LOCUS       NM_001081257            4235 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus heparanase 2 (Hpse2), mRNA.
ACCESSION   NM_001081257 XM_619590
VERSION     NM_001081257.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   Kayal,Y., Barash,U., Naroditsky,I., Ilan,N. and Vlodavsky,I.
  TITLE     Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar
            cell differentiation
  JOURNAL   Cell Death Dis 14 (7), 465 (2023)
   PUBMED   37491420
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Buijsers,B., Garsen,M., de Graaf,M., Bakker-van Bebber,M., Guo,C.,
            Li,X. and van der Vlag,J.
  TITLE     Heparanase-2 protein and peptides have a protective effect on
            experimental glomerulonephritis and diabetic nephropathy
  JOURNAL   Front Pharmacol 14, 1098184 (2023)
   PUBMED   37180718
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Roberts,N.A., Hilton,E.N., Lopes,F.M., Singh,S., Randles,M.J.,
            Gardiner,N.J., Chopra,K., Coletta,R., Bajwa,Z., Hall,R.J.,
            Yue,W.W., Schaefer,F., Weber,S., Henriksson,R., Stuart,H.M.,
            Hedman,H., Newman,W.G. and Woolf,A.S.
  TITLE     Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in
            the urinary bladder
  JOURNAL   Kidney Int 95 (5), 1138-1152 (2019)
   PUBMED   30885509
  REMARK    GeneRIF: Mice with homozygous mutations in either Lrig2 or Hpse2
            had increased nerve density within the urinary bladder body and
            decreased nerve density around the urinary outflow tract.
            Observations provide evidence that a peripheral neuropathy is
            central to the pathobiology of functional bladder outlet
            obstruction in urofacial syndrome and emphasize the importance of
            LRIG2 and Hpse2 for nerve patterning in the urinary tract.
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Guo,C., Kaneko,S., Sun,Y., Huang,Y., Vlodavsky,I., Li,X., Li,Z.R.
            and Li,X.
  TITLE     A mouse model of urofacial syndrome with dysfunctional urination
  JOURNAL   Hum Mol Genet 24 (7), 1991-1999 (2015)
   PUBMED   25510506
  REMARK    GeneRIF: Deletion of Hpse2 cause the urofacial syndrome-like
            phenotype in mice.
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Stuart,H.M., Roberts,N.A., Hilton,E.N., McKenzie,E.A., Daly,S.B.,
            Hadfield,K.D., Rahal,J.S., Gardiner,N.J., Tanley,S.W., Lewis,M.A.,
            Sites,E., Angle,B., Alves,C., Lourenco,T., Rodrigues,M., Calado,A.,
            Amado,M., Guerreiro,N., Serras,I., Beetz,C., Varga,R.E.,
            Silay,M.S., Darlow,J.M., Dobson,M.G., Barton,D.E., Hunziker,M.,
            Puri,P., Feather,S.A., Goodship,J.A., Goodship,T.H., Lambert,H.J.,
            Cordell,H.J., Saggar,A., Kinali,M., Lorenz,C., Moeller,K.,
            Schaefer,F., Bayazit,A.K., Weber,S., Newman,W.G. and Woolf,A.S.
  CONSRTM   UK VUR Study Group; 4C Study Group
  TITLE     Urinary tract effects of HPSE2 mutations
  JOURNAL   J Am Soc Nephrol 26 (4), 797-804 (2015)
   PUBMED   25145936
REFERENCE   7  (bases 1 to 4235)
  AUTHORS   Daly,S.B., Urquhart,J.E., Hilton,E., McKenzie,E.A., Kammerer,R.A.,
            Lewis,M., Kerr,B., Stuart,H., Donnai,D., Long,D.A., Burgu,B.,
            Aydogdu,O., Derbent,M., Garcia-Minaur,S., Reardon,W., Gener,B.,
            Shalev,S., Smith,R., Woolf,A.S., Black,G.C. and Newman,W.G.
  TITLE     Mutations in HPSE2 cause urofacial syndrome
  JOURNAL   Am J Hum Genet 86 (6), 963-969 (2010)
   PUBMED   20560210
  REMARK    Erratum:[Am J Hum Genet. 2010 Aug 13;87(2):309]
REFERENCE   8  (bases 1 to 4235)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140375.2, AC124716.4, AC122312.3 and AC125458.3.
