LOCUS       NM_133698              10658 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus hornerin (Hrnr), mRNA.
ACCESSION   NM_133698 XM_904442
VERSION     NM_133698.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10658)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10658)
  AUTHORS   Thyssen,J.P., Jakasa,I., Riethmuller,C., Schon,M.P., Braun,A.,
            Haftek,M., Fallon,P.G., Wroblewski,J., Jakubowski,H., Eckhart,L.,
            Declercq,W., Koppes,S., Engebretsen,K.A., Bonefeld,C., Irvine,A.D.,
            Keita-Alassane,S., Simon,M., Kawasaki,H., Kubo,A., Amagai,M.,
            Matsui,T. and Kezic,S.
  TITLE     Filaggrin Expression and Processing Deficiencies Impair Corneocyte
            Surface Texture and Stiffness in Mice
  JOURNAL   J Invest Dermatol 140 (3), 615-623 (2020)
   PUBMED   31479664
REFERENCE   3  (bases 1 to 10658)
  AUTHORS   Rahrig,S., Dettmann,J.M., Brauns,B., Lorenz,V.N., Buhl,T.,
            Kezic,S., Elias,P.M., Weidinger,S., Mempel,M., Schon,M.P. and
            Braun,A.
  TITLE     Transient epidermal barrier deficiency and lowered allergic
            threshold in filaggrin-hornerin (FlgHrnr-/-) double-deficient mice
  JOURNAL   Allergy 74 (7), 1327-1339 (2019)
   PUBMED   30828807
  REMARK    GeneRIF: our FlgHrnr(-/-) mouse model nicely reflects the
            epicutaneous sensitization susceptibilities and inflammatory
            reactions to environmental insults in humans with impaired skin
            barrier functions.
REFERENCE   4  (bases 1 to 10658)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10658)
  AUTHORS   Gutknecht,M.F., Seaman,M.E., Ning,B., Cornejo,D.A., Mugler,E.,
            Antkowiak,P.F., Moskaluk,C.A., Hu,S., Epstein,F.H. and Kelly,K.A.
  TITLE     Identification of the S100 fused-type protein hornerin as a
            regulator of tumor vascularity
  JOURNAL   Nat Commun 8 (1), 552 (2017)
   PUBMED   28916756
  REMARK    GeneRIF: These results indicate that hornerin is highly expressed
            in pancreatic tumor endothelium and alters tumor vessel parameters
            through a VEGF-independent mechanism. Murine-specific hornerin
            knockdown in PDAC xenografts results in tumor vessels with
            decreased radii and tortuosity. Hornerin knockdown tumors have
            significantly reduced leakiness, increased oxygenation, and greater
            apoptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10658)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   7  (bases 1 to 10658)
  AUTHORS   Cui,C.Y., Klar,J., Georgii-Heming,P., Frojmark,A.S., Baig,S.M.,
            Schlessinger,D. and Dahl,N.
  TITLE     Frizzled6 deficiency disrupts the differentiation process of nail
            development
  JOURNAL   J Invest Dermatol 133 (8), 1990-1997 (2013)
   PUBMED   23439395
REFERENCE   8  (bases 1 to 10658)
  AUTHORS   Ravasi,T., Hsu,K., Goyette,J., Schroder,K., Yang,Z., Rahimi,F.,
            Miranda,L.P., Alewood,P.F., Hume,D.A. and Geczy,C.
  TITLE     Probing the S100 protein family through genomic and functional
            analysis
  JOURNAL   Genomics 84 (1), 10-22 (2004)
   PUBMED   15203200
REFERENCE   9  (bases 1 to 10658)
  AUTHORS   Makino,T., Takaishi,M., Toyoda,M., Morohashi,M. and Huh,N.H.
  TITLE     Expression of hornerin in stratified squamous epithelium in the
            mouse: a comparative analysis with profilaggrin
  JOURNAL   J Histochem Cytochem 51 (4), 485-492 (2003)
   PUBMED   12642627
REFERENCE   10 (bases 1 to 10658)
  AUTHORS   Makino,T., Takaishi,M., Morohashi,M. and Huh,N.H.
