LOCUS       NM_001411252            3575 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus hematopoietic prostaglandin D synthase (Hpgds),
            transcript variant 2, mRNA.
ACCESSION   NM_001411252 XM_006506398
VERSION     NM_001411252.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3575)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 3575)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3575)
  AUTHORS   Horikami,D., Sekihachi,E., Omori,K., Kobayashi,Y., Kobayashi,K.,
            Nagata,N., Kurata,K., Uemura,A. and Murata,T.
  TITLE     Roles of lipocalin-type and hematopoietic prostaglandin D synthases
            in mouse retinal angiogenesis
  JOURNAL   J Lipid Res 64 (10), 100439 (2023)
   PUBMED   37666361
REFERENCE   4  (bases 1 to 3575)
  AUTHORS   Ouyang,L., Qiu,D., Fu,X., Wu,A., Yang,P., Yang,Z., Wang,Q., Yan,L.
            and Xiao,R.
  TITLE     Overexpressing HPGDS in adipose-derived mesenchymal stem cells
            reduces inflammatory state and improves wound healing in type 2
            diabetic mice
  JOURNAL   Stem Cell Res Ther 13 (1), 395 (2022)
   PUBMED   35922870
  REMARK    GeneRIF: Overexpressing HPGDS in adipose-derived mesenchymal stem
            cells reduces inflammatory state and improves wound healing in type
            2 diabetic mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3575)
  AUTHORS   Duncan,K.D., Sun,X., Baker,E.S., Dey,S.K. and Lanekoff,I.
  TITLE     In situ imaging reveals disparity between prostaglandin
            localization and abundance of prostaglandin synthases
  JOURNAL   Commun Biol 4 (1), 966 (2021)
   PUBMED   34389796
  REMARK    Erratum:[Commun Biol. 2021 Aug 20;4(1):1010. doi:
            10.1038/s42003-021-02560-w.. PMID: 34417560]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3575)
  AUTHORS   Trivedi,S.G., Newson,J., Rajakariar,R., Jacques,T.S., Hannon,R.,
            Kanaoka,Y., Eguchi,N., Colville-Nash,P. and Gilroy,D.W.
  TITLE     Essential role for hematopoietic prostaglandin D2 synthase in the
            control of delayed type hypersensitivity
  JOURNAL   Proc Natl Acad Sci U S A 103 (13), 5179-5184 (2006)
   PUBMED   16547141
  REMARK    GeneRIF: hPGD(2)S-derived cyclopentenone prostaglandins may protect
            against inflammatory diseases, where T lymphocytes play a
            pathogenic role, as in rheumatoid arthritis, atopic eczema, and
            chronic rejection
REFERENCE   7  (bases 1 to 3575)
  AUTHORS   Mohri,I., Eguchi,N., Suzuki,K., Urade,Y. and Taniike,M.
  TITLE     Hematopoietic prostaglandin D synthase is expressed in microglia in
            the developing postnatal mouse brain
  JOURNAL   Glia 42 (3), 263-274 (2003)
   PUBMED   12673832
REFERENCE   8  (bases 1 to 3575)
  AUTHORS   Jowsey,I.R., Thomson,A.M., Flanagan,J.U., Murdock,P.R., Moore,G.B.,
            Meyer,D.J., Murphy,G.J., Smith,S.A. and Hayes,J.D.
  TITLE     Mammalian class Sigma glutathione S-transferases: catalytic
            properties and tissue-specific expression of human and rat
            GSH-dependent prostaglandin D2 synthases
  JOURNAL   Biochem J 359 (Pt 3), 507-516 (2001)
   PUBMED   11672424
REFERENCE   9  (bases 1 to 3575)
  AUTHORS   Board,P.G., Coggan,M., Chelvanayagam,G., Easteal,S., Jermiin,L.S.,
            Schulte,G.K., Danley,D.E., Hoth,L.R., Griffor,M.C., Kamath,A.V.,
            Rosner,M.H., Chrunyk,B.A., Perregaux,D.E., Gabel,C.A.,
            Geoghegan,K.F. and Pandit,J.
  TITLE     Identification, characterization, and crystal structure of the
            Omega class glutathione transferases
  JOURNAL   J Biol Chem 275 (32), 24798-24806 (2000)
   PUBMED   10783391
REFERENCE   10 (bases 1 to 3575)
  AUTHORS   Kanaoka,Y., Fujimori,K., Kikuno,R., Sakaguchi,Y., Urade,Y. and
            Hayaishi,O.
