LOCUS       NM_152803               3140 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus heparanase (Hpse), mRNA.
ACCESSION   NM_152803 XM_982223
VERSION     NM_152803.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Nguyen,T.K., Paone,S., Baxter,A.A., Mayfosh,A.J., Phan,T.K.,
            Chan,E., Peter,K., Poon,I.K.H., Thomas,S.R. and Hulett,M.D.
  TITLE     Heparanase promotes the onset and progression of atherosclerosis in
            apolipoprotein E gene knockout mice
  JOURNAL   Atherosclerosis 392, 117519 (2024)
   PUBMED   38581737
  REMARK    GeneRIF: Heparanase promotes the onset and progression of
            atherosclerosis in apolipoprotein E gene knockout mice.
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Martinez,H.A., Koliesnik,I., Kaber,G., Reid,J.K., Nagy,N.,
            Barlow,G., Falk,B.A., Medina,C.O., Hargil,A., Zihsler,S.,
            Vlodavsky,I., Li,J.P., Perez-Cruz,M., Tang,S.W., Meyer,E.H.,
            Wrenshall,L.E., Lord,J.D., Garcia,K.C., Palmer,T.D., Steinman,L.,
            Nepom,G.T., Wight,T.N., Bollyky,P.L. and Kuipers,H.F.
  TITLE     Regulatory T cells use heparanase to access IL-2 bound to
            extracellular matrix in inflamed tissue
  JOURNAL   Nat Commun 15 (1), 1564 (2024)
   PUBMED   38378682
  REMARK    GeneRIF: Regulatory T cells use heparanase to access IL-2 bound to
            extracellular matrix in inflamed tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Munguba,H., Nikouei,K., Hochgerner,H., Oberst,P., Kouznetsova,A.,
            Ryge,J., Munoz-Manchado,A.B., Close,J., Batista-Brito,R.,
            Linnarsson,S. and Hjerling-Leffler,J.
  TITLE     Transcriptional maintenance of cortical somatostatin interneuron
            subtype identity during migration
  JOURNAL   Neuron 111 (22), 3590-3603 (2023)
   PUBMED   37625400
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Wu,S.J., Sevier,E., Dwivedi,D., Saldi,G.A., Hairston,A., Yu,S.,
            Abbott,L., Choi,D.H., Sherer,M., Qiu,Y., Shinde,A., Lenahan,M.,
            Rizzo,D., Xu,Q., Barrera,I., Kumar,V., Marrero,G., Pronneke,A.,
            Huang,S., Kullander,K., Stafford,D.A., Macosko,E., Chen,F., Rudy,B.
            and Fishell,G.
  TITLE     Cortical somatostatin interneuron subtypes form cell-type-specific
            circuits
  JOURNAL   Neuron 111 (17), 2675-2692 (2023)
   PUBMED   37390821
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Zetser,A., Levy-Adam,F., Kaplan,V., Gingis-Velitski,S.,
            Bashenko,Y., Schubert,S., Flugelman,M.Y., Vlodavsky,I. and Ilan,N.
  TITLE     Processing and activation of latent heparanase occurs in lysosomes
  JOURNAL   J Cell Sci 117 (Pt 11), 2249-2258 (2004)
   PUBMED   15126626
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Saijo,M., Kitazawa,R., Nakajima,M., Kurosaka,M., Maeda,S. and
            Kitazawa,S.
  TITLE     Heparanase mRNA expression during fracture repair in mice
  JOURNAL   Histochem Cell Biol 120 (6), 493-503 (2003)
   PUBMED   14618334
  REMARK    GeneRIF: expression of heparanase mRNA and VEGF, and vessel
            formation in mouse fractured bone
REFERENCE   8  (bases 1 to 3140)
  AUTHORS   Gong,F., Jemth,P., Escobar Galvis,M.L., Vlodavsky,I., Horner,A.,
            Lindahl,U. and Li,J.P.
  TITLE     Processing of macromolecular heparin by heparanase
  JOURNAL   J Biol Chem 278 (37), 35152-35158 (2003)
   PUBMED   12837765
REFERENCE   9  (bases 1 to 3140)
  AUTHORS   Miao,H.Q., Navarro,E., Patel,S., Sargent,D., Koo,H., Wan,H.,
            Plata,A., Zhou,Q., Ludwig,D., Bohlen,P. and Kussie,P.