  TITLE     Hornerin, a novel profilaggrin-like protein and
            differentiation-specific marker isolated from mouse skin
  JOURNAL   J Biol Chem 276 (50), 47445-47452 (2001)
   PUBMED   11572870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041026.1, AC158361.3 and BB373139.1.
            
            On Jun 30, 2009 this sequence version replaced NM_133698.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY027660.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN00849375,
                                    SAMN00849383 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AK041026.1         2-470
            470-6914            AC158361.3         150457-156901
            6915-10656          AC158361.3         157433-161174
            10657-10658         BB373139.1         258-259
FEATURES             Location/Qualifiers
     source          1..10658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.39 cM"
     gene            1..10658
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /note="hornerin"
                     /db_xref="GeneID:68723"
                     /db_xref="MGI:MGI:3046938"
     exon            1..51
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /inference="alignment:Splign:2.1.0"
     exon            52..211
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..9778
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /codon_start=1
                     /product="hornerin"
                     /protein_id="NP_598459.2"
                     /db_xref="CCDS:CCDS50979.1"
                     /db_xref="GeneID:68723"
                     /db_xref="MGI:MGI:3046938"
                     /translation="MPKLLESIVTVIDVFYQYATEYGNCDMLSKEEMKELLVTEFHQI
                     LKNPDDPDTVDIIMQNLDRDHNHKVDFTEYLLMILKLTKACNKIIGKDYCQASGSKQK
                     NHSHQHQEEQSKKETENKEQKGSLSSSAGENDSYSRGSRGSNKSKSKKLRKGKEQSSK
                     QTTKSNSSDHENSEDYEQGQHESGFSNSSGNGRPSSRKASGFPQPGSEPGQSSSSSTK
                     GSGECYSSGNGKHGSSSGGSAVSGSGHSNTYGKQGTGSRHSSSNRRSRSTSRESSGSQ
                     EYSSGSSEEPGFTHGSGRKNSSTCGKNGSYSGQSTGRHQQGFGSSHELESGQSITSAN
                     HGSHSNQSSCSGTRECGSSESSMKKTHVSGSGHSSSTGKYTSTSGQNYNSTRQGCGQG
                     KSSGSEQYGASSGQSSGCSSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQQFGSG
                     SGRSSGFSQGGSGQGRSSRGGQQGSFSGQTEGSQQHGSCCGQSSGYGQNEYGSGHSAS
                     SGQQGSHYSQSSSYGTHNSGGSPSSSQRGHGSRSGRSSGLGQYGSPSGQTSSSTRQGS
                     GQGQASGSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRY
                     GSGSGESSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQ
                     GSHHGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGHYGSTSGQTASSTRQGSGQG
                     QASGSGRCGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRYGSG
                     SGGSSGFSQGGSGQGRSSRGGQQGSFSGQTEGSQQHGSCCGQSSGYGQNEYGSGHSAS
