LOCUS       NM_001130443            1153 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus Harvey rat sarcoma virus oncogene (Hras), transcript
            variant 3, mRNA.
ACCESSION   NM_001130443
VERSION     NM_001130443.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1153)
  AUTHORS   Pundlik,S.S., Barik,A., Venkateshvaran,A., Sahoo,S.S.,
            Jaysingh,M.A., Math,R.G.H., Lal,H., Hashmi,M.A. and Ramanathan,A.
  TITLE     Senescent cells inhibit mouse myoblast differentiation via the
            SASP-lipid 15d-PGJ2 mediated modification and control of HRas
  JOURNAL   Elife 13, 95229 (2024)
   PUBMED   39196610
  REMARK    GeneRIF: Senescent cells inhibit mouse myoblast differentiation via
            the SASP-lipid 15d-PGJ2 mediated modification and control of HRas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1153)
  AUTHORS   Holl,D., Hau,W.F., Julien,A., Banitalebi,S., Kalkitsas,J.,
            Savant,S., Llorens-Bobadilla,E., Herault,Y., Pavlovic,G.,
            Amiry-Moghaddam,M., Dias,D.O. and Goritz,C.
  TITLE     Distinct origin and region-dependent contribution of stromal
            fibroblasts to fibrosis following traumatic injury in mice
  JOURNAL   Nat Neurosci 27 (7), 1285-1298 (2024)
   PUBMED   38849523
REFERENCE   3  (bases 1 to 1153)
  AUTHORS   Fuentes-Mateos,R., Garcia-Navas,R., Fernandez-Infante,C.,
            Hernandez-Cano,L., Calzada-Nieto,N., Juan,A.O., Guerrero,C.,
            Santos,E. and Fernandez-Medarde,A.
  TITLE     Combined HRAS and NRAS ablation induces a RASopathy phenotype in
            mice
  JOURNAL   Cell Commun Signal 22 (1), 332 (2024)
   PUBMED   38886790
  REMARK    GeneRIF: Combined HRAS and NRAS ablation induces a RASopathy
            phenotype in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1153)
  AUTHORS   Li,G., Liu,X., Sun,X., Huang,L., Kuang,W., Ou,J., Zhang,J.,
            Zhang,Z., Li,H., Tang,H., Feng,C., Gu,L., Yang,C., Peili,W. and
            Wang,J.
  TITLE     Polystyrene microplastics induce anxiety via HRAS derived
            PERK-NF-kappaB pathway
  JOURNAL   Environ Int 185, 108543 (2024)
   PUBMED   38452464
  REMARK    GeneRIF: Polystyrene microplastics induce anxiety via HRAS derived
            PERK-NF-kappaB pathway.
REFERENCE   5  (bases 1 to 1153)
  AUTHORS   Gallini,S., Annusver,K., Rahman,N.T., Gonzalez,D.G., Yun,S.,
            Matte-Martone,C., Xin,T., Lathrop,E., Suozzi,K.C., Kasper,M. and
            Greco,V.
  TITLE     Injury prevents Ras mutant cell expansion in mosaic skin
  JOURNAL   Nature 619 (7968), 167-175 (2023)
   PUBMED   37344586
REFERENCE   6  (bases 1 to 1153)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (bases 1 to 1153)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   8  (bases 1 to 1153)
  AUTHORS   Gollahon,L.S. and Aldaz,C.M.
  TITLE     Chromosomal localization of the rat Harvey-ras-1 gene (HRAS) by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 61 (2), 123-124 (1992)
   PUBMED   1395719
REFERENCE   9  (bases 1 to 1153)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   10 (bases 1 to 1153)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108908.16.
            
            On Sep 30, 2022 this sequence version replaced NM_001130443.1.
