LOCUS       NM_001110252            1866 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus hepsin (Hpn), transcript variant 1, mRNA.
ACCESSION   NM_001110252
VERSION     NM_001110252.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1866)
  AUTHORS   Lin,H.H., Yu,I.S., Cheng,M.S., Chang,T.J., Lin,H.Y., Chang,Y.C.,
            Ko,C.J., Chen,P.H., Lin,S.W., Huang,T.C., Huang,S.Y., Chen,T.Y.,
            Kan,K.W., Huang,H.P. and Lee,M.S.
  TITLE     Spint1 disruption in mouse pancreas leads to glucose intolerance
            and impaired insulin production involving HEPSIN/MAFA
  JOURNAL   Nat Commun 15 (1), 10537 (2024)
   PUBMED   39627229
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1866)
  AUTHORS   Chakraborty,P., Anderson,R.L. and Roy,S.K.
  TITLE     Bone morphogenetic protein 2- and estradiol-17beta-induced changes
            in ovarian transcriptome during primordial follicle formationdagger
  JOURNAL   Biol Reprod 107 (3), 800-812 (2022)
   PUBMED   35639639
REFERENCE   3  (bases 1 to 1866)
  AUTHORS   Li,S., Peng,J., Wang,H., Zhang,W., Brown,J.M., Zhou,Y. and Wu,Q.
  TITLE     Hepsin enhances liver metabolism and inhibits adipocyte browning in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 117 (22), 12359-12367 (2020)
   PUBMED   32404422
  REMARK    GeneRIF: Hepsin enhances liver metabolism and inhibits adipocyte
            browning in mice.
REFERENCE   4  (bases 1 to 1866)
  AUTHORS   Olinger,E., Lake,J., Sheehan,S., Schiano,G., Takata,T.,
            Tokonami,N., Debaix,H., Consolato,F., Rampoldi,L., Korstanje,R. and
            Devuyst,O.
  TITLE     Hepsin-mediated Processing of Uromodulin is Crucial for
            Salt-sensitivity and Thick Ascending Limb Homeostasis
  JOURNAL   Sci Rep 9 (1), 12287 (2019)
   PUBMED   31444371
  REMARK    GeneRIF: Hepsin-mediated Processing of Uromodulin is Crucial for
            Salt-sensitivity and Thick Ascending Limb Homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1866)
  AUTHORS   Somoza,J.R., Ho,J.D., Luong,C., Ghate,M., Sprengeler,P.A.,
            Mortara,K., Shrader,W.D., Sperandio,D., Chan,H., McGrath,M.E. and
            Katz,B.A.
  TITLE     The structure of the extracellular region of human hepsin reveals a
            serine protease domain and a novel scavenger receptor cysteine-rich
            (SRCR) domain
  JOURNAL   Structure 11 (9), 1123-1131 (2003)
   PUBMED   12962630
  REMARK    GeneRIF: crystal structure of human hepsin, confirming cleavage and
            association of the two chains
REFERENCE   6  (bases 1 to 1866)
  AUTHORS   Yu,I.S., Chen,H.J., Lee,Y.S., Huang,P.H., Lin,S.R., Tsai,T.W. and
            Lin,S.W.
  TITLE     Mice deficient in hepsin, a serine protease, exhibit normal
            embryogenesis and unchanged hepatocyte regeneration ability
  JOURNAL   Thromb Haemost 84 (5), 865-870 (2000)
   PUBMED   11127869
REFERENCE   7  (bases 1 to 1866)
  AUTHORS   Kawamura,S., Kurachi,S., Deyashiki,Y. and Kurachi,K.
  TITLE     Complete nucleotide sequence, origin of isoform and functional
            characterization of the mouse hepsin gene
  JOURNAL   Eur J Biochem 262 (3), 755-764 (1999)
   PUBMED   10411637
REFERENCE   8  (bases 1 to 1866)
  AUTHORS   Wu,Q., Yu,D., Post,J., Halks-Miller,M., Sadler,J.E. and Morser,J.
  TITLE     Generation and characterization of mice deficient in hepsin, a
            hepatic transmembrane serine protease
  JOURNAL   J Clin Invest 101 (2), 321-326 (1998)
   PUBMED   9435303
REFERENCE   9  (bases 1 to 1866)
  AUTHORS   Vu,T.K., Liu,R.W., Haaksma,C.J., Tomasek,J.J. and Howard,E.W.
  TITLE     Identification and cloning of the membrane-associated serine
            protease, hepsin, from mouse preimplantation embryos
  JOURNAL   J Biol Chem 272 (50), 31315-31320 (1997)
   PUBMED   9395459
REFERENCE   10 (bases 1 to 1866)
  AUTHORS   Torres-Rosado,A., O'Shea,K.S., Tsuji,A., Chou,S.H. and Kurachi,K.
