LOCUS       NM_015818               3732 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus heparan sulfate 6-O-sulfotransferase 1 (Hs6st1), mRNA.
ACCESSION   NM_015818 XM_915803
VERSION     NM_015818.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3732)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3732)
  AUTHORS   Moon,S. and Zhao,Y.T.
  TITLE     Convergent biological pathways underlying the Kallmann
            syndrome-linked genes Hs6st1 and Fgfr1
  JOURNAL   Hum Mol Genet 31 (24), 4207-4216 (2022)
   PUBMED   35899427
  REMARK    GeneRIF: Convergent biological pathways underlying the Kallmann
            syndrome-linked genes Hs6st1 and Fgfr1.
REFERENCE   3  (bases 1 to 3732)
  AUTHORS   Tao,C., Makrides,N., Chuang,J.Z., Wu,Y., Brooks,S.E., Esko,J.D.,
            Sung,C.H. and Zhang,X.
  TITLE     Chondroitin sulfate enhances the barrier function of basement
            membrane assembled by heparan sulfate
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35608020
REFERENCE   4  (bases 1 to 3732)
  AUTHORS   Patel,V.N., Pineda,D.L., Berenstein,E., Hauser,B.R., Choi,S.,
            Prochazkova,M., Zheng,C., Goldsmith,C.M., van Kuppevelt,T.H.,
            Kulkarni,A., Song,Y., Linhardt,R.J., Chibly,A.M. and Hoffman,M.P.
  TITLE     Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to
            reduce epithelial morphogenesis and adult salivary gland function
  JOURNAL   Matrix Biol 103-104, 37-57 (2021)
   PUBMED   34653670
REFERENCE   5  (bases 1 to 3732)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3732)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3732)
  AUTHORS   Ford-Perriss,M., Guimond,S.E., Greferath,U., Kita,M., Grobe,K.,
            Habuchi,H., Kimata,K., Esko,J.D., Murphy,M. and Turnbull,J.E.
  TITLE     Variant heparan sulfates synthesized in developing mouse brain
            differentially regulate FGF signaling
  JOURNAL   Glycobiology 12 (11), 721-727 (2002)
   PUBMED   12460940
REFERENCE   8  (bases 1 to 3732)
  AUTHORS   Mitchell,K.J., Pinson,K.I., Kelly,O.G., Brennan,J., Zupicich,J.,
            Scherz,P., Leighton,P.A., Goodrich,L.V., Lu,X., Avery,B.J.,
            Tate,P., Dill,K., Pangilinan,E., Wakenight,P., Tessier-Lavigne,M.
            and Skarnes,W.C.
  TITLE     Functional analysis of secreted and transmembrane proteins critical
            to mouse development
  JOURNAL   Nat Genet 28 (3), 241-249 (2001)
   PUBMED   11431694
REFERENCE   9  (bases 1 to 3732)
  AUTHORS   Leighton,P.A., Mitchell,K.J., Goodrich,L.V., Lu,X., Pinson,K.,
            Scherz,P., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Defining brain wiring patterns and mechanisms through gene trapping
            in mice
  JOURNAL   Nature 410 (6825), 174-179 (2001)
   PUBMED   11242070
REFERENCE   10 (bases 1 to 3732)
  AUTHORS   Habuchi,H., Tanaka,M., Habuchi,O., Yoshida,K., Suzuki,H., Ban,K.
            and Kimata,K.
  TITLE     The occurrence of three isoforms of heparan sulfate
            6-O-sulfotransferase having different specificities for hexuronic
            acid adjacent to the targeted N-sulfoglucosamine
  JOURNAL   J Biol Chem 275 (4), 2859-2868 (2000)
   PUBMED   10644753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052316.1 and AI182294.1.
