LOCUS       NM_010473               2443 bp    mRNA    linear   ROD 25-MAR-2020
DEFINITION  Mus musculus histidine rich calcium binding protein (Hrc), mRNA.
ACCESSION   NM_010473
VERSION     NM_010473.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2443)
  AUTHORS   Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos
            CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag
            S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG
            and Sanoudou D.
  TITLE     Impaired calcium homeostasis is associated with sudden cardiac
            death and arrhythmias in a genetic equivalent mouse model of the
            human HRC-Ser96Ala variant
  JOURNAL   Cardiovasc. Res. 113 (11), 1403-1417 (2017)
   PUBMED   28859293
REFERENCE   2  (bases 1 to 2443)
  AUTHORS   Rani S, Park CS, Sreenivasaiah PK and Kim DH.
  TITLE     Characterization of Ca(2+)-Dependent Protein-Protein Interactions
            within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum
  JOURNAL   Mol. Cells 39 (2), 149-155 (2016)
   PUBMED   26674963
  REMARK    GeneRIF: The minimal KEKE motif of TRN involved in the interactions
            with CSQ2, HRC and RyR2 within the Ca2+ release units of cardiac
            sarcoplasmic reticulum has been defined.
REFERENCE   3  (bases 1 to 2443)
  AUTHORS   Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L,
            Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG and
            Gyorke S.
  TITLE     Ablation of HRC alleviates cardiac arrhythmia and improves abnormal
            Ca handling in CASQ2 knockout mice prone to CPVT
  JOURNAL   Cardiovasc. Res. 108 (2), 299-311 (2015)
   PUBMED   26410369
  REMARK    GeneRIF: While CASQ2 stabilizes RyR2 rendering it refractory in the
            diastolic phase, HRC enhances RyR2 activity facilitating RyR2
            recovery from refractoriness.
REFERENCE   4  (bases 1 to 2443)
  AUTHORS   Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS,
            Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ,
            Bers DM, Kranias EG, Cho C and Kim DH.
  TITLE     Targeted ablation of the histidine-rich Ca(2+)-binding protein
            (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe
            pathology under pressure-overload stress
  JOURNAL   Basic Res. Cardiol. 108 (3), 344 (2013)
   PUBMED   23553082
  REMARK    GeneRIF: Ablation of HRC is associated with poorly regulated SR
            Ca(2+)-cycling, and severe pathology under pressure-overload
            stress, suggesting an essential role of HRC in maintaining the
            integrity of cardiac function.
REFERENCE   5  (bases 1 to 2443)
  AUTHORS   Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte
            F, Kontrogianni-Konstantopoulos A, Sanoudou D and Kranias EG.
  TITLE     Histidine-rich Ca-binding protein interacts with sarcoplasmic
            reticulum Ca-ATPase
  JOURNAL   Am. J. Physiol. Heart Circ. Physiol. 293 (3), H1581-H1589 (2007)
   PUBMED   17526652
  REMARK    GeneRIF: Histidine-rich Ca-binding protein may play a key role in
            the regulation of SR Ca cycling through its direct interactions
            with SERCA2 and triadin, mediating a fine cross talk between SR Ca
            uptake and release in the heart.
REFERENCE   6  (bases 1 to 2443)
  AUTHORS   van den Broek FA, Bakker R, den Bieman M, Fielmich-Bouwman AX,
            Lemmens AG, van Lith HA, Nissen I, Ritskes-Hoitinga JM, van
            Tintelen G and van Zutphen LF.
  TITLE     Genetic analysis of dystrophic cardiac calcification in DBA/2 mice
  JOURNAL   Biochem. Biophys. Res. Commun. 253 (2), 204-208 (1998)
   PUBMED   9878516
REFERENCE   7  (bases 1 to 2443)
  AUTHORS   Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE,
            Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM and
            Ashworth LK.
  TITLE     Detailed comparative map of human chromosome 19q and related
            regions of the mouse genome
  JOURNAL   Genomics 35 (3), 499-508 (1996)
   PUBMED   8812484
REFERENCE   8  (bases 1 to 2443)
  AUTHORS   Ivandic BT, Qiao JH, Machleder D, Liao F, Drake TA and Lusis AJ.
