LOCUS       NM_010474               1685 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heparan sulfate (glucosamine) 3-O-sulfotransferase 1
            (Hs3st1), transcript variant 1, mRNA.
ACCESSION   NM_010474
VERSION     NM_010474.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Wang,Z., Patel,V.N., Song,X., Xu,Y., Kaminski,A.M., Doan,V.U.,
            Su,G., Liao,Y., Mah,D., Zhang,F., Pagadala,V., Wang,C.,
            Pedersen,L.C., Wang,L., Hoffman,M.P., Gearing,M. and Liu,J.
  TITLE     Increased 3-O-sulfated heparan sulfate in Alzheimer's disease brain
            is associated with genetic risk gene HS3ST1
  JOURNAL   Sci Adv 9 (21), eadf6232 (2023)
   PUBMED   37235665
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Patel,V.N., Pineda,D.L., Berenstein,E., Hauser,B.R., Choi,S.,
            Prochazkova,M., Zheng,C., Goldsmith,C.M., van Kuppevelt,T.H.,
            Kulkarni,A., Song,Y., Linhardt,R.J., Chibly,A.M. and Hoffman,M.P.
  TITLE     Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to
            reduce epithelial morphogenesis and adult salivary gland function
  JOURNAL   Matrix Biol 103-104, 37-57 (2021)
   PUBMED   34653670
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Bachvarova,V., Dierker,T., Esko,J., Hoffmann,D., Kjellen,L. and
            Vortkamp,A.
  TITLE     Chondrocytes respond to an altered heparan sulfate composition with
            distinct changes of heparan sulfate structure and increased levels
            of chondroitin sulfate
  JOURNAL   Matrix Biol 93, 43-59 (2020)
   PUBMED   32201365
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Aikawa,J., Grobe,K., Tsujimoto,M. and Esko,J.D.
  TITLE     Multiple isozymes of heparan sulfate/heparin GlcNAc
            N-deacetylase/GlcN N-sulfotransferase. Structure and activity of
            the fourth member, NDST4
  JOURNAL   J Biol Chem 276 (8), 5876-5882 (2001)
   PUBMED   11087757
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Hernaiz,M., Liu,J., Rosenberg,R.D. and Linhardt,R.J.
  TITLE     Enzymatic modification of heparan sulfate on a biochip promotes its
            interaction with antithrombin III
  JOURNAL   Biochem Biophys Res Commun 276 (1), 292-297 (2000)
   PUBMED   11006120
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Shworak,N.W., Liu,J., Fritze,L.M., Schwartz,J.J., Zhang,L.,
            Logeart,D. and Rosenberg,R.D.
  TITLE     Molecular cloning and expression of mouse and human cDNAs encoding
            heparan sulfate D-glucosaminyl 3-O-sulfotransferase
  JOURNAL   J Biol Chem 272 (44), 28008-28019 (1997)
   PUBMED   9346953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ144446.1, AK087753.1 and BY585739.1.
