LOCUS       NM_007545               5366 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus harakiri, BCL2 interacting protein (contains only BH3
            domain) (Hrk), mRNA.
ACCESSION   NM_007545
VERSION     NM_007545.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5366)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   2  (bases 1 to 5366)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 5366)
  AUTHORS   Luo,X.J., Deng,M., Xie,X., Huang,L., Wang,H., Jiang,L., Liang,G.,
            Hu,F., Tieu,R., Chen,R. and Gan,L.
  TITLE     GATA3 controls the specification of prosensory domain and neuronal
            survival in the mouse cochlea
  JOURNAL   Hum Mol Genet 22 (18), 3609-3623 (2013)
   PUBMED   23666531
REFERENCE   4  (bases 1 to 5366)
  AUTHORS   Fernandes,K.A., Harder,J.M., Kim,J. and Libby,R.T.
  TITLE     JUN regulates early transcriptional responses to axonal injury in
            retinal ganglion cells
  JOURNAL   Exp Eye Res 112, 106-117 (2013)
   PUBMED   23648575
REFERENCE   5  (bases 1 to 5366)
  AUTHORS   Semenova,M.L., Zakharova,E.E., Zaletov,S.Iu., Zaeva,V.V. and
            Kosheleva,N.V.
  TITLE     [The effect of antisense oligonucleoties specific to the harakiri
            mRNA on spontaneous and induced defects of mouse preimplantation
            embryo development]
  JOURNAL   Genetika 44 (9), 1290-1293 (2008)
   PUBMED   18846829
  REMARK    GeneRIF: The effect of antisense oligonucleoties specific to the
            harakiri mRNA on spontaneous and induced defects of mouse
            preimplantation embryo development
REFERENCE   6  (bases 1 to 5366)
  AUTHORS   Jurisicova,A., Taniuchi,A., Li,H., Shang,Y., Antenos,M., Detmar,J.,
            Xu,J., Matikainen,T., Benito Hernandez,A., Nunez,G. and Casper,R.F.
  TITLE     Maternal exposure to polycyclic aromatic hydrocarbons diminishes
            murine ovarian reserve via induction of Harakiri
  JOURNAL   J Clin Invest 117 (12), 3971-3978 (2007)
   PUBMED   18037991
  REMARK    GeneRIF: in response to PAHs, Ahr-mediated activation of the
            harakiri, BCL2 interacting protein (contains only BH3 domain), was
            necessary for execution of cell death.
REFERENCE   7  (bases 1 to 5366)
  AUTHORS   Coultas,L., Terzano,S., Thomas,T., Voss,A., Reid,K., Stanley,E.G.,
            Scott,C.L., Bouillet,P., Bartlett,P., Ham,J., Adams,J.M. and
            Strasser,A.
  TITLE     Hrk/DP5 contributes to the apoptosis of select neuronal populations
            but is dispensable for haematopoietic cell apoptosis
  JOURNAL   J Cell Sci 120 (Pt 12), 2044-2052 (2007)
   PUBMED   17535852
  REMARK    GeneRIF: These results demonstrate that HRK contributes to
            apoptosis signalling elicited by trophic factor withdrawal in
            certain neuronal populations but is dispensable for apoptosis of
            haematopoietic cells.
REFERENCE   8  (bases 1 to 5366)
  AUTHORS   Imaizumi,K., Benito,A., Kiryu-Seo,S., Gonzalez,V., Inohara,N.,
            Lieberman,A.P., Kiyama,H. and Nunez,G.
  TITLE     Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only
            Bcl-2 family member, in axotomy-induced neuronal cell death
  JOURNAL   J Neurosci 24 (15), 3721-3725 (2004)
   PUBMED   15084651
  REMARK    GeneRIF: DP5 plays an important role in neuronal cell death induced
            by axotomy and NGF deprivation through the regulation of
            mitochondrial function and caspase-3 activation
            Erratum:[J Neurosci. 2004 May 5;24(18):4488. Leiberman AP
            [corrected to Lieberman AP]]
REFERENCE   9  (bases 1 to 5366)
  AUTHORS   Kanazawa,K., Imaizumi,K., Mori,T., Honma,Y., Tojo,M., Tanno,Y.,
            Yokoya,S., Niwa,S., Tohyama,M., Takagi,T. and Wanaka,A.
