LOCUS       NM_001413010            4589 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus histamine receptor H2 (Hrh2), transcript variant 4,
            mRNA.
ACCESSION   NM_001413010 XM_036157855
VERSION     NM_001413010.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4589)
  AUTHORS   Ma,Q., Jiang,L., Chen,H., An,D., Ping,Y., Wang,Y., Dai,H.,
            Zhang,X., Wang,Y., Chen,Z. and Hu,W.
  TITLE     Histamine H2 receptor deficit in glutamatergic neurons contributes
            to the pathogenesis of schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 120 (9), e2207003120 (2023)
   PUBMED   36812204
  REMARK    GeneRIF: Histamine H2 receptor deficit in glutamatergic neurons
            contributes to the pathogenesis of schizophrenia.
REFERENCE   2  (bases 1 to 4589)
  AUTHORS   Meng,R., Cai,W.K., Xu,W.M., Feng,Q., Wang,P., Huang,Y.H., Fan,Y.X.,
            Zhou,T., Yang,Q., Li,Z.R. and He,G.H.
  TITLE     Generation and identification of endothelial-specific Hrh2 knockout
            mice
  JOURNAL   Transgenic Res 30 (3), 251-261 (2021)
   PUBMED   33786748
  REMARK    GeneRIF: Generation and identification of endothelial-specific Hrh2
            knockout mice.
REFERENCE   3  (bases 1 to 4589)
  AUTHORS   Jiang,L., Cheng,L., Chen,H., Dai,H., An,D., Ma,Q., Zheng,Y.,
            Zhang,X., Hu,W. and Chen,Z.
  TITLE     Histamine H2 receptor negatively regulates oligodendrocyte
            differentiation in neonatal hypoxic-ischemic white matter injury
  JOURNAL   J Exp Med 218 (1) (2021)
   PUBMED   32991666
  REMARK    GeneRIF: Histamine H2 receptor negatively regulates oligodendrocyte
            differentiation in neonatal hypoxic-ischemic white matter injury.
REFERENCE   4  (bases 1 to 4589)
  AUTHORS   Erdogmus,S., Storch,U., Danner,L., Becker,J., Winter,M.,
            Ziegler,N., Wirth,A., Offermanns,S., Hoffmann,C., Gudermann,T. and
            Mederos Y Schnitzler,M.
  TITLE     Helix 8 is the essential structural motif of mechanosensitive GPCRs
  JOURNAL   Nat Commun 10 (1), 5784 (2019)
   PUBMED   31857598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4589)
  AUTHORS   Fultz,R., Engevik,M.A., Shi,Z., Hall,A., Herrmann,B., Ganesh,B.P.,
            Major,A., Haag,A., Mori-Akiyama,Y. and Versalovic,J.
  TITLE     Phagocytosis by macrophages depends on histamine H2 receptor
            signaling and scavenger receptor 1
  JOURNAL   Microbiologyopen 8 (10), e908 (2019)
   PUBMED   31369218
  REMARK    GeneRIF: These data suggest that Hrh2 signaling is required for
            effective phagocytosis by regulating the process of autophagy and
            scavenger receptor MSR1 abundance in macrophages.
REFERENCE   6  (bases 1 to 4589)
  AUTHORS   Jutel,M., Watanabe,T., Klunker,S., Akdis,M., Thomet,O.A.,
            Malolepszy,J., Zak-Nejmark,T., Koga,R., Kobayashi,T., Blaser,K. and
            Akdis,C.A.
  TITLE     Histamine regulates T-cell and antibody responses by differential
            expression of H1 and H2 receptors
  JOURNAL   Nature 413 (6854), 420-425 (2001)
   PUBMED   11574888
REFERENCE   7  (bases 1 to 4589)
  AUTHORS   Fleming,M.D., Campagna,D.R., Haslett,J.N., Trenor,C.C. 3rd and
            Andrews,N.C.
  TITLE     A mutation in a mitochondrial transmembrane protein is responsible
            for the pleiotropic hematological and skeletal phenotype of
            flexed-tail (f/f) mice
  JOURNAL   Genes Dev 15 (6), 652-657 (2001)
   PUBMED   11274051
REFERENCE   8  (bases 1 to 4589)
  AUTHORS   Kobayashi,T., Tonai,S., Ishihara,Y., Koga,R., Okabe,S. and
            Watanabe,T.
  TITLE     Abnormal functional and morphological regulation of the gastric
            mucosa in histamine H2 receptor-deficient mice
  JOURNAL   J Clin Invest 105 (12), 1741-1749 (2000)
   PUBMED   10862789
REFERENCE   9  (bases 1 to 4589)
  AUTHORS   Zhao,X., Ma,W., Das,S.K., Dey,S.K. and Paria,B.C.
  TITLE     Blastocyst H(2) receptor is the target for uterine histamine in
            implantation in the mouse
  JOURNAL   Development 127 (12), 2643-2651 (2000)
   PUBMED   10821762
REFERENCE   10 (bases 1 to 4589)
  AUTHORS   Kobayashi,T., Inoue,I., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and Watanabe,T.
