LOCUS       NM_001379479            5708 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus lysine demethylase and nuclear receptor corepressor
            (Hr), transcript variant 1, mRNA.
ACCESSION   NM_001379479 XM_011244966
VERSION     NM_001379479.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5708)
  AUTHORS   Wang,Y., Li,Q., Ding,Y., Luo,C., Yang,J., Wang,N., Jiang,N.,
            Yao,T., Wang,G., Shi,G. and Hou,S.X.
  TITLE     Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate
            Anti-Tumor Immunity
  JOURNAL   Adv Sci (Weinh) 11 (39), e2404442 (2024)
   PUBMED   39225354
REFERENCE   2  (bases 1 to 5708)
  AUTHORS   Wang,Q., Song,X., Zhang,Y., Liang,S., Zhang,M., Wang,H., Feng,Y.,
            Li,R., Ding,H., Chen,Y., Xia,W., Dong,G., Xu,L., Mao,Q. and
            Jiang,F.
  TITLE     A pro-metastatic tRNA fragment drives aldolase A oligomerization to
            enhance aerobic glycolysis in lung adenocarcinoma
  JOURNAL   Cell Rep 43 (8), 114550 (2024)
   PUBMED   39058593
REFERENCE   3  (bases 1 to 5708)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
REFERENCE   4  (bases 1 to 5708)
  AUTHORS   Wang,H., Guo,H., Zhu,K., He,L. and Yang,J.J.
  TITLE     Hairless (Hr) Deficiency Mitigates High-Fat Diet-Induced Obesity
            and Insulin Resistance in Mice
  JOURNAL   Adv Biol (Weinh) 8 (6), e2300635 (2024)
   PUBMED   38655702
  REMARK    GeneRIF: Hairless (Hr) Deficiency Mitigates High-Fat Diet-Induced
            Obesity and Insulin Resistance in Mice.
REFERENCE   5  (bases 1 to 5708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5708)
  AUTHORS   Wen,Y., Liu,Y., Xu,Y., Zhao,Y., Hua,R., Wang,K., Sun,M., Li,Y.,
            Yang,S., Zhang,X.J., Kruse,R., Cichon,S., Betz,R.C., Nothen,M.M.,
            van Steensel,M.A., van Geel,M., Steijlen,P.M., Hohl,D., Huber,M.,
            Dunnill,G.S., Kennedy,C., Messenger,A., Munro,C.S., Terrinoni,A.,
            Hovnanian,A., Bodemer,C., de Prost,Y., Paller,A.S., Irvine,A.D.,
            Sinclair,R., Green,J., Shang,D., Liu,Q., Luo,Y., Jiang,L.,
            Chen,H.D., Lo,W.H., McLean,W.H., He,C.D. and Zhang,X.
  TITLE     Loss-of-function mutations of an inhibitory upstream ORF in the
            human hairless transcript cause Marie Unna hereditary hypotrichosis
  JOURNAL   Nat Genet 41 (2), 228-233 (2009)
   PUBMED   19122663
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
REFERENCE   7  (bases 1 to 5708)
  AUTHORS   Cumming,R.B., Walton,M.F., Fuscoe,J.C., Taylor,B.A., Womack,J.E.
            and Gaertner,F.H.
  TITLE     Genetics of formamidase-5 (brain formamidase) in the mouse:
            localization of the structural gene on chromosome 14
  JOURNAL   Biochem Genet 17 (5-6), 415-431 (1979)
   PUBMED   92985
REFERENCE   8  (bases 1 to 5708)
  AUTHORS   Pottathil,R., Meier,H. and Huebner,R.J.
  TITLE     Suppression of leukemogenesis in hairless mice by anti-type C viral
            immune gamma globulins
  JOURNAL   Naturwissenschaften 65 (8), 443-444 (1978)
   PUBMED   213736
REFERENCE   9  (bases 1 to 5708)
  AUTHORS   Hiai,H., Morrissey,P., Khiroya,R. and Schwartz,R.S.
  TITLE     Selective expression of xenotropic virus in congenic HRS/J
            (hairless) mice
  JOURNAL   Nature 270 (5634), 247-249 (1977)
   PUBMED   201855
REFERENCE   10 (bases 1 to 5708)
  AUTHORS   Heiniger,H.J., Huebner,R.J. and Meier,H.