  TITLE     A locus on chromosome 7 determines myocardial cell necrosis and
            calcification (dystrophic cardiac calcinosis) in mice
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (11), 5483-5488 (1996)
   PUBMED   8643601
REFERENCE   9  (bases 1 to 2443)
  AUTHORS   Brown SD, Chartier F, Johnson K and Cavanna JS.
  TITLE     Mapping the Hrc gene to proximal mouse chromosome 7: delineation of
            a conserved linkage group with human 19q
  JOURNAL   Genomics 18 (2), 459-461 (1993)
   PUBMED   8288260
REFERENCE   10 (bases 1 to 2443)
  AUTHORS   Hofmann SL, Topham M, Hsieh CL and Francke U.
  TITLE     cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum
            protein, and localization of the gene to human chromosome 19 and
            mouse chromosome 7
  JOURNAL   Genomics 9 (4), 656-669 (1991)
   PUBMED   2037293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150897.2, AF132218.1 and AI322629.1.
            
            On Mar 20, 2007 this sequence version replaced NM_010473.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX523625.1, AF132218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1824              AC150897.2         9358-11181          c
            1825-2428           AF132218.1         1804-2407
            2429-2443           AI322629.1         380-394
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.26 cM"
     gene            1..2443
                     /gene="Hrc"
                     /note="histidine rich calcium binding protein"
                     /db_xref="GeneID:15464"
                     /db_xref="MGI:MGI:96226"
     exon            1..2106
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2375
                     /gene="Hrc"
                     /codon_start=1
                     /product="sarcoplasmic reticulum histidine-rich
                     calcium-binding protein precursor"
                     /protein_id="NP_034603.2"
                     /db_xref="CCDS:CCDS39950.1"
                     /db_xref="GeneID:15464"
                     /db_xref="MGI:MGI:96226"
                     /translation="MGFQGPWLHTCLLWATVAILLVPPVVTQELRGAGLGLGNWNNNA
                     GIPGSSEDLSTEFGHHIHRGYQGEKDRGHREEGEDFSREYGHRVQDHRYPGREVGEEN
                     VSEEVFRGHVRQLHGHREHDNEDLGDSAENHLPRQRSHSHEDEDGIVSSEYHRHVPRH
                     AHHGHGEEDDDDDGGEEEERVDVMEDSDDNEHQVHGHQSHSKERDELHHAHSHRHQGH
                     SDDDDDDGVSTEHGHQAHRYQDHEEEDDGDSDEDSHTHRVQGREDENDDEDGDSGEYR
                     HHTQDHQGHNEEQDDDDDDDDDDEDKEDSTEHRHQTQGHRKEEDEDESDEDDHHVSRH
                     GRQGYEEEEDDDDDDGDDDSTEHVHQAHRHRDHEHKDDEDDSEEDYHHVPSHGRQSHQ
                     NEEEEDEAVSTEHWHQSPRHAHHDLGRESEEEVAVKYSHHVASHRPQGHNADREEDSL
                     EEHMNEVPGHHHHRASRGDDEDISTEFGHKAPSHRLQDQDERARQGHREPVQGEIAHQ
                     PLQPTGPSSRESRKEGDHSSQEGDEDPEQRQAHSEEEKEEEEEEEEEEEEEKEGGHSL
                     PMSQEDDEEEEKDEKESKVDRAAVSAPLSHHRKQGEEEEEEEEEEEEEILEENLLPFT
                     IIPNPLAGREVAREGSSEEESREVTGQQDAQEYENYQPGSLCGYCSFCNRCTECESCH
                     CDEENMGEHCDQCQHCQFCYLCPLVCDTLCTPGSYVDYFSSSLYQALADMLETPEP"
     exon            2107..2177
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2246
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2301
