LOCUS       NM_013556               1349 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus hypoxanthine phosphoribosyltransferase 1 (Hprt1),
            mRNA.
ACCESSION   NM_013556 XM_356404
VERSION     NM_013556.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Dinakaran,S., Qutaina,S., Zhao,H., Tang,Y., Wang,Z., Ruiz,S.,
            Nomura-Kitabayashi,A., Metz,C.N., Arthur,H.M., Meadows,S.M.,
            Blanc,L., Faughnan,M.E. and Marambaud,P.
  TITLE     CDK6-mediated endothelial cell cycle acceleration drives
            arteriovenous malformations in hereditary hemorrhagic
            telangiectasia
  JOURNAL   Nat Cardiovasc Res 3 (11), 1301-1317 (2024)
   PUBMED   39487364
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Sigler,A.L., Thompson,S.B., Ellwood-Digel,L., Kandasamy,A.,
            Michaels,M.J., Thumkeo,D., Narumiya,S., Del Alamo,J.C. and
            Jacobelli,J.
  TITLE     FMNL1 and mDia1 promote efficient T cell migration through complex
            environments via distinct mechanisms
  JOURNAL   Front Immunol 15, 1467415 (2024)
   PUBMED   39430739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Mehlmann,L.M., Uliasz,T.F., Yee,S.P., Kaback,D. and Lowther,K.M.
  TITLE     Generation and Characterization of a TRIM21 Overexpressing Mouse
            Line
  JOURNAL   Genesis 62 (5), e23616 (2024)
   PUBMED   39487578
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Chen,J., Lewis,M.A., Wai,A., Yin,L., Dawson,S.J., Ingham,N.J. and
            Steel,K.P.
  TITLE     A new mutation of Sgms1 causes gradual hearing loss associated with
            a reduced endocochlear potential
  JOURNAL   Hear Res 451, 109091 (2024)
   PUBMED   39067415
REFERENCE   5  (bases 1 to 1349)
  AUTHORS   Moon,D., Padanilam,B.J., Park,K.M. and Kim,J.
  TITLE     Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair
            after Ischemia and Reperfusion Injury
  JOURNAL   Int J Mol Sci 25 (9), 4610 (2024)
   PUBMED   38731829
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1349)
  AUTHORS   Nesbitt,M.N., Bakay,B., Gardner,M.B. and Day,C.
  TITLE     Isoenzyme pattern of HPRT in murine erythrocytes: control by an
            autosomal locus
  JOURNAL   Biochem Genet 17 (9-10), 957-964 (1979)
   PUBMED   540025
REFERENCE   7  (bases 1 to 1349)
  AUTHORS   Francke,U. and Taggart,R.T.
  TITLE     Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1)
            to a region of chromosome 16 and of Hprt to a region of the X
            chromosome in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5230-5233 (1979)
   PUBMED   291939
REFERENCE   8  (bases 1 to 1349)
  AUTHORS   Lo,Y.F. and Palmour,R.M.
  TITLE     Developmental expression of murine HPRT. I. Activities, heat
            stabilities, and electrophoretic mobilities in adult tissues
  JOURNAL   Biochem Genet 17 (7-8), 737-746 (1979)
   PUBMED   540017
REFERENCE   9  (bases 1 to 1349)
  AUTHORS   Snyder,F.F., Cruikshank,M.K. and Seegmiller,J.E.
  TITLE     A comparison of purine metabolism and nucleotide pools in normal
            and hypoxanthine-guanine phosphoribosyltransferase-deficient
            neuroblastoma cells
  JOURNAL   Biochim Biophys Acta 543 (4), 556-569 (1978)
   PUBMED   718989
REFERENCE   10 (bases 1 to 1349)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY285280.1, AK146626.1 and
            AK002286.1.
            
            On May 16, 2006 this sequence version replaced NM_013556.1.