                     SGQQGSHYSQSSSYGTHNSGGSPSSSQRGHGSRSGRSSGLGQYGSPSGQTSSSTRQGS
                     GQGQASGSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRY
                     GSGSGESSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQ
                     GSHHGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGHYGSTSGQTASSTRHRSGQG
                     QASGSGRCGASSGQTSGCGSGQSTRYDEQGSGSRNSSTQSRGRSTSRESSTSQRFGSG
                     SGGSSGFSQGRSGQGRSSRGGQQGSFSGQTEGSQQHGSCCGQSSGYGQNEYGSGHSAS
                     SGQQGSHYSQSSSYGTHNSGGSPSSSQRGHGSRSGRSSGLGQYGSPSGQTSSSTRQGS
                     GQGQASGSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRY
                     GSGSGESSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQ
                     GSHHGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGHYGSTSGQTASSTRQGSGQG
                     QASGSGRCGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRFGSG
                     SGGSSGFSQGRSGQGRSSRGGQQGSFSGQTEGSQQHGSCCGQSSGYGQNEYGSGHSAS
                     SGQQGSHYSQSSSYGTHNSGGSPSSSQRGHGSRSGRSSGLGQYGSPSGQTSSSTRQGS
                     GQGQASGSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRY
                     GSGSGESSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQ
                     GSHHGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGHYGSTSGQTASSTRQGSGQG
                     QASGSGRCGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRYGSG
                     SGGSSGFSQGGSGQGRSSRGGQQGSFSGQTEGSQQHGSCCGQSSGYGQNEYGSGHSAS
                     SGQQGSHYSQSSSYGTHNSGGSPSSSQRGHGSRSGRSSGLGQYGSPSGQTSSSTRQGS
                     GQGQASGSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRY
                     GSGSGESSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQ
                     GSHHGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGHYGSTSGQTASSTRQGSGQG
                     QASGSGRCGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRYGSG
                     SGGSSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQGSH
                     HGHSSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGQYGSPSGQTSSSTRQGSGQGQAS
                     GSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRYGSGSGE
                     SSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQGSHHGH
                     SSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGHYGSTSGQTASSTRQGSGQGQASGSG
                     RCGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRFGSGSGGSSG
                     FSQGRSGQGRSSRGGQQGSFSGQTEGSQQHGSCCGQSSGYGQNEYGSGHSASSGQQGS
                     HYSQSSSYGTHNSGGSPSSSQRGHGSRSGRSSGLGQYGSPSGQTSSSTRQGSGQGQAS
                     GSGRYGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSTSQRYGSGSGE
                     SSGFSQGGSGQGRSSRGGQQGSFSGQTSGRSQHQSGSRHGSGSGQFPISGQQGSHHGH
                     SSSSGTHNSGSSQSSSTQWSHGSGSEQSSGLGHYGSTSGQTASSTRQGSGQGQASGSG