  TITLE     Cloning, expression, and purification of mouse heparanase
  JOURNAL   Protein Expr Purif 26 (3), 425-431 (2002)
   PUBMED   12460766
  REMARK    GeneRIF: A full-length heparanase gene was cloned from a mouse
            embryo cDNA library and determined to encode a protein of 535 amino
            acids. The full-length mouse gene was stably expressed in NS0
            myeloma cells.
REFERENCE   10 (bases 1 to 3140)
  AUTHORS   Hulett,M.D., Freeman,C., Hamdorf,B.J., Baker,R.T., Harris,M.J. and
            Parish,C.R.
  TITLE     Cloning of mammalian heparanase, an important enzyme in tumor
            invasion and metastasis
  JOURNAL   Nat Med 5 (7), 803-809 (1999)
   PUBMED   10395326
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY014662.1, AK040471.1,
            AC161510.10 and BC099521.1.
            
            On Aug 11, 2016 this sequence version replaced NM_152803.4.
            
            Summary: This gene encodes an endoglucuronidase enzyme that plays
            an important role in tumor invasion and metastasis. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active heterodimeric enzyme that cleaves the heparan sulfate
            proteoglycans associated with the cell surface and extracellular
            matrix. Mice lacking the encoded protein do not show any prominent
            pathological alterations under normal conditions but fail to
            develop albuminuria and renal damage in response to drug-induced
            diabetes. [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154628.1, AK040471.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY014662.1         1-33
            34-2205             AK040471.1         2-2173
            2206-2515           AC161510.10        165378-165687
            2516-3140           BC099521.1         1-625
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.51 cM"
     gene            1..3140
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /note="heparanase"
                     /db_xref="GeneID:15442"
                     /db_xref="MGI:MGI:1343124"
     exon            1..325
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1730
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /EC_number="3.2.1.166"
                     /note="endo-glucoronidase; endoglycosidase heparanase"
                     /codon_start=1
                     /product="heparanase preproprotein"
                     /protein_id="NP_690016.1"
                     /db_xref="CCDS:CCDS19466.1"
                     /db_xref="GeneID:15442"
                     /db_xref="MGI:MGI:1343124"
                     /translation="MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSV
                     SPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEP
                     TSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRS
                     SVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEP
                     NSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLK
                     AGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLG
                     ETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEP
                     LPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLH
                     NVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPL
                     PAGSALSLPAFSYGFFVIRNAKIAACI"
     exon            326..471
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..597
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..771
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..940
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..988
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1082
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1189
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1304
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1423
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1570
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..3117
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /note="hexamer: AATAAA"
     polyA_site      3117
                     /gene="Hpse"
