LOCUS       NM_001252072            3230 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 4
            (Hs3st4), mRNA.
ACCESSION   NM_001252072 XM_003086663 XM_893564
VERSION     NM_001252072.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Doyle,D.Z., Lam,M.M., Qalieh,A., Qalieh,Y., Sorel,A., Funk,O.H. and
            Kwan,K.Y.
  TITLE     Chromatin remodeler Arid1a regulates subplate neuron identity and
            wiring of cortical connectivity
  JOURNAL   Proc Natl Acad Sci U S A 118 (21) (2021)
   PUBMED   34011608
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Aydogdu,N., Rudat,C., Trowe,M.O., Kaiser,M., Ludtke,T.H.,
            Taketo,M.M., Christoffels,V.M., Moon,A. and Kispert,A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Qiu,H., Shi,S., Yue,J., Xin,M., Nairn,A.V., Lin,L., Liu,X., Li,G.,
            Archer-Hartmann,S.A., Dela Rosa,M., Galizzi,M., Wang,S., Zhang,F.,
            Azadi,P., van Kuppevelt,T.H., Cardoso,W.V., Kimata,K., Ai,X.,
            Moremen,K.W., Esko,J.D., Linhardt,R.J. and Wang,L.
  TITLE     A mutant-cell library for systematic analysis of heparan sulfate
            structure-function relationships
  JOURNAL   Nat Methods 15 (11), 889-899 (2018)
   PUBMED   30377379
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Caubit,X., Gubellini,P., Andrieux,J., Roubertoux,P.L., Metwaly,M.,
            Jacq,B., Fatmi,A., Had-Aissouni,L., Kwan,K.Y., Salin,P.,
            Carlier,M., Lieden,A., Rudd,E., Shinawi,M., Vincent-Delorme,C.,
            Cuisset,J.M., Lemaitre,M.P., Abderrehamane,F., Duban,B.,
            Lemaitre,J.F., Woolf,A.S., Bockenhauer,D., Severac,D., Dubois,E.,
            Zhu,Y., Sestan,N., Garratt,A.N., Lydia Kerkerian-Le,Goff. and
            Fasano,L.
  TITLE     TSHZ3 deletion causes an autism syndrome and defects in cortical
            projection neurons
  JOURNAL   Nat Genet 48 (11), 1359-1369 (2016)
   PUBMED   27668656
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 3230)
  AUTHORS   Yabe,T., Hata,T., He,J. and Maeda,N.
  TITLE     Developmental and regional expression of heparan sulfate
            sulfotransferase genes in the mouse brain
  JOURNAL   Glycobiology 15 (10), 982-993 (2005)
   PUBMED   15944372
REFERENCE   9  (bases 1 to 3230)
  AUTHORS   Wu,Z.L., Lech,M., Beeler,D.L. and Rosenberg,R.D.
  TITLE     Determining heparan sulfate structure in the vicinity of specific
            sulfotransferase recognition sites by mass spectrometry
  JOURNAL   J Biol Chem 279 (3), 1861-1866 (2004)
   PUBMED   14602711
REFERENCE   10 (bases 1 to 3230)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151718.5, CJ154897.1, AC126278.4 and BQ177219.1.
            
            On Feb 14, 2019 this sequence version replaced NM_001252072.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.621538.1,
                                           SRR1660815.119074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-822               AC151718.5         184197-185018       c
            823-1269            CJ154897.1         1-447
            1270-2631           AC126278.4         66546-67907         c
            2632-3230           BQ177219.1         18-616              c
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 67.56 cM"
     gene            1..3230
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
                     /note="heparan sulfate (glucosamine) 3-O-sulfotransferase
                     4"
                     /db_xref="GeneID:628779"
                     /db_xref="MGI:MGI:1333792"
     exon            1..1066
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1703
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
                     /EC_number="2.8.2.23"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     4"
                     /protein_id="NP_001239001.1"
                     /db_xref="CCDS:CCDS57584.1"
                     /db_xref="GeneID:628779"
                     /db_xref="MGI:MGI:1333792"
                     /translation="MARWPAPPPPPPPPPPLAAPPLLPGASTKGPPARKLLFMCTLSL
                     SVTYLCYSLLGGSGSLQFPLALQEPPGSAAEPPPSLLSPSLPPPRVRPGASSPPPDNA
                     SRGPPPEPPERFTTPAADGWGLASGGGARDAWPRSPPAPGDAVTEQDALLGRGAQEPG
                     AAEELEGRRAANGSAERGPASTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRA
                     VGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKL
                     IVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLE
                     NWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKK
                     PEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNMMFYQMTGQDFQWEQEEGDK"
