LOCUS       NM_008278               1719 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus hydroxyprostaglandin dehydrogenase 15 (NAD) (Hpgd),
            mRNA.
ACCESSION   NM_008278
VERSION     NM_008278.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Shu,L., Li,X., Liu,Z., Li,K., Shi,A., Tang,Y., Zhao,L., Huang,L.,
            Zhang,Z., Zhang,D., Huang,S., Lian,S., Sheng,G., Yan,Z., Zhang,Z.
            and Xu,Y.
  TITLE     Bile exosomal miR-182/183-5p increases cholangiocarcinoma stemness
            and progression by targeting HPGD and increasing PGE2 generation
  JOURNAL   Hepatology 79 (2), 307-322 (2024)
   PUBMED   37140231
  REMARK    GeneRIF: Bile exosomal miR-182/183-5p increases cholangiocarcinoma
            stemness and progression by targeting HPGD and increasing PGE2
            generation.
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Cui,Y., Lv,Z., Yang,Z. and Lei,J.
  TITLE     Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates
            Acute Murine Lung Allograft Rejection
  JOURNAL   Lung 201 (6), 591-601 (2023)
   PUBMED   37934242
  REMARK    GeneRIF: Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH
            Mitigates Acute Murine Lung Allograft Rejection.
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Choi,S.H., Huang,A.Y., Letterio,J.J. and Kim,B.G.
  TITLE     Smad4-deficient T cells promote colitis-associated colon cancer via
            an IFN-gamma-dependent suppression of 15-hydroxyprostaglandin
            dehydrogenase
  JOURNAL   Front Immunol 13, 932412 (2022)
   PUBMED   36045676
  REMARK    GeneRIF: Smad4-deficient T cells promote colitis-associated colon
            cancer via an IFN-gamma-dependent suppression of
            15-hydroxyprostaglandin dehydrogenase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Ho,W.J., Smith,J.N.P., Park,Y.S., Hadiono,M., Christo,K.,
            Jogasuria,A., Zhang,Y., Broncano,A.V., Kasturi,L., Dawson,D.M.,
            Gerson,S.L., Markowitz,S.D. and Desai,A.B.
  TITLE     15-PGDH regulates hematopoietic and gastrointestinal fitness during
            aging
  JOURNAL   PLoS One 17 (5), e0268787 (2022)
   PUBMED   35587945
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1719)
  AUTHORS   Backlund,M.G., Mann,J.R., Holla,V.R., Buchanan,F.G., Tai,H.H.,
            Musiek,E.S., Milne,G.L., Katkuri,S. and DuBois,R.N.
  TITLE     15-Hydroxyprostaglandin dehydrogenase is down-regulated in
            colorectal cancer
  JOURNAL   J Biol Chem 280 (5), 3217-3223 (2005)
   PUBMED   15542609
  REMARK    GeneRIF: novel tumor suppressive role for 15-PGDH due to loss of
            expression during colorectal tumor progression
REFERENCE   7  (bases 1 to 1719)
  AUTHORS   Coggins,K.G., Latour,A., Nguyen,M.S., Audoly,L., Coffman,T.M. and
            Koller,B.H.
  TITLE     Metabolism of PGE2 by prostaglandin dehydrogenase is essential for
            remodeling the ductus arteriosus
  JOURNAL   Nat Med 8 (2), 91-92 (2002)
   PUBMED   11821873
REFERENCE   8  (bases 1 to 1719)
  AUTHORS   Zhou,H., Yan,F. and Tai,H.H.
  TITLE     C-Terminal region of human NAD+-dependent 15-hydroxyprostaglandin
            dehydrogenase is involved in the interaction with prostaglandin
            substrates
  JOURNAL   Eur J Biochem 268 (12), 3368-3374 (2001)
   PUBMED   11422365
REFERENCE   9  (bases 1 to 1719)
  AUTHORS   Matsuo,M., Ensor,C.M. and Tai,H.H.
  TITLE     Characterization of the genomic structure and promoter of the mouse
            NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene
  JOURNAL   Biochem Biophys Res Commun 235 (3), 582-586 (1997)
   PUBMED   9207200
REFERENCE   10 (bases 1 to 1719)
  AUTHORS   Matsuo,M., Ensor,C.M. and Tai,H.H.
  TITLE     Cloning and expression of the cDNA for mouse NAD(+)-dependent
            15-hydroxyprostaglandin dehydrogenase
  JOURNAL   Biochim Biophys Acta 1309 (1-2), 21-24 (1996)
   PUBMED   8950170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB870447.1, AK146038.1 and BY581851.1.
