LOCUS       NM_019455               3572 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus hematopoietic prostaglandin D synthase (Hpgds),
            transcript variant 1, mRNA.
ACCESSION   NM_019455
VERSION     NM_019455.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 3572)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3572)
  AUTHORS   Horikami,D., Sekihachi,E., Omori,K., Kobayashi,Y., Kobayashi,K.,
            Nagata,N., Kurata,K., Uemura,A. and Murata,T.
  TITLE     Roles of lipocalin-type and hematopoietic prostaglandin D synthases
            in mouse retinal angiogenesis
  JOURNAL   J Lipid Res 64 (10), 100439 (2023)
   PUBMED   37666361
REFERENCE   4  (bases 1 to 3572)
  AUTHORS   Ouyang,L., Qiu,D., Fu,X., Wu,A., Yang,P., Yang,Z., Wang,Q., Yan,L.
            and Xiao,R.
  TITLE     Overexpressing HPGDS in adipose-derived mesenchymal stem cells
            reduces inflammatory state and improves wound healing in type 2
            diabetic mice
  JOURNAL   Stem Cell Res Ther 13 (1), 395 (2022)
   PUBMED   35922870
  REMARK    GeneRIF: Overexpressing HPGDS in adipose-derived mesenchymal stem
            cells reduces inflammatory state and improves wound healing in type
            2 diabetic mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3572)
  AUTHORS   Duncan,K.D., Sun,X., Baker,E.S., Dey,S.K. and Lanekoff,I.
  TITLE     In situ imaging reveals disparity between prostaglandin
            localization and abundance of prostaglandin synthases
  JOURNAL   Commun Biol 4 (1), 966 (2021)
   PUBMED   34389796
  REMARK    Erratum:[Commun Biol. 2021 Aug 20;4(1):1010. doi:
            10.1038/s42003-021-02560-w.. PMID: 34417560]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3572)
  AUTHORS   Trivedi,S.G., Newson,J., Rajakariar,R., Jacques,T.S., Hannon,R.,
            Kanaoka,Y., Eguchi,N., Colville-Nash,P. and Gilroy,D.W.
  TITLE     Essential role for hematopoietic prostaglandin D2 synthase in the
            control of delayed type hypersensitivity
  JOURNAL   Proc Natl Acad Sci U S A 103 (13), 5179-5184 (2006)
   PUBMED   16547141
  REMARK    GeneRIF: hPGD(2)S-derived cyclopentenone prostaglandins may protect
            against inflammatory diseases, where T lymphocytes play a
            pathogenic role, as in rheumatoid arthritis, atopic eczema, and
            chronic rejection
REFERENCE   7  (bases 1 to 3572)
  AUTHORS   Mohri,I., Eguchi,N., Suzuki,K., Urade,Y. and Taniike,M.
  TITLE     Hematopoietic prostaglandin D synthase is expressed in microglia in
            the developing postnatal mouse brain
  JOURNAL   Glia 42 (3), 263-274 (2003)
   PUBMED   12673832
REFERENCE   8  (bases 1 to 3572)
  AUTHORS   Jowsey,I.R., Thomson,A.M., Flanagan,J.U., Murdock,P.R., Moore,G.B.,
            Meyer,D.J., Murphy,G.J., Smith,S.A. and Hayes,J.D.
  TITLE     Mammalian class Sigma glutathione S-transferases: catalytic
            properties and tissue-specific expression of human and rat
            GSH-dependent prostaglandin D2 synthases
  JOURNAL   Biochem J 359 (Pt 3), 507-516 (2001)
   PUBMED   11672424
REFERENCE   9  (bases 1 to 3572)
  AUTHORS   Board,P.G., Coggan,M., Chelvanayagam,G., Easteal,S., Jermiin,L.S.,
            Schulte,G.K., Danley,D.E., Hoth,L.R., Griffor,M.C., Kamath,A.V.,
            Rosner,M.H., Chrunyk,B.A., Perregaux,D.E., Gabel,C.A.,
            Geoghegan,K.F. and Pandit,J.
  TITLE     Identification, characterization, and crystal structure of the
            Omega class glutathione transferases
  JOURNAL   J Biol Chem 275 (32), 24798-24806 (2000)
   PUBMED   10783391
REFERENCE   10 (bases 1 to 3572)
  AUTHORS   Kanaoka,Y., Fujimori,K., Kikuno,R., Sakaguchi,Y., Urade,Y. and
            Hayaishi,O.