            
            Summary: The protein encoded by this gene is a transferase, which
            catalyzes conversion of hypoxanthine to inosine monophosphate and
            guanine to guanosine monophosphate via transfer of the
            5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This
            enzyme plays a central role in the generation of purine nucleotides
            through the purine salvage pathway. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146626.1, BC004686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY285280.1         1-59
            60-754              AK146626.1         6-700
            755-1349            AK002286.1         700-1294
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 29.31 cM"
     gene            1..1349
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /note="hypoxanthine phosphoribosyltransferase 1"
                     /db_xref="GeneID:15452"
                     /db_xref="MGI:MGI:96217"
     exon            1..173
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..803
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /EC_number="2.4.2.8"
                     /note="hypoxanthine guanine phosphoribosyl transferase 1;
                     HGPRT; HPRT B; HGPRTase"
                     /codon_start=1
                     /product="hypoxanthine-guanine phosphoribosyltransferase"
                     /protein_id="NP_038584.2"
                     /db_xref="CCDS:CCDS40972.1"
                     /db_xref="GeneID:15452"
                     /db_xref="MGI:MGI:96217"
                     /translation="MPTRSPSVVISDDEPGYDLDLFCIPNHYAEDLEKVFIPHGLIMD
                     RTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRL
                     KSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVKQYSPKMVKV
                     ASLLVKRTSRSVGYRPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
                     "
     exon            174..280
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            281..464
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            465..530
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            531..548
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            549..631
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            632..678
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            679..755
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1349
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1332..1337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="Hprt1"
                     /gene_synonym="HPGRT; Hprt"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctggc cggcagcgtt tctgagccat tgctgaggcg gcgagggaga gcgttgggct
       61 tacctcactg ctttccggag cggtagcacc tcctccgccg gcttcctcct cagaccgctt
      121 tttgccgcga gccgaccggt cccgtcatgc cgacccgcag tcccagcgtc gtgattagcg
      181 atgatgaacc aggttatgac ctagatttgt tttgtatacc taatcattat gccgaggatt
      241 tggaaaaagt gtttattcct catggactga ttatggacag gactgaaaga cttgctcgag
      301 atgtcatgaa ggagatggga ggccatcaca ttgtggccct ctgtgtgctc aaggggggct
      361 ataagttctt tgctgacctg ctggattaca ttaaagcact gaatagaaat agtgatagat
      421 ccattcctat gactgtagat tttatcagac tgaagagcta ctgtaatgat cagtcaacgg
      481 gggacataaa agttattggt ggagatgatc tctcaacttt aactggaaag aatgtcttga
      541 ttgttgaaga tataattgac actggtaaaa caatgcaaac tttgctttcc ctggttaagc
      601 agtacagccc caaaatggtt aaggttgcaa gcttgctggt gaaaaggacc tctcgaagtg
      661 ttggatacag gccagacttt gttggatttg aaattccaga caagtttgtt gttggatatg
      721 cccttgacta taatgagtac ttcagggatt tgaatcacgt ttgtgtcatt agtgaaactg
      781 gaaaagccaa atacaaagcc taagatgagc gcaagttgaa tctgcaaata cgaggagtcc
      841 tgttgatgtt gccagtaaaa ttagcaggtg ttctagtcct gtggccatct gcctagtaaa
      901 gctttttgca tgaaccttct atgaatgtta ctgttttatt tttagaaatg tcagttgctg
      961 cgtccccaga cttttgattt gcactatgag cctataggcc agcctaccct ctggtagatt
     1021 gtcgcttatc ttgtaagaaa aacaaatctc ttaaattacc acttttaaat aataatactg
     1081 agattgtatc tgtaagaagg atttaaagag aagctatatt agttttttaa ttggtatttt
     1141 aatttttata tattcaggag agaaagatgt gattgatatt gttaatttag acgagtctga
     1201 agctctcgat ttcctatcag taacagcatc taagaggttt tgctcagtgg aataaacatg
     1261 tttcagcagt gttggctgta ttttcccact ttcagtaaat cgttgtcaac agttcctttt
     1321 aaatgcaaat aaataaattc taaaaattc
//
