LOCUS       NM_133849               2689 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus histamine receptor H3 (Hrh3), transcript variant 1,
            mRNA.
ACCESSION   NM_133849
VERSION     NM_133849.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2689)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 2689)
  AUTHORS   Davies,S., Lujan,K.S., Rappaport,E.J., Valenzuela,C.F. and
            Savage,D.D.
  TITLE     Effect of moderate prenatal ethanol exposure on the differential
            expression of two histamine H3 receptor isoforms in different brain
            regions of adult rat offspring
  JOURNAL   Front Neurosci 17, 1192096 (2023)
   PUBMED   37449267
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2689)
  AUTHORS   Xu,J. and Pittenger,C.
  TITLE     The histamine H3 receptor modulates dopamine D2 receptor-dependent
            signaling pathways and mouse behaviors
  JOURNAL   J Biol Chem 299 (4), 104583 (2023)
   PUBMED   36871761
  REMARK    GeneRIF: The histamine H3 receptor modulates dopamine D2
            receptor-dependent signaling pathways and mouse behaviors.
REFERENCE   4  (bases 1 to 2689)
  AUTHORS   Pittenger,C.
  TITLE     The histidine decarboxylase model of tic pathophysiology: a new
            focus on the histamine H3 receptor
  JOURNAL   Br J Pharmacol 177 (3), 570-579 (2020)
   PUBMED   30714121
  REMARK    GeneRIF: The histidine decarboxylase model of tic pathophysiology:
            a new focus on the histamine H3 receptor.
            Review article
REFERENCE   5  (bases 1 to 2689)
  AUTHORS   Erdogmus,S., Storch,U., Danner,L., Becker,J., Winter,M.,
            Ziegler,N., Wirth,A., Offermanns,S., Hoffmann,C., Gudermann,T. and
            Mederos Y Schnitzler,M.
  TITLE     Helix 8 is the essential structural motif of mechanosensitive GPCRs
  JOURNAL   Nat Commun 10 (1), 5784 (2019)
   PUBMED   31857598
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2689)
  AUTHORS   Takahashi,K., Suwa,H., Ishikawa,T. and Kotani,H.
  TITLE     Targeted disruption of H3 receptors results in changes in brain
            histamine tone leading to an obese phenotype
  JOURNAL   J Clin Invest 110 (12), 1791-1799 (2002)
   PUBMED   12488429
  REMARK    GeneRIF: These results suggest that neuronal histamine is a
            mediator of body-weight homeostasis and that neuronal histamine
            functions through H3 receptors in mice.
REFERENCE   7  (bases 1 to 2689)
  AUTHORS   Toyota,H., Dugovic,C., Koehl,M., Laposky,A.D., Weber,C., Ngo,K.,
            Wu,Y., Lee,D.H., Yanai,K., Sakurai,E., Watanabe,T., Liu,C.,
            Chen,J., Barbier,A.J., Turek,F.W., Fung-Leung,W.P. and
            Lovenberg,T.W.
  TITLE     Behavioral characterization of mice lacking histamine H(3)
            receptors
  JOURNAL   Mol Pharmacol 62 (2), 389-397 (2002)
   PUBMED   12130692
  REMARK    Erratum:[Mol Pharmacol 2002 Sep;62(3):763]
REFERENCE   8  (bases 1 to 2689)
  AUTHORS   Butterfield,R.J., Sudweeks,J.D., Blankenhorn,E.P., Korngold,R.,
            Marini,J.C., Todd,J.A., Roper,R.J. and Teuscher,C.
  TITLE     New genetic loci that control susceptibility and symptoms of
            experimental allergic encephalomyelitis in inbred mice
  JOURNAL   J Immunol 161 (4), 1860-1867 (1998)
   PUBMED   9712054
REFERENCE   9  (bases 1 to 2689)
  AUTHORS   Encinas,J.A., Lees,M.B., Sobel,R.A., Symonowicz,C., Greer,J.M.,
            Shovlin,C.L., Weiner,H.L., Seidman,C.E., Seidman,J.G. and
            Kuchroo,V.K.