            
            On Dec 14, 2007 this sequence version replaced NM_010474.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087753.1, BC009133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                CJ144446.1         3-24
            23-1677             AK087753.1         2-1656
            1678-1685           BY585739.1         373-380
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 21.14 cM"
     gene            1..1685
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /note="heparan sulfate (glucosamine) 3-O-sulfotransferase
                     1"
                     /db_xref="GeneID:15476"
                     /db_xref="MGI:MGI:1201606"
     exon            1..215
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /inference="alignment:Splign:2.1.0"
     exon            216..1685
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1257
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /EC_number="2.8.2.23"
                     /note="heparan sulfate 3-O-sulfotransferase 1; heparan
                     sulfate D-glucosaminyl 3-O-sulfotransferase 1"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     1 precursor"
                     /protein_id="NP_034604.1"
                     /db_xref="CCDS:CCDS19257.1"
                     /db_xref="GeneID:15476"
                     /db_xref="MGI:MGI:1201606"
                     /translation="MTLLLLGAVLLVAQPQLVHSHPAAPGPGLKQQELLRKVIILPED
                     TGEGTASNGSTQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSQ
                     GLGWYLTQMPFSSPHQLTVEKTPAYFTSPKVPERIHSMNPTIRLLLILRDPSERVLSD
                     YTQVLYNHLQKHKPYPPIEDLLMRDGRLNLDYKALNRSLYHAHMLNWLRFFPLGHIHI
                     VDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGKDRCLHESKGR
                     AHPQVDPKLLDKLHEYFHEPNKKFFKLVGRTFDWH"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /note="hexamer: AATAAG"
     polyA_site      1555
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /note="major polyA site"
     regulatory      1584..1589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /note="hexamer: AATATA"
     polyA_site      1612
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
                     /note="major polyA site"
     polyA_site      1685
                     /gene="Hs3st1"
                     /gene_synonym="3-Ost; D5Wsu110e; Hsg3ost"
ORIGIN      
        1 gcctgcctgc aaggtcctca gtgcgctgca gcccggagct gcggtcaccg ccgggtctct
       61 ctcggtgagt gcctgtgtcc cttcaccgct cgcccgtccc ggggtgagtg tgaatttgct
      121 ccaaagggcg caggtacttg gcggcggtgc tgcccatggc ccggccggag agaggattga
      181 gggcgccgga ccggctggac gggtacgcga ctcagtaatt ggcaactgga gatactcatg
      241 ttccagtaat caagagggag ccttgctgct acttcatgat ccaggcgcgt gtggcccagt
      301 gaagtccctg agctgtacag catgaccttg ctgctcctgg gtgcggtgct gctggtggcc
      361 cagccccagc ttgtgcattc ccacccggct gctcctggcc cggggctcaa acagcaggag
      421 cttctgagga aggtgattat tctcccagag gacaccggag aaggcacagc atccaatggt
      481 tccacacagc agctgccaca gaccatcatc attggggtgc gcaagggtgg tacccgagcc
      541 ctgctagaga tgctcagcct gcatcctgat gttgctgcag ctgaaaacga ggtccatttc
      601 tttgactggg aggagcatta cagccaaggc ctgggctggt acctcaccca gatgcccttc
      661 tcctcccctc accagctcac cgtggagaag acacccgcct atttcacttc gcccaaagtg
      721 cctgagagaa tccacagcat gaaccccacc atccgcctgc tgcttatcct gagggaccca
      781 tcagagcgcg tgctgtccga ctacacccag gtgttgtaca accaccttca gaagcacaag
      841 ccctatccac ccattgagga cctcctaatg cgggacggtc ggctgaacct ggactacaag
      901 gctctcaacc gcagcctgta ccatgcacac atgctgaact ggctgcgttt tttcccgttg
      961 ggccacatcc acattgtgga tggcgaccgc ctcatcagag accctttccc tgagatccag
     1021 aaggtcgaaa gattcctgaa gctttctcca cagatcaacg cctcgaactt ctactttaac
     1081 aaaaccaagg gcttctactg cctgcgggac agtggcaagg accgctgctt acacgagtcc
     1141 aaaggccggg cgcaccccca ggtggatccc aaactacttg ataaactgca cgaatacttt
     1201 catgagccaa ataagaaatt tttcaagctc gtgggcagaa cattcgactg gcactgattt
     1261 gccgtctcct aggctcggga cttttcctgt tgttaacttc tggtgtacat ctgaaggggg
     1321 gaggaaaata attttaaaaa ggcatttaag ctataattta tttgtaaaac ccacaaatga
     1381 cttctgtaca gtattagatt cacagttgcc atatatagta gttatatttt tctacttgtt
     1441 aaatggaggg cgttttgtat tgtttttcat ggttgttaac attgtgtata tgtctctata
     1501 atatgaagga acttaactat tgcactgaaa aaataagaga tttttttttt ctggagacct
     1561 ctttttttgt tgttgttgtt ttaaatataa ttaacctgcc tccaatccaa aatagctctt
     1621 tgttttcacc tccttgtcaa atctataatc tttttctgct taaaaaaatt tattggtatt
     1681 atgga
//
