LOCUS       NM_018805               6004 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
            (Hs3st3b1), mRNA.
ACCESSION   NM_018805
VERSION     NM_018805.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6004)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6004)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6004)
  AUTHORS   Sampath Kumar,A., Tian,L., Bolondi,A., Hernandez,A.A., Stickels,R.,
            Kretzmer,H., Murray,E., Wittler,L., Walther,M., Barakat,G.,
            Haut,L., Elkabetz,Y., Macosko,E.Z., Guignard,L., Chen,F. and
            Meissner,A.
  TITLE     Spatiotemporal transcriptomic maps of whole mouse embryos at the
            onset of organogenesis
  JOURNAL   Nat Genet 55 (7), 1176-1185 (2023)
   PUBMED   37414952
REFERENCE   4  (bases 1 to 6004)
  AUTHORS   Wang,Z., Patel,V.N., Song,X., Xu,Y., Kaminski,A.M., Doan,V.U.,
            Su,G., Liao,Y., Mah,D., Zhang,F., Pagadala,V., Wang,C.,
            Pedersen,L.C., Wang,L., Hoffman,M.P., Gearing,M. and Liu,J.
  TITLE     Increased 3-O-sulfated heparan sulfate in Alzheimer's disease brain
            is associated with genetic risk gene HS3ST1
  JOURNAL   Sci Adv 9 (21), eadf6232 (2023)
   PUBMED   37235665
REFERENCE   5  (bases 1 to 6004)
  AUTHORS   Patel,V.N., Pineda,D.L., Berenstein,E., Hauser,B.R., Choi,S.,
            Prochazkova,M., Zheng,C., Goldsmith,C.M., van Kuppevelt,T.H.,
            Kulkarni,A., Song,Y., Linhardt,R.J., Chibly,A.M. and Hoffman,M.P.
  TITLE     Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to
            reduce epithelial morphogenesis and adult salivary gland function
  JOURNAL   Matrix Biol 103-104, 37-57 (2021)
   PUBMED   34653670
  REMARK    GeneRIF: Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan
            sulfate to reduce epithelial morphogenesis and adult salivary gland
            function.
REFERENCE   6  (bases 1 to 6004)
  AUTHORS   Chen,Z., Huang,J., Liu,Y., Dattilo,L.K., Huh,S.H., Ornitz,D. and
            Beebe,D.C.
  TITLE     FGF signaling activates a Sox9-Sox10 pathway for the formation and
            branching morphogenesis of mouse ocular glands
  JOURNAL   Development 141 (13), 2691-2701 (2014)
   PUBMED   24924191
REFERENCE   7  (bases 1 to 6004)
  AUTHORS   Chiu,H.S., Szucsik,J.C., Georgas,K.M., Jones,J.L., Rumballe,B.A.,
            Tang,D., Grimmond,S.M., Lewis,A.G., Aronow,B.J., Lessard,J.L. and
            Little,M.H.
  TITLE     Comparative gene expression analysis of genital tubercle
            development reveals a putative appendicular Wnt7 network for the
            epidermal differentiation
  JOURNAL   Dev Biol 344 (2), 1071-1087 (2010)
   PUBMED   20510229
REFERENCE   8  (bases 1 to 6004)
  AUTHORS   Yabe,T., Hata,T., He,J. and Maeda,N.
  TITLE     Developmental and regional expression of heparan sulfate
            sulfotransferase genes in the mouse brain
  JOURNAL   Glycobiology 15 (10), 982-993 (2005)
   PUBMED   15944372
REFERENCE   9  (bases 1 to 6004)
  AUTHORS   Shukla,D., Liu,J., Blaiklock,P., Shworak,N.W., Bai,X., Esko,J.D.,
            Cohen,G.H., Eisenberg,R.J., Rosenberg,R.D. and Spear,P.G.
  TITLE     A novel role for 3-O-sulfated heparan sulfate in herpes simplex
            virus 1 entry
  JOURNAL   Cell 99 (1), 13-22 (1999)
   PUBMED   10520990
REFERENCE   10 (bases 1 to 6004)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603889.5 and AK085242.1.
