LOCUS       NM_001081327            2293 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 2
            (Hs3st2), transcript variant 1, mRNA.
ACCESSION   NM_001081327 XM_894488
VERSION     NM_001081327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Zhang,F., Li,F. and Lu,J.
  TITLE     microRNA-100 shuttled by human umbilical cord MSC-secreted
            extracellular vesicles induces endometriosis by inhibiting HS3ST2
  JOURNAL   Cell Signal 102, 110532 (2023)
   PUBMED   36423858
  REMARK    GeneRIF: microRNA-100 shuttled by human umbilical cord MSC-secreted
            extracellular vesicles induces endometriosis by inhibiting HS3ST2.
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Thacker,B.E., Seamen,E., Lawrence,R., Parker,M.W., Xu,Y., Liu,J.,
            Vander Kooi,C.W. and Esko,J.D.
  TITLE     Expanding the 3-O-Sulfate Proteome--Enhanced Binding of
            Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity
  JOURNAL   ACS Chem Biol 11 (4), 971-980 (2016)
   PUBMED   26731579
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Hasegawa,H. and Wang,F.
  TITLE     Visualizing mechanosensory endings of TrkC-expressing neurons in
            HS3ST-2-hPLAP mice
  JOURNAL   J Comp Neurol 511 (4), 543-556 (2008)
   PUBMED   18839409
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Hodge,L.K., Klassen,M.P., Han,B.X., Yiu,G., Hurrell,J., Howell,A.,
            Rousseau,G., Lemaigre,F., Tessier-Lavigne,M. and Wang,F.
  TITLE     Retrograde BMP signaling regulates trigeminal sensory neuron
            identities and the formation of precise face maps
  JOURNAL   Neuron 55 (4), 572-586 (2007)
   PUBMED   17698011
REFERENCE   6  (bases 1 to 2293)
  AUTHORS   Yabe,T., Hata,T., He,J. and Maeda,N.
  TITLE     Developmental and regional expression of heparan sulfate
            sulfotransferase genes in the mouse brain
  JOURNAL   Glycobiology 15 (10), 982-993 (2005)
   PUBMED   15944372
REFERENCE   7  (bases 1 to 2293)
  AUTHORS   Liu,J., Shworak,N.W., Sinay,P., Schwartz,J.J., Zhang,L.,
            Fritze,L.M. and Rosenberg,R.D.
  TITLE     Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase
            isoforms reveals novel substrate specificities
  JOURNAL   J Biol Chem 274 (8), 5185-5192 (1999)
   PUBMED   9988768
REFERENCE   8  (bases 1 to 2293)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125331.4 and AC098715.3.
            
            On Mar 29, 2023 this sequence version replaced NM_001081327.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4274320.1,
                                           SRR7652917.1135531.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-942               AC125331.4         24358-25299         c
            943-2293            AC098715.3         83633-84983         c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.07 cM"
     gene            1..2293
                     /gene="Hs3st2"
                     /gene_synonym="6430516N12Rik; A830061E14Rik"
                     /note="heparan sulfate (glucosamine) 3-O-sulfotransferase
                     2"
                     /db_xref="GeneID:195646"
                     /db_xref="MGI:MGI:1333802"
     exon            1..942
                     /gene="Hs3st2"
                     /gene_synonym="6430516N12Rik; A830061E14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..1561
                     /gene="Hs3st2"
                     /gene_synonym="6430516N12Rik; A830061E14Rik"
                     /EC_number="2.8.2.29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     heparan sulfate 3-O-sulfotransferase 2; heparan sulfate
                     D-glucosaminyl 3-O-sulfotransferase 2"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     2 isoform 1"
                     /protein_id="NP_001074796.1"
                     /db_xref="CCDS:CCDS40115.1"
                     /db_xref="GeneID:195646"
                     /db_xref="MGI:MGI:1333802"