                     RCGASSGQTSGCGSGQSTRYGEQGSGSRNSSTQSRGRSTSRESSCSQHDVSGSGESSS
                     FSQHRSCQSQASHNGQCGPFSGQSSGHIQHGPCFGQTEGSFQSSNCGQQGTTSYQSSG
                     FDQQRSGLHQSFPCSNHESTSQEYSSFGSCVSGSGECSGFGNQVSRPSQSTYEHHESN
                     RNQSSGYRQYNTASGQSYCGGQCGSNSNQSSSYREQGLGSNQSSQYGQYRCPSSHYSS
                     QSQHGVGCSHGFNTGQYGSGSYPSSNSRQNCPGSGLCPTSEQYGSGSCQSFSPGSCGS
                     GYGQYSNFEQPQSNRRCGNQWESGCSSSNCNENQSIRVHRQVETSSGCGFGQFSSQEQ
                     IRSDTTGKLSLCNVDNRQGNCKYQIIKGSNFGMRNTVSGPHSFNSSTPLYEYVQEQRR
                     "
     exon            212..6914
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /inference="alignment:Splign:2.1.0"
     exon            6915..10658
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10631..10636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /note="hexamer: AATAAA"
     polyA_site      10655
                     /gene="Hrnr"
                     /gene_synonym="1110033K19Rik; A530063N20Rik; S100a18"
                     /note="major polyA site"
ORIGIN      
        1 accctgcaag caacatcagt ctccatccct actgttcctc tggtgaacca ggttaacttg
       61 aatttgcaac aagatgccta aactcctgga aagcattgtc actgtcatcg atgttttcta
      121 ccagtatgcc actgaatatg ggaactgtga catgttaagc aaagaagaga tgaaagaact
      181 tctggtaaca gagtttcacc aaattctgaa gaatccagat gatccagaca ccgtagatat
      241 catcatgcaa aatctggatc gagatcataa ccacaaagtg gattttactg agtatcttct
      301 gatgatactc aagctgacta aggcttgtaa taaaattatt ggcaaagatt actgccaagc
      361 ttcagggtca aagcagaaaa atcacagtca ccagcaccaa gaggaacaga gtaaaaaaga
      421 aacagaaaac aaggagcaaa aaggctcttt aagttctagt gcaggagaga atgactctta
      481 ttccaggggc tcaagaggaa gcaataaaag caaatccaaa aaactaagaa aagggaagga
      541 gcaaagttct aaacaaacaa caaaatcaaa ttcaagtgat cacgaaaata gtgaggatta
      601 tgaacaaggc cagcatgaat caggattttc taactcatct ggcaacggga gacctagctc
      661 aaggaaagct tctggcttcc ctcaacctgg ttcagaacca ggacaatctt ctagctccag
      721 tacaaaagga tctggcgaat gttattcttc tggtaatgga aaacatggtt catcatcagg
      781 aggatcagca gtttctggct caggtcactc taacacctat ggtaaacaag gaacaggatc
      841 aaggcattca tcaagcaaca ggagaagcag gtctacctca agggaatctt ctggctccca
      901 agaatatagc tctggatcat cagaagaacc tggctttaca catggatctg gtcgaaaaaa
      961 ctcttctact tgtggaaaaa acggttccta ctctggacag tcaacaggca gacatcaaca
     1021 aggatttgga tctagtcatg aattagaatc cggtcaatca atcacctctg ctaaccatgg
     1081 ctctcattct aatcagtcat catgcagtgg cacaagagag tgtgggtcta gcgagtcttc
     1141 catgaagaag acccatgttt ctggttcagg acactcttca agtacaggta aatatacatc
     1201 cacttcagga caaaattata actccactag acaaggttgc ggacaaggca agtcttctgg
     1261 gtctgaacaa tatggtgcct catcaggaca gtcttcaggc tgttcgtcag gtcagtccac
     1321 tcgctatggt gaacaaggtt caggatcacg taactcatct acccaaagca gaggcaggtc
     1381 tacctcaagg gagtcttcta catctcaaca gtttggatct ggctcaggaa gatcttctgg