            
            Transcript Variant: This variant (3) differs in the 3' UTR,
            compared to variant 1, and encodes isoform 1. Variants 1 and 3-7
            all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO718230.1, CX239964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC108908.16        55320-55439
            121-272             AC108908.16        56298-56449
            273-451             AC108908.16        56659-56837
            452-611             AC108908.16        56989-57148
            612-1153            AC108908.16        57812-58353
FEATURES             Location/Qualifiers
     source          1..1153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.48 cM"
     gene            1..1153
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /note="Harvey rat sarcoma virus oncogene"
                     /db_xref="GeneID:15461"
                     /db_xref="MGI:MGI:96224"
     exon            1..120
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /inference="alignment:Splign:2.1.0"
     exon            121..272
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..731
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     GTPase HRas; H-ras 1 protein; transforming protein P21;
                     c-Ha-ras transgene; c-Ha-ras p21 protein; p21ras; H-Ras-1;
                     Harvey rat sarcoma virus oncogene 1"
                     /codon_start=1
                     /product="GTPase HRas isoform 1"
                     /protein_id="NP_001123915.1"
                     /db_xref="CCDS:CCDS22003.1"
                     /db_xref="GeneID:15461"
                     /db_xref="MGI:MGI:96224"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKR
                     VKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV
                     REIRQHKLRKLNPPDESGPGCMSCKCVLS"
     exon            273..451
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /inference="alignment:Splign:2.1.0"
     exon            452..611
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /inference="alignment:Splign:2.1.0"
     exon            612..1153
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1131..1136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /note="hexamer: AGTAAA"
     polyA_site      1153
                     /gene="Hras"
                     /gene_synonym="c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras;
                     Harvey-ras; Hras-1; Hras1; Kras2; ras"
                     /note="major polyA site"
ORIGIN      
        1 gcagcccgag ccgcacccgc cgcggacgga gctcatgcgc gggcccagcc ggcgcccgtc
       61 cgcgcccccg ccctgccccg gccccggccc cggccccggg ggcagtcgcg ccagcaagcg
      121 gtggggcagg agctcctgga ttggcagccg ctgtagaagc tatgacagaa tacaagcttg
      181 tggtggtggg cgctggaggc gtgggaaaga gtgccctgac catccagctg atccagaacc
      241 actttgtgga cgagtatgat cccactatag aggactccta ccggaaacag gtggtcattg
      301 atggggagac atgtctactg gacatcttag acacagcagg tcaagaagag tatagtgcca
      361 tgcgggacca gtacatgcgc acaggggagg gcttcctctg tgtatttgcc atcaacaaca
      421 ccaagtcctt cgaggacatc catcagtaca gggagcagat caagcgggtg aaagattcag
      481 atgatgtgcc aatggtgctg gtgggcaaca agtgtgacct ggctgctcgc actgttgagt
      541 ctcggcaggc ccaggacctt gctcgcagct atggcatccc ctacattgaa acatcagcca
      601 agacccggca gggcgtggag gatgccttct atacactagt ccgtgagatt cggcagcata
      661 aattgcggaa actgaaccca cccgatgaga gtggtcctgg ctgcatgagc tgcaaatgtg
      721 tgctgtcctg acaccaggtg aggcagggac cagcgagacg tctggggcag tgacctcagc
      781 tagccagatg aacttcatat ccactctgat gtccttgctc ccccaattct gccaatcccc
      841 cccgcctgca gtcagtcatg tcctttgtgc ccgtcccggc acaggctcag gacatggagg
      901 tgccggatgc agggaggagg tgccgacgga aggaaggaaa gaggcgggaa ggaaggaaac
      961 ggtgctggag ccaggccagt ccagggatgg tggacagatg tgaccaagac cttcgcatgg
     1021 acaatttgaa cagactgtca tgaactgtcc ctgttgccac tggcacccaa gtcctccacc
     1081 cctctcagtt ccctccgggc gcctgcctgt gagggcacac gttgcatcac agtaaattat
     1141 ttgatggtct tga
//