            
            On Feb 6, 2007 this sequence version replaced NM_008278.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146038.1, BC021157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BB870447.1         2-34
            34-1716             AK146038.1         2-1684
            1717-1719           BY581851.1         404-406
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.7 cM"
     gene            1..1719
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /note="hydroxyprostaglandin dehydrogenase 15 (NAD)"
                     /db_xref="GeneID:15446"
                     /db_xref="MGI:MGI:108085"
     exon            1..161
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..878
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /EC_number="1.1.1.141"
                     /EC_number="1.1.1.232"
                     /note="15-hydroxyprostaglandin dehydrogenase; PGDH;
                     prostaglandin dehydrogenase 1; eicosanoid/docosanoid
                     dehydrogenase"
                     /codon_start=1
                     /product="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"
                     /protein_id="NP_032304.2"
                     /db_xref="CCDS:CCDS40341.1"
                     /db_xref="GeneID:15446"
                     /db_xref="MGI:MGI:108085"
                     /translation="MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVK
                     CKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQ
                     TLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIIG
                     FTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQIKAMMKFYG
                     VLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS"
     exon            162..285
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            286..392
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            393..489
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            490..566
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            567..730
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1719
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /note="hexamer: AATAAA"
     polyA_site      1717
                     /gene="Hpgd"
                     /gene_synonym="15-PGDH"
                     /note="major polyA site"
ORIGIN      
        1 gggctataaa agctgctgcg gcgtccagac tctgagctcg cccaccaccc gcagagacgc
       61 gacccgccat gcacgtgaac ggcaaagtgg ctctggtgac cggcgcggca cagggcatag
      121 gcaaagcctt cgctgaggct ctgctgctcc atggcgccaa ggtagcattg gtggattgga
      181 atcttgaggc aggtgtaaaa tgtaaagctg ccctagatga gcagttcgaa cctcagaaga
      241 cactgttcgt ccagtgtgat gtggctgacc agaaacaact gagagatact tttagaaaag
      301 ttgtagacca tttcggaaga ttggatattt tggtcaacaa tgcaggcgtg aacaatgaga
      361 aaaactggga acagactcta caaattaatt tggtttctgt tatcagtggg acctatcttg
      421 gtttggatta catgagtaag caaaacggag gtgaaggcgg catcatcatc aatatgtctt
      481 cattagcagg gctcatgcct gttgcgcagc aacctgttta ttgtgcttcg aagcacggca
      541 tcatcggatt cacacgctca gcagcgatgg ctgctaacct catgaaaagc ggtgtaagac
      601 tgaatgtcat ttgcccaggc tttgtggaca cacccatcct tgaatccatt gaaaaagaag
      661 aaaatatggg ccaatatata gaatataagg accagatcaa ggctatgatg aaattctatg
      721 gggttttaca cccatcaacc attgccaatg gattaataaa tctcattgaa gatgatgctc
      781 tcaatggtgc cattatgaag atcacggcat cgaaaggaat tcattttcaa gattatgaca
      841 tctctccatt actcgtaaaa gctccattaa cctcctaagc gtcagccata actgaaaccc
      901 agcacaagtg actcactcag actgcatctt tactagtgta gctttttcaa tgaaatgcca
      961 tacgatgaaa cctaccttcc tgtatctgat gttaatattt ttctaaatga ttagttgaat
     1021 gtgtggttaa acctttttga taagctaaca aaaatgcagt gcaaaccaaa actaggttat
     1081 aacctataaa atcttaaaga caaaacaaag gatattccag aaatattctg cctctcagaa
     1141 aacatattta taacagtgcc tcataaatat taatggtttt caggaagtca tcttaaagga
     1201 gatacttgaa ttgttattta agtcaaagca gattttaaat gattcacttc gtgtgtttgc
     1261 acttcaaaag cgggaagctc ctttacaatg gaaatattta gtaataaaag cttgtccggg
     1321 acctgcaagc gaaccattcc actctttgaa gcagtgctgt atttgcgggc cagtgttagg
     1381 gaatgagttc cagtgtggct gtgtcccagt gacacgtctg atgggtggga atgtgaaact
     1441 gttaccaaca ctgaaaactc acagttcagg tccaaatcaa ggaagatgat tttcttttcc
     1501 ttcctaattt aaaatttgta atggattcca aaaccctcag gaatgaaact tttaacagtc
     1561 atagcaaaat ggaggtgggt gtaaatttta tatatatata tatattgtat atgcttatta
     1621 tgaaatgatg caaatgtatt ttccagatta tttctctgtt ggtttgtacc attttcaaaa
     1681 gtgcctatct ttcaataaaa ctctgtattc taactcaca
//
