LOCUS       NM_001317126            3081 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus histamine receptor H1 (Hrh1), transcript variant 6,
            mRNA.
ACCESSION   NM_001317126 XM_006505615
VERSION     NM_001317126.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3081)
  AUTHORS   Sung,C.Y.W., Hayase,N., Yuen,P.S.T., Lee,J., Fernandez,K., Hu,X.,
            Cheng,H., Star,R.A., Warchol,M.E. and Cunningham,L.L.
  TITLE     Macrophage depletion protects against cisplatin-induced ototoxicity
            and nephrotoxicity
  JOURNAL   Sci Adv 10 (30), eadk9878 (2024)
   PUBMED   39047106
REFERENCE   2  (bases 1 to 3081)
  AUTHORS   Cheng,L., Xiao,L., Lin,W., Li,M., Liu,J., Qiu,X., Li,M., Zheng,Y.,
            Xu,C., Wang,Y. and Chen,Z.
  TITLE     Histamine H1 receptors in dentate gyrus-projecting cholinergic
            neurons of the medial septum suppress contextual fear retrieval in
            mice
  JOURNAL   Nat Commun 15 (1), 5805 (2024)
   PUBMED   38987240
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3081)
  AUTHORS   Futagawa,A., Tsuneoka,Y., Lazarus,M. and Oishi,Y.
  TITLE     Comprehensive mapping of histamine H1 receptor mRNA in the mouse
            brain
  JOURNAL   J Comp Neurol 532 (5), e25622 (2024)
   PUBMED   38712635
  REMARK    GeneRIF: Comprehensive mapping of histamine H1 receptor mRNA in the
            mouse brain.
REFERENCE   4  (bases 1 to 3081)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3081)
  AUTHORS   Yang,X., Shi,Z., Wang,X., Yang,Y., Sun,D., Zhu,B., Song,F., Zhu,X.,
            Ding,S., Zou,Y., Xiao,C. and Yang,X.
  TITLE     Disruption of Histamine-H1R signaling exacerbates cardiac
            microthrombosis after periodontal disease via TLR4/NFkappaB-p65
            pathway
  JOURNAL   Int Immunopharmacol 123, 110774 (2023)
   PUBMED   37567012
  REMARK    GeneRIF: Disruption of Histamine-H1R signaling exacerbates cardiac
            microthrombosis after periodontal disease via TLR4/NFkappaB-p65
            pathway.
REFERENCE   6  (bases 1 to 3081)
  AUTHORS   Yanai,K., Son,L.Z., Endou,M., Sakurai,E., Nakagawasai,O.,
            Tadano,T., Kisara,K., Inoue,I., Watanabe,T. and Watanabe,T.
  TITLE     Behavioural characterization and amounts of brain monoamines and
            their metabolites in mice lacking histamine H1 receptors
  JOURNAL   Neuroscience 87 (2), 479-487 (1998)
   PUBMED   9740406
REFERENCE   7  (bases 1 to 3081)
  AUTHORS   Yanai,K., Son,L.Z., Endou,M., Sakurai,E. and Watanabe,T.
  TITLE     Targeting disruption of histamine H1 receptors in mice: behavioral
            and neurochemical characterization
  JOURNAL   Life Sci 62 (17-18), 1607-1610 (1998)
   PUBMED   9585144
REFERENCE   8  (bases 1 to 3081)
  AUTHORS   Inoue,I., Yanai,K., Kitamura,D., Taniuchi,I., Kobayashi,T.,
            Niimura,K., Watanabe,T. and Watanabe,T.
  TITLE     Impaired locomotor activity and exploratory behavior in mice
            lacking histamine H1 receptors
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 13316-13320 (1996)
   PUBMED   8917588
REFERENCE   9  (bases 1 to 3081)
  AUTHORS   Inoue,I., Taniuchi,I., Kitamura,D., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Watanabe,T.
  TITLE     Characteristics of the mouse genomic histamine H1 receptor gene
  JOURNAL   Genomics 36 (1), 178-181 (1996)
   PUBMED   8812432
REFERENCE   10 (bases 1 to 3081)
  AUTHORS   Sudweeks,J.D., Todd,J.A., Blankenhorn,E.P., Wardell,B.B.,
            Woodward,S.R., Meeker,N.D., Estes,S.S. and Teuscher,C.
