LOCUS       NP_705772                615 aa            linear   ROD 27-APR-2025
DEFINITION  homologous recombination OB-fold protein [Mus musculus].
ACCESSION   NP_705772
VERSION     NP_705772.3
DBSOURCE    REFSEQ: accession NM_153544.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 615)
  AUTHORS   Tucker,E.J., Bell,K.M., Robevska,G., van den Bergen,J., Ayers,K.L.,
            Listyasari,N., Faradz,S.M., Dulon,J., Bakhshalizadeh,S.,
            Sreenivasan,R., Nouyou,B., Carre,W., Akloul,L., Duros,S.,
            Domin-Bernhard,M., Belaud-Rotureau,M.A., Touraine,P., Jaillard,S.
            and Sinclair,A.H.
  TITLE     Meiotic genes in premature ovarian insufficiency: variants in HROB
            and REC8 as likely genetic causes
  JOURNAL   Eur J Hum Genet 30 (2), 219-228 (2022)
   PUBMED   34707299
  REMARK    GeneRIF: Meiotic genes in premature ovarian insufficiency: variants
            in HROB and REC8 as likely genetic causes.
REFERENCE   2  (residues 1 to 615)
  AUTHORS   Hustedt,N., Saito,Y., Zimmermann,M., Alvarez-Quilon,A.,
            Setiaputra,D., Adam,S., McEwan,A., Yuan,J.Y., Olivieri,M., Zhao,Y.,
            Kanemaki,M.T., Jurisicova,A. and Durocher,D.
  TITLE     Control of homologous recombination by the HROB-MCM8-MCM9 pathway
  JOURNAL   Genes Dev 33 (19-20), 1397-1415 (2019)
   PUBMED   31467087
REFERENCE   3  (residues 1 to 615)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB610688.1, AK029811.1 and AL954730.15.
            
            On Jul 14, 2006 this sequence version replaced NP_705772.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030867.1, SRR7345562.2445610.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.21 cM"
     Protein         1..615
                     /product="homologous recombination OB-fold protein"
                     /note="uncharacterized protein C17orf53 homolog"
                     /calculated_mol_wt=65932
     Region          42..75
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32P12.2)"
     Region          <44..374
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N3J3; propagated from
                     UniProtKB/Swiss-Prot (Q32P12.2)"
     Region          213..326
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32P12.2)"
     Region          458..539
                     /region_name="HROB"
                     /note="Homologous recombination OB-fold protein;
                     pfam15072"
                     /db_xref="CDD:464486"
     Region          546..590
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q32P12.2)"
     CDS             1..615
                     /gene="Hrob"
                     /coded_by="NM_153544.3:209..2056"
                     /db_xref="CCDS:CCDS36342.1"
                     /db_xref="GeneID:217216"
                     /db_xref="MGI:MGI:2387601"
ORIGIN      
        1 mtcgfqklfs veedfededf lsalenaenh vvsalprdag clrpvssrpq etvqtqssrp
       61 vpsyptsnqs vprlclppss mrenakapls tgvmslrpas isssslssqq rmtgakvfqe
      121 ssgpqpsaah sgyifeshqq gigdfeapdq ddldkalasm efegaglele adsgatqilp
      181 akhcedpvla kkarvadlsg slrkepmvhc rnpwpslrpt satgslpvpa tscvstsqqr
      241 gspapapqyl pvagrtirss pqnygpgqpl qsprawssgk prfsgpqrph gssaafcqgp
      301 lssrapvssv espvstprnt stpvtqpalq tpvvtnhlvq lvtatnrtpq qpsrpsirak
      361 trrfpgpagl lphqhsgenl eeimvstpqt pthgalakfq teiatssqgs veedfgqgpw
      421 ltmksalgld egdptcflyt ysivmvlrka alkqlprnkv pnmavmiksl trstmdasvv
      481 fkdptgemlg tvhrvlleth qselrpgsvl llkqigvfsp slrnhylnvt pnnlvhiysl
      541 dsgdgdflep pqplpkdlgn shgslqpdva aeptrglrta qnpavafpee elseaddldg
      601 llselpedff cepss
//
