LOCUS       NM_153544               2543 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus homologous recombination factor with OB-fold (Hrob),
            mRNA.
ACCESSION   NM_153544
VERSION     NM_153544.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2543)
  AUTHORS   Tucker,E.J., Bell,K.M., Robevska,G., van den Bergen,J., Ayers,K.L.,
            Listyasari,N., Faradz,S.M., Dulon,J., Bakhshalizadeh,S.,
            Sreenivasan,R., Nouyou,B., Carre,W., Akloul,L., Duros,S.,
            Domin-Bernhard,M., Belaud-Rotureau,M.A., Touraine,P., Jaillard,S.
            and Sinclair,A.H.
  TITLE     Meiotic genes in premature ovarian insufficiency: variants in HROB
            and REC8 as likely genetic causes
  JOURNAL   Eur J Hum Genet 30 (2), 219-228 (2022)
   PUBMED   34707299
  REMARK    GeneRIF: Meiotic genes in premature ovarian insufficiency: variants
            in HROB and REC8 as likely genetic causes.
REFERENCE   2  (bases 1 to 2543)
  AUTHORS   Hustedt,N., Saito,Y., Zimmermann,M., Alvarez-Quilon,A.,
            Setiaputra,D., Adam,S., McEwan,A., Yuan,J.Y., Olivieri,M., Zhao,Y.,
            Kanemaki,M.T., Jurisicova,A. and Durocher,D.
  TITLE     Control of homologous recombination by the HROB-MCM8-MCM9 pathway
  JOURNAL   Genes Dev 33 (19-20), 1397-1415 (2019)
   PUBMED   31467087
REFERENCE   3  (bases 1 to 2543)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB610688.1, AK029811.1 and AL954730.15.
            
            On Jul 14, 2006 this sequence version replaced NM_153544.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030867.1, SRR7345562.2445610.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               BB610688.1         2-500
            500-1994            AK029811.1         498-1992
            1995-2543           AL954730.15        98201-98749
FEATURES             Location/Qualifiers
     source          1..2543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.21 cM"
     gene            1..2543
                     /gene="Hrob"
                     /note="homologous recombination factor with OB-fold"
                     /db_xref="GeneID:217216"
                     /db_xref="MGI:MGI:2387601"
     exon            1..211
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2056
                     /gene="Hrob"
                     /note="uncharacterized protein C17orf53 homolog"
                     /codon_start=1
                     /product="homologous recombination OB-fold protein"
                     /protein_id="NP_705772.3"
                     /db_xref="CCDS:CCDS36342.1"
                     /db_xref="GeneID:217216"
                     /db_xref="MGI:MGI:2387601"
                     /translation="MTCGFQKLFSVEEDFEDEDFLSALENAENHVVSALPRDAGCLRP
                     VSSRPQETVQTQSSRPVPSYPTSNQSVPRLCLPPSSMRENAKAPLSTGVMSLRPASIS
                     SSSLSSQQRMTGAKVFQESSGPQPSAAHSGYIFESHQQGIGDFEAPDQDDLDKALASM
                     EFEGAGLELEADSGATQILPAKHCEDPVLAKKARVADLSGSLRKEPMVHCRNPWPSLR
                     PTSATGSLPVPATSCVSTSQQRGSPAPAPQYLPVAGRTIRSSPQNYGPGQPLQSPRAW
                     SSGKPRFSGPQRPHGSSAAFCQGPLSSRAPVSSVESPVSTPRNTSTPVTQPALQTPVV
                     TNHLVQLVTATNRTPQQPSRPSIRAKTRRFPGPAGLLPHQHSGENLEEIMVSTPQTPT
                     HGALAKFQTEIATSSQGSVEEDFGQGPWLTMKSALGLDEGDPTCFLYTYSIVMVLRKA
                     ALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMLGTVHRVLLETHQSELRPGS
                     VLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSLDSGDGDFLEPPQPLPKDLGNSHGSLQ
                     PDVAAEPTRGLRTAQNPAVAFPEEELSEADDLDGLLSELPEDFFCEPSS"
     exon            212..262
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            263..1330
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1414
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1555