     1441 ctttagtcaa ggtggatctg ggcaaggtcg atcttctcgt ggtggacagc agggttcctt
     1501 ctctggacag acagaaggca gtcaacagca tggatcttgt tgcggtcagt cttctgggta
     1561 tggtcaaaat gaatatggct caggtcattc tgccagctct ggtcagcagg gctctcatta
     1621 cagtcagtct tccagctatg gcacacataa ctcaggtgga agcccgtctt ccagccagag
     1681 gggacatggc tctcgttctg gacgatcttc aggtttaggt caatatggat ccccttcagg
     1741 acaaacttct agctccacta gacagggttc tggacaaggt caggcctctg ggtcaggacg
     1801 atatggtgcc tcatcaggac agacttcagg ctgtgggtca ggtcagtcca ctcgctatgg
     1861 tgaacaaggt tcaggatcac gtaactcatc tacccaaagc agaggcaggt ctacctcaag
     1921 ggagtcttct acatctcaaa ggtatggatc tggctcagga gaatcttctg gctttagtca
     1981 aggtggatct gggcaaggtc gatcttctcg tggtggacaa cagggttcgt tctctggaca
     2041 gacatcaggt agaagtcagc atcaatctgg ctccaggcat ggatctggct caggacagtt
     2101 tcccatctct ggacagcagg gctctcatca cggtcattct tccagttctg gcacacataa
     2161 ctcagggtca agccagtctt cttccaccca gtggagtcac ggttctggtt cagaacagtc
     2221 ttctggtttg ggtcattatg gttccacatc aggacaaact gctagctcca ctagacaggg
     2281 ttctggacaa ggtcaggcct ctgggtcagg acgatgtggc gcctcatcag gacagacttc
     2341 aggctgtggg tcaggtcagt ccactcgcta tggtgaacaa ggttcaggat cacgtaactc
     2401 atctacccaa agcagaggca ggtctacctc aagggagtct tctacatctc aaaggtatgg
     2461 atctggctca ggaggatctt ctggctttag tcaaggtgga tctgggcaag gtcgatcttc
     2521 tcgtggtgga cagcagggtt ccttctctgg acagacagaa ggcagtcaac agcatggatc
     2581 ttgttgcggt cagtcttctg ggtatggtca aaatgaatat ggctcaggtc attctgccag
     2641 ctctggtcag cagggctctc attacagtca gtcttccagc tatggcacac ataactcagg
     2701 tggaagcccc tcttccagcc agaggggaca tggctctcgt tctggacgat cttcaggttt
     2761 aggtcaatat ggatcccctt caggacaaac ttctagctcc actagacagg gttctggaca
     2821 aggtcaggcc tctgggtcag gacgatatgg tgcctcatca ggacagactt caggctgtgg
     2881 gtcaggtcag tccactcgct atggtgaaca aggttcagga tcacgtaact catctaccca
     2941 aagcagaggc aggtctacct caagggagtc ttctacatct caaaggtatg gatctggctc
     3001 aggagaatct tctggcttta gtcaaggtgg atctgggcaa ggtcgatctt ctcgtggtgg
     3061 acaacagggt tcgttctctg gacagacatc aggtagaagt cagcatcaat ctggctccag
     3121 gcatggatct ggctcaggac agtttcccat ctctggacag cagggctctc atcacggtca
     3181 ttcttccagt tctggcacac ataactcagg gtcaagccag tcttcttcca cccagtggag
     3241 tcacggttct ggttcagaac agtcttctgg tttgggtcat tatggttcca catcaggaca
     3301 aactgctagc tccactagac accgttctgg acaaggtcag gcctctgggt caggacgatg
     3361 tggcgcctca tcaggacaga cttcaggctg tgggtcaggt cagtccactc gctatgatga
     3421 acaaggttca ggatcacgta actcatctac ccaaagcaga ggcaggtcta cctcaaggga
     3481 gtcttctaca tctcaacggt ttggatctgg ctcaggagga tcttctggct ttagtcaagg
     3541 tagatctggg caaggtcgat cttctcgtgg tggacagcag ggttccttct ctggacagac
     3601 agaaggcagt caacagcatg gatcttgttg cggtcagtct tctgggtatg gtcaaaatga
     3661 atatggctca ggtcattctg ccagctctgg tcagcagggc tctcattaca gtcagtcttc
     3721 cagctatggc acacataact caggtggaag cccctcttcc agccagaggg gacatggctc
