LOCUS       NM_028299               1214 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus histone PARylation factor 1 (Hpf1), transcript variant
            1, mRNA.
ACCESSION   NM_028299 XM_001474993 XM_910498
VERSION     NM_028299.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Sun,F.H., Zhao,P., Zhang,N., Kong,L.L., Wong,C.C.L. and Yun,C.H.
  TITLE     HPF1 remodels the active site of PARP1 to enable the serine
            ADP-ribosylation of histones
  JOURNAL   Nat Commun 12 (1), 1028 (2021)
   PUBMED   33589610
  REMARK    GeneRIF: HPF1 remodels the active site of PARP1 to enable the
            serine ADP-ribosylation of histones.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114920.7.
            
            On Mar 18, 2020 this sequence version replaced NM_028299.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012304.1, BC042740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC114920.7         98529-98637
            110-269             AC114920.7         101802-101961
            270-459             AC114920.7         103562-103751
            460-558             AC114920.7         104839-104937
            559-709             AC114920.7         108185-108335
            710-797             AC114920.7         112101-112188
            798-970             AC114920.7         113649-113821
            971-1214            AC114920.7         115438-115681
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 30.9 cM"
     gene            1..1214
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /note="histone PARylation factor 1"
                     /db_xref="GeneID:72612"
                     /db_xref="MGI:MGI:1919862"
     exon            1..109
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1102
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0609 protein C4orf27 homolog"
                     /codon_start=1
                     /product="histone PARylation factor 1 isoform 1"
                     /protein_id="NP_082575.1"
                     /db_xref="CCDS:CCDS52553.1"
                     /db_xref="GeneID:72612"
                     /db_xref="MGI:MGI:1919862"
                     /translation="MVGGGGKRRTAGAGPQCEKTVEVKKSKFSEADVSSDLRKEVENL
                     YKLSLPEDFYHFWKFCEELDPEKPADALATSLGLRLVGPYDILAGKHKMKKKPTGLNC
                     NLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDELPVYVGTNEAKKNCIIIQNGDN
                     VFAAIKLFLMKKLKEVTDRKKISILKNIDEKLTEAARKLGYSLEQRTVKMRQRDKKVV
                     TKTFHGAGLVVPVDKNDVGYRELPETDADLKRICKAVVDAASDEERLKAFAPIQEMMT
                     FVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRDLFAKIIEDHLA
                     SRSEENIDQLAG"
     exon            110..269
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            270..459
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            460..558
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            559..709
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            710..797
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            798..970
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1214
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1194..1199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /note="hexamer: ATTAAA"
     polyA_site      1214
                     /gene="Hpf1"
                     /gene_synonym="2700029M09Rik; C230006B22Rik; C4orf27"
                     /note="major polyA site"
ORIGIN      
        1 actagcgggc gctcggaagc ggcaggagcg cgggccttgg ctcgctcgct gcggctgcgg
       61 gatggttggc ggtggcggga agcgccggac ggccggggcg ggaccgcagt gtgaaaagac
      121 agttgaggtg aagaagagta agttttctga ggctgatgtc tccagtgacc ttcgaaaaga
      181 agtggaaaat ctttataagc tttcactgcc tgaagatttc tatcatttct ggaagttctg
      241 tgaagagctt gatcctgaaa agccagctga tgcgcttgcc acaagcctgg gtcttcggtt
      301 agtgggtcct tatgatatcc ttgctgggaa acataaaatg aagaaaaaac ccacaggctt
      361 gaactgtaat cttcactgga ggttttacta tgaccctcct gagttccaga ccattattat
      421 tggagataat aaaactcagt accacatggg gtatttcagg gattctcctg atgaacttcc
      481 tgtatacgtg ggtacaaatg aagcaaagaa aaattgtata attattcaaa atggagacaa
      541 tgtgtttgct gccatcaaat tatttttaat gaaaaaactc aaagaagtaa cagatagaaa
      601 gaaaattagc attttgaaaa acatagatga aaaactcaca gaagcagcca gaaaactagg
      661 atactcactg gaacagagaa ccgtgaagat gagacagaga gataagaagg ttgtgacaaa
      721 gacttttcat ggtgcaggct tggttgttcc agtagataaa aatgatgttg gttaccgaga
      781 gctccctgaa acagatgctg accttaagag aatctgcaag gcagttgtcg acgctgcaag
      841 cgacgaggag agactgaaag cattcgctcc cattcaggag atgatgactt ttgtgcagtt
      901 tgctaatgat gagtgtgatt atggcatggg gctggaatta ggaatggacc tcttttgcta
      961 tggctctcat tattttcaca aagttgctgg tcagctttta cctcttgcgt ataatctatt
     1021 gaagagggat ctgtttgcaa aaattattga agatcatctg gcaagcagaa gtgaagagaa
     1081 catagaccag cttgcaggat gaacaagctg ccctgttagt gcagtgcttt gaagtgggac
     1141 cagcagacgg ggctttgttt ttaaggaatg gagaaataaa taatgggaat tttattaaaa
     1201 actttataat acgg
//