  TITLE     Effect of allelic substitutions at the hairless locus on endogenous
            ecotropic murine leukemia virus titers and leukemogenesis
  JOURNAL   J Natl Cancer Inst 56 (5), 1073-1074 (1976)
   PUBMED   186616
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122268.5.
            
            On Apr 6, 2020 this sequence version replaced XM_011244966.2.
            
            Summary: This gene encodes a protein that is involved in hair
            growth. This protein functions as a transcriptional corepressor of
            multiple nuclear receptors, including thyroid hormone receptor, the
            retinoic acid receptor-related orphan receptors and the vitamin D
            receptors, and it interacts with histone deacetylases. The
            translation of this protein is modulated by a regulatory ORF that
            exists upstream of the primary ORF. Mutations in this upstream ORF,
            U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an
            autosomal dominant form of genetic hair loss in human. [provided by
            RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z32675.1, AY312855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-874               AC122268.5         178557-179430
            875-1527            AC122268.5         180671-181323
            1528-2308           AC122268.5         181952-182732
            2309-2459           AC122268.5         183962-184112
            2460-2650           AC122268.5         184196-184386
            2651-2815           AC122268.5         186135-186299
            2816-2905           AC122268.5         187652-187741
            2906-3021           AC122268.5         187890-188005
            3022-3103           AC122268.5         189625-189706
            3104-3267           AC122268.5         190352-190515
            3268-3504           AC122268.5         190633-190869
            3505-3670           AC122268.5         191103-191268
            3671-3740           AC122268.5         191472-191541
            3741-3871           AC122268.5         191825-191955
            3872-3991           AC122268.5         192099-192218
            3992-4107           AC122268.5         192300-192415
            4108-4272           AC122268.5         195701-195865
            4273-4401           AC122268.5         196231-196359
            4402-5708           AC122268.5         196565-197871
FEATURES             Location/Qualifiers
     source          1..5708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..5708
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /note="lysine demethylase and nuclear receptor
                     corepressor"
                     /db_xref="GeneID:15460"
                     /db_xref="MGI:MGI:96223"
     exon            1..874
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1527
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     CDS             916..4464
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /EC_number="1.14.11.65"
                     /note="protein hairless; [histone H3]-dimethyl-L-lysine(9)
                     demethylase hairless"
                     /codon_start=1
                     /product="lysine-specific demethylase hairless"
                     /protein_id="NP_001366408.1"
                     /db_xref="GeneID:15460"
                     /db_xref="MGI:MGI:96223"
