactga tattaagtgg gggg
//