                     /translation="MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDGL
                     GQSRLLGAPRCLRGPSASGQKLLAKSRPCDPPGPTPSEPSAPSAPAAAAPAPRLSGSN
                     HSGSPKPGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDW
                     YRSLMPRTLETQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQT
                     LSKKPDIPTFEGLSFRNRSLGLVDVSWNAIRIGMYALHLESWLRYFPLAQIHFVSGER
                     LITDPAGEMGRIQDFLGIKRFITDKHFYFNKTKGFPCLKKPESTLLPRCLGKSKGRTH
                     VQIDPEVIDQLREFYRPYNIKFYETVGQDFRWE"
     exon            943..2293
                     /gene="Hs3st2"
                     /gene_synonym="6430516N12Rik; A830061E14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2266..2271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs3st2"
                     /gene_synonym="6430516N12Rik; A830061E14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="Hs3st2"
                     /gene_synonym="6430516N12Rik; A830061E14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcatttccc gaggagccag aacgcggccg gcgccagcgc caccgtccgg tccgctcatc
       61 ctcccgccgg cactgccgcg cggccacaga gcgtccccag aaaggcgctc ggagcatccg
      121 gaatggggct tcgggcgctg ggcgcgctcc gaacccgacg cgcgtgagaa tcgaagagcg
      181 ccgggagccg cccggctgtc cagagccctc atcgcttaat accgggagat gctggcaatg
      241 cagccacctg gtccccgagg agccaccgta cccgggaccc ccgggcacgg tgcttgccca
      301 ggccagctgc ccccagagga gatgatatcc cttacgccca acgcgcacag cggggacagc
      361 gccacgcgag ccctctaggc aatcgcagag ccacgcagca gctccgccgc aggtgccacc
      421 tcggaaacca tgacccccgg cgcgggccca tggagctatg gcctataggg tcctgggccg
      481 cgcggggcca cctcagccgc ggagagcgcg caggctgctc ttcgccttca cactgtcctt
      541 gtcctgcact tacctgtgtt acagcttcct gtgctgctgc gacggtctgg gccagagccg
      601 cctgctcggc gcaccgcgtt gcctccgcgg ccccagcgca agcggccaga aacttctggc
      661 gaagtcccgc ccgtgtgatc ccccggggcc gacgcccagt gagcccagcg ctcccagcgc
      721 gcccgccgct gccgctccag caccgcgcct ctccggatcc aatcactctg gctccccgaa
      781 gccaggcacc aaacggctgc cccaagccct cattgtgggc gtcaagaaag ggggaactcg
      841 ggcggtgctg gagtttatcc gcgtgcaccc ggacgtgcgg gccttgggca ctgagcccca
      901 cttcttcgac aggaactacg gacgaggact ggactggtac aggagcctga tgccgaggac
      961 cttggagacc cagatcacac tggagaagac gcccagctat ttcgtcactc aagaagcccc
     1021 tcgacggatc ttcaacatgt cacgagacac caagctgata gtggtggtgc ggaacccagt
     1081 gacccgagcc atctctgact acacgcagac tctttccaag aagccggaca tccccacctt
     1141 cgagggcctg tccttccgca accgcagtct aggcctggtg gacgtgtctt ggaacgctat
     1201 ccgcattggc atgtatgcac tgcacctgga aagctggctg cggtacttcc cactggccca
     1261 gatccacttc gtcagtggag agcggctcat caccgaccct gctggtgaga tgggtcgtat
     1321 tcaggacttc ctgggcatca agagattcat cacagacaag cacttctact tcaacaagac
     1381 caaaggattc ccttgcttga aaaaaccaga gtcaaccctc ctgcctcgat gcctgggcaa
     1441 atcaaaaggg agaactcatg tacagatcga ccctgaagtt atagaccagc tccgggaatt
     1501 ttatagacct tataatatta aattttatga aactgttggg caggacttcc ggtgggagtg
     1561 agtctccaag gtacaagggc tctactcttg tctcttccgc aaggtttgct cccagagatc
     1621 ctgaccccca tctccagccc ctcttctcat cttgaacccc atgatagttc atcttggaac
     1681 cagaaaactg aataaagtcc aagagactgg tggttcctgc tctgtccagg aaattctgtc
     1741 tgcttctggc acacccatcc agttctagaa tctgctccca tctgcccatg aatggtcctg
     1801 gggaattact gtaagaagaa aggatctctc gatgttgggg gatattctga gtagagatgg
     1861 ctctgttatg tgagaacagt agttcatccc aacactgtac actcagtggt gggcgtaatt
     1921 ccaagtggca tgtaccttcc ctctgagctt aattttcccc tgcagccctg agcggtggga
     1981 taggggaacg ccccccaccc ctcagaccac agcagttcat caacagtgtg cagagcccca
     2041 aacccctctc tgtccactcc aggagacgga ctctgatgct gaaataagcc agtgacttca
     2101 aagcctgtgg tctccactgt gctcggagga cgacgatatc tttgaaaagc actctgtgac
     2161 tctccctgct ccctgcggac aaaagcacat aatctgctgt tacgggtact ttcttcacgc
     2221 gagctttcat gttcagcatg cacgggatca tgcttgtcca tgtgaaataa atatggctct
     2281 ctcgtgtcct taa
//