                     /translation="MESMPSFLKDTPAWEKTAPVNGIVGQEPGTSPQDGLRHGALCLG
                     EPAPFWRGVLSTPDSWLPPGFLQGPKDTLSLVEGEGPRNGERKGSWLGGKEGLRWKEA
                     MLAHPLAFCGPACPPRYGPLIPEHSGGHPKSDPVAFRPLHCPFLLETKILERAPFWVP
                     TCLPPYLMSSLPPERPYDWPLAPNPWVYSGSQPKVPSAFGLGSKGFYHKDPNILRPAK
                     EPLAESGMLGLAPGGHLQQACESEGPSLHQRDGETGAGRQQNLCPVFLGYPDTVPRAP
                     WPSCPPGLVHSLGNIWAGPGSNSLGYQLGPPATPRCPSPGPPTPPGGCCSSHLPAREG
                     DLGPCRKCQDSPEGGSSGPGESSEERNKADSRACPPSHHTKLKKTWLTRHSEQFECPG
                     GCSGKEESPATGLRALKRAGSPEVQGASRGPAPKRPSHPFPGTGRQGARAWQETPETI
                     IGSKAEAEQQEEQRGPRDGRIRLQESRLVDTSCQHHLAGVTQCQSCVQAAGEVGVLTG
                     HSQKSRRSPLEEKQLEEEDSSATSEEGGGGPGPEASLNKGLAKHLLSGLGDRLCRLLR
                     KEREALAWAQREGQGPAMTEDSPGIPHCCSRCHHGLFNTHWRCSHCSHRLCVACGRIA
                     GAGKNREKTGSQEQHTDDCAQEAGHAACSLILTQFVSSQALAELSTVMHQVWAKFDIR
                     GHCFCQVDARVWAPGDGGQQKEPTEKTPPTPQPSCNGDSNRTKDIKEETPDSTESPAE
                     DGAGRSPLPCPSLCELLASTAVKLCLGHDRIHMAFAPVTPALPSDDRITNILDSIIAQ
                     VVERKIQEKALGPGLRAGSGLRKGLSLPLSPVRTRLSPPGALLWLQEPRPKHGFHLFQ
                     EHWRQGQPVLVSGIQKTLRLSLWGMEALGTLGGQVQTLTALGPPQPTNLDSTAFWEGF
                     SHPETRPKLDEGSVLLLHRTLGDKDASRVQNLASSLPLPEYCAHQGKLNLASYLPLGL
                     TLHPLEPQLWAAYGVNSHRGHLGTKNLCVEVSDLISILVHAEAQLPPWYRAQKDFLSG
                     LDGEGLWSPGSQTSTVWHVFRAQDAQRIRRFLQMVCPAGAGTLEPGAPGSCYLDAGLR
                     RRLREEWGVSCWTLLQAPGEAVLVPAGAPHQVQGLVSTISVTQHFLSPETSALSAQLY
                     HQGASLPPDHRMLYAQMDRAVFQAVKAAVGALQEAK"
     exon            1528..2308
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2459
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2650
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2815
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2905
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3021
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3103
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3267
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3504
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3670
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3740
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3871
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..3991
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            3992..4107
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            4108..4272
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4401
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..5708
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5683..5688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /note="hexamer: AATAAA"
     polyA_site      5708
                     /gene="Hr"
                     /gene_synonym="ALUNC; bldy; rh-bmh"
                     /note="major polyA site"
ORIGIN      
        1 agttcccggg cttggcacct atagtggggg tgctgcccgc ctgccaggct ccgggccggg
       61 cccacgggag ggtggggcgg ctgggaagct ggcacactgc cccaggggag cctctctcgg
      121 caggcgcccg ggtgccgcgg gggggagggg ggaacaaagg gctcattctc cccgtgcgca
      181 gccggtggca tcgccggggc gttggcggaa gcccccgggg ctcagaaggg ggcaggccca
      241 ggcggggccg ccgaatcacg ggctcctgtt tcccgcaggg tgctggagga ggaaaccggc
      301 ggagcagctt ccccactctc agttgcgcgt ctggcgatgg cgatcagagg tcctgctgcg