            
            On Dec 30, 2022 this sequence version replaced NM_001081257.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158131.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AC140375.2         78980-79319         c
            341-498             AC140375.2         75699-75856         c
            499-660             AC124716.4         28643-28804
            661-834             AC122312.3         188898-189071       c
            835-1006            AC122312.3         166963-167134       c
            1007-1054           AC122312.3         142806-142853       c
            1055-1148           AC122312.3         107414-107507       c
            1149-1255           AC122312.3         88950-89056         c
            1256-1370           AC122312.3         84472-84586         c
            1371-1516           AC125458.3         155551-155696       c
            1517-1663           AC125458.3         148961-149107       c
            1664-4235           AC125458.3         129212-131783       c
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.57 cM"
     gene            1..4235
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /note="heparanase 2"
                     /db_xref="GeneID:545291"
                     /db_xref="MGI:MGI:2685814"
     exon            1..340
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1829
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /note="inactive heparanase-2"
                     /codon_start=1
                     /product="inactive heparanase-2 precursor"
                     /protein_id="NP_001074726.1"
                     /db_xref="CCDS:CCDS37993.1"
                     /db_xref="GeneID:545291"
                     /db_xref="MGI:MGI:2685814"
                     /translation="MRVLCAFPEAMASSSSRPPSCLALVALFLALLLHLSLSFHAGNR
                     RPLPVDRATGLKEKTLILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLV
                     TLARGLSPAFLRFGGKRTDFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDK
                     QKGCKIAQHPDVMLELQREKASQMHLVLLKEQYSNTYSNLILTARSLDKLYNFADCSG
                     LHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNEPNNYRSIHGRAVNG
                     SQLGKDYIQLKSLLQPIRVYSRASLYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQ
                     HCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNN
                     LSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDYWLSLLYKR
                     LIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFIINLHRSR
                     KKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRPLRAG
                     RTLVIPPVTMGFYVVKNVNALACRYR"
     exon            341..498
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..660
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..834
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1006
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1054
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1148
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1255
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1370
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1516
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1663
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..4235
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4218..4223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /note="hexamer: ATTAAA"
     polyA_site      4235
                     /gene="Hpse2"
                     /gene_synonym="Gm968; Hpa2"
                     /note="major polyA site"
ORIGIN      
        1 agtcaccatc gagacccagt agggaaagaa gtttaaatca gagggattta atgagggtgc
       61 tctgtgcttt ccctgaagcc atggcctcca gcagctcccg ccccccctcg tgcctagccc
      121 tggtggctct cttcttggct ctgttgctcc atctctccct ctccttccac gctggaaaca
      181 ggagaccttt gcctgtagac agagctacag gtttgaagga aaagaccctg attctacttg
      241 atgtgagcac caagaaccca gtcaggacag tcaatgagaa cttcctctct ctgcagctgg
      301 atccctccat cattcatgat ggctggctcg atttcttaag ctccaagcgt ctggtgacct
      361 tggcccgggg actctcgccc gcctttctgc gcttcggggg caaaaggacg gatttcctgc
      421 agttccagaa cctgagaaat ccggcgaaaa gccgcggggg cccgggcccg gattactatc
      481 tcaaaaacta tgaggatgac attgtccgga gtgatgttgc cttggacaag cagaaaggct
      541 gtaagattgc ccagcaccct gatgtcatgc tggagctcca gagagagaag gcatcgcaga
      601 tgcatctggt tcttctgaag gagcaatact ccaatactta cagtaacctc atattaacag
      661 ccaggtctct agacaaactt tataactttg ctgattgctc tggactccac ctgatatttg