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2338
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2431
                     /gene="Hrc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggtcat ccaagacctg aggaagatag agaggcagag agtgggagct ataccacgac
       61 aaaagggaca atctgaaagt caaagccaaa aaggcacaag gacccatcag aggcagctga
      121 agccagcctg gtcagacgct cagctgctaa acgtccccat gggcttccag gggccatggt
      181 tgcacacttg tctcctttgg gccacagtgg ccatcctgct ggtccctcca gtggtgaccc
      241 aggagttgag aggggccggt ctgggcctgg gcaactggaa caacaatgca ggcatccctg
      301 ggtcctcaga ggacctatca actgagtttg gtcaccacat ccaccgggga tatcaaggtg
      361 agaaggacag aggccacaga gaagagggtg aagacttctc cagggaatat ggccacaggg
      421 tccaagacca caggtaccct ggccgcgagg ttggagagga gaatgtctct gaagaggtct
      481 tcagagggca tgttagacag ctccacgggc accgggaaca tgacaatgaa gatttaggag
      541 actcggcaga gaaccacctc cccagacaga ggagccacag ccacgaagat gaggatggca
      601 ttgtctccag tgagtatcac cgtcacgtcc ccaggcatgc ccaccatggc cacggagagg
      661 aagatgatga cgatgatgga ggagaggagg aggagagggt ggatgtgatg gaggactctg
      721 atgataatga acaccaggtc catggtcacc agagccactc aaaggagaga gatgaactcc
      781 atcatgccca cagccacagg caccaaggcc acagtgatga tgacgatgac gatggtgtct
      841 ctactgagca tggacaccaa gctcacagat atcaggatca tgaggaggaa gacgatgggg
      901 actcagatga agacagtcac acccacagag ttcaaggccg agaagatgaa aatgatgatg
      961 aagacggtga ctctggtgaa tacagacacc atacccagga ccaccaaggc cacaacgaag
     1021 agcaagatga cgatgatgat gatgatgatg atgatgaaga taaagaagac tccactgagc
     1081 accggcacca gacccaaggc cacaggaagg aagaagatga ggatgagtca gatgaagatg
     1141 atcatcatgt ctccaggcat ggacgccaag gctatgaaga agaagaagat gatgatgatg
     1201 atgatggaga tgatgactct actgagcatg tgcatcaagc ccacagacac agagaccatg
     1261 agcacaaaga tgatgaggat gactcagaag aagactacca tcatgtcccc agccatggcc
     1321 gccaaagcca ccaaaatgag gaagaggaag atgaggctgt atccactgaa cactggcacc
     1381 agtctcctag acatgctcac catgatcttg gacgtgagag tgaagaagag gtagcagtca
     1441 agtacagcca ccatgttgca agccaccgtc cccaaggcca caatgctgac agggaggagg
     1501 actctctaga agaacacatg aatgaagtcc caggccatca ccaccacaga gcctccaggg
     1561 gtgatgatga ggacatttct actgagtttg gccacaaggc ccccagccac aggctacaag
     1621 atcaagatga aagggcgagg cagggtcaca gagagcctgt tcagggagag attgctcatc
     1681 agcccctgca acccacagga cccagttcaa gagaatcaag gaaggaaggt gaccacagct
     1741 ctcaagaggg agatgaagac ccagagcaga ggcaagccca tagtgaggag gagaaggagg
     1801 aggaggagga ggaggaggag gaggaggagg aggagaaaga ggggggccat agcctcccca
     1861 tgagccagga agatgatgaa gaggaagaaa aagatgagaa agaaagcaag gtagacaggg
     1921 ctgcagtttc agctccactg agccatcata ggaagcaggg ggaggaagag gaggaggaag
     1981 aggaggagga agaggaggag atcctggagg aaaacctact acctttcacc attatcccaa
     2041 acccactcgc tgggagagag gtggccagag aaggttccag tgaagaggag agccgtgagg
     2101 tcacaggtca gcaggatgcc caggagtacg aaaattacca gccagggtct ttgtgtggct
     2161 actgttcttt ctgcaaccga tgtaccgaat gtgaaagctg tcactgtgat gaggagaaca
     2221 tgggggaaca ctgtgaccag tgtcagcact gtcaattctg ctacctctgt ccgctggtgt
     2281 gtgacacgct ctgcactcca ggaagctacg ttgactattt ctcctcctct ctgtatcaag
     2341 ccctggctga catgttggag actccagagc cctgacctgg ccgcctggca agagctgcat
     2401 ctatttcttt gaataaatgt gctcctagaa aaaaaaaaaa aaa
//