     exon            1067..3230
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
                     /note="hexamer: ATTAAA"
     polyA_site      3193
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
     regulatory      3209..3214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
                     /note="hexamer: TATAAA"
     polyA_site      3230
                     /gene="Hs3st4"
                     /gene_synonym="Gm6915"
                     /note="major polyA site"
ORIGIN      
        1 ctcccggcag aaagttagca gcagggaagg aactcggggc tgcgggagcg gtagccgcgg
       61 cagcgcgggg agagcggggc gctgcgcacg gagcaggtgc cgccgcgact aggcgccccc
      121 ctcgggctcc tggcctgagg ttgagggggg cggcgggggc tcgcgagggg agggggccat
      181 gcgtccgggc ttgtccccgg cgcagcggga cggcagccag ggccgggggc gcagcggcgt
      241 cgctccatgc agccggggcg gctgggcggc ggcggcggcg gcggcggggg cggcggctga
      301 aaccatgtcc gggcagcgcc gggggccgcc gccgccgcga gccgggagcc gcgatggccc
      361 ggtggcccgc accgcctccg cctccgccgc cgccgccgcc gctcgccgcg ccgccgctgc
      421 tgcccggcgc ctccactaag gggccgccgg cgcgcaagct gctcttcatg tgcaccctgt
      481 ccctgtccgt cacctacctg tgctacagcc tgctgggcgg ctcgggttcg ctgcagttcc
      541 cgctggcgct gcaggagccc ccgggatccg ccgcggagcc cccgccgagc ctgctgtctc
      601 cctcgctgcc gcctccccgc gtgcgccccg gcgcctcctc gccgccgccg gacaacgcga
      661 gccgcgggcc accgcccgag ccccccgagc gcttcacgac tcctgcggcc gacggctggg
      721 gactggcgag cggcggcggt gctcgggacg cctggcccag gagcccgcct gcccccggag
      781 acgcggtcac agagcaggac gcgctgttgg ggcgcggggc gcaggagcca ggcgcagccg
      841 aggagctgga aggccggagg gcggccaacg ggagtgcgga acggggcccc gccagcaccc
      901 ctgattatgg ggagaagaag ctgccccagg cactgatcat cggggtcaag aaaggaggga
      961 cacgcgcgct gctggaggct atccgagtcc acccggacgt aagggcagtg ggcgtagagc
     1021 cgcacttctt cgacaggaac tacgagaagg ggctggaatg gtacagaaat gtgatgccta
     1081 agacattgga tgggcagata accatggaga agacccccag ttattttgtg acgaatgagg
     1141 ctcccaagcg catccactct atggccaagg atatcaaact cattgtggtg gtacgaaacc
     1201 cagtgaccag ggccatttct gactataccc agacactgtc aaaaaagcca gagatcccca
     1261 cctttgaggt tctggccttc aaaaaccgga ccctggggct gattgatgcc tcttggagcg
     1321 ccattcgcat tgggatctat gctttgcacc tggagaactg gctgcagtac tttccccttt
     1381 ctcagatcct gtttgtcagt ggtgagcgac tcatagtgga ccctgcaggg gagatggcca
     1441 aggtccagga tttcctaggc ctcaagcgtg tggtgactga gaagcacttt tacttcaaca
     1501 aaaccaaggg gttcccctgc ctgaagaagc cagaagacag cagcgcccca agatgtttgg
     1561 gcaagagcaa aggtcggact catccccgaa ttgacccaga tgtcatccat agacttcgga
     1621 aattctacaa acccttcaac atgatgtttt accaaatgac tggtcaagat ttccagtggg
     1681 aacaggaaga gggtgataag tgaggctgat ggtgtggagg gaaggctaat gaatagcaag
     1741 gatactctta agcagagtcc caaatccccc aggttcagaa gtgtcagcca tgctggagta
     1801 ccaagtagat tgccaacctg atccatcagg ttacatccaa tgtcgtgggc ttaggcagag
     1861 gtatagatct catggcatcc ctggggagga atcaacaatg tctggttgac cagatggtta
     1921 ctaaaatcta ccatgaatag tatcttctac tagttaatag ttaaagagga taaacatctt
     1981 ccaatgtcac agacagatgc tatgttgagt ataagaaaga gagaaagaga gagagagagg
     2041 gagggggaga gggaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggagag
     2101 aagaaagaaa gaaagagaga gggggatgga gggaaggagg aaggaaggaa ggaaggaagg
     2161 aaggaaggaa ggaaggaagg aaggtgtatt ttgccggagc tcttactata gtcttgggag
     2221 tatggattct agccttgtat ttaatccctg gtacataaac ttctgctctg gcatctctcc
     2281 agaatgctat ttgtgactga gagcaccaag actcccaggg aacaatatcc tccctccaag
     2341 gcctgtctag ccttcccatc aaaggcctca tcccacaacc ctttgatttc ctccctcccc
     2401 acaatatgaa ggcaaaggca tgcacgtatg ttcttcacca aaaataaaat aaaataaaat
     2461 aaaacaaaac aaaaaatagc ctataccccc tagagccttc tatctgagag ccatccaagg
     2521 tgggtctctc tcttcatgag cgttctaaat tacagagaag cttagcacat cctcatattg
     2581 ggatctggcc tacatgaatg ctcccagaac agggagatag catctgtgtt ttgagccctg
     2641 aggttggcaa agatgaatgc ttgtaactgt gggtatcagg caaaccccag cctcttggtg
     2701 ggtggcccct tatctaaaga cccttgttcc taaggatcgt ggtcctgggg catgctctaa
     2761 gggataggct ctgctctgga ggcaaagaca gagcttgctt gttagttgtt cacagacacc
     2821 cttccaaatg tgaagaggaa gggagtaccc aatgtttttt gtttgtcttg atgctgcccc
     2881 ctcagggtca cctcatggtt catttttctc tactcagaga tggcattcat tgggccattg
     2941 gcaagaacgc tgctgctttg cagtgtgaag tggattgagg agggcaagga ctgtctgcag
     3001 acatcctttt caagggctgc caaataaagt gtcccttccc attagtatgg ttcaattaaa
     3061 acacagcgtt tgacataaag cacttgtttc tcagatctcc aaagccagga attgtagtaa
     3121 aattggaaat gtgtatgagt ggggagagtt gaatctgttc agctgttatt aaactgtcat
     3181 ttctcccact aaatggaaac tgtgttgtta taaagcttaa tgcaacctga
//