  TITLE     Expression pattern of a novel death-promoting gene, DP5, in the
            developing murine nervous system
  JOURNAL   Brain Res Mol Brain Res 54 (2), 316-320 (1998)
   PUBMED   9555074
REFERENCE   10 (bases 1 to 5366)
  AUTHORS   Imaizumi,K., Tsuda,M., Imai,Y., Wanaka,A., Takagi,T. and Tohyama,M.
  TITLE     Molecular cloning of a novel polypeptide, DP5, induced during
            programmed neuronal death
  JOURNAL   J Biol Chem 272 (30), 18842-18848 (1997)
   PUBMED   9228060
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D83698.1 and AC110254.11.
            
            On Feb 16, 2006 this sequence version replaced NM_007545.1.
            
            CCDS Note: This CCDS ID represents the protein described in PMID:
            9555074 and 15084651. This transcript is supported by D83698.1. It
            should be noted this transcript is predicted to undergo
            nonsense-mediated mRNA decay (NMD). However, the protein is
            represented because it was detected endogenously PMID: 9555074.  It
            is likely that the majority of transcripts representing this
            variant will undergo NMD, while some low level of NMD escape may
            allow for the expression of this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83698.1, SRR1660813.84025.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               D83698.1           1-365
            366-5366            AC110254.11        38229-43229         c
FEATURES             Location/Qualifiers
     source          1..5366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 58.16 cM"
     gene            1..5366
                     /gene="Hrk"
                     /gene_synonym="Bid3; DP5; harakiri"
                     /note="harakiri, BCL2 interacting protein (contains only
                     BH3 domain)"
                     /db_xref="GeneID:12123"
                     /db_xref="MGI:MGI:1201608"
     exon            1..365
                     /gene="Hrk"
                     /gene_synonym="Bid3; DP5; harakiri"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..298
                     /gene="Hrk"
                     /gene_synonym="Bid3; DP5; harakiri"
                     /note="neuronal death protein DP5; BH3-interacting
                     domain-containing protein 3; BH3 interacting (with BCL2
                     family) domain, apoptosis agonist"
                     /codon_start=1
                     /product="activator of apoptosis harakiri"
                     /protein_id="NP_031571.1"
                     /db_xref="CCDS:CCDS39236.1"
                     /db_xref="GeneID:12123"
                     /db_xref="MGI:MGI:1201608"
                     /translation="MCPCPRHRGRGPPAVCGCGDARPGLRWAAAQVTALRLQALGDEL
                     HRRAMRRRARPRDPLPALLPALRARWPWLCAAAQVAALAAWLLGRRSA"
     exon            366..5366
                     /gene="Hrk"
                     /gene_synonym="Bid3; DP5; harakiri"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5366
                     /gene="Hrk"
                     /gene_synonym="Bid3; DP5; harakiri"
                     /note="major polyA site"
ORIGIN      
        1 ggaggctcct ccgcacgcca tgtgcccgtg tccccggcat cgcggccgcg ggcccccggc
       61 cgtgtgcggt tgcggcgacg ctcgccccgg gctgcgctgg gcggcggcgc aggtgaccgc