     3781 tcgttctgga cgatcttcag gtttaggtca atatggatcc ccttcaggac aaacttctag
     3841 ctccactaga cagggttctg gacaaggtca ggcctctggg tcaggacgat atggtgcctc
     3901 atcaggacag acttcaggct gtgggtcagg tcagtccact cgctatggtg aacaaggttc
     3961 aggatcacgt aactcatcta cccaaagcag aggcaggtct acctcaaggg agtcttctac
     4021 atctcaaagg tatggatctg gctcaggaga atcttctggc tttagtcaag gtggatctgg
     4081 gcaaggtcga tcttctcgtg gtggacaaca gggttcgttc tctggacaga catcaggtag
     4141 aagtcagcat caatctggct ccaggcatgg atctggctca ggacagtttc ccatctctgg
     4201 acagcagggc tctcatcacg gtcattcttc cagttctggc acacataact cagggtcaag
     4261 ccagtcttct tccacccagt ggagtcacgg ttctggttca gaacagtctt ctggtttggg
     4321 tcattatggt tccacatcag gacaaactgc tagctccact agacagggtt ctggacaagg
     4381 tcaggcctct gggtcaggac gatgtggcgc ctcatcagga cagacttcag gctgtgggtc
     4441 aggtcagtcc actcgctatg gtgaacaagg ttcaggatca cgtaactcat ctacccaaag
     4501 cagaggcagg tctacctcaa gggagtcttc tacatctcaa cggtttggat ctggctcagg
     4561 aggatcttct ggctttagtc aaggtagatc tgggcaaggt cgatcttctc gtggtggaca
     4621 gcagggttcc ttctctggac agacagaagg cagtcaacag catggatctt gttgcggtca
     4681 gtcttctggg tatggtcaaa atgaatatgg ctcaggtcat tctgccagct ctggtcagca
     4741 gggctctcat tacagtcagt cttccagcta tggcacacat aactcaggtg gaagcccctc
     4801 ttccagccag aggggacatg gctctcgttc tggacgatct tcaggtttag gtcaatatgg
     4861 atccccttca ggacaaactt ctagctccac tagacagggt tctggacaag gtcaggcctc
     4921 tgggtcagga cgatatggtg cctcatcagg acagacttca ggctgtgggt caggtcagtc
     4981 cactcgctat ggtgaacaag gttcaggatc acgtaactca tctacccaaa gcagaggcag
     5041 gtctacctca agggagtctt ctacatctca aaggtatgga tctggctcag gagaatcttc
     5101 tggctttagt caaggtggat ctgggcaagg tcgatcttct cgtggtggac aacagggttc
     5161 gttctctgga cagacatcag gtagaagtca gcatcaatct ggctccaggc atggatctgg
     5221 ctcaggacag tttcccatct ctggacagca gggctctcat cacggtcatt cttccagttc
     5281 tggcacacat aactcagggt caagccagtc ttcttccacc cagtggagtc acggttctgg
     5341 ttcagaacag tcttctggtt tgggtcatta tggttccaca tcaggacaaa ctgctagctc
     5401 cactagacag ggttctggac aaggtcaggc ctctgggtca ggacgatgtg gcgcctcatc
     5461 aggacagact tcaggctgtg ggtcaggtca gtccactcgc tatggtgaac aaggttcagg
     5521 atcacgtaac tcatctaccc aaagcagagg caggtctacc tcaagggagt cttctacatc
     5581 tcaaaggtat ggatctggct caggaggatc ttctggcttt agtcaaggtg gatctgggca
     5641 aggtcgatct tctcgtggtg gacagcaggg ttccttctct ggacagacag aaggcagtca
     5701 acagcatgga tcttgttgcg gtcagtcttc tgggtatggt caaaatgaat atggctcagg
     5761 tcattctgcc agctctggtc agcagggctc tcattacagt cagtcttcca gctatggcac
     5821 acataactca ggtggaagcc cctcttccag ccagagggga catggctctc gttctggacg
     5881 atcttcaggt ttaggtcaat atggatcccc ttcaggacaa acttctagct ccactagaca
     5941 gggttctgga caaggtcagg cctctgggtc aggacgatat ggtgcctcat caggacagac
     6001 ttcaggctgt gggtcaggtc agtccactcg ctatggtgaa caaggttcag gatcacgtaa