      361 ctctccgctg cgctctccct ccattagccg cgctacgcgg tgctgcgccc tcgctggtgc
      421 ctcgctcctg gctcacagga tcggcccccc acttccaggc acgaccccct tccccggccc
      481 ctcggccttt ccccccactc agccatctcc gacccggggc gcgcgttccc cccggcccgg
      541 atccttctct ccctccgggg acacccgctc cctagccccg gctcgaccct ccccaaagcg
      601 cagcacggag tctcggcgtc ccatggcgca acccacagcc ttggcccaga agctggtgcg
      661 gcccatccgc gccgtgtgcc gcatcctgca aattccggag tccgacccct ccaacctgcg
      721 gccctagagc gcccccgacg cccgggggga aagagagcgc gagagcgctg agcagaaagc
      781 gggagaacgc cccgaagccg gcccatgggg agcgagtacc cagcaccggc tagcacgacc
      841 gccgcccaca ccgcgcccgg cctgtgaagc ccaggacccc cctccccggg agaggcccat
      901 gagggcagga gagtgatgga gagtatgccc agcttcctga aggacacccc agcctgggag
      961 aagacagccc ctgtgaacgg cattgtggga caggagcctg gtacctcacc acaggatggc
     1021 ttgcgccatg gggcactgtg cctaggagaa cctgctccct tttggagggg tgttctgagc
     1081 accccagact cctggctccc tcctggcttc ctccaaggcc ccaaggacac actctcactg
     1141 gtggagggtg agggtcctcg gaacggggag aggaagggca gctggctagg cggcaaggaa
     1201 ggactgcgct ggaaggaagc gatgctggcc catccactgg ccttttgtgg gccggcatgc
     1261 ccacctcgct atgggcccct gatacctgag catagtggtg gccatcccaa gagtgaccct
     1321 gtggccttcc ggcccttgca ctgccctttc ctgctggaga ccaagattct agagcgagct
     1381 cccttctggg ttcctacctg cttgcctccc tacctgatgt ccagcctgcc cccagagcgt
     1441 ccatatgact ggcctttggc cccaaaccca tgggtatact ctgggagcca gccaaaagtg
     1501 ccctctgcct ttggcttagg cagcaagggc ttttaccaca aggatccgaa catcctcagg
     1561 ccagcaaagg agcccttggc agagtctggg atgttgggct tagcccctgg tgggcatctc
     1621 cagcaagcct gtgaatcaga aggcccctca cttcaccaga gggatgggga gacaggagct
     1681 ggcaggcagc agaatctttg cccagttttc ttggggtacc cagacactgt tcctcgggcc
     1741 ccctggcctt cttgtccccc aggcctggtt cacagtcttg gcaacatttg ggctgggcca
     1801 ggaagtaata gccttgggta ccaactagga ccaccagcca caccaaggtg cccatctcct
     1861 gggcctccta cccctccagg gggctgttgc tcatcccatc tacctgccag agagggggat
     1921 cttggccctt gtaggaaatg ccaggatagc ccagagggag gtagcagtgg gccaggggaa
     1981 tccagtgaag aaaggaacaa agctgattcc agggcctgtc ccccaagcca tcacaccaag
     2041 ctgaaaaaga cctggctcac acgccactcg gaacagtttg agtgcccagg tggctgttca
     2101 gggaaggaag agagcccagc cactgggctc cgggcactca agagggcagg cagtccagag
     2161 gtccaaggag catcaagggg cccagctccc aaacgcccat cccacccttt cccaggcact
     2221 gggaggcagg gggccagggc ttggcaggag acaccggaga caatcatagg aagcaaggcg
     2281 gaggcagagc aacaagagga acagagaggg ccccgagatg gcaggattag gctccaggag
     2341 tccagacttg tggatacatc ctgccagcat cacttagcag gtgtcaccca gtgccaaagc
     2401 tgtgtccagg cagctggaga ggtaggggta ctgaccggcc actcccagaa atcacgtagg
     2461 tcacccctgg aggagaagca gttggaggag gaggattcct ctgccacttc cgaagaagga
     2521 ggaggagggc ctggcccaga agcttcactc aacaagggcc tggccaagca cctgctgagt
     2581 ggtttggggg accgactctg ccgcctgctg cggaaggagc gggaggccct tgcctgggca
     2641 cagcgagaag gccaggggcc agccatgaca gaggacagcc caggcattcc acattgctgc
     2701 agtcgatgcc accacggact cttcaacacc cactggagat gttcccactg tagccaccgg
     2761 ctgtgtgtag cctgtggtcg catagccggt gctggaaaga acagggagaa aacaggttct
     2821 caggaacagc acacagatga ctgcgcccag gaggctgggc atgctgcctg ttccctgatc
     2881 ctgacccagt ttgtctccag ccaggcgctg gcagaactga gcactgtgat gcaccaagtc
     2941 tgggccaagt ttgacattcg ggggcactgt ttctgccagg ttgatgcccg tgtgtgggcc