            
            On Jan 5, 2006 this sequence version replaced NM_018805.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171996.1, AK172015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-544               AL603889.5         100372-100915       c
            545-1635            AK085242.1         554-1644
            1636-6004           AL603889.5         63324-67692         c
FEATURES             Location/Qualifiers
     source          1..6004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 39.47 cM"
     gene            1..6004
                     /gene="Hs3st3b1"
                     /gene_synonym="3-OST-3B; 3Ost3b; 3OST3B1; Hs3st3b;
                     m3-OST-3B"
                     /note="heparan sulfate (glucosamine) 3-O-sulfotransferase
                     3B1"
                     /db_xref="GeneID:54710"
                     /db_xref="MGI:MGI:1333853"
     exon            1..951
                     /gene="Hs3st3b1"
                     /gene_synonym="3-OST-3B; 3Ost3b; 3OST3B1; Hs3st3b;
                     m3-OST-3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1570
                     /gene="Hs3st3b1"
                     /gene_synonym="3-OST-3B; 3Ost3b; 3OST3B1; Hs3st3b;
                     m3-OST-3B"
                     /EC_number="2.8.2.30"
                     /note="D-glycosaminyl 3-O-sulfotransferase-3B; heparan
                     sulfate 3-O-sulfotransferase 3B1; heparan sulfate
                     D-glucosaminyl 3-O-sulfotransferase 3B1"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     3B1"
                     /protein_id="NP_061275.2"
                     /db_xref="CCDS:CCDS24838.1"
                     /db_xref="GeneID:54710"
                     /db_xref="MGI:MGI:1333853"
                     /translation="MGQRLSGGRSCLDVPGRFLPQPPPPPPPVRRKLALLFAMLCIWL
                     YMFLYSCAGSCTAAPGLLLLGSGSRATHAQPALVTAPNETSPKMPFRAPPANSLAAGK
                     DKTVGAGSQEEQSPEAPDSPSPISSFFSGAGSKQLPQAIIIGVKKGGTRALLEFLRVH
                     PDVRAVGAEPHFFDRSYHKGLAWYRDLMPRTLKGQITMEKTPSYFVTREAPARISAMS
                     KDTKLIVVVRDPVTRAISDYTQTLSKRPDIPSFESLTFRNRSAGLIDTSWSAIQIGLY
                     AKHLEPWLRHFPLGQMLFVSGERLVSDPAGELRRVQDFLGLKRIITDKHFYFNQTKGF
                     PCLKKAEGSGKPHCLGKTKGRAHPTIAREVLRQLRDFYRPFNRKFYQMTGRDFGWD"
     exon            952..6004
                     /gene="Hs3st3b1"
                     /gene_synonym="3-OST-3B; 3Ost3b; 3OST3B1; Hs3st3b;
                     m3-OST-3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4886..4891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs3st3b1"
                     /gene_synonym="3-OST-3B; 3Ost3b; 3OST3B1; Hs3st3b;
                     m3-OST-3B"
                     /note="hexamer: AATAAA"
     polyA_site      4905
                     /gene="Hs3st3b1"
                     /gene_synonym="3-OST-3B; 3Ost3b; 3OST3B1; Hs3st3b;
                     m3-OST-3B"
                     /note="major polyA site"
ORIGIN      
        1 gcagttctcc gccgcagcct cagcgggcaa gcgccggggc tgctctcaat ctcctggctg
       61 cgaggaggca gccccggcga gctgtcgtgc gccccgtcca gagttactga gtgcggggca
      121 cagcgtaact gacagcgcgt ctgctcacag ttcccgtcgc ctggacttag ctttccaacc
      181 ccggcttctc gtgggcatca tgtcaagagc cgtcgccgct gcaaccgccg ccgccacccg
      241 gggaagagcc gcagcctcgg cagccgcgcg cgcaggaggg caataaaccg aatcactccg
      301 ggctcaaagt ggcaggggac cgtcgcggtg ctctctgttc cggcgggact cctgccatgt
      361 gctgagccat gcccctggcc gcgcccgcgg gccgcgtatg gggcagcgcc tgagcggcgg
