LOCUS       NM_178870               3933 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
            (Hs3st3a1), mRNA.
ACCESSION   NM_178870
VERSION     NM_178870.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3933)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3933)
  AUTHORS   Baert,L., Manfroi,B., Quintero,M., Chavarria,O., Barbon,P.V.,
            Clement,E., Zeller,A., Van Kuppevelt,T., Sturm,N., Moreaux,J.,
            Tveita,A., Bogen,B., McKee,T. and Huard,B.
  TITLE     3-O sulfation of syndecan-1 mediated by the sulfotransferase
            HS3ST3a1 enhances myeloma aggressiveness
  JOURNAL   Matrix Biol 120, 60-75 (2023)
   PUBMED   37201729
  REMARK    GeneRIF: 3-O sulfation of syndecan-1 mediated by the
            sulfotransferase HS3ST3a1 enhances myeloma aggressiveness.
REFERENCE   4  (bases 1 to 3933)
  AUTHORS   Patel,V.N., Pineda,D.L., Berenstein,E., Hauser,B.R., Choi,S.,
            Prochazkova,M., Zheng,C., Goldsmith,C.M., van Kuppevelt,T.H.,
            Kulkarni,A., Song,Y., Linhardt,R.J., Chibly,A.M. and Hoffman,M.P.
  TITLE     Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to
            reduce epithelial morphogenesis and adult salivary gland function
  JOURNAL   Matrix Biol 103-104, 37-57 (2021)
   PUBMED   34653670
  REMARK    GeneRIF: Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan
            sulfate to reduce epithelial morphogenesis and adult salivary gland
            function.
REFERENCE   5  (bases 1 to 3933)
  AUTHORS   Rutledge,E.A. and McMahon,A.P.
  TITLE     Mutational analysis of genes with ureteric progenitor cell-specific
            expression in branching morphogenesis of the mouse kidney
  JOURNAL   Dev Dyn 249 (6), 765-774 (2020)
   PUBMED   32017326
REFERENCE   6  (bases 1 to 3933)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   7  (bases 1 to 3933)
  AUTHORS   Chen,Z., Huang,J., Liu,Y., Dattilo,L.K., Huh,S.H., Ornitz,D. and
            Beebe,D.C.
  TITLE     FGF signaling activates a Sox9-Sox10 pathway for the formation and
            branching morphogenesis of mouse ocular glands
  JOURNAL   Development 141 (13), 2691-2701 (2014)
   PUBMED   24924191
REFERENCE   8  (bases 1 to 3933)
  AUTHORS   Liu,J., Shworak,N.W., Sinay,P., Schwartz,J.J., Zhang,L.,
            Fritze,L.M. and Rosenberg,R.D.
  TITLE     Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase
            isoforms reveals novel substrate specificities
  JOURNAL   J Biol Chem 274 (8), 5185-5192 (1999)
   PUBMED   9988768
REFERENCE   9  (bases 1 to 3933)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL646051.19 and AL672141.12.
            
            On Oct 19, 2007 this sequence version replaced NM_178870.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051284.1, AK032282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1295              AL646051.19        128821-130115
            1296-3933           AL672141.12        70840-73477
FEATURES             Location/Qualifiers
     source          1..3933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 40.24 cM"
     gene            1..3933
                     /gene="Hs3st3a1"
                     /gene_synonym="3Ost3a; Hs3st3a"
                     /note="heparan sulfate (glucosamine) 3-O-sulfotransferase
                     3A1"