     6061 ctcatctacc caaagcagag gcaggtctac ctcaagggag tcttctacat ctcaaaggta
     6121 tggatctggc tcaggagaat cttctggctt tagtcaaggt ggatctgggc aaggtcgatc
     6181 ttctcgtggt ggacaacagg gttcgttctc tggacagaca tcaggtagaa gtcagcatca
     6241 atctggctcc aggcatggat ctggctcagg acagtttccc atctctggac agcagggctc
     6301 tcatcacggt cattcttcca gttctggcac acataactca gggtcaagcc agtcttcttc
     6361 cacccagtgg agtcacggtt ctggttcaga acagtcttct ggtttgggtc attatggttc
     6421 cacatcagga caaactgcta gctccactag acagggttct ggacaaggtc aggcctctgg
     6481 gtcaggacga tgtggcgcct catcaggaca gacttcaggc tgtgggtcag gtcagtccac
     6541 tcgctatggt gaacaaggtt caggatcacg taactcatct acccaaagca gaggcaggtc
     6601 tacctcaagg gagtcttcta catctcaaag gtatggatct ggctcaggag gatcttctgg
     6661 ctttagtcaa ggtggatctg ggcaaggtcg atcttctcgt ggtggacaac agggttcgtt
     6721 ctctggacag acatcaggta gaagtcagca tcaatctggc tccaggcatg gatctggctc
     6781 aggacagttt cccatctctg gacagcaggg ctctcatcac ggtcattctt ccagttctgg
     6841 cacacataac tcagggtcaa gccagtcttc ttccacccag tggagtcacg gttctggttc
     6901 agaacagtct tctggtttag gtcaatatgg atccccttca ggacaaactt ctagctccac
     6961 tagacagggt tctggacaag gtcaggcctc tgggtcagga cgatatggtg cctcatcagg
     7021 acagacttca ggctgtgggt caggtcagtc cactcgctat ggtgaacaag gttcaggatc
     7081 acgtaactca tctacccaaa gcagaggcag gtctacctca agggagtctt ctacatctca
     7141 aaggtatgga tctggctcag gagaatcttc tggctttagt caaggtggat ctgggcaagg
     7201 tcgatcttct cgtggtggac aacagggttc gttctctgga cagacatcag gtagaagtca
     7261 gcatcaatct ggctccaggc atggatctgg ctcaggacag tttcccatct ctggacagca
     7321 gggctctcat cacggtcatt cttccagttc tggcacacat aactcagggt caagccagtc
     7381 ttcttccacc cagtggagtc acggttctgg ttcagaacag tcttctggtt tgggtcatta
     7441 tggttccaca tcaggacaaa ctgctagctc cactagacag ggttctggac aaggtcaggc
     7501 ctctgggtca ggacgatgtg gcgcctcatc aggacagact tcaggctgtg ggtcaggtca
     7561 gtccactcgc tatggtgaac aaggttcagg atcacgtaac tcatctaccc aaagcagagg
     7621 caggtctacc tcaagggagt cttctacatc tcaacggttt ggatctggct caggaggatc
     7681 ttctggcttt agtcaaggta gatctgggca aggtcgatct tctcgtggtg gacagcaggg
     7741 ttccttctct ggacagacag aaggcagtca acagcatgga tcttgttgcg gtcagtcttc
     7801 tgggtatggt caaaatgaat atggctcagg tcattctgcc agctctggtc agcagggctc
     7861 tcattacagt cagtcttcca gctatggcac acataactca ggtggaagcc cctcttccag
     7921 ccagagggga catggctctc gttctggacg atcttcaggt ttaggtcaat atggatcccc
     7981 ttcaggacaa acttctagct ccactagaca gggttctgga caaggtcagg cctctgggtc
     8041 aggacgatat ggtgcctcat caggacagac ttcaggctgt gggtcaggtc agtccactcg
     8101 ctatggtgaa caaggttcag gatcacgtaa ctcatctacc caaagcagag gcaggtctac
     8161 ctcaagggag tcttctacat ctcaaaggta tggatctggc tcaggagaat cttctggctt
     8221 tagtcaaggt ggatctgggc aaggtcgatc ttctcgtggt ggacaacagg gttcgttctc
     8281 tggacagaca tcaggtagaa gtcagcatca atctggctcc aggcatggat ctggctcagg
