LOCUS       NM_053176               1758 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus histidine-rich glycoprotein (Hrg), mRNA.
ACCESSION   NM_053176
VERSION     NM_053176.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Lv,K., Chen,S., Xu,X., Chiu,J., Wang,H.J., Han,Y., Yang,X.,
            Bowley,S.R., Wang,H., Tang,Z., Tang,N., Yang,A., Yang,S., Wang,J.,
            Jin,S., Wu,Y., Schmaier,A.H., Ju,L.A., Hogg,P.J. and Fang,C.
  TITLE     Protein disulfide isomerase cleaves allosteric disulfides in
            histidine-rich glycoprotein to regulate thrombosis
  JOURNAL   Nat Commun 15 (1), 3129 (2024)
   PUBMED   38605050
  REMARK    GeneRIF: Protein disulfide isomerase cleaves allosteric disulfides
            in histidine-rich glycoprotein to regulate thrombosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1758)
  AUTHORS   Foglia,B., Sutti,S., Cannito,S., Rosso,C., Maggiora,M.,
            Casalino,A., Bocca,C., Novo,E., Protopapa,F., Ramavath,N.N.,
            Provera,A., Gambella,A., Bugianesi,E., Tacke,F., Albano,E. and
            Parola,M.
  TITLE     Histidine-rich glycoprotein in metabolic dysfunction-associated
            steatohepatitis-related disease progression and liver
            carcinogenesis
  JOURNAL   Front Immunol 15, 1342404 (2024)
   PUBMED   38469298
  REMARK    GeneRIF: Histidine-rich glycoprotein in metabolic
            dysfunction-associated steatohepatitis-related disease progression
            and liver carcinogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1758)
  AUTHORS   Brutsch,S.M., Madzharova,E., Pantasis,S., Wustemann,T., Gurri,S.,
            Steenbock,H., Gazdhar,A., Kuhn,G., Angel,P., Bellusci,S.,
            Brinckmann,J., Auf dem Keller,U., Werner,S. and Bordoli,M.R.
  TITLE     Mesenchyme-derived vertebrate lonesome kinase controls lung
            organogenesis by altering the matrisome
  JOURNAL   Cell Mol Life Sci 80 (4), 89 (2023)
   PUBMED   36920550
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1758)
  AUTHORS   Nunes,Q.M., Su,D., Brownridge,P.J., Simpson,D.M., Sun,C., Li,Y.,
            Bui,T.P., Zhang,X., Huang,W., Rigden,D.J., Beynon,R.J., Sutton,R.
            and Fernig,D.G.
  TITLE     The heparin-binding proteome in normal pancreas and murine
            experimental acute pancreatitis
  JOURNAL   PLoS One 14 (6), e0217633 (2019)
   PUBMED   31211768
  REMARK    GeneRIF: Other HBPs such as alpha 2-HS glycoprotein (AHSG) and
            histidine-rich glycoprotein (HRG) need further investigation for
            potential applications in the management of Acute pancreatitis (AP)
            . Pancreas HBPs are extracellular and so easily accessible and are
            potential drug targets in AP, whereas plasma HBPs represent
            potential biomarkers for AP.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1758)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1758)
  AUTHORS   Tsuchida-Straeten,N., Ensslen,S., Schafer,C., Woltje,M.,
            Denecke,B., Moser,M., Graber,S., Wakabayashi,S., Koide,T. and
            Jahnen-Dechent,W.
  TITLE     Enhanced blood coagulation and fibrinolysis in mice lacking
            histidine-rich glycoprotein (HRG)
  JOURNAL   J Thromb Haemost 3 (5), 865-872 (2005)
   PUBMED   15869579
  REMARK    GeneRIF: HRG plays a role as both an anticoagulant and an
            antifibrinolytic modifier, and may regulate platelet function in
            vivo
REFERENCE   7  (bases 1 to 1758)
  AUTHORS   Simantov,R., Febbraio,M. and Silverstein,R.L.
  TITLE     The antiangiogenic effect of thrombospondin-2 is mediated by CD36
            and modulated by histidine-rich glycoprotein
  JOURNAL   Matrix Biol 24 (1), 27-34 (2005)
   PUBMED   15748999
  REMARK    GeneRIF: CD36 mediates the antiangiogenic effect of
            thrombospondin-2, which is modulated by histidine-rich glycoprotein
REFERENCE   8  (bases 1 to 1758)
  AUTHORS   Hsu,S.J., Nagase,H. and Balmain,A.
  TITLE     Identification of Fetuin-B as a member of a cystatin-like gene
            family on mouse chromosome 16 with tumor suppressor activity
  JOURNAL   Genome 47 (5), 931-946 (2004)
   PUBMED   15499407
REFERENCE   9  (bases 1 to 1758)
  AUTHORS   Jones,A.L., Hulett,M.D., Altin,J.G., Hogg,P. and Parish,C.R.