     3001 cccggggatg ggggtcagca gaaggaacca acagagaaaa ctcccccaac tccacaacct
     3061 tcctgcaatg gagattccaa tcggaccaag gacatcaaag aagagacccc agactccact
     3121 gagagcccag cagaggatgg tgctggccgg tcaccccttc cttgtccctc tctctgtgag
     3181 ctgctagcct ctactgctgt caaactctgc ctggggcatg accggattca catggccttt
     3241 gctccggtca ccccagctct gcccagtgat gaccgcatta ccaacatcct ggacagcatt
     3301 attgcgcagg tagtagaacg gaagatccaa gagaaagccc tggggccagg cctgcgagca
     3361 gggtcaggct tacgcaaggg cctgagcctt ccattgtcac cagtgcgaac ccggctgtct
     3421 cctcctggag ctttgctgtg gctgcaggag cccaggccta agcatggctt ccatctcttc
     3481 caggaacact ggcggcaggg ccagcccgtg ttagtgtcag gcatccagaa gacattgaga
     3541 cttagcctgt ggggaatgga agcccttggg acacttggtg gccaggtgca gacactgact
     3601 gcccttgggc ctccccagcc cacaaacctg gacagcacag cattctggga gggattctct
     3661 catcctgaga cacgtccaaa gttagatgag ggctctgtcc tcctgctaca ccgaaccctg
     3721 ggggataagg acgctagcag ggtgcagaac cttgcctcca gccttccact cccagaatac
     3781 tgtgcccacc aagggaaact caacctagcg tcctacctcc ccctgggcct cacactgcat
     3841 ccactggagc cccagctctg ggcggcctat ggtgtgaact cacaccgtgg acacctgggg
     3901 accaagaatc tatgcgtgga ggtgtctgac ctaatcagta tcctggtgca cgccgaggcc
     3961 cagctgcctc cctggtatcg agcacagaaa gatttcctct caggcctgga tggggaagga
     4021 ctctggtctc cagggagcca gaccagcact gtgtggcatg tgttccgggc ccaggatgcc
     4081 cagcgcatcc gtcgctttct ccagatggtg tgcccagctg gagcaggaac cttggagcct
     4141 ggtgccccag gcagctgcta cttggatgca gggttgcgcc gacggctaag agaagagtgg
     4201 ggtgtgagct gctggaccct gctgcaggct cctggggaag cggtgctggt cccggctggg
     4261 gcgccccatc aggtgcaggg cctggtgagc acaatcagtg tcactcagca ctttctgtct
     4321 cctgagacct ctgccctctc tgctcagctc taccaccagg gagccagcct accccctgac
     4381 caccgtatgc tttatgccca gatggaccgg gctgtgttcc aagcagtaaa ggcggctgtg
     4441 ggggcgttac aggaagctaa ataggggatc ctggtgcctg gaggggtggt gggtaggtaa
     4501 ccgagtgtcc agtctgcata atatcaacag ggaatgaatg gtactgggga acttagacgg
     4561 tgtggtccgt tctacaaata tctctttggg cacaagcagg gaaccttgtt cctcgtcctg
     4621 gccctggctc taaagggaac aactgtaatg cttacagctg cccccctctc catggtatca
     4681 ggttcatgct aggggtatat gatcccttct aacccctgca ctccacccca ggggatgaac
     4741 atccttcctt ggggaagctt gggattgttt tggtttaagc aacacttccc cttgctgctt
     4801 tatcctgtgt tgcccctggc accccaccct caccccagct cacaccaaca tccacacaaa
     4861 gcccttctga ctctgtaggt ctactggacc gggagccaca gaattcttcc cttatagaag
     4921 agctgtggag ttggggaagg gagggcctca gttaatgggc cagactggct ggagggaaga
     4981 acatgggcag aaccactggg ccctgcttct gcctctctcc tctctctcct tcccggtctc
     5041 tattaaaatc ggttgtctgg tgactgctgc cagcagtagt tggccttact ctgccagcca
     5101 cgtgggctag ggaaagaagg cgaatgcaga aatctgatct ggagcagaag ccagtggaca
     5161 gggtgagcag ggactgggga cctagtggca gagacctcaa ataccactgc cagatctttg
     5221 ggaggcctgg acccctggag cttcctggga ctgaagatat tcttgactga cagcggaaag
     5281 tggagttcta aggtgcagca ctcagatggc ctccctgggt ggcatcaacc tgtggagatt
     5341 acggaacccc ctgcctctgt cccacctatc ctgtgtgctc tgacctggag agacgtccag
     5401 gatagccctg gctcatccca actcctctta gtgtccaagc ccccaggaca gagcctcact
     5461 gcctccgaca gctgacccct cccccatggc ccttctggtg ccaacagctg acccctcccc
     5521 tcatggtcct tctggtgcca acagctgacc cctcccccca tggcccttct ggtactgctt
     5581 ttgccttcct acctcttcct ctgtgtatct caactgcaca cgtgcgccag ctcttgttat
     5641 acttaacagt tcctgctgtg gtttggggat tttttttaat taaataaaag tttttattat
     5701 aaatagaa
//