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1664
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1750
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1876
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1994
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2543
                     /gene="Hrob"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2521..2526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hrob"
                     /note="hexamer: AATAAA"
     polyA_site      2540
                     /gene="Hrob"
                     /note="major polyA site"
ORIGIN      
        1 ggcggctttg aaagccgctc tgggtgcacg ttcttaggcg cccctctctc agtttccgct
       61 gcggtcttaa agacgcttct cttggacctt gctctgggaa tgcgaccgga catagttccc
      121 tactctacgt ctgggtcgag ttggaggtga acccttgagt ctgacacggc cgggccgacc
      181 cgccggcccg agcccacggc ctgtcgttat gacgtgtggt tttcagaagt tgttttctgt
      241 ggaagaggac tttgaagatg aggatttctt atctgctttg gagaatgcag agaaccacgt
      301 tgttagtgca ctgcccaggg atgctgggtg cctgagacct gtctcttcca gaccacagga
      361 gactgtgcag acacaatcct caagaccagt gccatcatac cccacctcca accagtcagt
      421 cccaagactg tgtctccctc cctccagcat gcgggagaac gccaaggctc cactcagcac
      481 aggagtgatg tccctgagac ctgcctccat ttctagcagc agcttgagta gtcagcaaag
      541 aatgacggga gcaaaggtgt tccaagagtc gtcaggcccc cagccctcag ccgcacactc
      601 tggatatatt tttgagagcc atcaacaggg cattggtgac tttgaagcac ctgatcaaga
      661 tgaccttgac aaggccctgg caagcatgga gttcgaggga gctggcttgg agctagaagc
      721 cgacagtgga gccacccaga tcctgcctgc caagcactgt gaggatcctg tgttggcaaa
      781 aaaggcccga gtagctgatc tgagtggatc gttacggaag gagcctatgg tccactgtag
      841 aaatccatgg ccttccttga gacctacgtc agccacaggc agccttcctg tcccagctac
      901 atcatgtgtc tccacttccc aacaaagggg ctcccctgct cctgcacctc agtatctgcc
      961 agtggctgga aggaccatcc gaagcagccc acagaattat gggccgggcc agccacttca
     1021 gtctcccaga gcgtggtcaa gtggcaaacc ccgtttttct ggacctcaac gtccccacgg
     1081 cagctctgca gcattttgtc aggggccctt gtcatcccga gccccagtgt cttctgttga
     1141 atctcctgtc agcaccccca gaaatacttc caccccagtt actcagccag ctcttcagac
     1201 acctgtagtt accaaccacc tggtacagct tgtcactgct accaaccgga caccccagca
     1261 gccctcccgc ccctccattc gagctaaaac ccgccgcttt cctggcccag caggacttct
     1321 gcctcaccaa cacagcgggg agaatctgga ggagatcatg gtttccacac cccagactcc
     1381 gactcacggg gccctggcta aattccagac tgagattgct accagttccc agggatctgt
     1441 ggaagaggat ttcgggcagg ggccctggct caccatgaaa tctgctctgg gcctggacga
     1501 gggagacccc acctgctttc tctataccta cagtattgtc atggtgctac gcaaggcggc
     1561 cctcaagcag ctccccagga acaaggtccc caatatggcg gtgatgatca agtccctgac
     1621 tcggagcaca atggatgcca gtgtggtgtt taaggacccc acgggagaga tgcttggaac
     1681 ggtgcacaga gtgcttctag agacacacca gagtgagctg aggcctggct cggtgctgtt
     1741 gctgaagcag attggagtgt tttctccttc cctcagaaac cactacctga atgtgacacc
     1801 caacaaccta gtccacattt acagtctaga ttctggagat ggggacttcc tcgagccacc
     1861 tcagcccttg cccaaggatc tgggaaactc ccatggaagc ctccagcctg atgtggctgc
     1921 agagcccaca cggggcctca gaacagcaca gaacccagcg gtggcatttc cagaagagga
     1981 gctctcagag gcagatgacc tggatggact cctgagtgag ctccctgagg acttcttctg
     2041 tgagcccagc agctagggct gcctcaagac agggcatcca ccatgagctg gcagcctctc
     2101 tgctcccaga caagctaggt gcatctggga gagaacgcca gtgcactgga gacagctcaa
     2161 gcccatggtc tgatgcctcc cataaccacc ttgaaatgcc tagtgatggg ccagacagtg
     2221 ggctgcctgg cttaacgact cgacgacttc ttttggcatg ggcatcctgg aaatctggcc
     2281 agggcttgct cccctacatc cttatccctc tggcacattg tcctccagcc aataagaaaa
     2341 gtgggatcct cccaccccat cctaactttc aagaggctgg acttgatttc cttgttcctt
     2401 tattcctcaa tcccctgcca gctgaggagc ccaaaggagc cacaaccaca gcagaggtga
     2461 cctaaggcct gttgtccacc agggtgactg tgaggtgcag gctgctgtac ctggttctga
     2521 aataaagcgt cccttcctca ttt
//