     8341 acagtttccc atctctggac agcagggctc tcatcacggt cattcttcca gttctggcac
     8401 acataactca gggtcaagcc agtcttcttc cacccagtgg agtcacggtt ctggttcaga
     8461 acagtcttct ggtttgggtc attatggttc cacatcagga caaactgcta gctccactag
     8521 acagggttct ggacaaggtc aggcctctgg gtcaggacga tgtggcgcct catcaggaca
     8581 gacttcaggc tgtgggtcag gtcagtccac tcgctatggt gaacaaggtt caggatcacg
     8641 taactcatct acccaaagca gaggcaggtc tacctcaagg gagtcttcat gttcccaaca
     8701 cgatgtttca ggctcaggag agtcttctag ctttagtcag catcggtctt gtcaaagcca
     8761 ggcctctcac aatgggcaat gtggtccttt ttctggacaa tcatctggtc atattcaaca
     8821 tggaccttgt tttggtcaaa ctgaaggctc atttcagtca tctaactgtg gacagcaggg
     8881 tactacttca taccaatctt ctggttttga ccagcaaagg tctggattac atcagtcttt
     8941 tccctgtagt aatcatgagt ccacctctca agagtattct agctttggat catgtgtgtc
     9001 tggttcagga gaatgttctg gctttggtaa ccaagtatct agaccaagtc agtctactta
     9061 tgagcatcat gaatctaata gaaatcaatc ttctggctat agacaatata atactgcatc
     9121 aggacagtca tactgcggtg gtcagtgtgg atctaattca aaccaatcct ctagctacag
     9181 agaacaggga cttggttcaa atcagtcttc tcagtatggc caatatagat gtccctcaag
     9241 tcattactct agccagagcc aacatggagt tgggtgtagt catggtttta acactggtca
     9301 atatgggtct ggttcctatc cctcttctaa ctccagacaa aactgtccag gatctggtct
     9361 atgccctact tcagaacaat atgggtctgg ttcatgtcag tcctttagtc ctggatcatg
     9421 tggttctgga tatggtcaat attctaactt tgaacaacct cagtcaaata ggagatgcgg
     9481 aaaccagtgg gaatctggct gtagctcctc aaattgtaat gaaaatcaat caataagagt
     9541 gcatagacaa gtagaaacct cctcaggctg tggctttgga caattttctt cacaggaaca
     9601 gattagatct gatactactg gtaaattgtc actttgtaat gtggacaata gacaaggtaa
     9661 ctgtaagtat cagataatca agggaagtaa ctttggaatg agaaacacag tctcaggacc
     9721 tcatagtttc aatagtagca ctccactgta tgagtatgtc caagagcaga gacgctaatt
     9781 ctcatagtaa ataaagaact gtgataaaat taacataaat gttaatttaa gaaatgagaa
     9841 attatgatag ttaagaagct catcatgaaa ttcctttctc aatctggaca tatctgctct
     9901 catccattta aaatgaaaat tagcgtatat ttctagttat tgggttcctt ccaaataaca
     9961 tatgatagct gggttactta ggatctatta cagtggataa atgtttggtt taagggaatt
    10021 aagttaggaa gaataatttg aagaatatgg gatttaatta agtatctatc taaaagatta
    10081 ttatttagtt aagaatgatg ctaaagctaa gcttatagtt ttaaagggca atatattata
    10141 aatgtatcat cagtccagtt gccaaagctt tactttacat taacagtcta atttttaatg
    10201 tataaaatgt tagatggcaa aagcaagact tatatgtatg tgtgtttcta ttcttacaca
    10261 aatcaccaag atactctggc acagtttaaa tcaataaatg gacaagtggc actaagctat
    10321 tgttccagat gcatattccc agccaatgga aaagtggtgc aggagcaaag gatccaaatg
    10381 tggactttac ctttatttca gcaagagata tcctggcttc catttgtaag aaattgtttt
    10441 agattagaaa agtttatcca tagtacatac agctttgaag tctaagtagt ttactggtct
    10501 tcccatgtgg agatatcatt aataacaaga cagaaaggaa gcttgccatt gttataaaga
    10561 tctttgtttg actgtaatgt atttctttca cgtctttgga ttcaaacaac tggattacat
    10621 taatattgac aataaattgg atggtgatta aatactaa
//