      121 gctgcggctg caggcgctgg gcgacgagct gcaccgacgc gccatgcggc gtcgcgcgcg
      181 gccccgggac ccgctgcccg cgctgctgcc cgcgctccgc gcccgctggc cctggctgtg
      241 cgcggccgcg caggtggcgg cgctggcggc ctggctgctc ggcaggcgga gcgcgtaggc
      301 ggcgcgcgcg gggccttctt ggtggggggg accggagccg agacccagcc cggaccgagc
      361 aacaggttgg cgaaaccctg tgtccttgga ggaagctggt tcctgttttc ctgagggagt
      421 agcccagagc gtggaaggaa gcagaattgt aaagagctga tggtggaaac acagacagag
      481 gaagcccctc gggaggtcca gctacagaga gagccacccc agtgctattt agctatatat
      541 atacaaacca agagaaaata caaaattccg tacctgtgca tgcctgcggg ggacgtggtg
      601 gtccctttcc tttccacacg cgcaaccttg cgatgtgaac tctgagactt cgtaatgtct
      661 agggtggcag gggagagaga tgcttgtcgc tgcccatgca ggaaacttac atggaccggt
      721 gggatcagcg tggaccaact gttcagcaca gatgctggtg tggagtagag gggactgggc
      781 cgaaggcaag atggacaaga cagaggggac gtggggccca ttttgttggg ggcagcctgg
      841 gatccctcca tttcttgaca tgtcctagct tctttctgtc cccatcgaga cagctctcta
      901 gatctcatgg tggtcatatc cagagaaacg ggatgtcatt ttcttccctt acctatatag
      961 tgtgtctggt gcttcacttc acagtttctt ggtgctaagt gtatccttct tggtacggcc
     1021 agagtcttac agacggactg ggaaggccag ggatgagagg tttctatttt gctctttgga
     1081 tatactctca ttattattat tattattttt aaagggctag gtgacaagat ggccactgga
     1141 aagtctctct gtggggggga ggggtggtgc tcacagggct taggagcagc cccaccacca
     1201 ccaccaagtg ggagggctac gaggggggag ggccaggccg gtatacagga gctgcttagg
     1261 aaaaggaggt ccctcctctc cttgcagcag tactttgaga gactgctgtg gcctccccca
     1321 atttcctaca gggattcagg gcttaggttt tttatagatt aagagccaag aaatggctac
     1381 gttctgatgg ggcgtgattt ataagcaggg gatgttgggg aaagggggcg gaccatttaa
     1441 atgaaatgtc cgatttccca tggtccccaa acactcagaa taagctactg ttttcagaag
     1501 tttctagaag ggctaatata aatataaata tatatatata catatataac gaagctgtgt
     1561 gctagactga catttggctg caacggctca ccgcttcagg gctggtggtt atttttattt
     1621 tgctctcgtc ttttaaaaaa atctcaacat gaacaggtat tactcctctg cgtggatact
     1681 gtatcacccc catcgagatg gtgagggatg cttgtgtggg ctcagcgaga cagttactct
     1741 tatttttact ttattttatt ttttcctact taattgtgga gacaaggcct caccctggcg
     1801 cccaggctga cctcagctca tgagcctccc tcccgcctcg gtatctggca tttgggacgc
     1861 tagctaccgg agcagtgtca ttttttcctg gttggatttg cagatgactt gccaggtacc
     1921 tgggatcaga gggtctgcta gaaagcatca gttggttagg tgcacgggct acctggggaa
     1981 ccggtccctg gccagctctg ctgggcgtga ccagtagagt gggcgtgacc aggaaagtgc
     2041 acacctcctc agtctgctgt caaaaggctc ttttctccac tttaaatcta tgccttatat
     2101 ttttctaaat aacccagttt aaaaaaaaaa atgcaaccga gaactcagtg ctgaggcctc
     2161 ctgcttttat ctgccagaac tgaactcagc aaagaaaaat aaagagccga gcttgtctgg
     2221 cagggaagta gcagccagca ggccgtgccc ctccctcacc caaccagaat tacgtagagg
     2281 gtcccagaat gatctggaag ccaccctctg cttgtatttc gtccatttcc tagcaaagaa
     2341 atgagtcctt gcacgcctca catttccaga gaagatgtgt gccatggtag gacttggtgg
     2401 tgtcagcctc tttaaagaca cactgtccag atcacagtgg ggacatgctg accctggaga
     2461 gacccagtgc aagggtgagg ggtgggagaa aaacctcttc ttttctgttt tgtttttgag
     2521 cctggcttgg cctgttagct aatgatagct ccctggagga tttgaactcc aaacacaggg
     2581 gggggtttgg catctctggt gattttcatt tcaatgaagc tgtgttactg agagagccaa
     2641 gcagccctga ccctccttga tgggactttt cagccaagtc ctctgtaaat actctcctgt
     2701 agtaatggaa accacgtatt tatcaaatcc gggtcttggc acgcacacag ttcattttag