  TITLE     Cloning, RNA expression, and chromosomal location of a mouse
            histamine H2 receptor gene
  JOURNAL   Genomics 37 (3), 390-394 (1996)
   PUBMED   8938453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163343.2 and AC164086.3.
            
            On Oct 24, 2022 this sequence version replaced XM_036157855.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.2772958.1,
                                           SRR14995045.1852621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC163343.2         153037-153112
            77-1587             AC164086.3         82478-83988         c
            1588-4589           AC164086.3         61376-64377         c
FEATURES             Location/Qualifiers
     source          1..4589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 28.4 cM"
     gene            1..4589
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /note="histamine receptor H2"
                     /db_xref="GeneID:15466"
                     /db_xref="MGI:MGI:108482"
     exon            1..76
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     exon            77..1587
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..1780
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /note="isoform 3 is encoded by transcript variant 4;
                     histamine H2 receptor; gastric receptor I"
                     /codon_start=1
                     /product="histamine H2 receptor isoform 3"
                     /protein_id="NP_001399939.1"
                     /db_xref="GeneID:15466"
                     /db_xref="MGI:MGI:108482"
                     /translation="MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVS
                     LNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLC
                     TASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNS
                     RNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHI
                     SSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLG
                     YANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQ
                     EEKPLKLQVWSGTELTHPQGSPVRKTALSCTICSNNLLSCCKSLWRLRFLQQHPEGPS
                     KEQLGEPLSEETERTPSQEGMGLLSYEAV"
     exon            1588..4589
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4572..4577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /note="hexamer: AATAAA"
     polyA_site      4589
                     /gene="Hrh2"
                     /gene_synonym="H2R; HH2R"
                     /note="major polyA site"
ORIGIN      
        1 atccttgccc cagccagtgc aagcgcgcag tcctaagcga cccggtacag ccggtggcgc
       61 acagcagcag caccagctcc tatgacccca gaaagagtag ccagtagtgt tgtaccttaa
      121 gccatcgatg gaaacaggca ccagccatgg aaaaggacat gacagcctat gtgtgtgatc
      181 tcttacatat aaaacctaag ccacctcaag atacatccag cagtgcctca gtctccatga
      241 ggaacctaga agataggtgt atactacaga cctgggagaa gtctggcatg gaagacctgc
      301 tgaggactgg ggtgtgagct tttaaggccc tgccttactt cattcttacc tatgtcctgc
      361 acttcacaag aaaaagcttg aactattgct agaacagcat tgggtcagtc actacaccct
      421 cccaaacttt ggcttggttg ggagcccagt ggttagggct agaagagaag ccaccaaggc
      481 caagaagtga gtgtagaagc cacagggccc cagaatggag cccaatggca cggttcattc
      541 ctgctgtttg gactctattg cattgaaagt caccatcagt gtggtcctca ccaccctcat
      601 cttcatcact gttgctggca atgtggtcgt ctgcctggct gtcagcttga atcgtcggct
      661 ccgcagtctg accaattgct tcattgtgtc cctggcagcc actgacctgc ttcttggcct
      721 cctggtgatg cccttctctg ccatttacca gttgtccttc aagtggagct ttggccaggt
      781 cttctgcaac atctacacca gcctggatgt gatgctctgc acagcttcca tcctcaacct
      841 cttcatgatc agcttggacc gctactgcgc tgtcacggac ccactgcggt accccgtgtt
      901 ggtcacccct gttcgcgttg ccatctcttt ggtctttatt tgggtcattt ccatcaccct
      961 ctccttcctc tctattcacc taggatggaa cagcagaaat gggaccagag ggggcaatga
     1021 caccttcaag tgcaaagtgc aggtcaacga ggtatatgga ctggtggatg ggatggtcac
     1081 cttctacctg cctcttctca tcatgtgtgt cacctactac agaatcttta agatcgccag
     1141 ggagcaagcc aagaggatca accacatcag ctcctggaag gcagccacca tcagagaaca
     1201 caaagccacc gtgaccctgg ctgccgtcat gggagcattc atcgtctgct ggtttcctta