  TITLE     Plasminogen is tethered with high affinity to the cell surface by
            the plasma protein, histidine-rich glycoprotein
  JOURNAL   J Biol Chem 279 (37), 38267-38276 (2004)
   PUBMED   15220341
  REMARK    GeneRIF: HRG acts as a soluble adaptor molecule that binds to cells
            at sites of tissue injury, tumor growth, and angiogenesis
REFERENCE   10 (bases 1 to 1758)
  AUTHORS   Hulett,M.D. and Parish,C.R.
  TITLE     Murine histidine-rich glycoprotein: cloning, characterization and
            cellular origin
  JOURNAL   Immunol Cell Biol 78 (3), 280-287 (2000)
   PUBMED   10849117
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI196096.1, CB593922.1, CB946752.1, AI182388.1 and AI303163.1.
            
            On Apr 18, 2009 this sequence version replaced NM_053176.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB055897.1, AY135662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AI196096.1         1-37
            38-654              CB593922.1         10-626
            655-1304            CB946752.1         3-652
            1305-1728           AI182388.1         16-439              c
            1729-1758           AI303163.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..1758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.79 cM"
     gene            1..1758
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /note="histidine-rich glycoprotein"
                     /db_xref="GeneID:94175"
                     /db_xref="MGI:MGI:2146636"
     exon            1..267
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /inference="alignment:Splign:2.1.0"
     exon            268..378
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /inference="alignment:Splign:2.1.0"
     exon            379..469
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /inference="alignment:Splign:2.1.0"
     exon            470..636
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /inference="alignment:Splign:2.1.0"
     exon            637..717
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /inference="alignment:Splign:2.1.0"
     exon            718..819
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1737
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /note="hexamer: AATAAA"
     polyA_site      1734
                     /gene="Hrg"
                     /gene_synonym="D16jh2; D18020; Hprg; Hrgp"
                     /note="major polyA site"
ORIGIN      
        1 tataaagacc tttatcaatt gagtgtgcat cacggtagaa ttctctctgc tatggtggac
       61 cacagtcaag gatggtttag cacaatgaag gtgctcacca cagcattgct tctagtcacc
      121 ctgcagtgtt cccatgccct gagtcccacc aactgtgatg cttctgagcc tctggctgag
      181 aaagttctag acctgatcaa taaagggcgg aggagtggct atgttttcga gctgctgcgg
      241 gtctctgacg cccacttgga cagagcggga acggccacag tctactactt agctttagat
      301 gtgatagagt ctgactgttg ggtcctttcc acaaaagccc aggatgactg tcttccatcg
      361 aggtggcaat ctgaaatagt gattggacaa tgtaaggtaa tagccacaag atactcaaat
      421 gagtctcaag atcttagcgt gaatggctat aactgcacca caagttctgt ctcttcagca
      481 cttcgcaata ccaaggacag tcctgtactc ttggacttct ttgaggattc cgagctctac
      541 agaaagcaag cccgtaaagc cctggacaag tacaaaacgg ataatggtga ctttgcctct
      601 ttcagagtgg aacgggcaga acgggttata agagcgagag gaggggaaag aaccaattac
      661 tatgtggaat tctccatgag gaactgttcc acacagcatt tccccaggtc ccctctggtc
      721 tttggattct gcagagcact tttgtcctac agtatagaaa cctctgactt ggaaacccca
      781 gattccattg atataaactg cgaagtcttc aacattgagg atcataaaga cacaagtgac
      841 atgaaacccc attggggcca tgagcgtcct ctttgtgaca aacatctgtg taagctcagt
      901 ggatccaggg atcatcatca tacccataag acagataaac ttggatgccc acctccacca
      961 gaaggaaaag ataactcaga cagaccacgc cttcaagaag gagcccttcc acaactgccc
     1021 cctggctatc cccctcattc tggtgccaac agaacccata gaccctctta taatcacagt
     1081 tgtaatgagc atccttgtca tggacatcgt ccccatggac accaccccca cagtcaccat
     1141 ccccccggtc accattccca tggtcaccat ccccacggtc accatcccca cagtcaccat
     1201 tcccacggtc accatccccc cggtcaccat ccccatggtc accaccccca cggtcaccat
     1261 ccccatggtc accatcccca cggtcaccat cctcatggac atgacttcct tgactatgga
     1321 ccttgtgacc cgccctccaa tagtcaagaa ctcaaaggtc agtatcatcg gggctatggt
     1381 ccaccacatg gacactcaag aaaaagaggt ccaggcaaag gactctttcc tttccaccac
     1441 caacaaattg gatatgtcta ccgactccct ccactgaata taggtgaagt tctcactctt
     1501 cctgaagcca atttccccag cttctctttg ccaaattgca acagatccct acaaccagag
     1561 attcagccct tccctcagac agcctccagg tcatgtccag ggaaatttga gagtgaattt
     1621 ccacaaattt ccaagttttt tggatataca cctccaaaat aaaacctgat tccttggtag
     1681 ggggaagagg acaatattct gaataaataa aatatgatga gttagaaatg aaaagtgaaa
     1741 aaaaaaaaaa aaaaaaaa
//