  TITLE     Structure and chromosomal localization of human and mouse genes for
            hematopoietic prostaglandin D synthase. Conservation of the
            ancestral genomic structure of sigma-class glutathione
            S-transferase
  JOURNAL   Eur J Biochem 267 (11), 3315-3322 (2000)
   PUBMED   10824118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC143330.4.
            
            On Aug 23, 2022 this sequence version replaced NM_019455.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3629852.1, AK039392.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC143330.4         104268-104341
            75-216              AC143330.4         110708-110849
            217-309             AC143330.4         113321-113413
            310-419             AC143330.4         116815-116924
            420-518             AC143330.4         125358-125456
            519-3572            AC143330.4         128926-131979
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     gene            1..3572
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hematopoietic prostaglandin D synthase"
                     /db_xref="GeneID:54486"
                     /db_xref="MGI:MGI:1859384"
     exon            1..74
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            75..216
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..683
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /EC_number="2.5.1.18"
                     /EC_number="5.3.99.2"
                     /note="isoform 1 is encoded by transcript variant 1; GST
                     class-sigma; glutathione S-transferase; prostaglandin-H2
                     D-isomerase; glutathione-dependent PGD synthetase;
                     glutathione-requiring prostaglandin D synthase;
                     glutathione-dependent PGD synthase; prostaglandin D2
                     synthase 2, hematopoietic"
                     /codon_start=1
                     /product="hematopoietic prostaglandin D synthase isoform
                     1"
                     /protein_id="NP_062328.3"
                     /db_xref="CCDS:CCDS20205.1"
                     /db_xref="GeneID:54486"
                     /db_xref="MGI:MGI:1859384"
                     /translation="MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKP
                     TLPFGKIPVLEVEGLTIHQSLAIARYLTKNTDLAGKTALEQCQADAVVDTLDDFMSLF
                     PWAEKDQDLKERMFNELLTHQAPRLLKDLDTYLGDKEWFIGNYVTWADFYWDICSTTL
                     LVLKPGLLDIYPKLVSLRNKVQAIPAISAWILKRPQTKL"
     exon            217..309
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..419
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..518
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..3572
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1553..1558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hexamer: AATAAA"
     polyA_site      1571
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="major polyA site"
     regulatory      3292..3297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hexamer: AATAAA"
     polyA_site      3314
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
     regulatory      3535..3540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hexamer: AATAAA"
     polyA_site      3572
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="major polyA site"
ORIGIN      
        1 actcatcaca gaaaccactg tacagacagg aactgagaca cggagacacg gcacaggaaa
       61 ggctctctgc atagaattgt accatgccta actacaaact gctttatttt aatatgaggg
      121 gaagagccga aattattcgc tacatattcg cttatttgga cataaagtat gaggatcaca
      181 gaatagaaca agctgactgg cctaaaatca agccaactct tccatttggc aaaatccctg
      241 ttttggaggt ggaaggactt acaatccacc agagcctcgc aatagcaaga tatttgacca
      301 aaaacacaga tttggctggg aagacagcgt tggagcaatg tcaagctgat gcagtggtgg
      361 acacgctgga tgacttcatg tctctcttcc catgggcaga gaaagatcaa gatctaaaag
      421 agcggatgtt caatgaattg ctcacacatc aagcacctcg ccttctgaaa gatttggaca