     1261 cttcactgcc ttcgtttacc gtggactgag aggggatgac gctgtgaacg aggtggtcga
     1321 gggtatcgtc ctatggttgg gttatgccaa ttcagccctg aaccccatcc tgtacgccac
     1381 cctcaacaga gacttccgca tggcgtacca acagctcttc cactgcaagc ttgcaagcca
     1441 caactctcac aaaacttccc tgaggttgaa caactctctg ctgtccagga gccaaagccg
     1501 agaaggtaga tggcaggagg agaagcccct gaagcttcag gtgtggagtg ggacagaact
     1561 cacacacccc cagggaagcc cagtcaggaa aacagcattg tcttgcacca tatgctccaa
     1621 taacctccta agctgctgca agagcctgtg gaggcttcgt ttcctccagc aacacccaga
     1681 aggaccctca aaggagcaac tgggggagcc actgtctgaa gagacagaaa ggacaccatc
     1741 acaggaagga atggggctgt tgtcctatga ggctgtctag atcctgccca ggacaccaag
     1801 atgctggcct tatcacttgg atctcctttc tggagcccct gtataccaag ccccaccaaa
     1861 ccactgagga caaacttcag cctgagcctg gaggctcaca gaacacacaa aacatcttcc
     1921 ctgggagcag atttcagaca ggttaaaatc cttaggcaga attccttggg ttcaaagctc
     1981 atgttggtgc tggccctagg agtcatgagc agagagagca ggacagagat ggatacacag
     2041 gtgtacatgg acgtgcttct atagaaaaca tgcacatctg ccaagcaggg caaaggatac
     2101 tatcataaag cactgagaag cctcgcttcc ctgcgaggtc tcaatgtgag cagaaaagaa
     2161 gagaagcgag tggaagagaa agaagaggaa agaaattgcc ctccatggac acctaactaa
     2221 gttccagata ctttgcctac acaggctctc ataatttata tacatatgct taggataagc
     2281 atcactctcc agtctttaca gagatggaaa ctgagagtca gggtagtgtg gaatgtacct
     2341 caggccactc agccagaaag tatgtctggg atagaggtac taagaatgga tgtgtgggaa
     2401 gatgtgtgga tggatggaca aatggatgat ggatgaatga gtatatggat ggatggatgg
     2461 atggatggat ggatggatgg atggatgaat gaatggatga ataaataaaa atccaggctt
     2521 atgtccatgc cttctaaact acactgatac tcagaagaga agccaagaca attccttaac
     2581 tcagctaacc ctcctctagc aagtcttagc ccttcaggaa gccctccatg atgagctaca
     2641 gccattgatg gtgctcattt tcaacaagaa gtagtgtaca gtgggcttgt ggggcaaagt
     2701 gtgtctactg agtcccagga aagcacagac agaagctggg aagatgcaga gagtacaaat
     2761 gtgtaggttg acctaatgcc accctcatct ggctacatga ccagaacaaa tccctggccc
     2821 ctctgagcag ctctatattc ctctgtgtaa atgagtagac tccctttcta tagttagaga
     2881 atgactgaga gattcaagga ggtggagttg gcgagagccc cagagagaag aggatatctg
     2941 tggacttctc tccccgagga ctcctcattg ctgttgccct tccatgacct caactcctcc
     3001 ttgataccca ggtttccttg ggtttccaag accctctcct gccgcctcca cgcccacccc
     3061 caacccccgc catgtccacc ttttatgtgg ttttccagcc ctctttgtga cttgctgtcc
     3121 tccacacaac cattagatgt gactgtccct tggagttcag tgatgggacg tctcacctta
     3181 ggtctccctt tgagacctca tctgcatcca tgaccttagt caccaaacat aaggaaatta
     3241 tttgctgatt cacaactgta ggcaaagcat gagacactgg gtcacctcca tctgcatact
     3301 tcaaaggtac cttactgtta acaagtccac aactacccac tccaacttct ccctcgcctg
     3361 cttctccaaa gccctccttc tcaagcagag gatatatcct gggtttcaaa acccttggtc
     3421 agcctcggcc cctctttcta ccttgcttct tctcatggca gacactagag tcttagctcc
     3481 aacacatatc cgccacccaa ctgataatcc tcatcttccc tgtctcacat gaccctgctg
     3541 ctgtagtctc catcgggaca actggaaaag ctgcttagat ctctttccta cactcaccct
     3601 accttcttac ccccatcagt tctccacaca acagcctcag taggctgtga aaattcatag
     3661 cctactctgt cacatccagg atagaacctt ctttagacca gcccgccaac ctggccttgt
     3721 cagcttccat gttcctccag cttcctgctt tgccatcccc taccttctct taattccacc
     3781 cctgtttgtc atattgtttt atttagatct actatttcta gcaaacaagg cactcggagt
     3841 gctatttcca tgacctcaaa tgctcctttc tcttctggac aacttgacat catgagatct
     3901 catcgaaaat accattccct tggggatttc ctccttgtct gttctgaccc ttcctatacc
     3961 aggcccttgc cacacaccat gggactttat gtagaagcca ttggctctat attatatctt
     4021 ataatatgat agtcagctgt ggtttcttgg acactatctt cctcctctat gcatgagttc
     4081 cttctgctga cctttgcctg ttgggtctct ggaagagtac tcacacatag tagaagctta
     4141 gttaaagttg tcagggaaac aggcaaagaa tggtccacag caatatttta agggctagcc
     4201 tgccaataaa cttcaaggag taatttggcc tgataactcc cagagatgac cactgagtat
     4261 ctttatcaaa ttccctctga aagcccaaga gacccactta gacatcttct tgggagccaa
     4321 tggcaggtga gtctcttaag tcacagccaa ctaactggag gcacaagatc tctggtggac
     4381 ctgcgtgatc agagagacag ccagtcagac tcaagaccac agtgcccagg gacaacctgc
     4441 cacatcagaa gattcctgca catgtaaact ttcttctgga gcctttcctg gcagcacaaa
     4501 cggggtgcat gaagcctggg ggagcatcag ccgaggtgga acttcaagtc cattctgtgt
     4561 ttccatgttc caataaagct atcaacaca
//