  TITLE     Hepsin, a putative cell-surface serine protease, is required for
            mammalian cell growth
  JOURNAL   Proc Natl Acad Sci U S A 90 (15), 7181-7185 (1993)
   PUBMED   8346233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158993.2, BC138809.1 and
            CJ237993.1.
            
            On Jan 18, 2013 this sequence version replaced NM_001110252.1.
            
            Summary: This gene encodes a type II transmembrane serine protease
            that may function in diverse processes, including regulation of
            cell growth. Deficiency in this gene results in hearing loss. The
            protein is cleaved into a catalytic serine protease chain and a
            non-catalytic scavenger receptor cysteine-rich chain, which
            associate via a single disulfide bond. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145413.1, AK002694.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC158993.2         77325-77480         c
            157-1661            BC138809.1         1-1505
            1662-1860           CJ237993.1         479-677
            1861-1866           AC158993.2         60879-60884         c
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.3 cM"
     gene            1..1866
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /note="hepsin"
                     /db_xref="GeneID:15451"
                     /db_xref="MGI:MGI:1196620"
     exon            1..191
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            192..258
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            259..318
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            319..420
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            421..462
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            463..592
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            593..715
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            716..756
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            757..922
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1113
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1209
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1352
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1517
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1866
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /note="hexamer: AATAAA"
     polyA_site      1862
                     /gene="Hpn"
                     /gene_synonym="Hlb320"
                     /note="major polyA site"
ORIGIN      
        1 cgccccgtcc ccgcctccca cccagccccc tcctcctcag gtgaggccgc aggctcggca
       61 ggccccacgc tgctggctgc tgctgccacc cttgccttcc gggctgtccg ctgctgtggg
      121 gacagacacc atgcccctgc ccaggcccgg agactaaccc caaacctgca ccatctccgg
      181 cgaaccccag ggttccgccc cagcccaaca ggtcaacctg ggaatcatta acaagagtcc
      241 ctgacatggc gaaggaggat gaggaacctg gggctcacag aggaggttcc acttgttcaa
      301 gaccccaacc tggaaagggt ggccggactg cagcatgctg ctccagaccc aaggtggcag
      361 ctctcattgt gggtaccctg ctgttcctga caggcattgg ggccgcgtcc tgggccattg
      421 tgaccatcct actgcagagt gaccaggagc cactgtacca agtgcagctc agtccagggg
      481 actcacggct tgcggtgttt gacaagacgg agggaacgtg gaggctactg tgctcctcac
      541 gctccaatgc cagggtggca gggctcggct gtgaggagat gggctttctc agggctctgg
      601 cgcactcgga gctggatgtg cgcactgcgg gcgccaacgg cacatcgggc ttcttttgcg
      661 tggacgaggg cggactgcct ctggctcaga ggttgctgga tgtcatctct gtatgtgact
      721 gtcctagagg ccgattcctg actgccacct gccaagactg tggccgcagg aagctgccgg
      781 tggaccgcat tgtggggggc caggacagca gtctgggaag gtggccgtgg caggtcagcc
      841 tgcgttatga tgggacccac ctctgtgggg ggtccctgct gtctggggac tgggtgctga
      901 ctgctgcaca ttgctttcca gagcggaacc gggtcctgtc tcggtggcga gtatttgctg
      961 gtgctgtagc ccggacctca ccccatgctg tgcaactggg ggttcaggct gtgatctatc
     1021 atgggggcta ccttcccttt cgagacccta ctatcgacga aaacagcaat gacattgcct
     1081 tggtccacct ctctagctcc ctgcctctca cagaatacat ccagccagtg tgtctccctg
     1141 ctgcgggaca ggccctggtg gatggcaagg tctgtactgt gaccggctgg ggtaacacac
     1201 agttctatgg ccaacaggct atggtgctcc aagaggcccg ggttcccatc ataagcaacg
     1261 aagtttgcaa cagccccgac ttctacggga atcagatcaa gcccaagatg ttctgtgctg
     1321 gctatcctga gggtggcatt gatgcgtgcc agggcgacag tggaggcccc tttgtgtgtg
     1381 aagacagcat ctctgggaca tcaaggtggc ggctatgtgg cattgtaagc tggggtacgg
     1441 gctgtgcttt ggcccggaag ccaggagtgt acaccaaagt cactgacttc cgggagtgga
     1501 tcttcaaggc cataaagact cactccgaag ccagtggcat ggtgactcag ccctgatccc
     1561 gcctcatctc gctgctccgt gctgcactag catccagagt cagagttggt ctggtggctc
     1621 cagccccacg tggtaggctc cacactgggc ctcacatgga atggtttcct gctcagatcc
     1681 agtccacggg tccaaggatg ctggatccaa ggacttctct tccacagtgg ccggcccact
     1741 caatcccagg gccattggcc tcaccctccc accccatgta aatattactc tgtcctctgg
     1801 ggggcgctct agggagcccc ttgtgcagat gctctttaaa taataaaggt ggttttgatt
     1861 aatggg
//