                     /db_xref="GeneID:15478"
                     /db_xref="MGI:MGI:1333861"
     exon            1..1295
                     /gene="Hs3st3a1"
                     /gene_synonym="3Ost3a; Hs3st3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             736..1917
                     /gene="Hs3st3a1"
                     /gene_synonym="3Ost3a; Hs3st3a"
                     /EC_number="2.8.2.23"
                     /note="heparan sulfate 3-O-sulfotransferase 3A1; heparan
                     sulfate D-glucosaminyl 3-O-sulfotransferase 3A1"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     3A1"
                     /protein_id="NP_849201.1"
                     /db_xref="CCDS:CCDS24840.1"
                     /db_xref="GeneID:15478"
                     /db_xref="MGI:MGI:1333861"
                     /translation="MAPSGPTGAQPSPAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAE
                     RCPPGSGPVAGVPGRGVPAGPRELAMWPAGAPRKRLLQLRQRRRRGRSGPGDSSDQEE
                     QSPGLAAAPGGSGAGSSVAEAQPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLR
                     VHPDVRAVGAEPHFFDRSYHKGLAWYRDLMPRTLEGQITMEKTPSYFVTREAPARISA
                     MSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPSFESLTFRNRSAGLIDTSWSAIQIG
                     LYAKHLEPWLRHFPLGQMLFVSGERLVSDPAGELRRVQDFLGLKRIITDKHFYFNQTK
                     GFPCLKKAEGSGKPHCLGKTKGRAHPTIAREVLRQLRDFYRPFNRKFYQMTGRDFGWD
                     G"
     exon            1296..3933
                     /gene="Hs3st3a1"
                     /gene_synonym="3Ost3a; Hs3st3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtggcag cggtggctga caggtcccgc acagcggggc ccctccaagc tgttcccagc
       61 tggggcccca gaggagtggg tagacttccg gagcgctcaa gaggccagaa ggcttgagtc
      121 ccattcggat agagggacta gggggacttt gcttgctcgg ttgctgagac gagctgagcc
      181 aggactcagg gcacgctcct gggcgggcca ggagagcaga agctggaaaa agggtcactc
      241 gttctaaccg gagcgtacac aattcttcgg cccgagagtc ctgcgcccgc tccacggggg
      301 actgagccaa ggatgtgtta tcgctgagcc aagttccgca ccgctcagga ccctgctgag
      361 ccgagcacct tcgccactgc cgccgcagag actcccttgc cgggcgactc tcggagaccc
      421 agggcgcgga gctctgcgca gctaggctca ggactcgggc gcgtttcaga cccaagacca
      481 tggtttctta agcacggccc cgcacccctt tcctcctcgt cgcccgaagc ccaggacccc
      541 aagaagggct cgcagtgctt ggtccctagt tccagcccct gctgccgccc agcggggcag
      601 ctctcaggca cgcagggcgg ctcaggcgat gcggccgcgg ggcagcacgc tggctggcag
      661 cggggatggc ggagctccca gcacagtcgt ggcctagcat ggcccgctcg ccgtccgagg
      721 tcgcctctgg ctaggatggc cccctcgggt cccaccggcg cccagcccag cccggcggag
      781 ccactgtcgc gcagcatctt caggaagttc ttgctgatgc tctgctcgct actcacttcc
      841 ctctacgtct tctactgcct ggcggagcgc tgcccacccg gctcgggccc cgtcgcgggg
      901 gtcccggggc gcggcgtccc tgcaggaccc agggaactgg cgatgtggcc cgcgggagcg
      961 ccaaggaagc gcctcctgca gctgaggcaa cggaggaggc gcgggcggtc ggggccagga
     1021 gacagcagcg accaggagga gcagagccct gggctggccg ccgcaccagg aggctccggg
     1081 gcgggaagca gcgtggccga ggcccagccg gggaccctgg ccttacttct ggacgagggc
     1141 agcaagcagc tgccgcaggc catcatcatc ggcgtgaaga agggcggcac gcgggcgctg
     1201 ctggagttcc tgcgcgtgca ccccgacgtg cgtgccgtgg gtgctgagcc ccactttttt
     1261 gaccgcagct accacaaggg cctcgcctgg taccgggatt tgatgcccag aaccctcgag
