LOCUS       NM_153087               1537 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus histamine receptor H4 (Hrh4), mRNA.
ACCESSION   NM_153087
VERSION     NM_153087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1537)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1537)
  AUTHORS   Verta,R., Gurrieri,M., Borga,S., Benetti,E., Pollicino,P.,
            Cavalli,R., Thurmond,R.L., Chazot,P.L., Pini,A., Rosa,A.C. and
            Grange,C.
  TITLE     The Interplay between Histamine H4 Receptor and the Kidney
            Function: The Lesson from H4 Receptor Knockout Mice
  JOURNAL   Biomolecules 11 (10), 1517 (2021)
   PUBMED   34680152
  REMARK    GeneRIF: The Interplay between Histamine H4 Receptor and the Kidney
            Function: The Lesson from H4 Receptor Knockout Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1537)
  AUTHORS   Micheli,L., Durante,M., Lucarini,E., Sgambellone,S., Lucarini,L.,
            Di Cesare Mannelli,L., Ghelardini,C. and Masini,E.
  TITLE     The Histamine H4 Receptor Participates in the Anti-Neuropathic
            Effect of the Adenosine A3 Receptor Agonist IB-MECA: Role of CD4+ T
            Cells
  JOURNAL   Biomolecules 11 (10), 1447 (2021)
   PUBMED   34680083
  REMARK    GeneRIF: The Histamine H4 Receptor Participates in the
            Anti-Neuropathic Effect of the Adenosine A3 Receptor Agonist
            IB-MECA: Role of CD4(+) T Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1537)
  AUTHORS   Balbino,A.M., Lima,L.J.S., Fernandes,G.A.B., Correa,M.F., Gomes,E.,
            Landgraf,M.A., Fernandes,J.P.S. and Landgraf,R.G.
  TITLE     The Novel H4R Antagonist
            1-[(5-Chloro-2,
            3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007)
            Attenuates Several Symptoms in Murine Allergic Asthma
  JOURNAL   Cell Physiol Biochem 54 (6), 1163-1176 (2020)
   PUBMED   33216475
  REMARK    GeneRIF: The Novel H4R Antagonist
            1-[(5-Chloro-2,
            3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007)
            Attenuates Several Symptoms in Murine Allergic Asthma.
REFERENCE   5  (bases 1 to 1537)
  AUTHORS   Schirmer,B., Rother,T., Bruesch,I., Bleich,A., Werlein,C.,
            Jonigk,D., Seifert,R. and Neumann,D.
  TITLE     Genetic Deficiency of the Histamine H4-Receptor Reduces
            Experimental Colorectal Carcinogenesis in Mice
  JOURNAL   Cancers (Basel) 12 (4), 912 (2020)
   PUBMED   32276475
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1537)
  AUTHORS   Dunford,P.J., Williams,K.N., Desai,P.J., Karlsson,L., McQueen,D.
            and Thurmond,R.L.
  TITLE     Histamine H4 receptor antagonists are superior to traditional
            antihistamines in the attenuation of experimental pruritus
  JOURNAL   J Allergy Clin Immunol 119 (1), 176-183 (2007)
   PUBMED   17208599
REFERENCE   7  (bases 1 to 1537)
  AUTHORS   Dunford,P.J., O'Donnell,N., Riley,J.P., Williams,K.N., Karlsson,L.
            and Thurmond,R.L.
  TITLE     The histamine H4 receptor mediates allergic airway inflammation by
            regulating the activation of CD4+ T cells
  JOURNAL   J Immunol 176 (11), 7062-7070 (2006)
   PUBMED   16709868
REFERENCE   8  (bases 1 to 1537)
  AUTHORS   Nakayama,T., Kato,Y., Hieshima,K., Nagakubo,D., Kunori,Y.,
            Fujisawa,T. and Yoshie,O.
  TITLE     Liver-expressed chemokine/CC chemokine ligand 16 attracts
            eosinophils by interacting with histamine H4 receptor
  JOURNAL   J Immunol 173 (3), 2078-2083 (2004)
   PUBMED   15265943
  REMARK    GeneRIF: Mouse eosinophils express H4. CCL16 induced pertussis
            toxin-sensitive calcium mobilization and chemotaxis only in murine
            L1.2 cells expressing H4.
REFERENCE   9  (bases 1 to 1537)
  AUTHORS   Hofstra,C.L., Desai,P.J., Thurmond,R.L. and Fung-Leung,W.P.
  TITLE     Histamine H4 receptor mediates chemotaxis and calcium mobilization
            of mast cells
  JOURNAL   J Pharmacol Exp Ther 305 (3), 1212-1221 (2003)
   PUBMED   12626656
  REMARK    GeneRIF: Histamine H4 receptor mediates chemotaxis and calcium
            mobilization of mast cells.