  TITLE     Genetic analysis of susceptibility to experimental autoimmune
            encephalomyelitis in a cross between SJL/J and B10.S mice
  JOURNAL   J Immunol 157 (5), 2186-2192 (1996)
   PUBMED   8757345
REFERENCE   10 (bases 1 to 2689)
  AUTHORS   Baker,D., Rosenwasser,O.A., O'Neill,J.K. and Turk,J.L.
  TITLE     Genetic analysis of experimental allergic encephalomyelitis in mice
  JOURNAL   J Immunol 155 (8), 4046-4051 (1995)
   PUBMED   7561115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672130.14.
            
            On Jul 18, 2022 this sequence version replaced NM_133849.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY044153.2, AK140374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               AL672130.14        33719-34288         c
            571-737             AL672130.14        32546-32712         c
            738-2689            AL672130.14        29282-31233         c
FEATURES             Location/Qualifiers
     source          1..2689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.62 cM"
     gene            1..2689
                     /gene="Hrh3"
                     /gene_synonym="Eae8; H3R; HH3R"
                     /note="histamine receptor H3"
                     /db_xref="GeneID:99296"
                     /db_xref="MGI:MGI:2139279"
     exon            1..570
                     /gene="Hrh3"
                     /gene_synonym="Eae8; H3R; HH3R"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1658
                     /gene="Hrh3"
                     /gene_synonym="Eae8; H3R; HH3R"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histamine H3 receptor; experimental allergic
                     encephalomyelitis susceptibility 8"
                     /codon_start=1
                     /product="histamine H3 receptor isoform 1"
                     /protein_id="NP_598610.1"
                     /db_xref="CCDS:CCDS17169.1"
                     /db_xref="GeneID:99296"
                     /db_xref="MGI:MGI:2139279"
                     /translation="MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALL
                     IVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTF
                     GRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVW
                     VLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFN
                     LSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYG
                     VGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLE
                     KRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDY
                     WYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK"
     exon            571..737
                     /gene="Hrh3"
                     /gene_synonym="Eae8; H3R; HH3R"
                     /inference="alignment:Splign:2.1.0"
     exon            738..2689
                     /gene="Hrh3"
                     /gene_synonym="Eae8; H3R; HH3R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2661..2666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hrh3"
                     /gene_synonym="Eae8; H3R; HH3R"
                     /note="hexamer: AATAAA"
     polyA_site      2689
                     /gene="Hrh3"
                     /gene_synonym="Eae8; H3R; HH3R"
                     /note="major polyA site"
ORIGIN      