  TITLE     Locus controlling Bordetella pertussis-induced histamine
            sensitization (Bphs), an autoimmune disease-susceptibility gene,
            maps distal to T-cell receptor beta-chain gene on mouse chromosome
            6
  JOURNAL   Proc Natl Acad Sci U S A 90 (8), 3700-3704 (1993)
   PUBMED   8475118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159381.10.
            
            On Jul 26, 2022 this sequence version replaced NM_001317126.1.
            
            Transcript Variant: This variant (6) represents the longest
            transcript. Variants 1 thorugh 6 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.24723.1,
                                           ERR3363658.3499580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AC159381.10        57936-58269
            335-3081            AC159381.10        139575-142321
FEATURES             Location/Qualifiers
     source          1..3081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.05 cM"
     gene            1..3081
                     /gene="Hrh1"
                     /gene_synonym="Bphs; H1R; HH1R; Hir"
                     /note="histamine receptor H1"
                     /db_xref="GeneID:15465"
                     /db_xref="MGI:MGI:107619"
     exon            1..334
                     /gene="Hrh1"
                     /gene_synonym="Bphs; H1R; HH1R; Hir"
                     /inference="alignment:Splign:2.1.0"
     exon            335..3081
                     /gene="Hrh1"
                     /gene_synonym="Bphs; H1R; HH1R; Hir"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..1836
                     /gene="Hrh1"
                     /gene_synonym="Bphs; H1R; HH1R; Hir"
                     /note="Bordetella pertussis induced histamine
                     sensitization"
                     /codon_start=1
                     /product="histamine H1 receptor"
                     /protein_id="NP_001304055.1"
                     /db_xref="CCDS:CCDS20435.1"
                     /db_xref="GeneID:15465"
                     /db_xref="MGI:MGI:107619"
                     /translation="MSLPNTSSASEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGL
                     NLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLF
                     WLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFLSFLWVI
                     PILGWHHFTPLAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVR
                     RHCQHRQLTNGSLPTFLEIKLRSEDAKEGAKKPGKESPWGVQKRPSRDPTGGLDQKST
                     SEDPKVTSPTVFSQEGERETVTRPCFRLDVMQTQPVPEGDARGSKANDQTLSQPKMDE
                     QSLSTCRRISETSEDQTLVDRQSFSRTTDSDTSIEPGLGKVKARSRSNSGLDYIKVTW
                     KRLRSHSRQYVSGLHLNRERKAAKQLGCIMAAFILCWIPYFIFFMVIAFCNSCCSEPV
                     HMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS"
     polyA_site      3081
                     /gene="Hrh1"
                     /gene_synonym="Bphs; H1R; HH1R; Hir"
                     /note="major polyA site"
ORIGIN      
        1 gttccgcgcc cccgcagggc ggtggggaca tcccgcaggt ggccgcacga ggtgggcgcg
       61 ccggatgctc tagcggcctg ggcagggtat cggagctgtg gctgctatgc ccgtaagcac
      121 aaacacctgt ggcttcccgg agctggggcc gggctcaccg gttagagtcc gcctccgatt
      181 tctgggccag ggggcctcct caacggctcc ccgagattcc tcagggtttg gctttgatgc
      241 taaccgtgga cgcagactct gggttgaggt gcgatctccg tgccaagctc cggacatcca
      301 ctatctcaaa tccttctgaa tctccgggac ccagggaggg agccatcact ggaggctgcc