                     /gene_synonym="Hpa; Hpr1; HSE1"
                     /note="major polyA site"
ORIGIN      
        1 gagcgctgtg ggagggtact gagtcctggc gccagaggcg aagcaggacc ggttgcaggg
       61 ggcttgagcc agcgcgccgg ctgccccagc tctcccggca gcgggcggtc cagccaggtg
      121 ggatgctgag gctgctgctg ctgtggctct gggggccgct cggtgccctg gcccagggcg
      181 cccccgcggg gaccgcgccg accgacgacg tggtagactt ggagttttac accaagcggc
      241 cgctccgaag cgtgagtccc tcgttcctgt ccatcaccat cgacgccagc ctggccaccg
      301 acccgcgctt cctcaccttc ctgggctctc caaggctccg tgctctggct agaggcttat
      361 ctcctgcata cttgagattt ggcggcacaa agactgactt ccttattttt gatccggaca
      421 aggaaccgac ttccgaagaa agaagttact ggaaatctca agtcaaccat gatatttgca
      481 ggtctgagcc ggtctctgct gcggtgttga ggaaactcca ggtggaatgg cccttccagg
      541 agctgttgct gctccgagag cagtaccaaa aggagttcaa gaacagcacc tactcaagaa
      601 gctcagtgga catgctctac agttttgcca agtgctcggg gttagacctg atctttggtc
      661 taaatgcgtt actacgaacc ccagacttac ggtggaacag ctccaacgcc cagcttctcc
      721 ttgactactg ctcttccaag ggttataaca tctcctggga actgggcaat gagcccaaca
      781 gtttctggaa gaaagctcac attctcatcg atgggttgca gttaggagaa gactttgtgg
      841 agttgcataa acttctacaa aggtcagctt tccaaaatgc aaaactctat ggtcctgaca
      901 tcggtcagcc tcgagggaag acagttaaac tgctgaggag tttcctgaag gctggcggag
      961 aagtgatcga ctctcttaca tggcatcact attacttgaa tggacgcatc gctaccaaag
     1021 aagattttct gagctctgat gtgctggaca cttttattct ctctgtgcaa aaaattctga
     1081 aggtcactaa agagatcaca cctggcaaga aggtctggtt gggagagacg agctcagctt
     1141 acggtggcgg tgcacccttg ctgtccaaca cctttgcagc tggctttatg tggctggata
     1201 aattgggcct gtcagcccag atgggcatag aagtcgtgat gaggcaggtg ttcttcggag
     1261 caggcaacta ccacttagtg gatgaaaact ttgagccttt acctgattac tggctctctc
     1321 ttctgttcaa gaaactggta ggtcccaggg tgttactgtc aagagtgaaa ggcccagaca
     1381 ggagcaaact ccgagtgtat ctccactgca ctaacgtcta tcacccacga tatcaggaag
     1441 gagatctaac tctgtatgtc ctgaacctcc ataatgtcac caagcacttg aaggtaccgc
     1501 ctccgttgtt caggaaacca gtggatacgt accttctgaa gccttcgggg ccggatggat
     1561 tactttccaa atctgtccaa ctgaacggtc aaattctgaa gatggtggat gagcagaccc
     1621 tgccagcttt gacagaaaaa cctctccccg caggaagtgc actaagcctg cctgcctttt
     1681 cctatggttt ttttgtcata agaaatgcca aaatcgctgc ttgtatatga aaataaaagg
     1741 catacggtac ccctgagaca aaagccgagg ggggtgttat tcataaaaca aaaccctagt
     1801 ttaggaggcc acctccttgc cgagttccag agcttcggga gggtggggta cacttcagta
     1861 ttacattcag tgtggtgttc tcctctaaga agaatactgc aggtggtgac agttaatagc
     1921 actgtgtggc aaatgacgct tagccctttg catgcactat tttaggggtt gtttaaaaat
     1981 gtataggaat gcctccaatg tgaccaaaag gcaaataagt ggaggatatg cctgattttt
     2041 ttttaaaagg ctttgtttgt ttttatttaa ttgttattat tttggtaaga agattgtcaa
     2101 atatgacctt caggggcctc tctctagctc cagtggggga aggcgcattg ccgtaacgcc
     2161 ccactggctg taaaaaagac acctgctcac actcggagag gaactaaaac agagaaacag
     2221 accctgtgcc tcttctcttc gtccttcaca agtctgggaa aggacagatg gctgggtgga
     2281 gtagtcttaa acaaaggcga ataaaagacc agccgagagg gaagcgatgc ctgtggtttg
     2341 gaaatgacgg taaaggagcc ggttggctga ttgggagacg tttctggaaa cgcctgacgt
     2401 catcaccctc gattagggtt tactttttct acaccaatag ctgttgcttt gcctggaaag
     2461 ctttggcctg tgagtagcag aagcctctaa atgaggacat ttataacccc acaaacggag
     2521 ttgttgaagt gaggtagggt tggacagctg agcatgtcag caggggccca tcttctttct
     2581 ccctctctgt cccgatgtct gtagtgctgg ctcccttctt ggcctgggca cgtgatggct
     2641 acaactggtc tatcgattca ttgagatcca gcagcaatca gaggaagaag atgagtgctt
     2701 tcttcacaaa cctgaagagc tctttcttgg aagttatctt cgcaagcctt tcctcaagtc
     2761 tcctcaagtc ttaccggcaa ggaataggtc tgtggtcatt tctcgtcacc atccatgagt
     2821 agcaatgcct acaactgtat tcaagcaata ctccctgggg cagagaggtt tagtggagtc
     2881 cacggcactg gacacttgct ttggattaag taacaaaatg taattctccc cccaccccag
     2941 gattttaatc ctaaggatta cagttctgta tgtttgcctg ctatgaatat tatctccact
     3001 gaatttagta cattgatgaa gctagaacct aaagtttgta tgcttcaata ctctcaattt
     3061 ttatgcaagt aagttttata tttccacatt tgaaataaac taattttata gcctcaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa
//