      481 catacttagg agacaaagag tggtttatag gcaattatgt aacctgggca gacttctact
      541 gggatatctg cagcaccaca cttttggttt taaagcctgg cttgttggat atctacccca
      601 aactggtgtc attacggaac aaagtccaag ctatccctgc catttctgcc tggatactaa
      661 agaggccaca gacaaaactc tagatgaatc aggacccatc atcagatgag aactccatta
      721 gctggctaga ggatccacat acttctcacc aataggactg taactttgta gtactctgct
      781 tgctgtgtat agcaactcaa ggggtgttgc agttttgtct ttatctgcag gcacttagtt
      841 tccaatcttt tattttttca aaactttaca ctttataatt gcagggaaat agttcacaat
      901 atatgtagtt gtgcatatca agatgtatgg aagctttaaa caacactagt ttcctggcta
      961 gggtatcagt caacacagta tcttaactat gagtaagcat agttaactat gaaatacaga
     1021 ttttgcagct agctcttcaa tcagcaaatt cctacacaga aactaatggt cattataatg
     1081 atcactaact actgcatgtt attcaggtat acaccaaagt gtataagcta cttcacaaaa
     1141 atacacatct gtctgacatg tcacaaaatg ggtaataaag aagaaactca tcaagattaa
     1201 aggacagcca agaaaagtga tgttgaagtt taattgaaat tccacaaaat ggagtaacaa
     1261 aaagttactg agttcagcat tgttgcaatt cagaaggctg tagagacaag gaaaggagct
     1321 gtgacataga aagttcgata ccccagagac aagagacaga gggttacaat aatctttcac
     1381 atgagaaaaa caaaagcagg ctggagagat ggctcagcaa ttagcactga ctgctcttcc
     1441 agaggttctg agttcaattc ccagcaaacc acatggtggt tcacaactat ctgtaatggg
     1501 atctgatctt ctggtgtatc tgaagagaac gacagtgtac tcacatacat acaataaaga
     1561 aatctagccg agcggtggtg gcgcgcgcct ttaatcccag cacttgggaa gcagaggcag
     1621 gcggatttct gagttcgagg ccagcctggt ctacaaactg agttccagga cagccagagc
     1681 tacacagaga aaccatctcg gaaaaccaaa acaatagaaa accaaaacaa taaagaaatc
     1741 ttaaaaaaca aacaaacaaa caaacaaaaa acagtagact aagaagactg ggagaacatg
     1801 tgtgcagaac attcacctgg taaagatttg tttaaaatat aaaagaactg tgaaaattca
     1861 atagtaaaaa aaaataaata cccagattga aatgttagct ggaagataca cagatggcca
     1921 tgagcctgtg aggaggcagc aatacagtgg cactagggaa ttataatagc agtgctgact
     1981 agaacagtaa aatctcaaga ccaaataaac actggagaaa cactgaagtt atgggacctg
     2041 gggacaggaa tgcaaaagat ggcactgaga gaactagttt ctcaaaaatt aaaatgtccc
     2101 cttctgtggg gcccgtcagt ctcacattgt gtatttactc aatgagcatg tccacactaa
     2161 gcttgaacat atatcttgga tgctgcttca catacagctg ctaaaacttt aaaaacctca
     2221 aagatggcct ttagcaggaa atgcagaaca atccttggtg cgtacacatc agggctagta
     2281 agccacgaac agtacatggg tgagccagtg ccacacacag ctaagtgaaa ggagccaaca
     2341 caaaaaggct ccaactatgc aaaagaagag gatgagaagc tgcccaagcc agtggtgaca
     2401 tgggcaagac gggaggcaga tgggcagtcc gggcagtctg ttctgtggga tgctgtcaga
     2461 gagaatgagt acacgtcttt acatttataa acttactcag aatgcagaac acatgcaaac
     2521 tgtagcgtat gtagcacatg ttagcaacag aggagactgt aggtgtgggg acagcaggaa
     2581 atgggactgc tcctagtgtt gctgtgaact gaaaaaaaca aacagtctgc gataattagt
     2641 ttttatttgc tgacaaagtg taatagatac acaacagctt acagggaggg aagatttgtg
     2701 tggctccact cattggctcc actgggttgg aactgtggag cagtatgtgc caaaatgact
     2761 gtttacttac tcatggtggc tgagaaacag agtggaaagc acctctctac acaatcttct
     2821 aaacaacagg ccagtgagct ggctccatgg ataaaggcat ttggcgccaa acccagaagg
     2881 cctaagatca gtctctggca cctacataat ggaagcaaaa cactgacttt cacctactgt
     2941 ctgtcctctg ccctcccctt aagcactgtg gcatttgcac ttatactcat tttatttttt
     3001 ttttttaaat gcaaccattt tatttttgtt tataaagggt ctcctaatta gcaatattac
     3061 tccccaggac tgttttggac tgttttctca cttggtatct gaaggctgac tgggatgcac
     3121 aatgtggccc aggcccaagc tggcactgca ctcactgtaa tctcgtttcc atgctgccga
     3181 acctggatcc ctattttaaa ctatattgat ggaatgcaca ctttgctttg tatgttagct
     3241 tcattaatgt taatagtgtg tgtggtatgt tgcaaaatgt atggaaatac taataaagat
     3301 gatcttgtgc tttatgtgag attcagaaga acatattgct aaaaggcaaa aaataaaaat
     3361 aaaaaaggag attgtaggga gagagaaaga aatacatgtc cagataggtg tgctcttatt
     3421 taacatctct tcttttttta gaacattttc tctgatttaa cagggctggg ggggggggga
     3481 acagaggaca aaattttgta tgttaaacat aaaatgcatg aacttgatct tttaaataaa
     3541 attttaacat tggtggctgt taaaataaaa aa
//