      421 ccggtcctgt ctcgatgtcc cgggccggtt cctgccgcag ccgccgccgc ccccgccgcc
      481 ggtgaggagg aagctcgcgc tgctcttcgc catgctttgc atctggctgt acatgttttt
      541 gtactcgtgc gccggctcct gtaccgccgc tcccggcctg ctgctcctgg gctcggggtc
      601 ccgcgctact cacgctcagc cagccctggt cacagctccg aatgagacat cccctaagat
      661 gcccttccgg gcacctccgg ccaattcgct ggctgcaggc aaggataaga cagtaggcgc
      721 tgggagccag gaggagcaga gtccagaggc gccggactcc cccagtccca tctccagctt
      781 cttcagcggc gctgggagca agcagctgcc gcaggccatc atcatcgggg tgaagaaggg
      841 cggcacgcgg gcattgctgg agttcctgcg cgtgcacccc gacgtgcgcg ccgtgggcgc
      901 cgagccccac tttttcgacc gcagctacca caagggtctt gcctggtacc gagacttgat
      961 gcccagaacc ctcaagggac agatcaccat ggagaagacg cccagctact ttgtgacccg
     1021 ggaggcaccc gcgcgcatct cggccatgtc caaggacacc aagctcatcg tggtggtgcg
     1081 cgacccggtg accagggcca tctcggacta cacgcagacg ctgtccaagc ggccggacat
     1141 ccccagcttc gagagcctga cgttccgcaa ccgcagcgcg ggcctcatag acacgtcctg
     1201 gagcgccatc cagatcggcc tgtacgccaa gcacctggag ccctggctgc gccacttccc
     1261 gctcggccag atgctcttcg tgagcgggga gcggctggtc agcgacccgg ccggcgagct
     1321 gcgccgcgtg caggatttcc tgggcctcaa gcgcatcatc accgacaagc acttctactt
     1381 caaccagacc aagggcttcc cgtgcctcaa gaaggcggag ggcagcggca agccgcactg
     1441 cctgggcaag actaagggcc gcgcgcaccc caccatcgcg cgcgaggtgc tgcggcagct
     1501 gcgtgacttt taccggccct tcaaccgcaa gttctaccag atgaccggcc gcgacttcgg
     1561 ctgggactga gtctcccctc gcagcttatc tattgagaga gagtatatgt atgtaaaatg
     1621 tacagaaatc tattttataa taatttattt ttaattcacg agcaattaat tcactaagct
     1681 gcctagccac aatctgcaga gagttcgaat cacggtctgt taacattcca gagtgtttaa
     1741 ctccgatgtt ttgttctgtc cctcacaatc gatggtgctt ccatgttctc ttccccctct
     1801 ccccactgta tttaagaaga agaaaagcac aacttgagaa tttttgttac gggtattcag
     1861 ccttcagtca ccttgggtct tccacctgct atctccttgg gtcttggctg cctcagctgg
     1921 gtgtggtatt ttcttgcctg gataccctcc cggaagcact gagctgcctc agtgtgctgt
     1981 agtcggaagg tggaattcac ttaagcagtt cattaccctc agtgacatag cacctaggtg
     2041 catttctccc gcctccctta cagggatgtc cttatgaccc cgactcccct cctcctcctc
     2101 taccctccgt ccattattca gctggaagtg tatgcaaaca cttgatccct ttcccaggtc
     2161 ccatgtgtca gaggcttggg tgctgcttta aaaaaaaaat gtgacatctc ctttgcataa
     2221 gagggtgcca cactcctttc ttcagtcaga cagtcatgct atgacacacc aaagagtctc
     2281 ccaggattcc atacataggc agcagcacaa gcctaggatg ctggatgttg aggcccacag
     2341 gggtcagatg gatctcttga cattcagcat ttatagaagt gttgctctgt gtagacccac
     2401 ctagtgttgg gcaggaagct catggcctca gtagagagat ctggcaagca gcccagcaga
     2461 ggaagagggt gcccagcatg ccagccaaaa gcctctgagt ttctagccca tcccagagat
     2521 tatgaaatgg tctaggcagt gtccacagca ggctttgaag gatgggccta ttgggcccag
     2581 gctgggaaag ctggctgcgt gcggtactcg aatctgactc ttgtgcagcg tcctctgagg
     2641 tagtggagtc ttagcagaga agtccccagc tttgctgcta atatgtagat ggtactccct
     2701 gtgcctctgt gttgggagga cactggaggg tcctttggct agttagtggc agttggataa
     2761 ctgtacttag atgacatcat gatatattca gttaatcttc agtttcttaa accagaaggc
     2821 ttctaccccc caaaggattg gtgtctgagt tagactttca tcaagaatga gtagatggtt
     2881 gaaatgactg cattgtgatc tttgcagagg cttttttttt ttttttttgg atactttttg
     2941 ggctaacttg acaggataag caaagttaca tggaaagaga agatatactg tctttagaaa
     3001 ctagtgagag aggtgtctct agggatattt tgataaccaa atttgtggtt ttctacaagt
     3061 tatagcccag catgaattag ctcattctgg gccacaaaat ggtccctggg ctatattcat
     3121 cctttagctg ttacatccat ttcttccctc ttttcttttt tcttctgcag agctgggggt
     3181 agaatcctgg gcctattgca cactaggcaa acactgagcc acattcccca gcccatttca