  TITLE     Structure and chromosomal localization of human and mouse genes for
            hematopoietic prostaglandin D synthase. Conservation of the
            ancestral genomic structure of sigma-class glutathione
            S-transferase
  JOURNAL   Eur J Biochem 267 (11), 3315-3322 (2000)
   PUBMED   10824118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC143330.4.
            
            On Aug 23, 2022 this sequence version replaced XM_006506398.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.5189022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC143330.4         104268-104341
            75-216              AC143330.4         110708-110849
            217-309             AC143330.4         113321-113413
            310-419             AC143330.4         116815-116924
            420-518             AC143330.4         125358-125456
            519-3575            AC143330.4         128923-131979
FEATURES             Location/Qualifiers
     source          1..3575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     gene            1..3575
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hematopoietic prostaglandin D synthase"
                     /db_xref="GeneID:54486"
                     /db_xref="MGI:MGI:1859384"
     exon            1..74
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            75..216
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..686
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /EC_number="2.5.1.18"
                     /EC_number="5.3.99.2"
                     /note="isoform 2 is encoded by transcript variant 2; GST
                     class-sigma; glutathione S-transferase; prostaglandin-H2
                     D-isomerase; glutathione-dependent PGD synthetase;
                     glutathione-requiring prostaglandin D synthase;
                     glutathione-dependent PGD synthase; prostaglandin D2
                     synthase 2, hematopoietic"
                     /codon_start=1
                     /product="hematopoietic prostaglandin D synthase isoform
                     2"
                     /protein_id="NP_001398181.1"
                     /db_xref="GeneID:54486"
                     /db_xref="MGI:MGI:1859384"
                     /translation="MPNYKLLYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPKIKP
                     TLPFGKIPVLEVEGLTIHQSLAIARYLTKNTDLAGKTALEQCQADAVVDTLDDFMSLF
                     PWAEKDQDLKERMFNELLTHQAPRLLKDLDTYLGDKEWFIGNYQVTWADFYWDICSTT
                     LLVLKPGLLDIYPKLVSLRNKVQAIPAISAWILKRPQTKL"
     exon            217..309
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..419
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..518
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..3575
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1556..1561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hexamer: AATAAA"
     polyA_site      1574
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="major polyA site"
     regulatory      3295..3300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hexamer: AATAAA"
     polyA_site      3317
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
     regulatory      3538..3543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="hexamer: AATAAA"
     polyA_site      3575
                     /gene="Hpgds"
                     /gene_synonym="H-PGDS; Ptgds2"
                     /note="major polyA site"
ORIGIN      
        1 actcatcaca gaaaccactg tacagacagg aactgagaca cggagacacg gcacaggaaa
       61 ggctctctgc atagaattgt accatgccta actacaaact gctttatttt aatatgaggg
      121 gaagagccga aattattcgc tacatattcg cttatttgga cataaagtat gaggatcaca
      181 gaatagaaca agctgactgg cctaaaatca agccaactct tccatttggc aaaatccctg
      241 ttttggaggt ggaaggactt acaatccacc agagcctcgc aatagcaaga tatttgacca
      301 aaaacacaga tttggctggg aagacagcgt tggagcaatg tcaagctgat gcagtggtgg
      361 acacgctgga tgacttcatg tctctcttcc catgggcaga gaaagatcaa gatctaaaag