     2761 tgcgcttctc cattgccccg ggtttgatgg ggttgttttt aaaaaatgcc tgtgttttgt
     2821 tttgttttgt tttgtttttc tatgagatct gacttcttga cggacatttg tattaggata
     2881 ttgaagcatg ctggctgtgt ctttattgtc tcactgtctc tgccatggtg ttacttggac
     2941 tgcatgaggt aatgggacga cagcctttct gttggtggtg ttattgaaaa aaaagaagaa
     3001 aaaaagagaa aaaaaaaaaa aaccaacttc cacagtgtgt gaagcgctgg catgatcact
     3061 ccctttatcc tgctttccct ggctgccaag acgcattgat tttgactcgc ttctatgtag
     3121 agtctgtgaa gagggagaga ggctttgaaa taaattttaa aaagacctca tactgggttt
     3181 cagcagacag cagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3241 gtgtgtacga gtgtgcacaa agcctgggag gtctgagatc attgctaggg agttggttgt
     3301 gtgatgagct gaggggctat ctgccacctg ggcccaaagc tgctggctgc tctctgaggg
     3361 tgagccccgg agtctgtggg accgaagcct ttgtgagatg gtccactccc ttcgggaagc
     3421 ttctcttctt cacttcattc cccccaccag caagagctct gttcacattt ggggttccag
     3481 ctccctttga ctagatggat ttggagccag acttcttttg gatagcctga gaaggaccgt
     3541 gtctatgatc ctgggccagg aggtcatgcc cccactctcc catccctcag cccttcccag
     3601 ttatcctgga ggctgcttcc ccatctctgt gatagccttg atctttttcc tttctacctt
     3661 gatggagggt ggtggtggtg actgaagccc agtgtcacag gataacaaga ccctgaatgc
     3721 cctgatgaca ctctgtagag ctgagctcat gtcttctgtc cacctgactt tactgtcatg
     3781 cttctaaaat agacagaatg tcattcttgc tcactgagaa ctggtgggga ggcagcatgt
     3841 cctggcacga gctacacaag tatctctggg agacactggg tcactattgg ggagtgcttg
     3901 cttgttatca ttgttttttg agacacggag ccaggctgac cttgaactca ctatacagca
     3961 gaggatatac ccctgaactc catctcccga ttcctggcat gggccactac ccctggctta
     4021 tattgtggac tgtttggatg tccacacgga actgttagaa gcggcagtga ccagaacaca
     4081 gggctctctt ctgggttcat gctattttct attctgagtc tggagtcaac ttggggagat
     4141 cagtgggggt cagaggctgc ctggagattt ggggagaggg gcagcagact attctcatag
     4201 gagctggttc agaagcccca ctaagacatc acagtgtctc ttgaaagctc tagccaaaag
     4261 tttatctttt taacgtttta atgtattcac ttgacaccta tttattgatc atctacagta
     4321 tgccagctga agacctcccc gtctgaacaa accgactcag ttatggtaca gcaacagtcc
     4381 tttttggaga ccagatgccg tgaaatgtcc ctttccagtc tggctcataa tttagaacag
     4441 atctgccagg tcaccattgt gaccccaagc cttgctggca gattgctata tagtattttc
     4501 tgcatgccac tctctgggct gaatgcaatt aaaaaaattg ctacgttgtc tccttctcaa
     4561 agggaggatt ggtccctttt gtacaatagt taaagacccc cccacccccc gcaggagcac
     4621 agccactgaa cactgcacaa ggcgctttcc aaggcttccc cggagagact cccatcctat
     4681 tgttattggt agtaccatgg gtcccatttt acaggcgagg aagctgaggg catgcaaatg
     4741 gcaaagtggc tgaactaagg gagtctgtgt gccgctcccc cacccacccc caagccaacg
     4801 tggtacccgc tctgttgtat cagatcaagt ggctctggtg tggctcattg aaaaacaggc
     4861 attgtgggtg aaggcagggt attctagctc aagggccaat gttgctaatc caagggctgg
     4921 gacaaccctg tggcccagca gggagtgtct actttagctg aaaagagaat gccttatttg
     4981 ggggacactt gagggcaggc tgaaggattt caggggactg tccccagttt cagaaaactc
     5041 cagggtaaag ggtatctgat gtacaaactg cttgtcccaa ccactctgga ggctctggga
     5101 agtctgtcta cccctctcct tctatcttct ctcccaaccc tggatcctca aggtctttgc
     5161 actagaagag tcaaagagcc cgtaagcatg gtaaagatgg cggtgagggc atttggagcc
     5221 tgggggaggc agtaacttgg gggaacattc tgtctgggtc ctgaccttgt tgccttgtgc
     5281 tcttttgtaa ggggaggggt cccctacctg gatgctttgt acatatttgt tacactttta
     5341 tttaaaaatt gactgtgcac ctctaa
//