REFERENCE   10 (bases 1 to 1537)
  AUTHORS   Liu,C., Wilson,S.J., Kuei,C. and Lovenberg,T.W.
  TITLE     Comparison of human, mouse, rat, and guinea pig histamine H4
            receptors reveals substantial pharmacological species variation
  JOURNAL   J Pharmacol Exp Ther 299 (1), 121-130 (2001)
   PUBMED   11561071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131672.3.
            
            On Feb 6, 2010 this sequence version replaced NM_153087.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF358859.1, SRR13422601.1065959.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849390 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AC131672.3         107731-107983       c
            254-417             AC131672.3         99034-99197         c
            418-1537            AC131672.3         92091-93210         c
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 6.88 cM"
     gene            1..1537
                     /gene="Hrh4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /note="histamine receptor H4"
                     /db_xref="GeneID:225192"
                     /db_xref="MGI:MGI:2429635"
     exon            1..253
                     /gene="Hrh4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1236
                     /gene="Hrh4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /codon_start=1
                     /product="histamine H4 receptor"
                     /protein_id="NP_694727.1"
                     /db_xref="CCDS:CCDS29069.1"
                     /db_xref="GeneID:225192"
                     /db_xref="MGI:MGI:2429635"
                     /translation="MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDR
                     NLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASV
                     YNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNS
                     TNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGF
                     STTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAF
                     KVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRT
                     ERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS"
     exon            254..417
                     /gene="Hrh4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /inference="alignment:Splign:2.1.0"
     exon            418..1537
                     /gene="Hrh4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hrh4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /note="hexamer: AATAAA"
     polyA_site      1374
                     /gene="Hrh4"
                     /gene_synonym="AXOR35; BG26; GPCR105; GPRv53; H4; H4R;
                     HH4R"
                     /note="major polyA site"
ORIGIN      
        1 gtctggttgt taagactgcc tggccaagtg gatctcctgt actagccatc atttgatgtg
       61 atgtcggagt ctaacagtac tggcatcttg ccaccagctg ctcaggtccc cttggcattt
      121 ttaatgtctt catttgcctt tgctataatg gtaggcaatg ctgtggtcat cttagccttt
      181 gtggtggaca gaaaccttag acatcgaagt aattattttt ttcttaattt ggctatttct
      241 gacttcctcg tgggtttgat ttccattcct ctgtacatcc ctcacgtgtt gtttaactgg
      301 aattttggaa gtggaatctg catgttttgg ctcattactg actatctttt gtgcaccgca
      361 tctgtctaca atattgtcct cattagctac gatcgatacc agtcagtttc aaatgctgtg
      421 tcttataggg ctcaacacac tggcatcatg aagattgttg ctcaaatggt ggctgtttgg
      481 atactggctt tcttggtaaa tggcccgatg attctggctt cagattcttg gaagaacagc
      541 acgaacacaa aggactgtga gcctggcttt gttacagagt ggtacatcct caccattaca
      601 atgctcttgg aattcctgct tcctgtcatc tctgtggctt atttcaatgt acagatttac
      661 tggagcctgt ggaagcgtag ggctctcagt aggtgcccta gccatgctgg attctccact
      721 acctcttcca gtgcttcagg acacttacac agagctgggg tggcttgcag gacaagtaat
      781 cctggattga aggaatcagc tgcatctcgt cactcagaaa gtcctcgaag aaagagcagc
      841 atcctggtgt ccttaaggac tcacatgaac agcagtatca ctgccttcaa agtgggttcc
      901 ttctggcgat cggaaagtgc agcgcttcgc caaagggagt acgcagagct tctcagaggc
      961 aggaagctag ccaggtcact ggccatcctt ctgagcgctt ttgccatttg ctgggctcca
     1021 tactgtctgt tcacaattgt cctttcaact taccccagaa cggaacgccc caaatcggtg
     1081 tggtacagca ttgccttctg gctgcaatgg ttcaattcgt ttgttaatcc ctttctgtac
     1141 cctttgtgtc acaggcgttt ccagaaggct ttctggaaga tactttgtgt gacaaagcaa
     1201 ccagcgctgt cacagaacca gtcagtatct tcttgaggag aattgcttca cgagtgccaa
     1261 ctttagtttc tgtcctctga atggatctga gcttccatgt tgctctatcc actcaagcaa
     1321 acagtgtaca aaatgtaatg tctgaaaact ttaataaaac ccctccacat gcaagtcagt
     1381 ggaacatgag tccacagtag tttaggaaac atgacagact gagagctgca aaaatactaa
     1441 tattttcctc agggctctct gtctctttcc tgatacaaca tttattgtgc tatgcctgat
     1501 ttctttctgc actcagtgtt ttccccagta gtgttag
//
