LOCUS       NM_017371               1489 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus hemopexin (Hpx), mRNA.
ACCESSION   NM_017371
VERSION     NM_017371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   Ramos,S., Jeney,V., Figueiredo,A., Paixao,T., Sambo,M.R.,
            Quinhentos,V., Martins,R., Gouveia,Z., Carlos,A.R., Ferreira,A.,
            Pais,T.F., Laine,H., Faisca,P., Rebelo,S., Cardoso,S., Tolosano,E.,
            Penha-Goncalves,C. and Soares,M.P.
  TITLE     Targeting circulating labile heme as a defense strategy against
            malaria
  JOURNAL   Life Sci Alliance 7 (4), e202302276 (2024)
   PUBMED   38307624
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Greite,R., Schott,S., Wang,L., Gohlke,L., Kreimann,K., Derlin,K.,
            Gutberlet,M., Schmidbauer,M., Leffler,A., Tudorache,I., Salman,J.,
            Ius,F., Natanov,R., Fegbeutel,C., Haverich,A., Lichtinghagen,R.,
            Husing,A.M., von Vietinghoff,S., Schmitt,R., Shushakova,N.,
            Rong,S., Haller,H., Schmidt-Ott,K.M., Gram,M., Vijayan,V.,
            Scheffner,I., Gwinner,W. and Immenschuh,S.
  TITLE     Free heme and hemopexin in acute kidney injury after
            cardiopulmonary bypass and transient renal ischemia
  JOURNAL   Clin Transl Sci 16 (12), 2729-2743 (2023)
   PUBMED   37899696
  REMARK    GeneRIF: Free heme and hemopexin in acute kidney injury after
            cardiopulmonary bypass and transient renal ischemia.
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Seika,P., Janikova,M., Asokan,S., Janovicova,L., Csizmadia,E.,
            O'Connell,M., Robson,S.C., Glickman,J. and Wegiel,B.
  TITLE     Free heme exacerbates colonic injury induced by anti-cancer therapy
  JOURNAL   Front Immunol 14, 1184105 (2023)
   PUBMED   37342339
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1489)
  AUTHORS   Liu,J., Lane,S., Lall,R., Russo,M., Farrell,L., Debreli Coskun,M.,
            Curtin,C., Araujo-Gutierrez,R., Scherrer-Crosbie,M.,
            Trachtenberg,B.H., Kim,J., Tolosano,E., Ghigo,A., Gerszten,R.E. and
            Asnani,A.
  TITLE     Circulating hemopexin modulates anthracycline cardiac toxicity in
            patients and in mice
  JOURNAL   Sci Adv 8 (51), eadc9245 (2022)
   PUBMED   36563141
REFERENCE   5  (bases 1 to 1489)
  AUTHORS   Nagase,T. and Tohda,C.
  TITLE     Skeletal muscle atrophy-induced hemopexin accelerates onset of
            cognitive impairment in Alzheimer's disease
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (6), 2199-2210 (2021)
   PUBMED   34658156
  REMARK    GeneRIF: Skeletal muscle atrophy-induced hemopexin accelerates
            onset of cognitive impairment in Alzheimer's disease.
REFERENCE   6  (bases 1 to 1489)
  AUTHORS   Vinchi,F., Gastaldi,S., Silengo,L., Altruda,F. and Tolosano,E.
  TITLE     Hemopexin prevents endothelial damage and liver congestion in a
            mouse model of heme overload
  JOURNAL   Am J Pathol 173 (1), 289-299 (2008)
   PUBMED   18556779
  REMARK    GeneRIF: the importance of hemopexin in heme detoxification, thus
            suggesting that drugs mimicking hemopexin activity might be useful
            to prevent endothelial damage in patients suffering from hemolytic
            disorders.
REFERENCE   7  (bases 1 to 1489)
  AUTHORS   Tolosano,E., Fagoonee,S., Hirsch,E., Berger,F.G., Baumann,H.,
            Silengo,L. and Altruda,F.
  TITLE     Enhanced splenomegaly and severe liver inflammation in
            haptoglobin/hemopexin double-null mice after acute hemolysis
  JOURNAL   Blood 100 (12), 4201-4208 (2002)
   PUBMED   12393471
  REMARK    GeneRIF: haptoglobin and hemopexin together are essential for
            protection from splenomegaly and liver fibrosis resulting from
            intravascular hemolysis
REFERENCE   8  (bases 1 to 1489)
  AUTHORS   McKie,A.T., Barrow,D., Latunde-Dada,G.O., Rolfs,A., Sager,G.,
            Mudaly,E., Mudaly,M., Richardson,C., Barlow,D., Bomford,A.,
            Peters,T.J., Raja,K.B., Shirali,S., Hediger,M.A., Farzaneh,F. and
            Simpson,R.J.