      361 cttgtgccaa tgagccttcc caacacctct tctgcctccg aagacaagat gtgtgagggg
      421 aacaggacag ccatggccag ccctcagctg ctgcccctgg tggtggttct aagtagtatc
      481 tccctggtca cagtgggcct caacctgctg gtgctgtatg cagtgcgcag tgagcgcaag
      541 ctacacaccg tgggcaacct gtacattgtc agcctgtcgg tagcagacct gattgtaggg
      601 gcagtcgtca tgcccatgaa catcctctat cttatcatga ccaagtggtc cctgggccgc
      661 cccctctgcc tcttttggct ctctatggat tatgtggcca gcacggcatc catctttagt
      721 gtcttcatcc tgtgtattga tcgctaccgc tctgtccagc aacccctccg gtacctgagg
      781 tatcgaacca agacccgtgc ttcagctacc atcctggggg cctggtttct ctccttcctg
      841 tgggttatac ctatacttgg ctggcatcac ttcacgcccc tggccccaga gcttcgggaa
      901 gataagtgtg agacagattt ctacaatgtc acttggttca agatcatgac cgccatcatc
      961 aacttctacc tccccacttt gctcatgctg tggttctatg tgaagatcta caaggctgtg
     1021 cggcgacact gtcagcaccg ccagctcacc aacgggtccc tccctacctt tttagaaatc
     1081 aagctgaggt cggaggatgc caaagagggt gccaagaaac ctgggaaaga gtctccctgg
     1141 ggggtccaga agaggccgtc aagagaccct actggaggtc tggatcagaa gtcaacatct
     1201 gaagacccca aggtgacctc tccgactgtc ttcagccaag agggggaaag ggaaacagtc
     1261 acacgcccct gtttccgtct tgacgtcatg cagacacagc ctgtgcctga gggagatgcc
     1321 aggggctcaa aggccaatga ccagaccttg agccagccca aaatggatga gcagagcctg
     1381 agtacttgcc ggcggatcag tgagacatca gaggaccaga ccttggtgga tcgacagtcc
     1441 ttctcccgga ccacagactc agacaccagc atagagccag ggctgggcaa agtcaaagcg
     1501 agaagcaggt ctaacagtgg cctggactac atcaaagtca cctggaagag gctccgctca
     1561 cattccagac agtatgtgtc cgggttgcac ttgaaccgag agcggaaggc agccaagcag
     1621 ttgggttgta tcatggcagc attcattctc tgctggattc cctatttcat cttcttcatg
     1681 gtcattgcct tctgcaacag ctgctgcagc gaacctgtgc acatgttcac catttggctg
     1741 ggctacatca actccacgct gaaccccctc atctacccgc tgtgcaacga gaacttcaag
     1801 aagacattca aaaaaattct gcacattcgt tcctaagggc atgtccaaag gatgccacat
     1861 ggtggataga caacgtctga tgtccaagag ggagccagag gaagaaagca tgggcgtcgc
     1921 tagacccctg agccttagga agtggaatcg aaggtcctgg gctgagcagt gtgaaggcat
     1981 tcccagggtc tgtcagaagg aaagcaggca gcagagcaat tgtaccctgg gtagaaagca
     2041 gagcatctga aagagaccca ggcagagcac gcctggccct cagggactgt gggagtctca
     2101 gatactcctt ggaagtcaaa gtctctgact tgaagttcct tagtaaccga agtgggaatg
     2161 tgtggctaca gttcttctgg agagttagcc tggactcaga cttcctgaac aaaagctatg
     2221 tgactgcaga ggcaggtata cggatgctgt ccccttccag tggtcacctg gagaggtatg
     2281 gcagctattc cattgcagcc gcacttctta aaacacagtc cttctgagcc tcgcctctct
     2341 tagagctttg tccggagctg tctgccccac cgtggaacct gccttacccg tgtctcagag
     2401 ttgctaggaa attaggcagc ttgtgagtcc atcattttca acccttagtt cttttggctt
     2461 tttaaaatgg tggcacagta acaaaacctg tcctcaagtg tcaagaaggg gaggaagtgg
     2521 tttctccacg gttgtatttt aagcaaaggt gaggcaagag agccttgttt cttaagactc
     2581 caccagggca ctctcactcc aggcctcaca tgacaagcgg gtaacagcca agggaaaaga
     2641 aggttcctgg gatcatttga cacttggaaa cttgggatga gaactttgta tggtcccaac
     2701 tccttgtcac tcgccttctc caaaaaggaa gaaatgaccc ctgtcatgta ctcgcaatgt
     2761 tccccgggag acgtgactgt cacgaagcac atctgtccac agagggtgac cttcagaagg
     2821 gacacatgtg cttttctctg tgagactgtg tggcttctag tcacacatgc taagtgaatc
     2881 ctgttgaagg catgggagcg tccagtttta tttatgccac agttgggttg tgatttgtgt
     2941 tttaaaatgt aatgttaaac atctatgtgt gtcacaagta ggaacccctg taaaagctgg
     3001 tcttttgtgt ctgtgttcct gtttgcatga tctgtccaaa cgagatattt ttgcttacct
     3061 aaaacatgac attcggaagg a
//
