LOCUS       NM_001012402            1249 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 6
            (Hs3st6), transcript variant 1, mRNA.
ACCESSION   NM_001012402 XM_283407 XM_484613
VERSION     NM_001012402.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Patel,V.N., Pineda,D.L., Berenstein,E., Hauser,B.R., Choi,S.,
            Prochazkova,M., Zheng,C., Goldsmith,C.M., van Kuppevelt,T.H.,
            Kulkarni,A., Song,Y., Linhardt,R.J., Chibly,A.M. and Hoffman,M.P.
  TITLE     Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to
            reduce epithelial morphogenesis and adult salivary gland function
  JOURNAL   Matrix Biol 103-104, 37-57 (2021)
   PUBMED   34653670
REFERENCE   3  (bases 1 to 1249)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1249)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1249)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1249)
  AUTHORS   Motamedi,F.J., Badro,D.A., Clarkson,M., Lecca,M.R., Bradford,S.T.,
            Buske,F.A., Saar,K., Hubner,N., Brandli,A.W. and Schedl,A.
  TITLE     WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal
            progenitors
  JOURNAL   Nat Commun 5, 4444 (2014)
   PUBMED   25031030
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1249)
  AUTHORS   Xu,D., Tiwari,V., Xia,G., Clement,C., Shukla,D. and Liu,J.
  TITLE     Characterization of heparan sulphate 3-O-sulphotransferase isoform
            6 and its role in assisting the entry of herpes simplex virus type
            1
  JOURNAL   Biochem J 385 (Pt 2), 451-459 (2005)
   PUBMED   15303968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146974.1 and AY574375.1.
            
            On Oct 26, 2017 this sequence version replaced NM_001012402.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY574375.1, BC132520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK146974.1         2-16
            16-1249             AY574375.1         1-1234
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1249
                     /gene="Hs3st6"
                     /gene_synonym="3-OST-6"
                     /note="heparan sulfate (glucosamine) 3-O-sulfotransferase
                     6"
                     /db_xref="GeneID:328779"
                     /db_xref="MGI:MGI:3580487"
     exon            1..511
                     /gene="Hs3st6"
                     /gene_synonym="3-OST-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1127
                     /gene="Hs3st6"
                     /gene_synonym="3-OST-6"
                     /EC_number="2.8.2.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     6 isoform 1"
                     /protein_id="NP_001012402.1"
                     /db_xref="CCDS:CCDS28496.1"
                     /db_xref="GeneID:328779"
                     /db_xref="MGI:MGI:3580487"
                     /translation="MAGSGGLGGGAGDLQGAGTGQGTALRALRAPLALVVLLLSAYCL
                     FALPGRCPPAARAPAPVPAPAEPPHTSLRLRAPGLPVASGPGRRRFPQALIVGVKKGG
                     TRALLEFLRLHPDVRALGSEPHFFDRCYDRGLAWYRGLMPRTLDGQITMEKTPSYFVT
                     QEAPRRIHGMSPDTKLIVVVRNPVTRAISDYAQTLSKTPGLPSFRALAFRHGLGPVDT
                     AWSAVRIGLYAQHLDNWLRYFPLSHFLFVSGERLVSDPAGEVGRVQDFLGLKRVVTDK
                     HFYFNATKGFPCLKKAQGSGRPRCLGKSKGRPHPRVPEAVVQRLQAFYRPFNRKFYQM
                     TGQDFGWD"
     exon            512..1235
                     /gene="Hs3st6"
                     /gene_synonym="3-OST-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1209..1214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs3st6"
                     /gene_synonym="3-OST-6"
                     /note="hexamer: AATAAA"
     polyA_site      1235
                     /gene="Hs3st6"
                     /gene_synonym="3-OST-6"
                     /note="major polyA site"
ORIGIN      
        1 gaagccgggc gccctggggt tgagcgggcg acgcactata gccgggatgc gcacctgtct
       61 gcggttcccg ctcccgagcc tgagcgcgaa gcgaccccat ggcaggtagc ggtggcctgg
      121 gcggcggggc cggtgacctc cagggtgcgg ggacgggcca ggggactgca ctgcgtgctc
      181 tccgtgctcc gctggcgctc gtagttctgt tgctaagcgc ctactgcctc ttcgccctcc
      241 ccggccgctg tccacctgcc gcccgcgccc ctgctccggt tcctgcaccc gccgagccgc
      301 cccacacctc cctccgtctg agagcacccg gcctgccggt ggccagcggc ccggggcgcc
      361 ggcgctttcc tcaggcgctc attgtgggtg tgaagaaagg cggcacgcgc gcattgctgg
      421 agttcctgcg gttgcacccc gacgtccgtg cacttggctc tgaaccccac ttcttcgaca
      481 ggtgctatga tcgcggcctc gcctggtacc ggggcctaat gccacggacc ctggatgggc
      541 agatcaccat ggagaagacg cccagctact ttgtgactca ggaggctccc cgccgaatcc
      601 atggcatgtc cccagatacc aagctgattg tggtggtgcg gaaccccgtg acccgggcca
      661 tctctgatta tgcacagaca ctctccaaga ccccaggctt gcctagcttc cgtgccctgg
      721 ccttccgcca cggcctgggt cccgtggaca cagcctggag tgctgtgcgc attggcctct
      781 atgctcagca cttggacaac tggctccgct actttcctct gtcccacttc ctgtttgtaa
      841 gcggtgagcg cctggtcagt gatccagctg gcgaagtggg ccgtgtacag gactttctgg
      901 gtctcaaacg ggttgtcact gacaagcact tctacttcaa tgctactaag ggcttcccct
      961 gcctcaaaaa ggcccagggt agtgggagac cccgctgctt gggtaaatcc aagggccggc
     1021 ctcacccccg agtgccggag gcagtggttc agcgcctgca ggctttctac cggccattca
     1081 accgcaagtt ctaccagatg actggccagg actttggctg ggactgatca aggcccagcc
     1141 tagcctttcc ctgaaggccc agtaccttta atttatgtct gtctgctggc tcactgcagt
     1201 atttagggaa taaagcctag atttgtcttc ttccaaaaaa aaaaaaaaa
//