     3241 cagtcatttg ctcattttct tctgtccata ctcagcacgg tgtacattga ggccaacccc
     3301 acactgtcag cagaatcccc tggctggcag gtgtgtggag acgcctgcac gcaaggtgct
     3361 cacccgcctg tgcttttctg tgcagaaggc tgtttgacat cagaacaagg ctcactcccc
     3421 tcacgtacag cagaaccttg ctcccagcca gaggcagttg tcaaaggcct tcaccaaggc
     3481 ttgctggctg ctcccggagt ctgatgtgac acatgaagta gaagagcaaa aagagttcag
     3541 agaatggtac atagccaagt gggggaaggg aggggagaga tgtgtgagcc ttcctgttct
     3601 ctttccaagc tggacacctt tttgtttttt taaattcagt cgtttatttt ttttaattat
     3661 tattattatt atttgcttga gaatataaca aaaacaagac atactgaggt agaaggaagt
     3721 catttagtca tgaacactga agtgagttag gagtctgttc tgggtcaaat ccttggatct
     3781 gagcagatgt cgataattag tggtgatgga gcagggtgag gttttcagtg ttagtcaaat
     3841 aaatcaaaca acatgtgcac ctctttggtc aggctccact gcttgtagtc cctggatgat
     3901 tggatgctgc atctgcccaa gatgccgctc catcatcatg tgatagtcgt tacacacagg
     3961 gcctcttctc ggaggagtta gggaacatgg agaattaagc cttaggtctg tctcttcctt
     4021 cactggccat ctgcaagccc actgagtgtc acttctgagc tgctaggctg ctaggagaca
     4081 gacaccagtt catgtcctgg cagtttgtcc tgctacatgt ttggtatttt ttaaattttt
     4141 taattttttc tccagtttat aggaaagcta tggcatattc ctggtgtact ttatttctga
     4201 aaagtttcat ttctttcctt gtttgaaaac aaaaaagaaa agtttttttt ccccccgtgt
     4261 ttgtttgttt ttttttttga attcctatcc atggaaagcc ttctctctgg ggatgtttgc
     4321 atgtaggtct gtgctcgttt actctgtagc acctacaaag gtaacttcag gcagagtgac
     4381 tatggaataa agtctgcatt gagtggtgga gagatgttct ggggggaggg gactcttggg
     4441 gagttcttct cagtgatgaa tgcacttcag tctttgggag aaacccaggt gtagatcatg
     4501 cctggctgct ctcctaagaa ccgaaaatgg aggctccaac aagtcagtga gaatcagagg
     4561 tgttgatgtg ggcgctgggg ggtcagttct cttttcagtt ttccatacaa atggttaatg
     4621 aattttgaag gtgtggttag ttttttattt catttttata acattaattt atgacttgag
     4681 tttcattcag cccagtaatc aaaagtgctg tgcaaattct cgcagtatgt cttctataac
     4741 gtggatgtta gaatagccaa tatgtacaaa aaagaattaa atcaagtatt ttgtcctatg
     4801 tataacacaa attaatttta cacagagaaa gatgtttcta ggaaaatgaa attctggtaa
     4861 ttcatacttt ttctttgtat gaacaaataa aatatatttt accaacatgt gagtatgttc
     4921 ctattttgct atgtacatcg gttggaaaat ttaatattga tatttttata ttttgaaata
     4981 tctattgata tttttcaata acttgtcagg tgtggcatat ttacacactg tcaaaggcag
     5041 gtagattttt tttgggaggg ggaacttctt tgttgtttgt gtttttgaga cagtcttaca
     5101 ctgtagcata ggctggcttc aaactaacag cgttcctgtg tcagtctcct gagtgctgga
     5161 attacaggct ctgctgattt ttcagcctaa tttgttatta cattaaaata actctgttta
     5221 gggtgtgtgt gtgtgtgcac atgtgtgtgc tgtgtgtgtg tacctgtaat atctgattcc
     5281 tatcatgtag tctcagggtt gaacacaggt catcagaatt ggtagcaagc acccttcctt
     5341 acccactgag ccatcttgcc agcactgatt gttcatattt ttaaaaagtg aagtaacaga
     5401 agccaattga tccgtaagta ttgtggatgg atttttctcg taaatggctg tgaaagccag
     5461 agtgtaggag ccctgtgctc tggagagagc ttctaccacc caccacgtat tacccaaata
     5521 ctcaggatcc taccagctac tgaggccact gtgtgcatgg gctttcggaa ccaaggtgga
     5581 taggagtggg cagccacaga tactatgaca gtgtggggag ggtatgctgc atggccggtg
     5641 aaatcgcgct gtttccttct catatctgct gcgtgtgctc atggcaaagt gggaccttta
     5701 tctgtgagga aaaggcagac tggacaagac aatgcagatc tccagttttt ccaaaaccac
     5761 catagatttc ttcccgacac agcatagcat ctgcatgatt acaggttttt acatttaaaa
     5821 caaaacaaaa aaaaattcca accgattctt attgcactta agtttttaaa acaaaaacct
     5881 gttttatttt cccagatcca gaagtttgcc tgttgcacca accttgcttc agggtagcct
     5941 tcgtgtgtgc agagccttct gtctgtagca tgcgaacaca aatgtgtatc ccaggcgctg
     6001 tgct
//