        1 gcacttggct gcgcgctgag ctaggggtgc accgacgcgc cgcgggcggc tggagctcgg
       61 ctttgctctc gctgcagcag ccgcgcagcc cgccccactc tgctcagatt ccgataccag
      121 ccccctctgc atcaccctcc cggactccag actcggctct cgctccggtc ccgcggacca
      181 tgctccgggc gccccccgga aaaccgggct gggtgaagag ccggcaaaga ttaggctcaa
      241 gagcaggggc cccgcccggc cacccagcac tcggcccctg ccctgcccag tgtccccgag
      301 ccctgtgagc ctgctgggcc atggagcgcg cgccgcccga cgggctgatg aacgcgtcgg
      361 gcgctctggc cggagaggcg gcggctgcag gcggggcgcg cggcttctcg gctgcctgga
      421 ccgctgtcct ggctgcgctc atggcgctgc tcatcgtggc cacagtgctg ggcaacgcgc
      481 tggtcatgct cgccttcgtg gcggattcga gcctccgcac ccagaacaac ttctttctgc
      541 tcaacctcgc catctccgac ttcctcgtgg gtgccttctg catcccattg tatgtaccct
      601 atgtgctgac cggccgttgg acctttggcc ggggcctctg caagctgtgg ctggtggtag
      661 actacctact gtgtgcctcc tcagtcttca acatcgtgct gatcagctat gaccgattcc
      721 tgtcagtcac tcgagctgtc tcctaccggg cccagcaggg ggacacaaga cgggctgttc
      781 ggaagatggc actggtgtgg gtgctggcct tcctgctgta tgggcctgcc atcctgagtt
      841 gggagtacct gtccggtggc agctccatcc ccgagggcca ctgctatgct gagttcttct
      901 acaactggta ctttctcatc acggcctcca ccctcgagtt cttcacaccc ttcctcagcg
      961 ttaccttctt caacctcagc atctacctga acatccagag gcgcactcgt cttcggctgg
     1021 atgggggccg agaggctggt ccagaacccc cacctgatgc ccaaccctcg ccacctccag
     1081 ctccccccag ctgctggggc tgctggccaa aggggcacgg ggaggccatg ccattgcaca
     1141 ggtatggggt gggtgaggca ggccctggtg ttgagactgg ggaggctggc ctcgggggtg
     1201 gcagcggtgg aggcgctgct gcctcgccta cctccagctc cggcagctcc tcaaggggca
     1261 ctgagaggcc acgctcactc aaaaggggct ccaagccatc agcgtcttca gcgtccttgg
     1321 agaagcgcat gaagatggta tcccaaagca tcacccagcg ctttcggctg tcgcgggaca
     1381 agaaggtagc caagtcgctg gctatcatcg tgagcatctt tgggctctgc tgggccccgt
     1441 acacactcct catgatcatc cgggctgctt gccatggcca ctgcgtcccc gactactggt
     1501 acgagacgtc cttctggctt ctgtgggcca actcggccgt caaccccgtc ctctacccac
     1561 tgtgccacta cagcttccgt agagccttca ccaagctcct ctgcccccag aagctcaagg
     1621 tccagcccca tggctccctg gagcagtgct ggaagtgagc agctgcccca cccttctacg
     1681 gccaggccct tgtacctgtt ctgaggggga gcccgagcgt gggccctgcc tttgtccggg
     1741 gtctgctcca aatgccatgg cagcctctta gagcatcaac ccggcagtgg ggcagcatgg
     1801 taggagggcc aagagccctc gttggtggaa ctggagtgtg ctggctggct ttgccgccac
     1861 attctccttc accccagaag agacaatccg ggagtcccag gcatgccttc cacctccaca
     1921 cactcagtgc agtgccagtg atgtcctcct ttgcatactt agtggttggt gtcctcccta
     1981 atgcaaacct tggtgtgtgc tcccagctcc tgccctggca atgcgccctg catgtgcaca
     2041 cacctgccac ttccaccaca cacttgcaat accttctctc tcccaagacg atctggggcg
     2101 atgccctttg ctgccgctgt ctcttcctta atcccggagc ccagctccta accccctctc
     2161 ccttcaactc tttgccccat gaagtgtcaa gcgccccagg aaccttgaag cttctctgct
     2221 cttccattct ggatgttttc aggaagatgg aggagaagaa aacatcaagt ctgtgaactt
     2281 gatgttcctt ggatgtttaa tcaagagaga caaaattgcc gaggagctcg gggctggatt
     2341 ggcaggtgtg ggctcccacg ccctcctccc tcggcgctgc agcttccggc tgagccgcgc
     2401 cagctgcttc tgcctgcccc acccccaggc tcgggacgat agccctgccc tgcttgcccc
     2461 atctgcgcag tcagaatttg ggggtgggtt ggttgtgggg tagagcggct cttcggctca
     2521 tgggacagtc agcaggaggg agagcaggtt ctcgacacct gggaggaatg ctttgcctcg
     2581 tcctgtgtac ttacctcagg cctctgcatg ctctgcaatc cttgtgccct ggtgtgctgc
     2641 ctctgccaat gtgaagacac aataaagtgt atttttttat gggtgctga
//