  TITLE     An iron-regulated ferric reductase associated with the absorption
            of dietary iron
  JOURNAL   Science 291 (5509), 1755-1759 (2001)
   PUBMED   11230685
REFERENCE   9  (bases 1 to 1489)
  AUTHORS   Tolosano,E., Hirsch,E., Patrucco,E., Camaschella,C., Navone,R.,
            Silengo,L. and Altruda,F.
  TITLE     Defective recovery and severe renal damage after acute hemolysis in
            hemopexin-deficient mice
  JOURNAL   Blood 94 (11), 3906-3914 (1999)
   PUBMED   10572107
REFERENCE   10 (bases 1 to 1489)
  AUTHORS   Tolosano,E., Cutufia,M.A., Hirsch,E., Silengo,L. and Altruda,F.
  TITLE     Specific expression in brain and liver driven by the hemopexin
            promoter in transgenic mice
  JOURNAL   Biochem Biophys Res Commun 218 (3), 694-703 (1996)
   PUBMED   8579576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY088352.1, AK145928.1 and AA985967.1.
            
            On Nov 16, 2007 this sequence version replaced NM_017371.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011246.1, AK145928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY088352.1         2-4
            4-1468              AK145928.1         2-1466
            1469-1489           AA985967.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.91 cM"
     gene            1..1489
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /note="hemopexin"
                     /db_xref="GeneID:15458"
                     /db_xref="MGI:MGI:105112"
     exon            1..109
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            110..168
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            169..240
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            241..359
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            360..513
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            514..726
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            727..855
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            856..986
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1149
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1480
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1452..1457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /note="hexamer: AATAAA"
     polyA_site      1480
                     /gene="Hpx"
                     /gene_synonym="Hpxn; hx"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgtgtg gcctttgcag ctcagcatgg ctaggacagc agtggcgcta aatatcctgg
       61 tgttgctggg cctgtgctgg tccctggctg ttgccagccc tcttcctact gccaacggga
      121 gagttgccga agttgaaaat gggaccaagc cagattcaga tgtacccgaa cactgcttgg
      181 atacctggag ctttgatgct gcgaccatgg atcacaatgg gaccatgctg ttctttaaag
      241 gggagtttgt gtggaggggt cactcaggga cccgggagtt gatctcagcg aggtggaaga
      301 atcccatcac ctcagtggat gctgcattcc gtggtcctga cagtgtcttc ctgatcaagg
      361 aagacaaagt ctgggtgtac cctcctgaaa agaaggaaaa cgggtatcca aagttgttcc
      421 aagaagagtt tcctggaatc ccatacccac cagacgcagc tgtggaatgc caccgtggag
      481 agtgccagag tgaaggcgtc cttttcttcc aaggtaaccg caagtggttc tgggactttg
      541 ccacaagaac ccaaaaggaa cgttcctggt caactgttgg gaattgcact gcggccttga
      601 ggtggcttga acgctactac tgcttccagg gtaacaagtt cctgcgattc aaccctgtca
      661 caggagaggt gcctcccaga taccctctgg atgcccgtga ctacttcgta tcctgccctg
      721 gcagaggcca tggtagaccc agaaatggaa ctgctcatgg aaatagcacc catcctatgc
      781 attcacgttg tagcccagat cctggcctga ctgcactgct gtctgaccat cgcggtgcca
      841 cctatgcctt cactggctcc cactactggc gtctggactc cagccgtgat ggatggcata
      901 gctggcccat tgctcatcac tggcctcagg gtccttcaac agtagatgct gccttttcct
      961 gggatgataa agtctatctg atccagggca ctcaagtgta tgtcttcctg acaaagggag
     1021 gcaataacct agtaagtggt tatccaaagc ggctggagaa ggaacttggg agccctcctg
     1081 ggatcagcct tgagaccata gatgcagcct tttcctgccc tggttcttcc aggctctatg
     1141 tctcatcagg acggcggctt tggtggctgg acctgaagtc aggagcccag gcaacatgga
     1201 cagaggtttc ctggccccat gagaaagttg atggggccct gtgtttggac aagtctcttg
     1261 gccccaacac atgttcttcc aatggttcca gcttgtactt tatccatggg cccaatttgt
     1321 actgctatag cagtatagac aaactgaatg cagccaagag tctgcctcag cctcagaagg
     1381 tgaacagcat ccttggctgc agtcagtaaa gagccctgat atggcccagc ccacctctcc
     1441 attttcatcc taataaagcc agatggtttc ttcacatgaa aaaaaaaaa
//