      721 ctctaaatgc actgcgtcgt aatcccaata actcctggaa cagttctagt gccctgagcc
      781 tgttgaagta cagtgccagc aaaaagtaca acatttcttg ggaactgggt aatgagccaa
      841 ataactatcg gagcatccat ggccgggcag taaatggtag ccagttggga aaggattaca
      901 tccagctgaa gagcctgctc caacccatcc gggtttactc cagagccagc ctgtacggcc
      961 ccaacatcgg acggcccagg aagaacgtca ttgctctcct agatggattc atgaaggtgg
     1021 caggaagcac agtggatgcg gttacctggc aacattgcta cattgatggc cgggtggtca
     1081 aggtgatgga cttcctgaaa actcgtctgt tagatacact ctctgaccag attaggaaaa
     1141 ttcagaaagt ggtcaacaca tacactccag gaaagaagat ttggctggaa ggcgtggtga
     1201 ccacctcagc tggaggcaca aacaatctgt cggattccta cgctgcagga ttcttatggc
     1261 taaacacttt aggaatgttg gccaatcagg gcattgatgt cgtgatacga cattcatttt
     1321 tcgaccacgg atacaaccat ctggtggacc agaattttaa cccattacca gactattggc
     1381 tttctctgct ttacaagcgt ctgattggcc ccaaagtcct ggcagtgcat gtagctgggc
     1441 tccagcggaa gcctcggcca ggaagagtca tccgagacaa actaagaatc tatgctcact
     1501 gcacaaacca ccacaaccac aactatgtcc gtggctctat cacacttttc atcatcaacc
     1561 tacatcgatc aagaaagaaa atcaaactgg ctgggactct gagggacaag ctcgtgcacc
     1621 agtatctgct gcagccctat gggcaggaag gcctaaagtc caagtcagtg cagctcaatg
     1681 gccagccctt agtgatggtg gacgacggga cccttccaga actgaagccc cgcccgctgc
     1741 gggccggccg gacattggtc atccctccag tcaccatggg cttttatgtg gtcaagaatg
     1801 tcaatgcttt ggcctgccgt tatcgataag tcaccctctg ttcctgagct actggtgggc
     1861 ctgctggact gctctctgct cttccacaca cgtagcgtcc ttattcctca gacaccttct
     1921 ttagcaacca gcctctactc ccatgctgct gggagcaaca tagactctcc aaagggagtc
     1981 taaccgtcat agtgtgagct tagtctaggt aggtggcatc tgtccgtaag gaaaaggtag
     2041 acatcctctg gtgtgtctgt ttacgcatgg acagctgaca gcaagcttcc agagcagtgt
     2101 ttgcaaacca gctgcctgcg gtcctgacca cacagcaatg taactaactg taaagcccag
     2161 gccctagcct atggctgctg ccatcagcag aggatggggg aggaagagat gggggtgcaa
     2221 ctctaatcct cttgtaactc ctcctttgtc tgtttcctgc tgctgcctcg ggtttcctga
     2281 cacctctctt cccataggga gctaatgggt gagtcagctc tggcctgctg ggtgagctgt
     2341 ttatataatt tcctggctga tgtatgagtg cgtgcatctg ggtttctgac agtggcatcc
     2401 atcactgctg gtcctctggg aacgggtgct tcgcaagtag aatgacagtc atactctaaa
     2461 gttctattcc tctggggatc tagattccct ccagctcaga atgggggtca ggtaacaata
     2521 ttcactgagt ggagagcaat gtattaggct ccacaagaag aaatcatcat tctttatgct
     2581 gctgggaggg agggagttgt agtacaaaga aaaagcacac ggaaacatca aacccaagtg
     2641 tgcgcgagca cacacacaca cacacacaca cacacacacc aatccaacaa agcaatttag
     2701 accttgccct caaactgaaa ggatttcaaa gactcaaaac agtaagaagg ccttagttgt
     2761 ctggttgacc aaaaaccatt tagaagaaga aagtatcaat gaagtcactg cagacagtcg
     2821 aacttttctg tctcttccca agtagccgag tcttagtgca ttttagggag aaagcttgaa
     2881 ggtgaccagt tccaccctac cccaggtggg tgtgcttacg catggtgcaa agtcttctgt
     2941 tggctctatt aaggaaggat gggaaactgg tctgatagca aaacagatga atgctatgtg
     3001 gagggcttct gagttgggca ggcaggagag ggacttaaag cccacgcctg ggacctttat
     3061 ttggcaacag ggtatgggag tctttggaag caagttgcag tcacacggac tttctgtgga
     3121 catggctgac ctcaggaaaa aaacaacgtg aatgatgctg ccttcaagga gaaagaggac
     3181 ccttgactct cctgggtacc agataagtca gggacactgt tttggtgtga atagacaggc
     3241 ctgggggagc agcagaggtg tgcctaagat gcctgaagaa taagggctta gtcctgtttg
     3301 caaagtgaga gacaagagga aggttagacc gcaaggtgcc caagactttc agcttggaga
     3361 gctggggatt tggtagaggg gagccaccca tctgattctc cctataagga agacagtggg
     3421 attggacttt ggggtgctta ttttcagtac agaatgagca tcacacagca gatacactag
     3481 ggcatgcaag ggcagaggac tgaagacagg ctggacccag cagcatctgg aagggtggcc
     3541 catgagactg ctcacccaga gaggctccca gggagcttcc cttctcaggc accttccatg
     3601 gaagcccagc atagcactgg aggtcggagg ggagggagga agggaaggag ggaagaagga
     3661 agagaaaaga caaacaggtg gaccaaagtc aggaagaatg tgggaggatg ggaaaggaga
     3721 cagatgggtt gttgtttttt gggttttttt gttatttgtt ttttgggttt tttttgtttt
     3781 tttttttcct tgaacatgta tcagaatctc ttctaagtac ttgtctgggg gcagctgcag
     3841 ggccgctgat aacagcaagg tgatcagagg cccttaatgc caggccccag gctagtttgc
     3901 tttacatata tagaagccgc ataataaagt tactgttgtt atcccaagca cttgtgaggc
     3961 atgggacggt cgctaggctg cccagcatca cacagtgaaa tgggttggtt tgaagaatca
     4021 tccagaacct acttagtcac caagcacagc ggcttttcct gtcaccgact tgcccctcac
     4081 ctggtggact gcttgttcgg tatagccaag acttccagag ccccacccaa acacattttc
     4141 tgtaaatagg cgttaattct tcactaagcc tcccagaatg taggtcattt tttgccgcct
     4201 ttgtcttttt tctgtgaatt aaatgctgca cccaa
//