      421 agcggatgtt caatgaattg ctcacacatc aagcacctcg ccttctgaaa gatttggaca
      481 catacttagg agacaaagag tggtttatag gcaattatca ggtaacctgg gcagacttct
      541 actgggatat ctgcagcacc acacttttgg ttttaaagcc tggcttgttg gatatctacc
      601 ccaaactggt gtcattacgg aacaaagtcc aagctatccc tgccatttct gcctggatac
      661 taaagaggcc acagacaaaa ctctagatga atcaggaccc atcatcagat gagaactcca
      721 ttagctggct agaggatcca catacttctc accaatagga ctgtaacttt gtagtactct
      781 gcttgctgtg tatagcaact caaggggtgt tgcagttttg tctttatctg caggcactta
      841 gtttccaatc ttttattttt tcaaaacttt acactttata attgcaggga aatagttcac
      901 aatatatgta gttgtgcata tcaagatgta tggaagcttt aaacaacact agtttcctgg
      961 ctagggtatc agtcaacaca gtatcttaac tatgagtaag catagttaac tatgaaatac
     1021 agattttgca gctagctctt caatcagcaa attcctacac agaaactaat ggtcattata
     1081 atgatcacta actactgcat gttattcagg tatacaccaa agtgtataag ctacttcaca
     1141 aaaatacaca tctgtctgac atgtcacaaa atgggtaata aagaagaaac tcatcaagat
     1201 taaaggacag ccaagaaaag tgatgttgaa gtttaattga aattccacaa aatggagtaa
     1261 caaaaagtta ctgagttcag cattgttgca attcagaagg ctgtagagac aaggaaagga
     1321 gctgtgacat agaaagttcg ataccccaga gacaagagac agagggttac aataatcttt
     1381 cacatgagaa aaacaaaagc aggctggaga gatggctcag caattagcac tgactgctct
     1441 tccagaggtt ctgagttcaa ttcccagcaa accacatggt ggttcacaac tatctgtaat
     1501 gggatctgat cttctggtgt atctgaagag aacgacagtg tactcacata catacaataa
     1561 agaaatctag ccgagcggtg gtggcgcgcg cctttaatcc cagcacttgg gaagcagagg
     1621 caggcggatt tctgagttcg aggccagcct ggtctacaaa ctgagttcca ggacagccag
     1681 agctacacag agaaaccatc tcggaaaacc aaaacaatag aaaaccaaaa caataaagaa
     1741 atcttaaaaa acaaacaaac aaacaaacaa aaaacagtag actaagaaga ctgggagaac
     1801 atgtgtgcag aacattcacc tggtaaagat ttgtttaaaa tataaaagaa ctgtgaaaat
     1861 tcaatagtaa aaaaaaataa atacccagat tgaaatgtta gctggaagat acacagatgg
     1921 ccatgagcct gtgaggaggc agcaatacag tggcactagg gaattataat agcagtgctg
     1981 actagaacag taaaatctca agaccaaata aacactggag aaacactgaa gttatgggac
     2041 ctggggacag gaatgcaaaa gatggcactg agagaactag tttctcaaaa attaaaatgt
     2101 ccccttctgt ggggcccgtc agtctcacat tgtgtattta ctcaatgagc atgtccacac
     2161 taagcttgaa catatatctt ggatgctgct tcacatacag ctgctaaaac tttaaaaacc
     2221 tcaaagatgg cctttagcag gaaatgcaga acaatccttg gtgcgtacac atcagggcta
     2281 gtaagccacg aacagtacat gggtgagcca gtgccacaca cagctaagtg aaaggagcca
     2341 acacaaaaag gctccaacta tgcaaaagaa gaggatgaga agctgcccaa gccagtggtg
     2401 acatgggcaa gacgggaggc agatgggcag tccgggcagt ctgttctgtg ggatgctgtc
     2461 agagagaatg agtacacgtc tttacattta taaacttact cagaatgcag aacacatgca
     2521 aactgtagcg tatgtagcac atgttagcaa cagaggagac tgtaggtgtg gggacagcag
     2581 gaaatgggac tgctcctagt gttgctgtga actgaaaaaa acaaacagtc tgcgataatt
     2641 agtttttatt tgctgacaaa gtgtaataga tacacaacag cttacaggga gggaagattt
     2701 gtgtggctcc actcattggc tccactgggt tggaactgtg gagcagtatg tgccaaaatg
     2761 actgtttact tactcatggt ggctgagaaa cagagtggaa agcacctctc tacacaatct
     2821 tctaaacaac aggccagtga gctggctcca tggataaagg catttggcgc caaacccaga
     2881 aggcctaaga tcagtctctg gcacctacat aatggaagca aaacactgac tttcacctac
     2941 tgtctgtcct ctgccctccc cttaagcact gtggcatttg cacttatact cattttattt
     3001 ttttttttta aatgcaacca ttttattttt gtttataaag ggtctcctaa ttagcaatat
     3061 tactccccag gactgttttg gactgttttc tcacttggta tctgaaggct gactgggatg
     3121 cacaatgtgg cccaggccca agctggcact gcactcactg taatctcgtt tccatgctgc
     3181 cgaacctgga tccctatttt aaactatatt gatggaatgc acactttgct ttgtatgtta
     3241 gcttcattaa tgttaatagt gtgtgtggta tgttgcaaaa tgtatggaaa tactaataaa
     3301 gatgatcttg tgctttatgt gagattcaga agaacatatt gctaaaaggc aaaaaataaa
     3361 aataaaaaag gagattgtag ggagagagaa agaaatacat gtccagatag gtgtgctctt
     3421 atttaacatc tcttcttttt ttagaacatt ttctctgatt taacagggct gggggggggg
     3481 ggaacagagg acaaaatttt gtatgttaaa cataaaatgc atgaacttga tcttttaaat
     3541 aaaattttaa cattggtggc tgttaaaata aaaaa
//