            
            On Mar 26, 2009 this sequence version replaced NM_015818.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052316.1, AK157556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3717              BC052316.1         1-3717
            3718-3732           AI182294.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3732
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.15 cM"
     gene            1..3732
                     /gene="Hs6st1"
                     /gene_synonym="6Ost1"
                     /note="heparan sulfate 6-O-sulfotransferase 1"
                     /db_xref="GeneID:50785"
                     /db_xref="MGI:MGI:1354958"
     exon            1..785
                     /gene="Hs6st1"
                     /gene_synonym="6Ost1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..3719
                     /gene="Hs6st1"
                     /gene_synonym="6Ost1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs6st1"
                     /gene_synonym="6Ost1"
                     /note="hexamer: AATAAA"
     polyA_site      3719
                     /gene="Hs6st1"
                     /gene_synonym="6Ost1"
                     /note="major polyA site"
ORIGIN      
        1 gctttgcggg cgggtgcggg cgcgcgcggc tgcggggcgc tgtggcgggg gccgggctgt
       61 acgctagccg agccgggatc ggggcgggga gcagccacgg cgccgccgag gcccggggcc
      121 cgcgacgctg cgcacagcct gggcgccgag tagccgggcc gggccggagc gcgggcggcg
      181 gtggcggcgg cggtggcgga gcagctgcgc cccccgccct cccaggcccg gcgcccgggc
      241 cgctggcgat ggtgacacat gcggcggcgg cgcgccggcg gcaggaccat ggttgagcgc
      301 gccagcaagt tcgtgctggt ggtggcgggc tcggcgtgct tcatgctcat cctttaccag
      361 tacgcgggcc cggggctgag tctgggcgcg cccggtggcc gcgtgccccc cgacgacctg
      421 gatctcttcc ccacgccgga cccacattac gagaaaaagt actacttccc ggtgcgcgag
      481 ctggagcgct cgctgcgctt cgacatgaag ggcgacgacg tgatcgtctt cctgcacatc
      541 cagaagaccg gcggcaccac cttcggccgc cacctagtgc agaacgtgcg cctcgaggtg
      601 ccctgcgact gtcgcccggg ccagaagaag tgcacctgct atcggcccaa tcgccgcgag
      661 acctggctct tctctcgctt ctccacgggc tggagctgcg ggctgcacgc tgactggacc
      721 gaactcacca actgtgtgcc cggtgtgcta gaccgccgcg acccagcagg tctgcgttcg
      781 cccagaaagt tctactacat caccctgctg cgagaccccg tatcccgcta cctgagtgaa
      841 tggcgacatg tacagcgtgg ggccacgtgg aagacctcct tgcacatgtg tgacgggcgc
      901 acaccgaccc cagaggagct gccgccctgc tacgagggca cagactggtc gggctgcacg
      961 ttgcaggagt tcatggattg cccctataac ctggctaaca accggcaggt gcgcatgctg
     1021 gccgacctca gcctggtggg ctgctacaac ctatctttca tccccgagag caagcgggcc
     1081 cagttgctgc tggagagcgc caagaagaac ctgcgaggca tggccttctt cggcctcact
     1141 gagttccagc gcaagacgca gtacctattt gagcggacgt tcaacctcaa gttcatccgg
     1201 ccattcatgc aatacaacag cacgcgggcg ggcggtgtgg aggtggatga ggacactatc
     1261 cgccacatcg aggagctcaa cgacctggac atgcagctgt atgactatgc caaggacctc
     1321 tttcagcagc gttaccagta caagagacag ctggagcgca gggaacagcg cctgcgcaat