     1321 ggacagatca ccatggagaa gacgcccagc tactttgtga cccgggaggc acccgcgcgc
     1381 atctcggcca tgtccaagga caccaaactc atcgtggtgg tgcgcgaccc ggtgaccagg
     1441 gccatctcgg actacacgca gacgctgtcc aagcggccgg acatccccag cttcgagagc
     1501 ctgacgttcc gcaaccgcag cgcgggcctc atagacacgt cctggagcgc catccagatc
     1561 ggcctgtacg ccaagcacct ggagccctgg ctgcgccact tcccgctcgg ccagatgctc
     1621 ttcgtgagcg gggagcggct ggtcagcgac ccggccggcg agctgcgccg cgtgcaggat
     1681 ttcctgggcc tcaagcgcat catcaccgac aagcacttct acttcaacca gaccaagggc
     1741 ttcccgtgcc tcaagaaggc ggagggcagc ggcaagccgc actgcctggg caagactaag
     1801 ggccgcgctc accccaccat tgcgcgggag gtgctgcggc agctgcgtga cttttaccgg
     1861 cccttcaacc gcaagttcta ccagatgacc ggccgcgact ttggctggga tggatagcag
     1921 aagtaattta aaaagaaaaa aaaataatat caaaatataa tatatttttt taccagtcgg
     1981 tagagaaaag acggtttaat atttctgtat taagagtatg tgttgcagta tttttttttc
     2041 ttccggtccc cgtggataac cagcaccaaa catgcgcata gcagaaaagg agatttcatg
     2101 tatctaagca tctcatatct cccgttcctt tgcgttataa gctttcattc acaaagaatg
     2161 agcaccagta ctccactaaa ctgttttagg aaacccccca gggtaaacct ctcttgttac
     2221 ccacaaagac ctgatagaac tgagacttgg ccttccagtt ttctttctcc tgtgccactt
     2281 ttctcctaag tcatttctcg ctaagatact cagcatgcac agggccattt tcgatggtag
     2341 ttttggccct tacaccacca ctgcaagcat gtagtgtgtt tctcgagatc atcattttct
     2401 agttcagaga tgagggaaac tgagtctcag ggaggtcgaa tgactcatct taaagctgga
     2461 tagtggatcc tggacaaaaa tcctgtctgc cgctgctttt tctctatttt atgacaccgc
     2521 ccctgacccc acccggctag agcatataag acacctggag ctttagaagc tccggagtgg
     2581 tccggaaagc acaaggggga cttgtcactg caatgtgagt cccgggctgg cctatggcac
     2641 acagcctcat tacaaagctg tattcaagga agtcacagag atggggacac aagccctcta
     2701 gggagcctat cttgcccctt ggctgatcaa aggatgctta gacaaggaga tctgaccgat
     2761 gggtggtcat ctgagtccca gagaaattac tgagctcttc tgttgagaga agatggacag
     2821 acagaaccag gagtgtcgca gagtagcact tactagctgt tggtttgact tctttatttc
     2881 tttttaaaga aaaacccaat tcaattagaa cttatcaata cgaattccat tttccttatt
     2941 ttagaacccc cccccttttc tttgtagtat ctccggtctg acctcagtta acaacttctt
     3001 cccagctccc cctacagatt gaagctgtca ctcggtcact ttatccatgt ccatcatttc
     3061 cctctcatat gaattataac ctaatgctca ttaatgtttg gaaaatattc taagcaaaga
     3121 gacatagttg tggatggaat ggtgatgtct cctcccttcc ctgtctaaat ggctcaaatg
     3181 aatcaatagt ttattaagag tactccttgc tctctgagtg ggtattaacg agattaacat
     3241 taatgggaat taaattggtt tagcgaggag cacgtatgtg ctgatcatat aaaacattca
     3301 taattactct gtcagcgcca ttttaccaca ggtttaagac catgaggaac atgtttgcta
     3361 tcccatcaat atttctctta tctgctgaaa tttaaagggc cagacacgct aatacagtaa
     3421 aagagtgtgc tgttttctct gctgtcaatc aagagaaact agagtttgtt ttacaatatg
     3481 ctgggtgact gtgggtttgt cataggtgcc ctgtcaggga tgtacatgcc tcttaggaag
     3541 actaatacgg cgttaaaatg aagtgaagac atcattttaa gtttctaaat attttgtcat
     3601 ctttggattt atttgctgat atctcatgca tgggaattaa gccctgaact taggtcgccc
     3661 tttccacttt gtctccgaca tttctatgcc cttggtgtcc agagccagtc tgtttttagt
     3721 cgctgagagc catcacctgt ggccaccgga gactcacttt cagccctgct catcttttga
     3781 tttgtttgtg tttctgaatc ttttgtattc ccctctctgc ctgccattac gcaaaagcag
     3841 cttgcacaaa acccagaatt gtatctaaca gctgcactca gcaacctccc tcttttccca
     3901 tggaagagat aataaaagaa caaaattgaa tgc
//