     1381 cgcgaagagc gcctcctgca ccgctccaag gaagcgctgc cacgggagga cccagaagag
     1441 ccgggccgtg tgcccaccga ggactacatg agccatatca ttgagaagtg gtagtagtgt
     1501 caggggcaga gagtgatggg cacgatttaa cagggaaaga aatggggcca acagttcttc
     1561 ctgttcggtg cagcgggtgc tagtaggatg ccctagtcct tgatggggca gggtaggacc
     1621 tctggggcag atggcctccc tgctcttctg gcccccatgt catagttaaa actgacaagg
     1681 atttgaaaaa gactggcgag ggaacgtgtc tgcttagccg agactcccat acctactatg
     1741 cacgcactgg cccccaacga ccagccccct aggaacgtgt tactagctcc taatagcttg
     1801 gttgaagctc cttggcctct gaggacccct aataacccag aatcttgggg agccctttcc
     1861 tttgagaata caagcatgtc tctgaggcat cctcagacct ggagtgctcc ccaaccccca
     1921 cctatcaaag ctgctttcaa ggtcagggtc agccccagct gtggcagaga agactcaagt
     1981 ctggtgcctg gcctctgcac tgtctggagc atgatcagaa tccacggtgt atcctggctt
     2041 taggggaacc aggttcaagc aggaaaggga tggacaccaa gaggtcttcc ccccaccccc
     2101 agctccccac caatccctat gctttctgat gcactgcccc tcccccatca ctgaaacatt
     2161 tatacaaggg cttgtgtgcc aatgttccta ccataccagc aactctttct atcccgtgaa
     2221 taaaagcatc ccttggctgg gatatagggc cacatcaacc tgagttggta ctgggtggcc
     2281 aggatgggga ctttcccatt ctcagctgag gttggaagaa accactctgg gtgtcctttc
     2341 tgggacctgt ctgcataacc ctccccatcc tggctctcct gcatcttctt accctttaca
     2401 aagtctgacc cggccatttc cagcagacct gtgagccagc cagggaccgg actagaagcc
     2461 atgttgcata ttggggtttt tgtttgtttg ttttttaagc acttaccaag tgccctatcc
     2521 ctggcaggcc cctagtgggg gtgtcgtggc ttttttcaga gtctataagc atgcagccat
     2581 gggttgtgag ctgaccttga gacaggacgg gtcccacact ccctgcctct gtctcactca
     2641 acactcaggc taagaaggag cgggtcacca cagacaagag tggggccata tgtagcacag
     2701 caatattcca gatgctggtg ggtattgctg ctgccctaga gcaatggctt aatcttcaca
     2761 catgtgtggt gtggcaccag gcacttgacc ttggggggtc tacaagcaag atgagttctg
     2821 ataggcacag tccagcccag tctagcacca ccttttatgg tagttgatca ctctgaggag
     2881 gtgggtagca agatgaatta ggaggtcaag gtcactgaga ggaatttgtt tagatgccca
     2941 gtttagagtg aatagatatc tgcggggaac ctggggcatt ttggggaacc ctggggtctt
     3001 ttacaggtca tgttggttgc tgctgcttct gtcaggaagt accctagctc cacgtactcc
     3061 ccgccccccg ccgccccctt cacaacctta tgtgtacatg acctgaacat aggatctgtt
     3121 ctatacatac tggaatatgt tttaacatat gccccaccat cctgactcac acggaagcac
     3181 gggtctcttc tcaatctttg ctgcatttgg aaaatgttcc ctcccatctc aggccagcgc
     3241 catgtcgagg catcttcagt ccacccctgc ctaaggctca ggctacctgc tttggggcac
     3301 agcttcctgg tactcacagc atctcagaac agggtgcttc cctctgcctc cagctccaag
     3361 gactctgcct acaggagtgt gccttggggc tgaaaggcca tgcaaacaca acaaactaat
     3421 aactcagtcc caaagcaccc tgcagccctg cagacacccc ccccctccaa gagtgggagg
     3481 cagggaccac agaactgtcc agccaacacg tctgaactgg aactgttcca cttgaacccg
     3541 ggagctttaa agctttattt atttatagct tcttattaaa aatttaaaaa aagcgttgag
     3601 gaggaatcct ttggttattc atacggaatt gatgatggaa aagcaactgg ttgtcttcta
     3661 attgtctttg tctagatgga aactgaacct tagcagatga ataaaccctg aaaaggtcaa
     3721 aaaaaaaaaa aa
//
